 Anti-Inflammatory Agents, Non-Steroidal
"Anti-Inflammatory Agents, Non-Steroidal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Anti-inflammatory agents that are not steroids. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They are used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. Certain NSAIDs also may inhibit lipoxygenase enzymes or TYPE C PHOSPHOLIPASES or may modulate T-cell function. (AMA Drug Evaluations Annual, 1994, p 1814-5)
| Descriptor ID |
D000894
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| MeSH Number(s) |
D27.505.696.663.850.014.040.500 D27.505.954.158.030 D27.505.954.329.030
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| Concept/Terms |
Anti-Inflammatory Agents, Non-Steroidal- Anti-Inflammatory Agents, Non-Steroidal
- Anti Inflammatory Agents, Non Steroidal
- Anti Inflammatory Agents, Nonsteroidal
- NSAIDs
- Antiinflammatory Agents, Non Steroidal
- Antiinflammatory Agents, Nonsteroidal
- Agents, Nonsteroidal Antiinflammatory
- Nonsteroidal Antiinflammatory Agents
- Non-Steroidal Anti-Inflammatory Agents
- Agents, Non-Steroidal Anti-Inflammatory
- Non Steroidal Anti Inflammatory Agents
- Nonsteroidal Anti-Inflammatory Agents
- Agents, Nonsteroidal Anti-Inflammatory
- Anti-Inflammatory Agents, Nonsteroidal
- Nonsteroidal Anti Inflammatory Agents
Anti-Rheumatic Agents, Non-Steroidal- Anti-Rheumatic Agents, Non-Steroidal
- Agents, Non-Steroidal Anti-Rheumatic
- Anti Rheumatic Agents, Non Steroidal
- Non-Steroidal Anti-Rheumatic Agents
- Antirheumatic Agents, Non-Steroidal
- Agents, Non-Steroidal Antirheumatic
- Antirheumatic Agents, Non Steroidal
- Non-Steroidal Antirheumatic Agents
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Below are MeSH descriptors whose meaning is more general than "Anti-Inflammatory Agents, Non-Steroidal".
Below are MeSH descriptors whose meaning is more specific than "Anti-Inflammatory Agents, Non-Steroidal".
This graph shows the total number of publications written about "Anti-Inflammatory Agents, Non-Steroidal" by people in UAMS Profiles by year, and whether "Anti-Inflammatory Agents, Non-Steroidal" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 5 | 2 | 7 | | 2020 | 2 | 2 | 4 | | 2019 | 2 | 2 | 4 | | 2018 | 4 | 0 | 4 | | 2017 | 1 | 1 | 2 | | 2016 | 3 | 0 | 3 | | 2013 | 7 | 4 | 11 | | 2012 | 3 | 4 | 7 | | 2011 | 3 | 3 | 6 | | 2010 | 1 | 2 | 3 | | 2009 | 0 | 2 | 2 | | 2008 | 3 | 1 | 4 | | 2007 | 1 | 5 | 6 | | 2006 | 4 | 2 | 6 | | 2005 | 1 | 1 | 2 | | 2004 | 6 | 1 | 7 | | 2003 | 3 | 3 | 6 | | 2002 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 1999 | 0 | 2 | 2 | | 1996 | 1 | 0 | 1 | | 1990 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Anti-Inflammatory Agents, Non-Steroidal" by people in Profiles over the past ten years.
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Schleiff MA, Crosby S, Blue M, Schleiff BM, Boysen G, Miller GP. CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs. Biochem Pharmacol. 2021 12; 194:114824.
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Musayeva A, Unkrig JC, Zhutdieva MB, Manicam C, Ruan Y, Laspas P, Chronopoulos P, G?bel ML, Pfeiffer N, Brochhausen C, Daiber A, Oelze M, Li H, Xia N, Gericke A. Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina. Cells. 2021 09 16; 10(9).
