 Proteins
"Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
| Descriptor ID |
D011506
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| MeSH Number(s) |
D12.776
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Proteins".
Below are MeSH descriptors whose meaning is more specific than "Proteins".
This graph shows the total number of publications written about "Proteins" by people in UAMS Profiles by year, and whether "Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2023 | 1 | 3 | 4 | | 2022 | 4 | 1 | 5 | | 2021 | 3 | 0 | 3 | | 2020 | 5 | 2 | 7 | | 2019 | 5 | 0 | 5 | | 2018 | 3 | 3 | 6 | | 2017 | 4 | 1 | 5 | | 2016 | 7 | 2 | 9 | | 2015 | 1 | 3 | 4 | | 2014 | 6 | 4 | 10 | | 2013 | 5 | 4 | 9 | | 2012 | 4 | 5 | 9 | | 2011 | 4 | 2 | 6 | | 2010 | 14 | 4 | 18 | | 2009 | 6 | 1 | 7 | | 2008 | 12 | 4 | 16 | | 2007 | 9 | 2 | 11 | | 2006 | 10 | 4 | 14 | | 2005 | 11 | 4 | 15 | | 2004 | 8 | 4 | 12 | | 2003 | 21 | 7 | 28 | | 2002 | 10 | 8 | 18 | | 2001 | 2 | 2 | 4 | | 2000 | 4 | 0 | 4 | | 1999 | 6 | 3 | 9 | | 1998 | 1 | 3 | 4 | | 1997 | 6 | 0 | 6 | | 1996 | 1 | 2 | 3 | | 1995 | 2 | 1 | 3 | | 1993 | 1 | 1 | 2 | | 1992 | 0 | 2 | 2 | | 1991 | 2 | 1 | 3 | | 1990 | 1 | 1 | 2 | | 1989 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Proteins" by people in Profiles over the past ten years.
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Deutz NEP, Haines KL, Wischmeier PE, Engelen MPKJ. Amino acid kinetics in the critically ill. Curr Opin Clin Nutr Metab Care. 2024 01 01; 27(1):61-69.
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Engelen MPKJ, Kirschner SK, Coyle KS, Argyelan D, Neal G, Dasarathy S, Deutz NEP. Sex related differences in muscle health and metabolism in chronic obstructive pulmonary disease. Clin Nutr. 2023 09; 42(9):1737-1746.
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Hestekin CN, Pakkaner E, Hestekin JA, De Souza LS, Chowdhury PP, Mar?al JL, Moore J, Hesse SA, Takacs CJ, Tassone CJ, Dachavaram SS, Crooks PA, Williams K, Kurtz I. High flux novel polymeric membrane for renal applications. Sci Rep. 2023 07 20; 13(1):11703.
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Olson KR, Clear KJ, Gao Y, Ma Z, Cieplik NM, Fiume AR, Gaziano DJ, Kasko SM, Luu J, Pfaff E, Travlos A, Velander C, Wilson KJ, Edwards ED, Straub KD, Wu G. Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate. Int J Mol Sci. 2023 Apr 19; 24(8).
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Sato S, Gillette M, de Santiago PR, Kuhn E, Burgess M, Doucette K, Feng Y, Mendez-Dorantes C, Ippoliti PJ, Hobday S, Mitchell MA, Doberstein K, Gysler SM, Hirsch MS, Schwartz L, Birrer MJ, Skates SJ, Burns KH, Carr SA, Drapkin R. LINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma. Sci Rep. 2023 01 27; 13(1):1537.
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Li Y, Zhou D, Zheng G, Li X, Wu D, Yuan Y. DyScore: A Boosting Scoring Method with Dynamic Properties for Identifying True Binders and Nonbinders in Structure-Based Drug Discovery. J Chem Inf Model. 2022 11 28; 62(22):5550-5567.
