 Antifungal Agents
"Antifungal Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
| Descriptor ID |
D000935
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| MeSH Number(s) |
D27.505.954.122.136
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| Concept/Terms |
Antifungal Agents- Antifungal Agents
- Agents, Antifungal
- Fungicides, Therapeutic
- Therapeutic Fungicides
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Below are MeSH descriptors whose meaning is more general than "Antifungal Agents".
Below are MeSH descriptors whose meaning is more specific than "Antifungal Agents".
This graph shows the total number of publications written about "Antifungal Agents" by people in UAMS Profiles by year, and whether "Antifungal Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 1 | 4 | 5 | | 2022 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2020 | 4 | 3 | 7 | | 2019 | 4 | 1 | 5 | | 2018 | 1 | 2 | 3 | | 2017 | 3 | 2 | 5 | | 2016 | 6 | 1 | 7 | | 2015 | 4 | 2 | 6 | | 2014 | 5 | 3 | 8 | | 2013 | 3 | 0 | 3 | | 2012 | 2 | 4 | 6 | | 2011 | 5 | 1 | 6 | | 2010 | 5 | 6 | 11 | | 2009 | 6 | 3 | 9 | | 2008 | 2 | 4 | 6 | | 2007 | 6 | 1 | 7 | | 2006 | 6 | 1 | 7 | | 2005 | 9 | 2 | 11 | | 2004 | 3 | 3 | 6 | | 2003 | 8 | 1 | 9 | | 2002 | 3 | 2 | 5 | | 2001 | 2 | 0 | 2 | | 2000 | 2 | 0 | 2 | | 1999 | 3 | 0 | 3 | | 1998 | 4 | 3 | 7 | | 1997 | 3 | 2 | 5 | | 1996 | 4 | 0 | 4 | | 1995 | 3 | 0 | 3 | | 1994 | 3 | 1 | 4 | | 1993 | 1 | 0 | 1 | | 1992 | 2 | 0 | 2 | | 1991 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Antifungal Agents" by people in Profiles over the past ten years.
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Nucci M, Anaissie E. Invasive fusariosis. Clin Microbiol Rev. 2023 12 20; 36(4):e0015922.
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Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature. 2023 Nov; 623(7989):1079-1085.
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Rivera A, Young Lim W, Park E, Dome PA, Hoy MJ, Spasojevic I, Sun S, Averette AF, Pina-Oviedo S, Juvvadi PR, Steinbach WJ, Ciofani M, Hong J, Heitman J. Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans. mBio. 2023 Oct 31; 14(5):e0181023.
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Marquez L, Lee Y, Duncan D, Whitesell L, Cowen LE, Quave C. Potent Antifungal Activity of Penta-O-galloyl-?-d-Glucose against Drug-Resistant Candida albicans, Candida auris, and Other Non-albicans Candida Species. ACS Infect Dis. 2023 09 08; 9(9):1685-1694.
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Naeem F, McCarty J, Rowe MR, Davis AW, Tablizo MA, Hady KK, Vijayan V. Pediatric Laryngeal Coccidioidomycosis: A Case Series in an Endemic Region. Pediatr Infect Dis J. 2023 08 01; 42(8):654-659.
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Otto WR, Dvorak CC, Boge CLK, Ostrosky-Zeichner L, Esbenshade AJ, Nieder ML, Alexander S, Steinbach WJ, Dang H, Villaluna D, Chen L, Skeens M, Zaoutis TE, Sung L, Fisher BT. Prospective Evaluation of the Fungitell? (1?3) Beta-D-Glucan Assay as a Diagnostic Tool for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplantation: A?Report from the Children's Oncology Group. Pediatr Transplant. 2023 02; 27(1):e14399.
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Nucci M, Jenks J, Thompson GR, Hoenigl M, Dos Santos MC, Forghieri F, Rico JC, Bonuomo V, L?pez-Soria L, Lass-Fl?rl C, Candoni A, Garcia-Vidal C, Cattaneo C, Buil J, Rabagliati R, Roiz MP, Gudiol C, Fracchiolla N, Campos-Herrero MI, Delia M, Farina F, Fortun J, Nadali G, Sastre E, Colombo AL, P?rez Nadales E, Alastruey-Izquierdo A, Pagano L. Do high MICs predict the outcome in invasive fusariosis? J Antimicrob Chemother. 2021 03 12; 76(4):1063-1069.