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Selamet Tierney ES, Runeckles K, Tremoulet AH, Dahdah N, Portman MA, Mackie AS, Harahsheh AS, Lang SM, Choueiter NF, Li JS, Manlhiot C, Low T, Mathew M, Friedman KG, Raghuveer G, Norozi K, Szmuszkovicz JR, McCrindle BW. Variation in Pharmacologic Management of Patients with Kawasaki Disease with Coronary Artery Aneurysms. J Pediatr. 2022 01; 240:164-170.e1.
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Datta A, Flynn NR, Barnette DA, Woeltje KF, Miller GP, Swamidass SJ. Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs (NSAIDs) from a retrospective electronic health record (EHR) cohort. PLoS Comput Biol. 2021 07; 17(7):e1009053.
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Schleiff MA, Payakachat S, Schleiff BM, Swamidass SJ, Boysen G, Miller GP. Impacts of diphenylamine NSAID halogenation on bioactivation risks. Toxicology. 2021 06 30; 458:152832.
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Romano-Munive AF, Garc?a-Correa JJ, Garc?a-Contreras LF, Ram?rez-Garc?a J, Uscanga L, Barbero-Becerra VJ, Moctezuma-Vel?zquez C, Ochoa-Rub? JA, Toledo-Cuque J, V?zquez-Anaya G, Keil-R?os D, Grajales-Figueroa G, Ram?rez-Luna M?, Valdovinos-Andraca F, Zamora-Nava LE, Tellez-Avila F. Can topical epinephrine application to the papilla prevent pancreatitis after endoscopic retrograde cholangiopancreatography? Results from a double blind, multicentre, placebo controlled, randomised clinical trial. BMJ Open Gastroenterol. 2021 02; 8(1).
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Salah HM, Mehta JL. Meta-Analysis of the Effect of Aspirin on Mortality in COVID-19. Am J Cardiol. 2021 03 01; 142:158-159.
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Barnette DA, Schleiff MA, Datta A, Flynn N, Swamidass SJ, Miller GP. Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam. Toxicol Lett. 2021 Mar 01; 338:10-20.
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Schleiff MA, Flynn NR, Payakachat S, Schleiff BM, Pinson AO, Province DW, Swamidass SJ, Boysen G, Miller GP. Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics. Drug Metab Dispos. 2021 02; 49(2):133-141.
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Madsen S, Price KN, Shi VY, Lio PA. Pearls in Mitigating Application Pain of Topical Nonsteroidal Agents. Dermatology. 2020; 236(5):477-480.
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Laoveeravat P, Perisetti A, Garcia-Saenz-de-Sicilia M, Garg S, Tharian B. Is combining therapy with indomethacin and epinephrine useful for preventing post-ERCP pancreatitis? The answer from a meta-analysis. Eur J Gastroenterol Hepatol. 2020 03; 32(3):459-460.
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Faraji E, Sukumaran S, Vijayan V. A 3 Year Old With Fever and Rash: An Atypical Cause of Shock. Clin Pediatr (Phila). 2020 06; 59(7):740-742.
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Johnson KD, Perisetti A, Tharian B, Thandassery R, Jamidar P, Goyal H, Inamdar S. Endoscopic Retrograde Cholangiopancreatography-Related Complications and Their Management Strategies: A "Scoping" Literature Review. Dig Dis Sci. 2020 02; 65(2):361-375.
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Dom?nguez Camacho A, Vel?squez SA, Benjumea Marulanda NJ, Moreno M. Photobiomodulation as oedema adjuvant in post-orthognathic surgery patients: A randomized clinical trial. Int Orthod. 2020 Mar; 18(1):69-78.
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Abdelaziz HK, Saad M, Pothineni NVK, Megaly M, Potluri R, Saleh M, Kon DLC, Roberts DH, Bhatt DL, Aronow HD, Abbott JD, Mehta JL. Aspirin for Primary Prevention of Cardiovascular?Events. J Am Coll Cardiol. 2019 06 18; 73(23):2915-2929.
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Gebreselassie A, Aduli F, Howell CD. Rheumatologic Diseases and the Liver. Clin Liver Dis. 2019 05; 23(2):247-261.
