 Hypoglycemic Agents
"Hypoglycemic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances which lower blood glucose levels.
| Descriptor ID |
D007004
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| MeSH Number(s) |
D27.505.696.422
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| Concept/Terms |
Hypoglycemic Agents- Hypoglycemic Agents
- Agents, Hypoglycemic
- Hypoglycemics
- Hypoglycemic Drugs
- Drugs, Hypoglycemic
- Antihyperglycemic Agents
- Agents, Antihyperglycemic
- Antihyperglycemics
Hypoglycemic Effect- Hypoglycemic Effect
- Effect, Hypoglycemic
- Hypoglycemic Effects
- Effects, Hypoglycemic
Antidiabetics- Antidiabetics
- Antidiabetic Drugs
- Drugs, Antidiabetic
- Antidiabetic Agents
- Agents, Antidiabetic
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Below are MeSH descriptors whose meaning is more general than "Hypoglycemic Agents".
Below are MeSH descriptors whose meaning is more specific than "Hypoglycemic Agents".
This graph shows the total number of publications written about "Hypoglycemic Agents" by people in UAMS Profiles by year, and whether "Hypoglycemic Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 5 | 2 | 7 | | 2023 | 0 | 2 | 2 | | 2022 | 1 | 3 | 4 | | 2021 | 0 | 4 | 4 | | 2020 | 3 | 3 | 6 | | 2019 | 5 | 2 | 7 | | 2018 | 2 | 2 | 4 | | 2017 | 2 | 3 | 5 | | 2016 | 6 | 6 | 12 | | 2015 | 4 | 1 | 5 | | 2014 | 4 | 1 | 5 | | 2013 | 5 | 3 | 8 | | 2012 | 6 | 2 | 8 | | 2011 | 1 | 1 | 2 | | 2010 | 5 | 1 | 6 | | 2009 | 3 | 1 | 4 | | 2008 | 5 | 1 | 6 | | 2007 | 4 | 4 | 8 | | 2006 | 2 | 5 | 7 | | 2005 | 3 | 2 | 5 | | 2004 | 3 | 1 | 4 | | 2003 | 3 | 0 | 3 | | 2002 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Hypoglycemic Agents" by people in Profiles over the past ten years.
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Samanta A, Bordbar DD, Weng CY, Chancellor JR. Glucagon-like Peptide-1 Receptor Agonists in the Management of Diabetic Retinopathy. Int Ophthalmol Clin. 2025 Jan 01; 65(1):23-26.
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Kudva YC, Henderson RJ, Kanapka LG, Weinstock RS, Rickels MR, Pratley RE, Chaytor N, Janess K, Desjardins D, Pattan V, Peleckis AJ, Casu A, Rizvi SR, Bzdick S, Whitaker KJ, Jo Kamimoto JL, Miller K, Kollman C, Beck RW. Automated Insulin Delivery in Older Adults with Type 1 Diabetes. NEJM Evid. 2025 Jan; 4(1):EVIDoa2400200.
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Dickerson RN, McLeod AR, Stonecipher AE, Farrar JE, Byerly S, Filiberto DM, Fischer PE. Outpatient diabetes management influences glycemic control for critically ill patients during nutrition support: A retrospective observational study. Nutr Clin Pract. 2025 Feb; 40(1):134-146.
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Singh S, Rahman SH, Khan N, Rajagopal A, Shafique N, Tawde P, Bhardwaj V, Suresh Kumar VC, Aswath G, Inamdar S, Dutta S, Hurairah A, Mohan BP. Effects of glucagon-like peptide-1 receptor agonists on endoscopy outcomes: systematic review and meta-analysis. Gastrointest Endosc. 2025 Feb; 101(2):343-349.e5.
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Nemiroff S, Goulden P. Tailoring an antihyperglycaemic regimen to a monogenic diabetes variant. BMJ Case Rep. 2024 Sep 20; 17(9).
