Item Type | Name |
Concept
|
Antibiotics, Antineoplastic
|
Concept
|
Ethanol
|
Concept
|
Amines
|
Concept
|
Acetylcysteine
|
Concept
|
Acetates
|
Concept
|
Acetylcholinesterase
|
Concept
|
Anti-Inflammatory Agents, Non-Steroidal
|
Concept
|
Alkaloids
|
Concept
|
Boronic Acids
|
Concept
|
Analgesics, Opioid
|
Concept
|
Antimetabolites, Antineoplastic
|
Concept
|
Antiviral Agents
|
Concept
|
Alkynes
|
Concept
|
Anabasine
|
Concept
|
Antineoplastic Agents
|
Concept
|
Bacterial Proteins
|
Concept
|
Benzyl Compounds
|
Concept
|
Carboxy-Lyases
|
Concept
|
Biphenyl Compounds
|
Concept
|
Carboxylic Acids
|
Concept
|
Alcohol Deterrents
|
Concept
|
Cyclohexanols
|
Concept
|
Choline
|
Concept
|
Benzazepines
|
Concept
|
Benzofurans
|
Concept
|
Codeine
|
Concept
|
Cisplatin
|
Concept
|
Anti-Infective Agents
|
Concept
|
Butyrylcholinesterase
|
Concept
|
Deoxyglucose
|
Concept
|
Aerosols
|
Concept
|
Agmatine
|
Concept
|
Anti-Bacterial Agents
|
Concept
|
Dactinomycin
|
Concept
|
Dihydroxyphenylalanine
|
Concept
|
Drug Tolerance
|
Concept
|
Drug Evaluation, Preclinical
|
Concept
|
Dihydromorphine
|
Concept
|
Estrenes
|
Concept
|
Dextromethorphan
|
Concept
|
Antineoplastic Agents, Phytogenic
|
Concept
|
Antitubercular Agents
|
Concept
|
Acetamides
|
Concept
|
Acetonitriles
|
Concept
|
Anticonvulsants
|
Concept
|
Analgesics
|
Concept
|
Angiotensin-Converting Enzyme Inhibitors
|
Concept
|
Antifungal Agents
|
Concept
|
Antioxidants
|
Concept
|
Central Nervous System Stimulants
|
Concept
|
Arginine
|
Concept
|
Amino Acids
|
Concept
|
Amphetamine
|
Concept
|
Antihypertensive Agents
|
Concept
|
Acrylonitrile
|
Concept
|
Acetylcholine
|
Concept
|
Aminobutyrates
|
Concept
|
Aniline Compounds
|
Concept
|
Arginine-tRNA Ligase
|
Concept
|
Adhesives
|
Concept
|
Antibodies, Monoclonal
|
Concept
|
Aconitine
|
Concept
|
Aminopyrine
|
Concept
|
Quaternary Ammonium Compounds
|
Concept
|
Anti-Inflammatory Agents
|
Concept
|
Adrenergic beta-Antagonists
|
Concept
|
Aldehydes
|
Concept
|
Glass
|
Concept
|
Glutathione Peroxidase
|
Concept
|
Guanidines
|
Concept
|
Octanols
|
Concept
|
Azetidines
|
Concept
|
Amides
|
Concept
|
Immunotoxins
|
Concept
|
Estradiol
|
Concept
|
Benzylidene Compounds
|
Concept
|
Benzopyrans
|
Concept
|
Caproates
|
Concept
|
Carbonates
|
Concept
|
Formates
|
Concept
|
Cations
|
Concept
|
Boron
|
Concept
|
Carbamates
|
Concept
|
Fluorouracil
|
Concept
|
Guaiacol
|
Concept
|
Dopa Decarboxylase
|
Concept
|
Drug Combinations
|
Concept
|
Esters
|
Concept
|
Aza Compounds
|
Concept
|
Benzylamines
|
Concept
|
Caffeine
|
Concept
|
Dopamine
|
Concept
|
Dose-Response Relationship, Drug
|
Concept
|
DNA-Directed DNA Polymerase
|
Concept
|
Drug Utilization
|
Concept
|
Carrier Proteins
|
Concept
|
Canavanine
|
Concept
|
Chelating Agents
|
Concept
|
Atenolol
|
Concept
|
Benzene
|
Concept
|
Binding Sites
|
Concept
|
Butyrates
|
Concept
|
Cannabinoids
|
Concept
|
Gels
|
Concept
|
Cholinesterase Inhibitors
|
Concept
|
Colchicine
|
Concept
|
Crystallization
|
Concept
|
Cytoskeletal Proteins
|
Concept
|
Delayed-Action Preparations
