 Fluorouracil
"Fluorouracil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
| Descriptor ID |
D005472
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| MeSH Number(s) |
D03.383.742.698.875.404
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| Concept/Terms |
Fluorouracil- Fluorouracil
- 5-FU
- Fluoruracil
- 5-Fluorouracil
- 5 Fluorouracil
- 5FU
5-FU medac- 5-FU medac
- 5 FU medac
- medac Brand of Fluorouracil
5-HU Hexal- 5-HU Hexal
- 5 HU Hexal
- Hexal Brand of Fluorouracil
Adrucil- Adrucil
- Teva Brand of Fluorouracil
- Fluorouracil Teva Brand
Carac- Carac
- Dermik Brand of Fluorouracil
Efudix- Efudix
- Dermatech Brand of Fluorouracil
- Roche Brand of Fluorouracil
- Fluoro-Uracile ICN
- Fluoro Uracile ICN
- ICN Brand of Fluorouracil
- CSP Brand of Fluorouracil
- Efudex
Fluoroplex- Fluoroplex
- Flurodex
- Allergan Brand of Fluorouracil
Fluracedyl- Fluracedyl
- Pharmachemie Brand of Fluorouracil Monosodium Salt
Haemato-fu- Haemato-fu
- Haemato fu
- Haemato Brand of Fluorouracil
Neofluor- Neofluor
- Neocorp Brand of Fluorouracil
Onkofluor- Onkofluor
- Onkoworks Brand of Fluorouracil
Ribofluor- Ribofluor
- ribosepharm Brand of Fluorouracil
5-FU Lederle- 5-FU Lederle
- 5 FU Lederle
- Riemser Brand of Fluorouracil
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Below are MeSH descriptors whose meaning is more general than "Fluorouracil".
Below are MeSH descriptors whose meaning is more specific than "Fluorouracil".
This graph shows the total number of publications written about "Fluorouracil" by people in UAMS Profiles by year, and whether "Fluorouracil" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 1 | 2 | | 2022 | 1 | 1 | 2 | | 2021 | 0 | 1 | 1 | | 2020 | 3 | 1 | 4 | | 2019 | 0 | 1 | 1 | | 2017 | 1 | 2 | 3 | | 2016 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2007 | 1 | 1 | 2 | | 2006 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2004 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1992 | 0 | 2 | 2 | | 1991 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Fluorouracil" by people in Profiles over the past ten years.
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Delgado-Coka LA, Roa-Pe?a L, Babu S, Horowitz M, Petricoin EF, Matrisian LM, Blais EM, Marchenko N, Allard FD, Akalin A, Jiang W, Larson BK, Hendifar AE, Picozzi VJ, Choi M, Shroyer KR, Escobar-Hoyos LF. Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma. Am J Clin Pathol. 2024 Sep 03; 162(3):314-326.
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El Sala AA, Khawaja G, Khalil M, Salam SA. Rosemary essential oil potentiates the antitumour activity of 5-fluorouracil in human colorectal carcinoma cells. J Pharm Pharmacol. 2024 Jun 06; 76(6):691-700.
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Homer NA, Hanafy MS, Baer SC, Watson AH, Somogyi M, Shore JW, Blaydon S, Durairaj VD, Cui Z, Nakra T. 5-Fluorouracil With Microneedling Modulates Wound Healing in a Murine Model: An Immunohistochemical Analysis of Mechanism and Dose Efficacy. Ophthalmic Plast Reconstr Surg. 2022 Nov-Dec 01; 38(6):596-601.
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Bess SN, Greening GJ, Rajaram N, Muldoon TJ. Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy. BMC Immunol. 2022 04 23; 23(1):20.
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Allen CJ, Pointer DT, Blumenthaler AN, Mehta RJ, Hoffe SE, Minsky BD, Smith GL, Blum M, Mansfield PF, Ikoma N, Das P, Ajani J, Dineen SP, Fleming JB, Badgwell BD, Pimiento JM. Chemotherapy Versus Chemotherapy Plus Chemoradiation as Neoadjuvant Therapy for Resectable Gastric Adenocarcinoma: A Multi-institutional Analysis. Ann Surg. 2021 10 01; 274(4):544-548.