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Harmon DC, Levene JA, Rutlen CL, White ES, Freeman IR, Lapidus JA. Preadmission Metformin Use Is Associated with Reduced Mortality in Patients with Diabetes Mellitus Hospitalized with COVID-19. J Gen Intern Med. 2024 Dec; 39(16):3253-3260.
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Knop FK, Urva S, Rettiganti M, Benson CT, Roell WC, Mather KJ, Haupt A, Pratt EJ. A long-acting glucose-dependent insulinotropic polypeptide receptor agonist improves the gastrointestinal tolerability of glucagon-like peptide-1 receptor agonist therapy. Diabetes Obes Metab. 2024 Nov; 26(11):5474-5478.
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Gendron WH, Fertan E, Roddick KM, Wong AA, Maliougina M, Hiani YE, Anini Y, Brown RE. Intranasal insulin treatment ameliorates spatial memory, muscular strength, and frailty deficits in 5xFAD mice. Physiol Behav. 2024 Jul 01; 281:114583.
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Hiramoto B, McCarty TR, Lodhia NA, Jenkins A, Elnaiem A, Muftah M, Flanagan R, Chan WW. Quantified Metrics of Gastric Emptying Delay by Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management. Am J Gastroenterol. 2024 06 01; 119(6):1126-1140.
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Lopez-Candales A, Monte S, Sawalha K, Norgard NB. Time to revisit the true role of metformin in type 2 diabetes mellitus. Postgrad Med. 2023 08; 135(6):539-542.
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Lopez-Candales A, Sawalha K, Drees BM, Norgard NB. In search of mechanisms to explain the unquestionable benefit derived from sodium-glucose cotransporter-2 (SGLT-2) inhibitors use in heart failure patients. Postgrad Med. 2023 05; 135(4):323-326.
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Scarton L, Jo A, Xie Z, O'Neal LJ, Munoz Pena JM, George TJ, Bian J. Examining the relationship between metformin dose and cancer survival: A SEER-Medicare analysis. PLoS One. 2022; 17(10):e0275681.
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Russell SJ, Beck RW, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro CA, Li Z, Calhoun P, Wadwa RP, Buckingham B, Zhou K, Daniels M, Raskin P, White PC, Lynch J, Pettus J, Hirsch IB, Goland R, Buse JB, Kruger D, Mauras N, Muir A, McGill JB, Cogen F, Weissberg-Benchell J, Sherwood JS, Castellanos LE, Hillard MA, Tuffaha M, Putman MS, Sands MY, Forlenza G, Slover R, Messer LH, Cobry E, Shah VN, Polsky S, Lal R, Ekhlaspour L, Hughes MS, Basina M, Hatipoglu B, Olansky L, Bhangoo A, Forghani N, Kashmiri H, Sutton F, Choudhary A, Penn J, Jafri R, Rayas M, Escaname E, Kerr C, Favela-Prezas R, Boeder S, Trikudanathan S, Williams KM, Leibel N, Kirkman MS, Bergamo K, Klein KR, Dostou JM, Machineni S, Young LA, Diner JC, Bhan A, Jones JK, Benson M, Bird K, Englert K, Permuy J, Cossen K, Felner E, Salam M, Silverstein JM, Adamson S, Cedeno A, Meighan S, Dauber A. Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes. N Engl J Med. 2022 09 29; 387(13):1161-1172.
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Gonz?lez-Saldivar G, Millan-Alanis JM, Gonz?lez-Gonz?lez JG, S?nchez-G?mez RA, Obeso-Fern?ndez J, McCoy RG, Maraka S, Brito JP, Ospina NS, Oyervides-Fuentes S, Rodr?guez-Guti?rrez R. Treatment burden and perceptions of glucose-lowering therapy among people living with diabetes. Prim Care Diabetes. 2022 08; 16(4):568-573.
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Gerardo Gonz?lez-Gonz?lez J, Cesar Solis R, D?az Gonz?lez-Colmenero A, Raygoza-Cortez K, Moreno-Pe?a PJ, S?nchez AL, McCoy RG, Singh Ospina N, Maraka S, Brito JP, Rodriguez-Gutierrez R. Effect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Res Clin Pract. 2022 Apr; 186:109821.
