 Thioredoxins
"Thioredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.
| Descriptor ID |
D013879
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| MeSH Number(s) |
D12.776.915
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thioredoxins".
Below are MeSH descriptors whose meaning is more specific than "Thioredoxins".
This graph shows the total number of publications written about "Thioredoxins" by people in UAMS Profiles by year, and whether "Thioredoxins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2020 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2016 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2014 | 2 | 1 | 3 | | 2013 | 2 | 1 | 3 | | 2010 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2005 | 2 | 0 | 2 | | 2004 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thioredoxins" by people in Profiles over the past ten years.
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Hilgers RHP, Das KC. Redox Regulation of K+ Channel: Role of Thioredoxin. Antioxid Redox Signal. 2024 Nov; 41(13-15):818-844.
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Raghavan S, Kundumani-Sridharan V, Kumar S, White CW, Das KC. Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4-p38 MAPK-PGC1a Signaling and Limits Oxygen Toxicity. Am J Respir Cell Mol Biol. 2022 03; 66(3):323-336.
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Kundumani-Sridharan V, Subramani J, Owens C, Das KC. Nrg1? Released in Remote Ischemic Preconditioning Improves Myocardial Perfusion and Decreases Ischemia/Reperfusion Injury via ErbB2-Mediated Rescue of Endothelial Nitric Oxide Synthase and Abrogation of Trx2 Autophagy. Arterioscler Thromb Vasc Biol. 2021 08; 41(8):2293-2314.
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Dunn S, Hilgers RH, Das KC. Thioredoxin deficiency exacerbates vascular dysfunction during diet-induced obesity in small mesenteric artery in mice. Microcirculation. 2021 05; 28(4):e12674.
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Das KC, Muniyappa H, Kundumani-Sridharan V, Subramani J. Thioredoxin Decreases Anthracycline Cardiotoxicity, But Sensitizes Cancer Cell Apoptosis. Cardiovasc Toxicol. 2021 02; 21(2):142-151.
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Fertan E, Rodrigues GJ, Wheeler RV, Goguen D, Wong AA, James H, Stadnyk A, Brown RE, Weaver ICG. Cognitive Decline, Cerebral-Spleen Tryptophan Metabolism, Oxidative Stress, Cytokine Production, and Regulation of the Txnip Gene in a Triple Transgenic Mouse Model of Alzheimer Disease. Am J Pathol. 2019 07; 189(7):1435-1450.
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Das KC, Kundumani-Sridharan V, Subramani J. Role of Thioredoxin in Age-Related Hypertension. Curr Hypertens Rep. 2018 02 14; 20(1):6.
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Hilgers RH, Kundumani-Sridharan V, Subramani J, Chen LC, Cuello LG, Rusch NJ, Das KC. Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function. Sci Transl Med. 2017 02 08; 9(376).
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Chakravarti A, Camp K, McNabb DS, Pinto I. The Iron-Dependent Regulation of the Candida albicans Oxidative Stress Response by the CCAAT-Binding Factor. PLoS One. 2017; 12(1):e0170649.
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Subramani J, Kundumani-Sridharan V, Hilgers RH, Owens C, Das KC. Thioredoxin Uses a GSH-independent Route to Deglutathionylate Endothelial Nitric-oxide Synthase and Protect against Myocardial Infarction. J Biol Chem. 2016 Nov 04; 291(45):23374-23389.
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Vance TM, Azabdaftari G, Pop EA, Lee SG, Su LJ, Fontham ET, Bensen JT, Steck SE, Arab L, Mohler JL, Chen MH, Koo SI, Chun OK. Intake of dietary antioxidants is inversely associated with biomarkers of oxidative stress among men with prostate cancer. Br J Nutr. 2016 Jan 14; 115(1):68-74.
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Kundumani-Sridharan V, Subramani J, Das KC. Thioredoxin Activates MKK4-NF?B Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells. J Biol Chem. 2015 Jul 10; 290(28):17505-19.
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