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Steinbach WJ. Latest Thoughts on Treating Pediatric Mucormycosis. J Pediatric Infect Dis Soc. 2020 Nov 10; 9(5):640-644.
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Roundtree MT, Juvvadi PR, Shwab EK, Cole DC, Steinbach WJ. Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors. Antimicrob Agents Chemother. 2020 09 21; 64(10).
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Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, Clancy CJ, Wingard JR, Lockhart SR, Groll AH, Sorrell TC, Bassetti M, Akan H, Alexander BD, Andes D, Azoulay E, Bialek R, Bradsher RW, Bretagne S, Calandra T, Caliendo AM, Castagnola E, Cruciani M, Cuenca-Estrella M, Decker CF, Desai SR, Fisher B, Harrison T, Heussel CP, Jensen HE, Kibbler CC, Kontoyiannis DP, Kullberg BJ, Lagrou K, Lamoth F, Lehrnbecher T, Loeffler J, Lortholary O, Maertens J, Marchetti O, Marr KA, Masur H, Meis JF, Morrisey CO, Nucci M, Ostrosky-Zeichner L, Pagano L, Patterson TF, Perfect JR, Racil Z, Roilides E, Ruhnke M, Prokop CS, Shoham S, Slavin MA, Stevens DA, Thompson GR, Vazquez JA, Viscoli C, Walsh TJ, Warris A, Wheat LJ, White PL, Zaoutis TE, Pappas PG. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2020 09 12; 71(6):1367-1376.
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Assress HA, Selvarajan R, Nyoni H, Ogola HJO, Mamba BB, Msagati TAM. Azole antifungal resistance in fungal isolates from wastewater treatment plant effluents. Environ Sci Pollut Res Int. 2021 Jan; 28(3):3217-3229.
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Groll AH, Abdel-Azim H, Lehrnbecher T, Steinbach WJ, Paschke A, Mangin E, Winchell GA, Waskin H, Bruno CJ. Pharmacokinetics and safety of posaconazole intravenous solution and powder for oral suspension in children with neutropenia: an open-label, sequential dose-escalation trial. Int J Antimicrob Agents. 2020 Sep; 56(3):106084.
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Lehrnbecher T, Fisher BT, Phillips B, Beauchemin M, Carlesse F, Castagnola E, Duong N, Dupuis LL, Fioravantti V, Groll AH, Haeusler GM, Roilides E, Science M, Steinbach WJ, Tissing W, Warris A, Patel P, Robinson PD, Sung L. Clinical Practice Guideline for Systemic Antifungal Prophylaxis in Pediatric Patients With Cancer and Hematopoietic Stem-Cell Transplantation Recipients. J Clin Oncol. 2020 09 20; 38(27):3205-3216.
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Gurram PR, Castillo NE, Esquer Garrigos Z, Vijayvargiya P, Abu Saleh OM. A Dimorphic Diagnosis of a Pleomorphic Disease: An Unusual Cause of Hypercalcemia. Am J Med. 2020 11; 133(11):e659-e662.
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Assress HA, Nyoni H, Mamba BB, Msagati TAM. Occurrence and risk assessment of azole antifungal drugs in water and wastewater. Ecotoxicol Environ Saf. 2020 Jan 15; 187:109868.
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Juvvadi PR, Fox D, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun. 2019 09 19; 10(1):4275.
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Assress HA, Nyoni H, Mamba BB, Msagati TAM. Target quantification of azole antifungals and retrospective screening of other emerging pollutants in wastewater effluent using UHPLC -QTOF-MS. Environ Pollut. 2019 Oct; 253:655-666.
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McLawhorn JM, Khattab M, Martinez-Parachini R, Thind S, Kirkpatrick A, Vaseer S. Osteoarticular Sporotrichosis vs Rheumatoid Arthritis: A Tale of Two Granulomatous Arthritides. Am J Med. 2019 07; 132(7):826-829.