|
Concept
|
Hydrazines
|
Concept
|
Chromones
|
Concept
|
Cocaine
|
Concept
|
Base Sequence
|
Concept
|
Cellulose, Oxidized
|
Concept
|
Chlorobenzoates
|
Concept
|
Isoquinolines
|
Concept
|
Carcinogens
|
Concept
|
Catalase
|
Concept
|
Hydrogen
|
Concept
|
Deoxyribonuclease I
|
Concept
|
Dioxolanes
|
Concept
|
Drug Resistance
|
Concept
|
Pharmaceutical Preparations
|
Concept
|
Ketamine
|
Concept
|
Drug Carriers
|
Concept
|
Enzyme Inhibitors
|
Concept
|
Solvents
|
Concept
|
Sulfhydryl Compounds
|
Concept
|
Transcription Factors
|
Concept
|
Dipeptides
|
Concept
|
DNA-Binding Proteins
|
Concept
|
Morphine
|
Concept
|
Fluorescent Dyes
|
Concept
|
Food
|
Concept
|
Drugs, Investigational
|
Concept
|
Formaldehyde
|
Concept
|
Drug Synergism
|
Concept
|
Prostaglandin-Endoperoxide Synthases
|
Concept
|
Polyethylene Glycols
|
Concept
|
Prodrugs
|
Concept
|
Promoter Regions, Genetic
|
Concept
|
Pyrimidines
|
Concept
|
Reserpine
|
Concept
|
Nomifensine
|
Concept
|
Indolizines
|
Concept
|
Quinoxalines
|
Concept
|
Cytotoxins
|
Concept
|
Membrane Proteins
|
Concept
|
Stereoisomerism
|
Concept
|
Streptozocin
|
Concept
|
Sucrose
|
Concept
|
Tablets
|
Concept
|
Membrane Glycoproteins
|
Concept
|
Sulfones
|
Concept
|
Plant Extracts
|
Concept
|
Oxygen
|
Concept
|
Pregnanes
|
Concept
|
Protein Disulfide Reductase (Glutathione)
|
Concept
|
Sulfates
|
Concept
|
Triazoles
|
Concept
|
Growth Inhibitors
|
Concept
|
Polyamines
|
Concept
|
Tritium
|
Concept
|
Vinyl Compounds
|
Concept
|
2,2'-Dipyridyl
|
Concept
|
Drug Design
|
Concept
|
Amyloid beta-Peptides
|
Concept
|
Phenylurea Compounds
|
Concept
|
Receptors, Cholinergic
|
Concept
|
Sesquiterpenes
|
Concept
|
Protein Subunits
|
Concept
|
Indole Alkaloids
|
Concept
|
Neurotransmitter Agents
|
Concept
|
Muscarinic Antagonists
|
Concept
|
Cytochrome P-450 CYP1A2
|
Concept
|
Semicarbazones
|
Concept
|
Urea
|
Concept
|
Vincristine
|
Concept
|
Receptors, N-Methyl-D-Aspartate
|
Concept
|
Receptors, Opioid, kappa
|
Concept
|
Dialysis Solutions
|
Concept
|
Tryptophan
|
Concept
|
Urethane
|
Concept
|
Pregnanolone
|
Concept
|
Proteins
|
Concept
|
Superoxide Dismutase
|
Concept
|
Barbiturates
|
Concept
|
Calcium
|
Concept
|
RNA, Small Interfering
|
Concept
|
NADP
|
Concept
|
Cholinergic Antagonists
|
Concept
|
Phosphoserine
|
Concept
|
Quinuclidines
|
Concept
|
RNA
|
Concept
|
Morphine Derivatives
|
Concept
|
Nicotine
|
Concept
|
Peptide Fragments
|
Concept
|
Pyrazines
|
Concept
|
Reference Standards
|
Concept
|
GTP-Binding Proteins
|
Concept
|
Timolol
|
Concept
|
Valerates
|
Concept
|
Guanidine
|
Concept
|
Nicotinic Agonists
|
Concept
|
Cyclooxygenase 2
|
Concept
|
BRCA1 Protein
|
Concept
|
Ubiquitin
|
Concept
|
DNA-(Apurinic or Apyrimidinic Site) Lyase
|
Concept
|
Recombinant Proteins
|
Concept
|
Salts
|
Concept
|
Mitogen-Activated Protein Kinase 9
|
Concept
|
Tetradecanoylphorbol Acetate
|
Concept
|
Neurotransmitter Uptake Inhibitors
|
Concept
|
Cotinine
|
Concept
|
Coumarins
|
Concept
|
Granulocyte Colony-Stimulating Factor
|
Concept
|
Proto-Oncogene Proteins p21(ras)
|
