 Sirolimus
"Sirolimus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
| Descriptor ID |
D020123
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| MeSH Number(s) |
D02.540.505.760
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| Concept/Terms |
Rapamune- Rapamune
- Wyeth Brand of Sirolimus
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Below are MeSH descriptors whose meaning is more general than "Sirolimus".
Below are MeSH descriptors whose meaning is more specific than "Sirolimus".
This graph shows the total number of publications written about "Sirolimus" by people in UAMS Profiles by year, and whether "Sirolimus" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2023 | 0 | 3 | 3 | | 2022 | 2 | 1 | 3 | | 2019 | 2 | 0 | 2 | | 2018 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2016 | 2 | 1 | 3 | | 2015 | 2 | 0 | 2 | | 2014 | 4 | 0 | 4 | | 2013 | 3 | 1 | 4 | | 2012 | 3 | 0 | 3 | | 2011 | 1 | 0 | 1 | | 2010 | 3 | 2 | 5 | | 2009 | 1 | 0 | 1 | | 2008 | 0 | 2 | 2 | | 2006 | 3 | 2 | 5 | | 2004 | 1 | 1 | 2 | | 2003 | 3 | 1 | 4 | | 2002 | 0 | 2 | 2 | | 2000 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sirolimus" by people in Profiles over the past ten years.
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Cavazos R, Patil MS, Gowda SH, Iacobas I, Rosenberg T, Fernandes CJ, Pammi M. Sirolimus for vascular anomalies in the first year of life: a systematic review. J Perinatol. 2024 Aug; 44(8):1087-1097.
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Borst AJ, Eng W, Griffin M, Ricci KW, Engel E, Adams DM, Dayneka J, Cohen-Cutler SJ, Andreoli SM, Wu MD, Wheeler AP, Heym KM, Crary SE, Nakano TA, Schulte RR, Setty BA, McLean TW, Pahl KS, Intzes S, Pateva I, Teitelbaum M, Zong Z, Li Y, Jeng MR. Treatment practices and response in kaposiform hemangioendothelioma: A multicenter cohort study. Pediatr Blood Cancer. 2024 Mar; 71(3):e30779.
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Wagle Shukla A, Lunny C, Mahboob O, Khalid U, Joyce M, Jha N, Nagaraja N, Shukla AM. Tremor Induced by Cyclosporine, Tacrolimus, Sirolimus, or Everolimus: A Review of the Literature. Drugs R D. 2023 Dec; 23(4):301-329.
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Roy T, Banang-Mbeumi S, Boateng ST, Ruiz EM, Chamcheu RN, Kang L, King JA, Walker AL, Nagalo BM, Kousoulas KG, Esnault S, Huang S, Chamcheu JC. Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation. Front Immunol. 2022; 13:1075804.
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Mehl SC, Whitlock RS, Ortega RM, Creden S, Iacobas I, Maricevich RS, Rosenberg TL, Rialon KL. No Association of Sirolimus with Wound Complications in Children With Vascular Anomalies. J Pediatr Surg. 2023 Aug; 58(8):1555-1559.
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Cawich I, Armstrong EJ, George JC, Golzar J, Shishehbor MH, Razavi M, Lee V, Ouriel K. Temsirolimus Adventitial Delivery to Improve ANGiographic Outcomes Below the Knee. J Endovasc Ther. 2024 Aug; 31(4):562-575.
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Mehl SC, Kinley A, Todd HF, Mir DI, Iacobas I, Pezeshkmehr A, Mahajan P, Rialon KL. Institutional Management of Abdominal Lymphatic Malformations: Evolution of Treatment Over a Decade. J Surg Res. 2022 12; 280:296-303.
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Fajgenbaum DC, Langan RA, Japp AS, Partridge HL, Pierson SK, Singh A, Arenas DJ, Ruth JR, Nabel CS, Stone K, Okumura M, Schwarer A, Jose FF, Hamerschlak N, Wertheim GB, Jordan MB, Cohen AD, Krymskaya V, Rubenstein A, Betts MR, Kambayashi T, van Rhee F, Uldrick TS. Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease. J Clin Invest. 2019 08 13; 129(10):4451-4463.
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Mack JM, Verkamp B, Richter GT, Nicholas R, Stewart K, Crary SE. Effect of sirolimus on coagulopathy of slow-flow vascular malformations. Pediatr Blood Cancer. 2019 10; 66(10):e27896.
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Fridell JA, Mangus RS, Chen JM, Taber TE, Cabrales AE, Sharfuddin AA, Yaqub MS, Powelson JA. Steroid-free three-drug maintenance regimen for pancreas transplant alone: Comparison of induction with rabbit antithymocyte globulin +/- rituximab. Am J Transplant. 2018 12; 18(12):3000-3006.
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Samanta D. Surendra Nath Sehgal: A pioneer in rapamycin discovery. Indian J Cancer. 2017 Oct-Dec; 54(4):697-698.
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Garc?a-Casarrubios E, de Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ?M. Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. Biochim Biophys Acta. 2016 12; 1861(12 Pt A):1929-1941.
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Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. J Biol Chem. 2016 Oct 14; 291(42):21984-22000.
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Myers AP, Filiaci VL, Zhang Y, Pearl M, Behbakht K, Makker V, Hanjani P, Zweizig S, Burke JJ, Downey G, Leslie KK, Van Hummelen P, Birrer MJ, Fleming GF. Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2016 Apr; 141(1):43-8.
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Samanta D. Acneiform Lesion: Importance of Detailed Skin Examination. Indian J Pediatr. 2016 May; 83(5):485-6.
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Sereno J, Vala H, Nunes S, Rocha-Pereira P, Carvalho E, Alves R, Teixeira F, Reis F. Cyclosporine A-induced nephrotoxicity is ameliorated by dose reduction and conversion to sirolimus in the rat. J Physiol Pharmacol. 2015 Apr; 66(2):285-99.
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