 Lobeline
"Lobeline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid that has actions similar to NICOTINE on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.
| Descriptor ID |
D008120
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| MeSH Number(s) |
D03.132.478 D03.383.621.418
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| Concept/Terms |
Smokeless- Smokeless
- Inibsa Brand of Lobelin Sulfate
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Below are MeSH descriptors whose meaning is more general than "Lobeline".
Below are MeSH descriptors whose meaning is more specific than "Lobeline".
This graph shows the total number of publications written about "Lobeline" by people in UAMS Profiles by year, and whether "Lobeline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2016 | 2 | 1 | 3 | | 2015 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2013 | 4 | 1 | 5 | | 2012 | 1 | 0 | 1 | | 2011 | 3 | 0 | 3 | | 2010 | 4 | 0 | 4 | | 2009 | 4 | 0 | 4 | | 2008 | 1 | 0 | 1 | | 2007 | 2 | 0 | 2 | | 2006 | 1 | 0 | 1 | | 2005 | 2 | 0 | 2 | | 2004 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lobeline" by people in Profiles over the past ten years.
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Chandler CM, Nickell JR, George Wilson A, Culver JP, Crooks PA, Bardo MT, Dwoskin LP. Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats. Biochem Pharmacol. 2024 10; 228:116189.
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Lee NR, Zheng G, Crooks PA, Bardo MT, Dwoskin LP. New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. AAPS J. 2018 02 09; 20(2):29.
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Kangiser MM, Dwoskin LP, Zheng G, Crooks PA, Stairs DJ. Varenicline and GZ-793A differentially decrease methamphetamine self-administration under a multiple schedule of reinforcement in rats. Behav Pharmacol. 2018 02; 29(1):87-97.
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Nickell JR, Siripurapu KB, Horton DB, Zheng G, Crooks PA, Dwoskin LP. GZ-793A inhibits the neurochemical effects of methamphetamine via a selective interaction with the vesicular monoamine transporter-2. Eur J Pharmacol. 2017 Jan 15; 795:143-149.
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Nickell JR, Culver JP, Janganati V, Zheng G, Dwoskin LP, Crooks PA. 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 07 01; 26(13):2997-3000.
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Joolakanti SR, Nickell JR, Janganati V, Zheng G, Dwoskin LP, Crooks PA. Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2016 05 15; 26(10):2422-2427.
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Ding D, Nickell JR, Dwoskin LP, Crooks PA. Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2015 Jul 01; 25(13):2613-6.
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