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He S, Bhatt R, Brown C, Brown EA, Buhr DL, Chantranuvatana K, Danaher P, Dunaway D, Garrison RG, Geiss G, Gregory MT, Hoang ML, Khafizov R, Killingbeck EE, Kim D, Kim TK, Kim Y, Klock A, Korukonda M, Kutchma A, Lewis ZR, Liang Y, Nelson JS, Ong GT, Perillo EP, Phan JC, Phan-Everson T, Piazza E, Rane T, Reitz Z, Rhodes M, Rosenbloom A, Ross D, Sato H, Wardhani AW, Williams-Wietzikoski CA, Wu L, Beechem JM. High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging. Nat Biotechnol. 2022 12; 40(12):1794-1806.
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Kim IY, Park S, Kim Y, Kim HJ, Wolfe RR. Tracing metabolic flux in vivo: basic model structures of tracer methodology. Exp Mol Med. 2022 09; 54(9):1311-1322.
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Stenhouse C, Halloran KM, Moses RM, Seo H, Gaddy D, Johnson GA, Wu G, Suva LJ, Bazer FW. Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling?. Biol Reprod. 2022 05 17; 106(5):888-899.
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Hirsch KR, Church DD, Wolfe RR, Ferrando AA. Continuous oral stable isotope ingestion to measure whole-body protein turnover. Clin Nutr ESPEN. 2022 06; 49:385-389.
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Tasker R, Rowlands J, Ahmed Z, Di Pietro V. Co-Expression Network Analysis of Micro-RNAs and Proteins in the Alzheimer's Brain: A Systematic Review of Studies in the Last 10 Years. Cells. 2021 12 09; 10(12).
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Miles AJ, Janes RW, Wallace BA. Tools and methods for circular dichroism spectroscopy of proteins: a tutorial review. Chem Soc Rev. 2021 Aug 07; 50(15):8400-8413.
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Kang JW, Zhan Z, Ji G, Sang Y, Zhou D, Li Y, Feng H, Cheng T. PUMA facilitates EMI1-promoted cytoplasmic Rad51 ubiquitination and inhibits DNA repair in stem and progenitor cells. Signal Transduct Target Ther. 2021 03 31; 6(1):129.
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Gwin JA, Church DD, Hatch-McChesney A, Allen JT, Wilson MA, Varanoske AN, Carrigan CT, Murphy NE, Margolis LM, Carbone JW, Wolfe RR, Ferrando AA, Pasiakos SM. Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study. J Int Soc Sports Nutr. 2021 Jan 07; 18(1):4.
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Cross KM, Granados JZ, Ten Have GAM, Thaden JJ, Engelen MPKJ, Lightfoot JT, Deutz NEP. Protein fractional synthesis rates within tissues of high- and low-active mice. PLoS One. 2020; 15(11):e0242926.
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Ryan KR, Giles F, Morgan GJ. Targeting both BET and CBP/EP300 proteins with the novel dual inhibitors NEO2734 and NEO1132 leads to anti-tumor activity in multiple myeloma. Eur J Haematol. 2021 Jan; 106(1):90-99.
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Ligthart-Melis GC, Engelen MPKJ, Simbo SY, Ten Have GAM, Thaden JJ, Cynober L, Deutz NEP. Metabolic Consequences of Supplemented Methionine in a Clinical Context. J Nutr. 2020 10 01; 150(Suppl 1):2538S-2547S.
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van der Meij BS, Deutz NEP, Rodriguez RE, Engelen MPKJ. Early Signs of Impaired Gut Function Affect Daily Functioning in Patients With Advanced Cancer Undergoing Chemotherapy. JPEN J Parenter Enteral Nutr. 2021 05; 45(4):752-760.
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Drew ED, Janes RW. PDBMD2CD: providing predicted protein circular dichroism spectra from multiple molecular dynamics-generated protein structures. Nucleic Acids Res. 2020 07 02; 48(W1):W17-W24.
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Khan S, He Y, Zhang X, Yuan Y, Pu S, Kong Q, Zheng G, Zhou D. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics. Oncogene. 2020 06; 39(26):4909-4924.