Concept
|
Cyclin A
|
Concept
|
Membrane Transport Modulators
|
Concept
|
NF-kappa B p52 Subunit
|
Concept
|
Vesicular Monoamine Transport Proteins
|
Concept
|
Cyclooxygenase 2 Inhibitors
|
Concept
|
Succinates
|
Concept
|
Large Neutral Amino Acid-Transporter 1
|
Concept
|
Neuroprotective Agents
|
Concept
|
Tyrosine 3-Monooxygenase
|
Concept
|
Mitochondrial Proteins
|
Concept
|
RNA Helicases
|
Concept
|
Drug Stability
|
Concept
|
Hydrazones
|
Concept
|
Glutathione
|
Concept
|
Vesicular Biogenic Amine Transport Proteins
|
Concept
|
Paraquat
|
Concept
|
Propionates
|
Concept
|
Rubidium
|
Concept
|
Serotonin Plasma Membrane Transport Proteins
|
Concept
|
Glutamate-Cysteine Ligase
|
Concept
|
DNA
|
Concept
|
Drug Interactions
|
Concept
|
Formamides
|
Concept
|
Melphalan
|
Concept
|
NAD
|
Concept
|
Narcotic Antagonists
|
Concept
|
Nitrosamines
|
Concept
|
Piperazines
|
Concept
|
Tetrazoles
|
Concept
|
NF-kappa B
|
Concept
|
Angiogenesis Inhibitors
|
Concept
|
Chitosan
|
Concept
|
Neuropeptides
|
Concept
|
Radiation-Protective Agents
|
Concept
|
RNA, Messenger
|
Concept
|
Vancomycin
|
Concept
|
Durapatite
|
Concept
|
Histones
|
Concept
|
Sulindac
|
Concept
|
Thiobarbiturates
|
Concept
|
Tumor Suppressor Protein p53
|
Concept
|
Dihydro-beta-Erythroidine
|
Concept
|
Environmental Pollutants
|
Concept
|
omega-N-Methylarginine
|
Concept
|
Receptors, Opioid, delta
|
Concept
|
Adrenergic Uptake Inhibitors
|
Concept
|
Chemokines, C
|
Concept
|
Taxoids
|
Concept
|
BH3 Interacting Domain Death Agonist Protein
|
Concept
|
Benzodioxoles
|
Concept
|
Mecamylamine
|
Concept
|
beta-Cyclodextrins
|
Concept
|
PTEN Phosphohydrolase
|
Concept
|
Rad51 Recombinase
|
Concept
|
Benzothiazoles
|
Concept
|
DNA Primers
|
Concept
|
Serotonin Antagonists
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
Concept
|
bcl-X Protein
|
Concept
|
Ethacrynic Acid
|
Concept
|
Glucose
|
Concept
|
Small Molecule Libraries
|
Concept
|
Vitamin E
|
Concept
|
Cannabinoid Receptor Agonists
|
Concept
|
3,4-Dihydroxyphenylacetic Acid
|
Concept
|
Luminol
|
Concept
|
Excitatory Amino Acid Antagonists
|
Concept
|
Drug Delivery Systems
|
Concept
|
Drug Therapy, Combination
|
Concept
|
Excipients
|
Concept
|
Dopamine Uptake Inhibitors
|
Concept
|
Plasma Membrane Neurotransmitter Transport Proteins
|
Concept
|
Deoxycytidine
|
Concept
|
Blood Glucose
|
Concept
|
Bungarotoxins
|
Concept
|
Drug Discovery
|
Concept
|
Drug Repositioning
|
Concept
|
Antigens, CD34
|
Concept
|
Drug Therapy
|
Concept
|
Conotoxins
|
Concept
|
Naltrexone
|
Concept
|
Thiazoles
|
Concept
|
Lactones
|
Concept
|
Multienzyme Complexes
|
Concept
|
Tromethamine
|
Concept
|
Drug Inverse Agonism
|
Concept
|
Tubulin Modulators
|
Concept
|
Neurotransmitter Transport Proteins
|
Concept
|
Fentanyl
|
Concept
|
Endodeoxyribonucleases
|
Concept
|
Nucleic Acid Synthesis Inhibitors
|
Concept
|
Sirolimus
|
Concept
|
Mutant Chimeric Proteins
|
Concept
|
Nerve Tissue Proteins
|
Concept
|
Ligands
|
Concept
|
Iodine Radioisotopes
|
Concept
|
Indoles
|
Concept
|
Hydroquinones
|
Concept
|
Imidazoles
