 Receptors, Opioid, mu
"Receptors, Opioid, mu" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of opioid receptors recognized by its pharmacological profile. Mu opioid receptors bind, in decreasing order of affinity, endorphins, dynorphins, met-enkephalin, and leu-enkephalin. They have also been shown to be molecular receptors for morphine.
| Descriptor ID |
D017450
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| MeSH Number(s) |
D12.776.543.750.100.620.550 D12.776.543.750.720.600.610.550 D12.776.543.750.750.555.610.550
|
| Concept/Terms |
Receptors, Opioid, mu- Receptors, Opioid, mu
- Opioid Receptors, mu
- mu Opioid Receptors
- Receptors, mu Opioid
- Receptors, mu
- mu Receptor
- Receptor, mu
- mu Receptors
- mu Opioid Receptor
- Opioid Receptor, mu
- Receptor, mu Opioid
Morphine Receptor- Morphine Receptor
- Receptor, Morphine
- Receptors, Morphine
- Morphine Receptors
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Below are MeSH descriptors whose meaning is more general than "Receptors, Opioid, mu".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Opioid [D12.776.543.750.100.620]
- Receptors, Opioid, mu [D12.776.543.750.100.620.550]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Opioid [D12.776.543.750.720.600.610]
- Receptors, Opioid, mu [D12.776.543.750.720.600.610.550]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Opioid [D12.776.543.750.750.555.610]
- Receptors, Opioid, mu [D12.776.543.750.750.555.610.550]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Opioid, mu".
This graph shows the total number of publications written about "Receptors, Opioid, mu" by people in UAMS Profiles by year, and whether "Receptors, Opioid, mu" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2020 | 2 | 2 | 4 | | 2019 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2017 | 0 | 1 | 1 | | 2016 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2013 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2009 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1991 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, Opioid, mu" by people in Profiles over the past ten years.
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Obeng S, Crowley ML, Mottinelli M, Le?n F, Zuarth Gonzalez JD, Chen Y, Gamez-Jimenez LR, Restrepo LF, Ho NP, Patel A, Martins Rocha J, Alvarez MA, Thadisetti AM, Park CR, Pallares VLC, Milner MJ, Canal CE, Hampson AJ, McCurdy CR, McMahon LR, Wilkerson JL, Hiranita T. The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic a2 receptor activity in vitro and in vivo. Eur J Pharmacol. 2024 Oct 05; 980:176863.
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Tobacyk J, Parks BJ, Salazar P, Coward LU, Berquist MD, Gorman GS, Brents LK. Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome. Drug Alcohol Depend. 2023 08 01; 249:110832.
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Obeng S, Leon F, Patel A, Zuarth Gonzalez JD, Chaves Da Silva L, Restrepo LF, Gamez-Jimenez LR, Ho NP, Guerrero Calvache MP, Pallares VLC, Helmes JA, Shiomitsu SK, Soto PL, McCurdy CR, McMahon LR, Wilkerson JL, Hiranita T. Interactive Effects of ?-Opioid and Adrenergic-a2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine. J Pharmacol Exp Ther. 2022 12; 383(3):182-198.
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Chear NJ, Le?n F, Sharma A, Kanumuri SRR, Zwolinski G, Abboud KA, Singh D, Restrepo LF, Patel A, Hiranita T, Ramanathan S, Hampson AJ, McMahon LR, McCurdy CR. Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors. J Nat Prod. 2021 04 23; 84(4):1034-1043.
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Obeng S, Wilkerson JL, Le?n F, Reeves ME, Restrepo LF, Gamez-Jimenez LR, Patel A, Pennington AE, Taylor VA, Ho NP, Braun T, Fortner JD, Crowley ML, Williamson MR, Pallares VLC, Mottinelli M, Lopera-Londo?o C, McCurdy CR, McMahon LR, Hiranita T. Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for ?-Opioid Receptor and Opioid-Like Behavioral Effects in Rats. J Pharmacol Exp Ther. 2021 03; 376(3):410-427.
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Albores-Garcia D, McGlothan JL, Bursac Z, Guilarte TR. Chronic developmental lead exposure increases ?-opiate receptor levels in the adolescent rat brain. Neurotoxicology. 2021 01; 82:119-129.
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Behnood-Rod A, Chellian R, Wilson R, Hiranita T, Sharma A, Leon F, McCurdy CR, McMahon LR, Bruijnzeel AW. Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats. Drug Alcohol Depend. 2020 10 01; 215:108235.
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Slavov S, Mattes W, Beger RD. Determination of structural factors affecting binding to mu, kappa and delta opioid receptors. Arch Toxicol. 2020 04; 94(4):1215-1227.
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Hiranita T, Leon F, Felix JS, Restrepo LF, Reeves ME, Pennington AE, Obeng S, Avery BA, McCurdy CR, McMahon LR, Wilkerson JL. The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats. Psychopharmacology (Berl). 2019 Sep; 236(9):2725-2734.
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Yadlapalli JSK, Bommagani SB, Mahelona RD, Wan A, Gannon BM, Penthala NR, Dobretsov M, Crooks PA, Fantegrossi WE. Evaluation of morphine-like effects of the mixed mu/delta agonist morphine-6-O-sulfate in rats: Drug discrimination and physical dependence. Pharmacol Res Perspect. 2018 07; 6(4):e00403.
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Tiwari V, Anderson M, Yang F, Tiwari V, Zheng Q, He SQ, Zhang T, Shu B, Chen X, Grenald SA, Stephens KE, Chen Z, Dong X, Raja SN, Guan Y. Peripherally Acting ?-Opioid Receptor Agonists Attenuate Ongoing Pain-associated Behavior and Spontaneous Neuronal Activity after Nerve Injury in Rats. Anesthesiology. 2018 06; 128(6):1220-1236.
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Yadlapalli JSK, Dogra N, Walbaum AW, Wessinger WD, Prather PL, Crooks PA, Dobretsov M. Evaluation of Analgesia, Tolerance, and the Mechanism of Action of Morphine-6-O-Sulfate Across Multiple Pain Modalities in Sprague-Dawley Rats. Anesth Analg. 2017 09; 125(3):1021-1031.
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Owens SM, Pollard GT, Howard JL, Fennell TR, Snyder RW, Carroll FI. Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats. ACS Chem Neurosci. 2016 12 21; 7(12):1737-1745.
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Yadlapalli JSK, Ford BM, Ketkar A, Wan A, Penthala NR, Eoff RL, Prather PL, Dobretsov M, Crooks PA. Antinociceptive effects of the 6-O-sulfate ester of morphine in normal and diabetic rats: Comparative role of mu- and delta-opioid receptors. Pharmacol Res. 2016 11; 113(Pt A):335-347.
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Lovallo WR, Enoch MA, Acheson A, Cohoon AJ, Sorocco KH, Hodgkinson CA, Vincent AS, Glahn DC, Goldman D. Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G. Neuropsychopharmacology. 2015 Oct; 40(11):2546-54.
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