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Roberts SC, Zembower TR, Bolon MK, Kadakia AR, Gilley JH, Ko JH, Clark J, Ward-Fore S, Taiwo BO. Successful treatment of a Candida auris intra-articular infection. Emerg Microbes Infect. 2019; 8(1):866-868.
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Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2018 11 02; 505(3):740-746.
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Barnette DA, Davis MA, Dang NL, Pidugu AS, Hughes T, Swamidass SJ, Boysen G, Miller GP. Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches. Biochem Pharmacol. 2018 10; 156:10-21.
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Kuriakose K, Nesbitt WJ, Greene M, Harris B. Posaconazole-Induced Pseudohyperaldosteronism. Antimicrob Agents Chemother. 2018 05; 62(5).
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Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ. Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. J Proteome Res. 2018 02 02; 17(2):780-793.
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Russ A, Rjoop A, Levy RA, Arthur C, Post GR. A Female Infant With Vomiting and Failure to Thrive. Clin Pediatr (Phila). 2018 07; 57(8):1004-1007.
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Moreno-Vel?squez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND. Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in ?-1,3-Glucan Synthase Localization. Antimicrob Agents Chemother. 2017 10; 61(10).
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Xu XH, Zhang L, Cao XX, Li J, Zhang W, Zhu TN, Cai HC, Chen M, Han X, Yang C, Han B, Zhang Y, Zhuang JL, Zhou DB, Duan MH. Evaluation of the implementation rate of primary antifungal prophylaxis and the prognosis of invasive fungal disease in acute leukemia patients in China. J Infect Chemother. 2017 Jun; 23(6):360-367.
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Hardin JS, Sutton DA, Wiederhold NP, Mele J, Goyal S. Fungal Keratitis Secondary to Trametes betulina: A Case Report and Review of Literature. Mycopathologia. 2017 Aug; 182(7-8):755-759.
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Kothari A, Shalin SC, Crescencio JC, Burgess MJ. Skin lesion in a patient with acute myeloid leukemia. Transpl Infect Dis. 2017 Feb; 19(1).
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Shaaban KA, Saunders MA, Zhang Y, Tran T, Elshahawi SI, Ponomareva LV, Wang X, Zhang J, Copley GC, Sunkara M, Kharel MK, Morris AJ, Hower JC, Tremblay MS, Prendergast MA, Thorson JS. Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6. J Nat Prod. 2017 01 27; 80(1):2-11.
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Mohan M, Fogel B, Eluvathingal T, Schinke C, Kothari A. Gastrointestinal histoplasmosis in a patient after autologous stem cell transplant for multiple myeloma. Transpl Infect Dis. 2016 Dec; 18(6):939-941.
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Kheir SM, Kafi SK, Ryden P, Elbir H, Soliman MA, Ali S, Abulikailik R, Ahamed K, Abu-Aisha H. Results of application of the ISPD guidelines to the management of peritoneal dialysis in a single center in Sudan. J Infect Public Health. 2017 May - Jun; 10(3):348-352.
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Mohan M, Shalin SC, Kothari A, Rico JC, Caradine K, Burgess M. Lasiodiplodia species fungal osteomyelitis in a multiple myeloma patient. Transpl Infect Dis. 2016 Oct; 18(5):761-764.
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Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 08 15; 63(4):433-42.
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Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 08 15; 63(4):e1-e60.
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Juvvadi PR, Lee SC, Heitman J, Steinbach WJ. Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. Virulence. 2017 02 17; 8(2):186-197.
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Balogh J, Gordon Burroughs S, Boktour M, Patel S, Saharia A, Ochoa RA, McFadden R, Victor DW, Ankoma-Sey V, Galati J, Monsour HP, Fainstein V, Li XC, Grimes KA, Gaber AO, Aloia T, Ghobrial RM. Efficacy and cost-effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high-risk liver transplant recipients. Liver Transpl. 2016 Feb; 22(2):163-70.
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Nucci F, Nou?r SA, Capone D, Anaissie E, Nucci M. Fusariosis. Semin Respir Crit Care Med. 2015 Oct; 36(5):706-14.
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Falloon K, Juvvadi PR, Richards AD, Vargas-Mu?iz JM, Renshaw H, Steinbach WJ. Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. PLoS One. 2015; 10(9):e0137869.
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