|
Concept
|
Heterocyclic Compounds
|
Concept
|
Heterocyclic Compounds, 2-Ring
|
Concept
|
Indomethacin
|
Concept
|
Isoxazoles
|
Concept
|
Hypoglycemic Agents
|
Concept
|
Insecticides
|
Concept
|
Drug-Seeking Behavior
|
Concept
|
Lobeline
|
Concept
|
Ganglionic Stimulants
|
Concept
|
NADH, NADPH Oxidoreductases
|
Concept
|
Norepinephrine
|
Concept
|
Serotonin
|
Concept
|
Sulfuric Acids
|
Concept
|
Octanes
|
Concept
|
Methamphetamine
|
Concept
|
Naphthalenes
|
Concept
|
Oligopeptides
|
Concept
|
Thiophenes
|
Concept
|
Norepinephrine Plasma Membrane Transport Proteins
|
Concept
|
Psychotropic Drugs
|
Concept
|
Pyridinium Compounds
|
Concept
|
Stilbenes
|
Concept
|
Teratogens
|
Concept
|
Oxycodone
|
Concept
|
Piperidines
|
Concept
|
Pyrazoles
|
Concept
|
Receptors, Nicotinic
|
Concept
|
Pyridines
|
Concept
|
Ki-67 Antigen
|
Concept
|
Dinoprostone
|
Concept
|
Viral Nonstructural Proteins
|
Concept
|
Picolines
|
Concept
|
Phosphatidylinositol 3-Kinases
|
Concept
|
Nicotinic Antagonists
|
Concept
|
Radiation-Sensitizing Agents
|
Concept
|
Toxins, Biological
|
Concept
|
Glucuronosyltransferase
|
Concept
|
Water
|
Concept
|
Tubulin
|
Concept
|
Receptor, Cannabinoid, CB1
|
Concept
|
Thiadiazoles
|
Concept
|
Tetracycline
|
Concept
|
Intracellular Signaling Peptides and Proteins
|
Concept
|
Phosphoprotein Phosphatases
|
Concept
|
Tosyl Compounds
|
Concept
|
Anticarcinogenic Agents
|
Concept
|
Sulfonamides
|
Concept
|
Bupropion
|
Concept
|
Cyclooxygenase Inhibitors
|
Concept
|
Pyrrolidines
|
Concept
|
Oxyquinoline
|
Concept
|
Reactive Oxygen Species
|
Concept
|
I-kappa B Proteins
|
Concept
|
Tetrabenazine
|
Concept
|
Thiazines
|
Concept
|
Apoptosis
|
Concept
|
Thioredoxins
|
Concept
|
Cyclin D1
|
Concept
|
Membrane Transport Proteins
|
Concept
|
Tropanes
|
Concept
|
Cholinergic Agonists
|
Concept
|
Receptors, Opioid, mu
|
Concept
|
Glucuronides
|
Concept
|
Drug Resistance, Neoplasm
|
Concept
|
Imidazolidines
|
Concept
|
Dopamine Plasma Membrane Transport Proteins
|
Concept
|
Myeloablative Agonists
|
Concept
|
Molecular Chaperones
|
Concept
|
Drug Partial Agonism
|
Concept
|
bcl-2-Associated X Protein
|
Concept
|
Ether-A-Go-Go Potassium Channels
|
Concept
|
NF-E2-Related Factor 2
|
Concept
|
Chromatin
|
Concept
|
Dioxanes
|
Concept
|
Drug Administration Schedule
|
Concept
|
Drug Screening Assays, Antitumor
|
Concept
|
Benzoquinones
|
Concept
|
gamma-Cyclodextrins
|
Concept
|
Caspase 3
|
Concept
|
Neoplasm Proteins
|
Concept
|
Norbornanes
|
Concept
|
Proto-Oncogene Proteins c-bcl-2
|
Concept
|
Receptor, Cannabinoid, CB2
|
Concept
|
Oncogene Protein v-akt
|
Concept
|
Forkhead Transcription Factors
|
Concept
|
Cyclooctanes
|
Concept
|
Transcription Factor RelA
|
Concept
|
TOR Serine-Threonine Kinases
|
Concept
|
Phosphates
|
Concept
|
Hemicholinium 3
|
Concept
|
Proto-Oncogene Proteins c-akt
|
Concept
|
Mineral Oil
|
Concept
|
Mucins
|
Concept
|
Nuclear Proteins
|
Concept
|
Progesterone
|
Concept
|
Recombinant Fusion Proteins
|
Concept
|
Rubidium Radioisotopes
|
Concept
|
Cytokines
|
Concept
|
Symporters
|