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Zhang L, Beatty A, Lu L, Abdalrahman A, Makris TM, Wang G, Wang Q. Microfluidic-assisted polymer-protein assembly to fabricate homogeneous functionalnanoparticles. Mater Sci Eng C Mater Biol Appl. 2020 Jun; 111:110768.
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Ferruzzi MG, Hamaker BR, Bordenave N. Phenolic compounds are less degraded in presence of starch than in presence of proteins through processing in model porridges. Food Chem. 2020 Mar 30; 309:125769.
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Huang XF, Jian S, Lu JL, Shen KN, Feng J, Zhang CL, Tian Z, Wang JL, Lei WJ, Cao XX, Zhou DB, Liang ZY, Li J. Genomic profiling in amyloid light-chain amyloidosis reveals mutation profiles associated with overall survival. Amyloid. 2020 Mar; 27(1):36-44.
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Fletcher AM, Tellier P, Douville J, Mansell P, Graziano MJ, Mangipudy RS, Brodie TA, Achanzar WE. Adverse vacuolation in multiple tissues in cynomolgus monkeys following repeat-dose administration of a PEGylated protein. Toxicol Lett. 2019 Dec 15; 317:120-129.
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Engelen MPKJ, Ten Have GAM, Thaden JJ, Deutz NEP. New advances in stable tracer methods to assess whole-body protein and amino acid metabolism. Curr Opin Clin Nutr Metab Care. 2019 09; 22(5):337-346.
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Luiking YC, Poeze M, Deutz NE. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clin Nutr. 2020 06; 39(6):1764-1773.
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Wolfe RR, Park S, Kim IY, Starck C, Marquis BJ, Ferrando AA, Moughan PJ. Quantifying the contribution of dietary protein to whole body protein kinetics: examination of the intrinsically labeled proteins method. Am J Physiol Endocrinol Metab. 2019 07 01; 317(1):E74-E84.
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Coker RH, Shin K, Scholten K, Johannsen M, Tsigonis J, Kim IY, Schutzler SE, Wolfe RR. Essential amino acid-enriched meal replacement promotes superior net protein balance in older, overweight adults. Clin Nutr. 2019 12; 38(6):2821-2826.
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Kartakoullis A, Comaposada J, Cruz-Carri?n A, Serra X, Gou P. Feasibility study of smartphone-based Near Infrared Spectroscopy (NIRS) for salted minced meat composition diagnostics at different temperatures. Food Chem. 2019 Apr 25; 278:314-321.
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Nikam RM, Gripp KW, Choudhary AK, Kandula V. Imaging phenotype of multiple mitochondrial dysfunction syndrome 2, a rare BOLA3-associated leukodystrophy. Am J Med Genet A. 2018 12; 176(12):2787-2790.
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Balasubramaniam M, Ayyadevara S, Shmookler Reis RJ. Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2. Sci Rep. 2018 10 05; 8(1):14891.
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Tan QK, Cope H, Spillmann RC, Stong N, Jiang YH, McDonald MT, Rothman JA, Butler MW, Frush DP, Lachman RS, Lee B, Bacino CA, Bonner MJ, McCall CM, Pendse AA, Walley N, Shashi V, Pena LDM. Further evidence for the involvement of EFL1 in a Shwachman-Diamond-like syndrome and expansion of the phenotypic features. Cold Spring Harb Mol Case Stud. 2018 10; 4(5).
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O'Brien CA, Morello R. Modeling Rare Bone Diseases in Animals. Curr Osteoporos Rep. 2018 08; 16(4):458-465.
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Liu X, Wang Y, Zhang X, Gao Z, Zhang S, Shi P, Zhang X, Song L, Hendrickson H, Zhou D, Zheng G. Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation. Bioorg Med Chem. 2018 08 07; 26(14):3925-3938.
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Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D. Oxidation resistance 1 is a novel senolytic target. Aging Cell. 2018 08; 17(4):e12780.
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Thakali KM, Faske JB, Ishwar A, Alfaro MP, Cleves MA, Badger TM, Andres A, Shankar K. Maternal obesity and gestational weight gain are modestly associated with umbilical cord DNA methylation. Placenta. 2017 Sep; 57:194-203.
