 Dactinomycin
"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
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| MeSH Number(s) |
D03.494.200 D04.345.566.252 D12.644.641.252
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| Concept/Terms |
Cosmegen- Cosmegen
- Cosmegen Lyovac
- Lyovac, Cosmegen
- MSD Brand of Dactinomycin
- Merck Brand of Dactinomycin
- Merck Frosst Brand of Dactinomycin
- Lyovac-Cosmegen
- Merck Sharp & Dohme Brand of Dactinomycin
Ac-De- Ac-De
- Lemery Brand of Dactinomycin
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Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in UAMS Profiles by year, and whether "Dactinomycin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 | | 2017 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1991 | 1 | 2 | 3 | | 1990 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dactinomycin" by people in Profiles over the past ten years.
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Lamture G, Crooks PA, Borrelli MJ. Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. Drug Dev Res. 2018 09; 79(6):287-294.
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Salazar G, Huang J, Feresin RG, Zhao Y, Griendling KK. Zinc regulates Nox1 expression through a NF-?B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells. Free Radic Biol Med. 2017 07; 108:225-235.
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