Concept
|
Thiazolidines
|
Academic Article
|
Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation.
|
Academic Article
|
Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.
|
Academic Article
|
Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs.
|
Academic Article
|
Novel cytoprotective inhibitors for apoptotic endonuclease G.
|
Academic Article
|
Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4.
|
Academic Article
|
Enhancement of transdermal delivery of 6-beta-naltrexol via a codrug linked to hydroxybupropion.
|
Academic Article
|
Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).
|
Academic Article
|
L-Canavanine as a radiosensitization agent for human pancreatic cancer cells.
|
Academic Article
|
An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine.
|
Academic Article
|
A duplex "Gemini" prodrug of naltrexone for transdermal delivery.
|
Academic Article
|
N-n-alkylnicotinium analogs, a novel class of nicotinic receptor antagonist: inhibition of S(-)-nicotine-evoked [(3)H]dopamine overflow from superfused rat striatal slices.
|
Academic Article
|
Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin equivalent.
|
Academic Article
|
Evaluation of O(3alpha)-, O(21)-di-(N(1)-methyloxycarbonyl-2, 4-dioxo-5-fluoropyrimidinyl) 17alpha-hydroxy-5beta-pregnan-20-one as a novel potential antiangiogenic codrug.
|
Academic Article
|
An HPLC method for the simultaneous determination of neurotoxic dipyridyl isomers in human plasma.
|
Academic Article
|
Effects of norketamine enantiomers in rodent models of persistent pain.
|
Academic Article
|
The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins.
|
Academic Article
|
Synthesis and antitubercular activity of a series of hydrazone and nitrovinyl analogs derived from heterocyclic aldehydes.
|
Academic Article
|
Lobelane decreases methamphetamine self-administration in rats.
|
Academic Article
|
Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery.
|
Academic Article
|
Antileukemic activity of aminoparthenolide analogs.
|
Academic Article
|
In vivo evaluation of 3-O-alkyl ester transdermal prodrugs of naltrexone in hairless guinea pigs.
|
Academic Article
|
In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.
|
Academic Article
|
Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence.
|
Academic Article
|
The antiproliferative and immunotoxic effects of L-canavanine and L-canaline.
|
Academic Article
|
Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents.
|
Academic Article
|
The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery.
|
Academic Article
|
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
|
Academic Article
|
Physicochemical evaluation, in vitro human skin diffusion, and concurrent biotransformation of 3-O-alkyl carbonate prodrugs of naltrexone.
|
Academic Article
|
Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
|
Academic Article
|
Indolyl-quinuclidinols inhibit ENOX activity and endothelial cell morphogenesis while enhancing radiation-mediated control of tumor vasculature.