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Norgard NB, Lopez-Candales A. The rise of SGLT2 inhibitors: the time is now for cardiovascular specialists to lead the charge. Postgrad Med. 2022 01; 134(1):11-13.
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DeYoung OA, Boehmer K, Hung D, McAdam-Marx C. A historical cohort study of glycemic control in patients with concurrent type 2 diabetes and substance use disorder treated in a primary care setting. Fam Pract. 2021 09 25; 38(5):562-568.
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Yun JS, Park YM, Han K, Kim HW, Cha SA, Ahn YB, Ko SH. Severe hypoglycemia and the risk of end stage renal disease in type 2 diabetes. Sci Rep. 2021 02 22; 11(1):4305.
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Park YM, Bookwalter DB, O'Brien KM, Jackson CL, Weinberg CR, Sandler DP. A prospective study of type 2 diabetes, metformin use, and risk of breast cancer. Ann Oncol. 2021 03; 32(3):351-359.
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Tsai CY, Rosa F, Bionaz M, Rezamand P. Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis. J Dairy Res. 2020 Nov; 87(4):416-423.
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Kulkarni AS, Peck BD, Walton RG, Kern PA, Mar JC, Windham ST, Bamman MM, Barzilai N, Peterson CA. Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults. Aging (Albany NY). 2020 10 18; 12(20):19852-19866.
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Lakey H, Boehmer K, Johnson C. Impact of a Pharmacist-Led Group Diabetes Class. J Pharm Pract. 2022 Feb; 35(1):54-56.
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Desai R, Singh S, Parekh T, Sachdeva S, Sachdeva R, Kumar G. COVID-19 and diabetes mellitus: A need for prudence in elderly patients from a pooled analysis. Diabetes Metab Syndr. 2020 Jul - Aug; 14(4):683-685.
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Martin LD, Hoagland MA, Rhodes ET, Wolfsdorf JI, Hamrick JL. Perioperative Management of Pediatric Patients With Type 1 Diabetes Mellitus, Updated Recommendations for Anesthesiologists. Anesth Analg. 2020 04; 130(4):821-827.
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Pabona JMP, Burnett AF, Brown DM, Quick CM, Simmen FA, Montales MTE, Liu SJ, Rose T, Alhallak I, Siegel ER, Simmen RC. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reprod Sci. 2020 01; 27(1):267-277.
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Hacimuftuoglu A, Mohammadzadeh M, Taghizadehghalehjoughi A, Taspinar N, Togar B, Nalci KA, Okkay U, Gundogdu B. The analgesic effect of metformin on paclitaxel-induced neuropathic pain model in rats: By considering pathological results. J Cancer Res Ther. 2020 Jan-Mar; 16(1):34-39.
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Rodriguez-Gutierrez R, Salcido-Montenegro A, Singh-Ospina NM, Maraka S, I?iguez-Ariza N, Spencer-Bonilla G, Tamhane SU, Lipska KJ, Montori VM, McCoy RG. Documentation of hypoglycemia assessment among adults with diabetes during clinical encounters in primary care and endocrinology practices. Endocrine. 2020 03; 67(3):552-560.
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Amr BS, Lippmann M, Tobbia P, Isom N, Dalia T, Buechler T, Pierpoline M, Patel N, Hockstad E, Wiley M, Tadros P, Mehta A, Earnest M, Chen JG, Gupta K. Impact of short term oral steroid use for intravenous contrast media hypersensitivity prophylaxis in diabetic patients undergoing nonemergent coronary angiography or interventions. Catheter Cardiovasc Interv. 2020 12; 96(7):1392-1398.
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Walton RG, Dungan CM, Long DE, Tuggle SC, Kosmac K, Peck BD, Bush HM, Villasante Tezanos AG, McGwin G, Windham ST, Ovalle F, Bamman MM, Kern PA, Peterson CA. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double-blind, placebo-controlled, multicenter trial: The MASTERS trial. Aging Cell. 2019 12; 18(6):e13039.