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Ferrell JK, Singer MC, Farwell DG, Stack BC, Shindo M. Evaluating contemporary pain management practices in thyroid and parathyroid surgery: A national survey of head and neck endocrine surgeons. Head Neck. 2019 07; 41(7):2315-2323.
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Imig JD. Prospective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics. Pharmacol Ther. 2018 12; 192:1-19.
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Lovell DJ, Dare JA, Francis-Sedlak M, Ball J, LaMoreaux BD, Von Scheven E, Reinhardt A, Jerath R, Alpan O, Gupta R, Goldsmith D, Zeft A, Naddaf H, Gottlieb B, Jung L, Holt RJ. A 6-month, multicenter, open-label study of fixed dose naproxen/esomeprazole in adolescent patients with juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2018 Jun 26; 16(1):41.
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Franks LN, Ford BM, Fujiwara T, Zhao H, Prather PL. The tamoxifen derivative ridaifen-B is a high affinity selective CB2 receptor inverse agonist exhibiting anti-inflammatory and anti-osteoclastogenic effects. Toxicol Appl Pharmacol. 2018 08 15; 353:31-42.
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Stehlik P, Rosella L, Henry D. Commentary: Renewed controversy over cardiovascular risk with non-steroidal anti-inflammatory drugs. Int J Epidemiol. 2018 04 01; 47(2):362-367.
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Henry D, Stehlik P, Rosella L. Response to authors re commentary: Renewed controversy over cardiovascular risk with non-steroidal anti-inflammatory drugs. Int J Epidemiol. 2018 04 01; 47(2):675-676.
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Jacobs V, May HT, Bair TL, Crandall BG, Cutler DO MJ, Day JD, Mallender C, Osborn JS, Weiss JP, Bunch TJ. Long-term aspirin does not lower risk of stroke and increases bleeding risk in low-risk atrial fibrillation ablation patients. J Cardiovasc Electrophysiol. 2017 Nov; 28(11):1241-1246.
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Pandey S, Cottler-Fox M. Acetylsalicylic Acid During Leukapheresis Reduces the Incidence of Clotting in Hematopoietic Progenitor Cell Products. Ann Clin Lab Sci. 2017 Sep; 47(5):551-555.
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Akolkar G, da Silva Dias D, Ayyappan P, Bagchi AK, Jassal DS, Salemi VMC, Irigoyen MC, De Angelis K, Singal PK. Vitamin C mitigates oxidative/nitrosative stress and inflammation in doxorubicin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2017 Oct 01; 313(4):H795-H809.
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Zhang YP, Brown RE, Zhang PC, Zhao YT, Ju XH, Song C. DHA, EPA and their combination at various ratios differently modulated A?25-35-induced neurotoxicity in SH-SY5Y cells. Prostaglandins Leukot Essent Fatty Acids. 2018 09; 136:85-94.
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Heath JL, Heath RD, Tamboli C, Johnson L, Wilson AS, Chervinskiy S, Bell MC, Kennedy JL. Mesalamine desensitization in a patient with treatment refractory ulcerative colitis and aspirin and nonsteroidal anti-inflammatory drug hypersensitivity. Ann Allergy Asthma Immunol. 2017 Apr; 118(4):518-520.
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Inamdar S, Han D, Passi M, Sejpal DV, Trindade AJ. Rectal indomethacin is protective against post-ERCP pancreatitis in high-risk patients but not average-risk patients: a?systematic review and meta-analysis. Gastrointest Endosc. 2017 Jan; 85(1):67-75.
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Goyal S, Lyzogubov VV, Ali O, Bora PS, Bora NS, Uwaydat SH. Effect of aspirin on models of retinal pigment epithelium pathology. Clin Exp Ophthalmol. 2016 Sep; 44(7):610-617.
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O'Neal RM, Cryer KA, Edwards PK, Barnes CL, Mears SC. Narcotic Use: A Modifiable Risk Factor for Hip and Knee Arthroplasty. J Surg Orthop Adv. 2016 Winter; 25(4):227-233.
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Hutchison MR, White PC. Prostacyclin regulates bone growth via the Epac/Rap1 pathway. Endocrinology. 2015 Feb; 156(2):499-510.
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