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Academic Article
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Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines.
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Academic Article
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Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter.
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Academic Article
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Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents.
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Academic Article
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The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.
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Academic Article
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Nicotinic receptor antagonists as treatments for nicotine abuse.
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Academic Article
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One-pot multicomponent synthesis of indole incorporated thiazolylcoumarins and their antibacterial, anticancer and DNA cleavage studies.
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Academic Article
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Synthesis and in vitro stability of amino acid prodrugs of 6-?-naltrexol for microneedle-enhanced transdermal delivery.
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Academic Article
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Scopolamine sublingual spray: an alternative route of delivery for the treatment of motion sickness.
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Academic Article
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Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture.
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Academic Article
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The mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery.
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Academic Article
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The effects of a novel nicotinic receptor antagonist N,N-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) on acute and repeated nicotine-induced increases in extracellular dopamine in rat nucleus accumbens.
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Academic Article
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In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin.
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Academic Article
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Pharmacokinetics of the novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide in the rat.
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Academic Article
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In vitro release studies on matrix type transdermal drug delivery systems of naltrexone and its acetyl prodrug.
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Academic Article
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Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach.
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Academic Article
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Effect of celecoxib and the novel anti-cancer agent, dimethylamino-parthenolide, in a developmental model of pancreatic cancer.
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Academic Article
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Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2.
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Academic Article
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Vesicular monoamine transporter 2: role as a novel target for drug development.
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Academic Article
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A pharmacokinetic study on Z-(+/-)-2-(1-benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol; a novel radio-sensitization agent.
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Academic Article
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Phenyl ring-substituted lobelane analogs: inhibition of [?H]dopamine uptake at the vesicular monoamine transporter-2.
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Academic Article
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Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones.
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Academic Article
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bPiDI: a novel selective a6?2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse.
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Academic Article
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Inhibition of NF-?B and DNA double-strand break repair by DMAPT sensitizes non-small-cell lung cancers to X-rays.
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Academic Article
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Human skin permeation of branched-chain 3-0-alkyl ester and carbonate prodrugs of naltrexone.
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Academic Article
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Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release.
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Academic Article
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N-n-alkylnicotinium analogs, a novel class of antagonists at alpha 4 beta 2* nicotinic acetylcholine receptors: inhibition of S(-)-nicotine-evoked 86Rb+ efflux from rat thalamic synaptosomes.
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Academic Article
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Nornicotine inhibition of dopamine transporter function in striatum via nicotinic receptor activation.
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Academic Article
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Design, synthesis and interaction at the vesicular monoamine transporter-2 of lobeline analogs: potential pharmacotherapies for the treatment of psychostimulant abuse.
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Academic Article
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Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.
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Academic Article
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Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
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Academic Article
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Nicotinic receptor-based therapeutics and candidates for smoking cessation.
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Academic Article
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The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
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Academic Article
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bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.
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Academic Article
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The effect of VMAT2 inhibitor GZ-793A on the reinstatement of methamphetamine-seeking in rats.
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Academic Article
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Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.
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Academic Article
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Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents.
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Academic Article
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Antinociceptive effects and toxicity of morphine-6-O-sulfate sodium salt in rat models of pain.
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Academic Article
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Oral administration of GZ-793A, a VMAT2 inhibitor, decreases methamphetamine self-administration in rats.
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Academic Article
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Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release.
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Academic Article
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The novel nicotinic receptor antagonist N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide decreases nicotine-induced dopamine metabolism in rat nucleus accumbens.
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Academic Article
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The NF-kappaB inhibitor LC-1 has single agent activity in multiple myeloma cells and synergizes with bortezomib.
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Academic Article
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The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
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Academic Article
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Dimers of Melampomagnolide B Exhibit Potent Anticancer Activity against Hematological and Solid Tumor Cells.