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Yun JS, Park YM, Han K, Cha SA, Ahn YB, Ko SH. Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study. Cardiovasc Diabetol. 2019 08 14; 18(1):103.
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King J, McAdam-Marx C, McCaleb R, Davis D, Bemberg GB, Johnson JT. Cost and Utilization Outcomes After Exclusion of Dipeptidyl Peptidase-4 Inhibitors and Other Diabetes Drug Category Changes in a Self-Funded, State Employee Managed Care Plan. J Manag Care Spec Pharm. 2019 Jun; 25(6):646-651.
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Faustino EVS, Hirshberg EL, Asaro LA, Biagas KV, Pinto N, Srinivasan V, Bagdure DN, Steil GM, Coughlin-Wells K, Wypij D, Nadkarni VM, Agus MSD, Mourani PM, Chima R, Thomas NJ, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder KJ, Kandil S, Wintergerst K, Schwarz A, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin JC, Jouvet P, Yanay O, Allen C. Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children. Crit Care Med. 2019 05; 47(5):706-714.
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Lansing AH, Stoianova M, Stanger C. Adolescent Emotional Control Moderates Benefits of a Multicomponent Intervention to Improve Type 1 Diabetes Adherence: A Pilot Randomized Controlled Trial. J Pediatr Psychol. 2019 01 01; 44(1):126-136.
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Kalaitzoglou E, Fowlkes JL, Popescu I, Thrailkill KM. Diabetes pharmacotherapy and effects on the musculoskeletal system. Diabetes Metab Res Rev. 2019 02; 35(2):e3100.
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O'Keeffe DT, Maraka S. Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy. Ann Intern Med. 2018 10 02; 169(7):510-511.
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Sedgeman LR, Beysen C, Allen RM, Ramirez Solano MA, Turner SM, Vickers KC. Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes. Am J Physiol Gastrointest Liver Physiol. 2018 11 01; 315(5):G810-G823.
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Yun JS, Park YM, Han K, Cha SA, Ahn YB, Ko SH. Association between BMI and risk of severe hypoglycaemia in type 2 diabetes. Diabetes Metab. 2019 01; 45(1):19-25.
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Moonschi FH, Hughes CB, Mussman GM, Fowlkes JL, Richards CI, Popescu I. Advances in micro- and nanotechnologies for the GLP-1-based therapy and imaging of pancreatic beta-cells. Acta Diabetol. 2018 May; 55(5):405-418.
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Rozance PJ, Bai S, Kaiser JR. Searching for the Best Oral Treatment for Hypoglycemic Newborns. J Pediatr. 2017 11; 190:10-12.
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Schaeffer SE, DesLauriers C, Spiller HA, Aleguas A, Baeza S, Ryan ML. Retrospective review of SGLT2 inhibitor exposures reported to 13 poison centers. Clin Toxicol (Phila). 2018 03; 56(3):204-208.
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Geer EB, Shafiq I, Gordon MB, Bonert V, Ayala A, Swerdloff RS, Katznelson L, Lalazar Y, Manuylova E, Pulaski-Liebert KJ, Carmichael JD, Hannoush Z, Surampudi V, Broder MS, Cherepanov D, Eagan M, Lee J, Said Q, Neary MP, Biller BMK. BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. Endocr Pract. 2017 Aug; 23(8):962-970.
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Bader AP, Barone CP, Smeds MR. Risk Factor Modification Behaviors of Practicing Vascular Surgeons. Ann Vasc Surg. 2018 Jan; 46:90-96.
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Chung J, Modrall JG, Knowles M, Xiang Q, Lavery LA, Timaran CH, Valentine RJ. Arteriographic Patterns of Atherosclerosis and the Association between Diabetes Mellitus and Ethnicity in Chronic Critical Limb Ischemia. Ann Vasc Surg. 2017 Apr; 40:198-205.
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Saad M, Mahmoud AN, Elgendy IY, Abuzaid A, Barakat AF, Elgendy AY, Al-Ani M, Mentias A, Nairooz R, Bavry AA, Mukherjee D. Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors in patients with type II diabetes mellitus: A meta-analysis of placebo-controlled randomized trials. Int J Cardiol. 2017 Feb 01; 228:352-358.