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Mavros MN, Moris D, Karanicolas PJ, Katz MHG, O'Reilly EM, Pawlik TM. Clinical Trials of Systemic Chemotherapy for Resectable Pancreatic Cancer: A Review. JAMA Surg. 2021 07 01; 156(7):663-672.
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Hajiran A, Zemp L, Aydin AM, Cheryian SK, Pow-Sang JM, Chahoud J, Spiess PE. Topical chemotherapy for penile carcinoma in situ: Contemporary outcomes and reported toxicity. Urol Oncol. 2021 01; 39(1):72.e1-72.e5.
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Wolfe AR, Prabhakar D, Yildiz VO, Cloyd JM, Dillhoff M, Abushahin L, Alexandra Diaz D, Miller ED, Chen W, Frankel WL, Noonan A, Williams TM. Neoadjuvant-modified FOLFIRINOX vs nab-paclitaxel plus gemcitabine for borderline resectable or locally advanced pancreatic cancer patients who achieved surgical resection. Cancer Med. 2020 07; 9(13):4711-4723.
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Mundo AI, Greening GJ, Fahr MJ, Hale LN, Bullard EA, Rajaram N, Muldoon TJ. Diffuse reflectance spectroscopy to monitor murine colorectal tumor progression and therapeutic response. J Biomed Opt. 2020 03; 25(3):1-16.
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Anderson JE, Trujillo M, McElroy T, Groves T, Alexander T, Kiffer F, Allen AR. Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model. Toxicol Sci. 2020 01 01; 173(1):156-170.
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Maarouf M, Kromenacker BW, Brucks ES, Hendricks AJ, Shi VY. 5-fluorouracil-induced erythema and transepidermal water loss associated with complete actinic keratosis resolution. Dermatol Ther. 2019 05; 32(3):e12890.
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Maarouf M, Kromenacker BW, Brucks ES, Hendricks A, Shi VY. Reducing unpleasant side effects of topical 5-Fluorouracil treatment for actinic keratosis: a randomized controlled trial. J Dermatolog Treat. 2020 Mar; 31(2):175-179.
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Larsen V, Barlow WE, Yang JJ, Zhu Q, Liu S, Kwan ML, Ergas IJ, Roh JM, Hutchins LF, Kadlubar SA, Albain KS, Rae JM, Yeh IT, Ravdin PM, Martino S, Lyss AP, Osborne CK, Hortobagyi GN, Kushi LH, Hayes DF, Ambrosone CB, Yao S. Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study. Clin Breast Cancer. 2019 08; 19(4):225-235.e2.
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Ikoma N, Cloyd J, Badgwell BD, Agnes A, Rodriguez-Bigas M, Ajani JA, You YN. Clinical features and survival of gastric cancer patients with DNA mismatch repair deficiency. J Surg Oncol. 2018 Mar; 117(4):707-709.
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Groves TR, Wang J, Boerma M, Allen AR. Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method. J Vis Exp. 2017 06 22; (124).
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Viswanath V, Shah RJ, Gada JL. Intralesional 5-fluorouracil: Novel therapy for extensive molluscum contagiosum in an immunocompetent adult. Indian J Dermatol Venereol Leprol. 2017 Mar-Apr; 83(2):265-266.
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Sparano JA, Lee JY, Palefsky J, Henry DH, Wachsman W, Rajdev L, Aboulafia D, Ratner L, Fitzgerald TJ, Kachnic L, Mitsuyasu R. Cetuximab Plus Chemoradiotherapy for HIV-Associated Anal Carcinoma: A Phase II AIDS Malignancy Consortium Trial. J Clin Oncol. 2017 Mar; 35(7):727-733.
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Groves TR, Farris R, Anderson JE, Alexander TC, Kiffer F, Carter G, Wang J, Boerma M, Allen AR. 5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice. Behav Brain Res. 2017 01 01; 316:215-224.
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Badgwell B, Blum M, Estrella J, Chiang YJ, Das P, Matamoros A, Fournier K, Mansfield P, Ajani J. Predictors of Survival in Patients with Resectable Gastric Cancer Treated with Preoperative Chemoradiation Therapy and Gastrectomy. J Am Coll Surg. 2015 Jul; 221(1):83-90.
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