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Academic Article
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Discovery of non-peptide, small molecule antagonists of a9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.
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Academic Article
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Anti-cancer activity of carbamate derivatives of melampomagnolide B.
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Academic Article
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Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs.
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Academic Article
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The effect of a novel VMAT2 inhibitor, GZ-793A, on methamphetamine reward in rats.
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Academic Article
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Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells.
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Academic Article
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5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties.
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Academic Article
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Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.
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Academic Article
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Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines.
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Academic Article
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Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes.
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Academic Article
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Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone.
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Academic Article
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1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1).
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Academic Article
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Effect of celecoxib and novel agent LC-1 in a hamster model of lung cancer.
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Academic Article
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Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells.
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Academic Article
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1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2.
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Academic Article
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Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
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Academic Article
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Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells.
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Academic Article
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N-[11CH3]Dimethylaminoparthenolide (DMAPT) uptake into orthotopic 9LSF glioblastoma tumors in the rat.
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Academic Article
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Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells.
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Academic Article
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Identification of resveratrol analogs as potent anti-dengue agents using a cell-based assay.
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Academic Article
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Identification of a melampomagnolide B analog as a potential lead molecule for treatment of acute myelogenous leukemia.
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Academic Article
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Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells.
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Academic Article
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Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors.
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Academic Article
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Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats.
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Academic Article
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Succinamide derivatives of melampomagnolide B and their anti-cancer activities.
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Academic Article
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Stability studies of potent opioid analgesic, morphine-6-O-sulfate in various buffers and biological matrices by HPLC-DAD analysis.
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Academic Article
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The analgesic and toxic effects of nornicotine enantiomers alone and in interaction with morphine in rodent models of acute and persistent pain.
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Academic Article
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Interaction between morphine and norketamine enantiomers in rodent models of nociception.
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Academic Article
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Bioavailability of ??-tetrahydrocannabinol following intranasal administration of a mucoadhesive gel spray delivery system in conscious rabbits.
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Academic Article
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Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats.
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Academic Article
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Characterization of structurally novel G protein biased CB1 agonists: Implications for drug development.
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Academic Article
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A novel chemical delivery system comprising an ocular sustained release formulation of a 3alpha, 17alpha, 21-trihydroxy-5beta-pregnan-20-one-BIS-5-fluorouracil [correction of flourouracil] codrug.
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Academic Article
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Development of a GC-MS assay for the determination of fentanyl pharmacokinetics in rabbit plasma after sublingual spray delivery.
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Academic Article
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Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents.
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Academic Article
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Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats.
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Academic Article
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Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence.
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Academic Article
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MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells.
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Academic Article
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An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic a6?2* antagonist r-bPiDI.
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Academic Article
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Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells.
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Academic Article
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A novel tetrazole analogue of resveratrol is a potent anticancer agent.
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Academic Article
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N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
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Grant
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Early Events in Alzheimer Pathogenesis
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Academic Article
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Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein-Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with ?9-Tetrahydrocannabinol and JWH-018.
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Grant
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Use of precision deuteration to determine the contribution of norbuprenorphine to buprenorphine-associated neonatal abstinence syndrome
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Academic Article
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GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine.
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Academic Article
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Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence.
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Academic Article
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Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases.
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Academic Article
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A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease.
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Academic Article
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Deuteration of the farnesyl terminal methyl groups of d-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.
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Academic Article
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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of A? Self-Aggregation and Metal Chelation-Induced A? Aggregation.
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Academic Article
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7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands.
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Academic Article
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A pharmacokinetic study of morphine-6-O-sulfate in rat plasma and brain.
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Academic Article
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International care models for chronic kidney disease: methods and economics--United States.
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Academic Article
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Tablet formulation studies on nimesulide and meloxicam-cyclodextrin binary systems.
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Academic Article
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Antitumor properties of novel sesquiterpene lactone analogs as NF?B inhibitors that bind to the IKK? ubiquitin-like domain (ULD).
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Academic Article
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Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
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Academic Article
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Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion.
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Academic Article
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Selected Antihypertensive Agents and Their Fixed-Dose Combinations Effectively Ameliorate Trastuzumab-Mediated Cardiac Dysfunction In Rats.
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