 bcl-2-Associated X Protein
"bcl-2-Associated X Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.
| Descriptor ID |
D051028
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| MeSH Number(s) |
D12.644.360.075.718.400 D12.776.476.075.718.400
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| Concept/Terms |
bcl-2-Associated X Protein- bcl-2-Associated X Protein
- Protein, bcl-2-Associated X
- X Protein, bcl-2-Associated
- bcl 2 Associated X Protein
- Bax Protein
- bcl2-Associated X Protein
- bcl2 Associated X Protein
- Bax Apoptosis Regulator Protein
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Below are MeSH descriptors whose meaning is more general than "bcl-2-Associated X Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2-Associated X Protein".
This graph shows the total number of publications written about "bcl-2-Associated X Protein" by people in UAMS Profiles by year, and whether "bcl-2-Associated X Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 3 | 3 | | 2021 | 0 | 1 | 1 | | 2020 | 1 | 2 | 3 | | 2017 | 1 | 2 | 3 | | 2016 | 0 | 1 | 1 | | 2015 | 0 | 3 | 3 | | 2014 | 1 | 2 | 3 | | 2013 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2008 | 2 | 1 | 3 | | 2007 | 0 | 2 | 2 | | 2006 | 0 | 3 | 3 | | 2005 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 |
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Below are the most recent publications written about "bcl-2-Associated X Protein" by people in Profiles over the past ten years.
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El Sala AA, Khawaja G, Khalil M, Salam SA. Rosemary essential oil potentiates the antitumour activity of 5-fluorouracil in human colorectal carcinoma cells. J Pharm Pharmacol. 2024 Jun 06; 76(6):691-700.
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Moldoveanu T. Apoptotic mitochondrial poration by a growing list of pore-forming BCL-2 family proteins. Bioessays. 2023 03; 45(3):e2200221.
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Dunham D, Viswanathan P, Gill J, Manzano M. Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi's Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1. J Virol. 2022 12 14; 96(23):e0136022.
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Segura IG, Secchi DG, Gal?ndez MF, Carrica A, Bologna-Molina R, Brunotto M, Centeno VA. Connexin 43, Bcl-2, Bax, Ki67, and E-cadherin patterns in oral squamous cell carcinoma and its relationship with GJA1 rs12197797 C/G. Med Oral Patol Oral Cir Bucal. 2022 Jul 01; 27(4):e366-e374.
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Sekar G, Ojoawo A, Moldoveanu T. Protein-protein and protein-lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation. Biochem Soc Trans. 2022 06 30; 50(3):1091-1103.
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Delgado M, Rainwater RR, Heflin B, Urbaniak A, Butler K, Davidson M, Protacio RM, Baldini G, Edwards A, Reed MR, Raney KD, Chambers TC. Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways. J Biol Chem. 2022 06; 298(6):101939.
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Ojoawo AM, Moldoveanu T. A killer metamorphosis: catching BAK in action at the membrane. EMBO J. 2021 10 18; 40(20):e109529.
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Jin X, An C, Jiao B, Safirstein RL, Wang Y. AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury. Am J Physiol Renal Physiol. 2020 12 01; 319(6):F1073-F1080.
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Elsawy H, Algefare AI, Alfwuaires M, Khalil M, Elmenshawy OM, Sedky A, Abdel-Moneim AM. Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells. Biosci Rep. 2020 06 26; 40(6).
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Moldoveanu T, Czabotar PE. BAX, BAK, and BOK: A Coming of Age for the BCL-2 Family Effector Proteins. Cold Spring Harb Perspect Biol. 2020 04 01; 12(4).
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Talpur HS, Worku T, Rehman ZU, Dad R, Bhattarai D, Bano I, Liang A, He C, Yang L. Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function. Reprod Biol. 2017 Dec; 17(4):380-388.
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Mendonca MS, Turchan WT, Alpuche ME, Watson CN, Estabrook NC, Chin-Sinex H, Shapiro JB, Imasuen-Williams IE, Rangel G, Gilley DP, Huda N, Crooks PA, Shapiro RH. DMAPT inhibits NF-?B activity and increases sensitivity of prostate cancer cells to X-rays in vitro and in tumor xenografts in vivo. Free Radic Biol Med. 2017 11; 112:318-326.
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Pan J, Li D, Xu Y, Zhang J, Wang Y, Chen M, Lin S, Huang L, Chung EJ, Citrin DE, Wang Y, Hauer-Jensen M, Zhou D, Meng A. Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice. Int J Radiat Oncol Biol Phys. 2017 10 01; 99(2):353-361.
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Khan MA, Zafaryab M, Mehdi SH, Ahmad I, Rizvi MM. Characterization and anti-proliferative activity of curcumin loaded chitosan nanoparticles in cervical cancer. Int J Biol Macromol. 2016 Dec; 93(Pt A):242-253.
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Zheng JH, Viacava Follis A, Kriwacki RW, Moldoveanu T. Discoveries and controversies in BCL-2 protein-mediated apoptosis. FEBS J. 2016 07; 283(14):2690-700.
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Nalluri S, Ghoshal-Gupta S, Kutiyanawalla A, Gayatri S, Lee BR, Jiwani S, Rojiani AM, Rojiani MV. TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2. PLoS One. 2015; 10(9):e0137673.
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Dan H, Zhang L, Qin X, Peng X, Wong M, Tan X, Yu S, Fang N. Moutan cortex extract exerts protective effects in a rat model of cardiac ischemia/reperfusion. Can J Physiol Pharmacol. 2016 Mar; 94(3):245-50.
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