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Ayyadevara S, Balasubramaniam M, Kakraba S, Alla R, Mehta JL, Shmookler Reis RJ. Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. Antioxid Redox Signal. 2017 Dec 10; 27(17):1383-1396.
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Janes RW. PDB2CD visualises dynamics within protein structures. Eur Biophys J. 2017 Oct; 46(7):607-616.
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Nounamo B, Li Y, O'Byrne P, Kearney AM, Khan A, Liu J. An interaction domain in human SAMD9 is essential for myxoma virus host-range determinant M062 antagonism of host anti-viral function. Virology. 2017 03; 503:94-102.
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Engelen MPKJ, Klimberg VS, Allasia A, Deutz NE. Presence of early stage cancer does not impair the early protein metabolic response to major surgery. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):447-456.
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Gulia R, Sharma R, Bhattacharyya S. A Critical Role for Ubiquitination in the Endocytosis of Glutamate Receptors. J Biol Chem. 2017 01 27; 292(4):1426-1437.
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Natale DA, Arighi CN, Blake JA, Bona J, Chen C, Chen SC, Christie KR, Cowart J, D'Eustachio P, Diehl AD, Drabkin HJ, Duncan WD, Huang H, Ren J, Ross K, Ruttenberg A, Shamovsky V, Smith B, Wang Q, Zhang J, El-Sayed A, Wu CH. Protein Ontology (PRO): enhancing and scaling up the representation of protein entities. Nucleic Acids Res. 2017 01 04; 45(D1):D339-D346.
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Jackson MP, Hewitt EW. Cellular proteostasis: degradation of misfolded proteins by lysosomes. Essays Biochem. 2016 10 15; 60(2):173-180.
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Mavridis L, Janes RW. PDB2CD: a web-based application for the generation of circular dichroism spectra from protein atomic coordinates. Bioinformatics. 2017 01 01; 33(1):56-63.
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Roberts DW, Lee WM, Hinson JA, Bai S, Swearingen CJ, Stravitz RT, Reuben A, Letzig L, Simpson PM, Rule J, Fontana RJ, Ganger D, Reddy KR, Liou I, Fix O, James LP. An Immunoassay to Rapidly Measure Acetaminophen Protein?Adducts Accurately Identifies Patients With Acute Liver?Injury or Failure. Clin Gastroenterol Hepatol. 2017 Apr; 15(4):555-562.e3.
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Whitmore L, Miles AJ, Mavridis L, Janes RW, Wallace BA. PCDDB: new developments at the Protein Circular Dichroism Data Bank. Nucleic Acids Res. 2017 01 04; 45(D1):D303-D307.
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Earthman CP, Wolfe RR, Heymsfield SB. Dudrick Research Symposium 2015-Lean Tissue and Protein in Health and Disease. JPEN J Parenter Enteral Nutr. 2017 02; 41(2):226-237.
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Eguchi A, Lazic M, Armando AM, Phillips SA, Katebian R, Maraka S, Quehenberger O, Sears DD, Feldstein AE. Circulating adipocyte-derived extracellular vesicles are novel markers of metabolic stress. J Mol Med (Berl). 2016 11; 94(11):1241-1253.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016 06; 103(6):1458-64.
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Chng WJ, Chung TH, Kumar S, Usmani S, Munshi N, Avet-Loiseau H, Goldschmidt H, Durie B, Sonneveld P. Gene signature combinations improve prognostic stratification of multiple myeloma patients. Leukemia. 2016 05; 30(5):1071-8.
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Alonso EM, James LP, Zhang S, Squires RH. Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2015 Jul; 61(1):102-7.
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Smith HL, Li W, Cheetham ME. Molecular chaperones and neuronal proteostasis. Semin Cell Dev Biol. 2015 Apr; 40:142-52.
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MacDonald L, Baldini G, Storrie B. Does super-resolution fluorescence microscopy obsolete previous microscopic approaches to protein co-localization? Methods Mol Biol. 2015; 1270:255-75.
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