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Lim TS, Yun JS, Cha SA, Song KH, Yoo KD, Ahn YB, Park YM, Ko SH. Elevated lipoprotein(a) levels predict cardiovascular disease in type 2 diabetes mellitus: a 10-year prospective cohort study. Korean J Intern Med. 2016 Nov; 31(6):1110-1119.
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Azoulay L, Filion KB, Platt RW, Dahl M, Dormuth CR, Clemens KK, Durand M, Hu N, Juurlink DN, Paterson JM, Targownik LE, Turin TC, Ernst P, Suissa S, Dormuth CR, Hemmelgarn BR, Teare GF, Caetano P, Chateau D, Henry DA, Paterson JM, LeLorier J, Levy AR, Ernst P, Platt RW, Sketris IS. Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis. JAMA Intern Med. 2016 Oct 01; 176(10):1464-1473.
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Lansing AH, Stanger C, Budney A, Christiano AS, Casella SJ. Pilot Study of a Web-Delivered Multicomponent Intervention for Rural Teens with Poorly Controlled Type 1 Diabetes. J Diabetes Res. 2016; 2016:7485613.
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Choudhary A. Sick Day Management in Children and Adolescents with Type 1 Diabetes. J Ark Med Soc. 2016 Jun; 112(14):284-6.
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Pinheiro BS, Lemos C, Neutzling Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, K?falvi A. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016 06; 124:222-30.
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Bilandzic A, Fitzpatrick T, Rosella L, Henry D. Risk of Bias in Systematic Reviews of Non-Randomized Studies of Adverse Cardiovascular Effects of Thiazolidinediones and Cyclooxygenase-2 Inhibitors: Application of a New Cochrane Risk of Bias Tool. PLoS Med. 2016 Apr; 13(4):e1001987.
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Yamashita Y, Asakura M, Mitsugi R, Fujii H, Nagai K, Atsuda K, Itoh T, Fujiwara R. MicroRNA expression in the vildagliptin-treated two- and three-dimensional HepG2 cells. Drug Metab Pharmacokinet. 2016 Jun; 31(3):201-9.
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O'Keeffe DT, Maraka S, Rizza RA. HbA1c in the Evaluation of Diabetes Mellitus. JAMA. 2016 Feb 09; 315(6):605-6.
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Hall C, Stone RL, Gehlot A, Zorn KK, Burnett AF. Use of Metformin in Obese Women With Type I Endometrial Cancer Is Associated With a Reduced Incidence of Cancer Recurrence. Int J Gynecol Cancer. 2016 Feb; 26(2):313-7.
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Hasan R, Firwana B, Elraiyah T, Domecq JP, Prutsky G, Nabhan M, Prokop LJ, Henke P, Tsapas A, Montori VM, Murad MH. A systematic review and meta-analysis of glycemic control for the prevention of diabetic foot syndrome. J Vasc Surg. 2016 Feb; 63(2 Suppl):22S-28S.e1-2.
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Burgeiro A, Fuhrmann A, Cherian S, Espinoza D, Jarak I, Carvalho RA, Loureiro M, Patr?cio M, Antunes M, Carvalho E. Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes. Am J Physiol Endocrinol Metab. 2016 Apr 01; 310(7):E550-64.
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Abualsuod A. Response to Letter to the Editor: Effects of New Antiplatelet Agents and Aldosterone Receptor Antagonists on Mortality in Patients with Myocardial Infarction. Cardiovasc Drugs Ther. 2015 Oct; 29(5):497.
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Pothineni NV, Mehta JL. Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2015 09 03; 373(10):977-8.
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Low Y, White WD, Habib AS. Postoperative hyperglycemia after 4- vs 8-10-mg dexamethasone for postoperative nausea and vomiting prophylaxis in patients with type II diabetes mellitus: a retrospective database analysis. J Clin Anesth. 2015 Nov; 27(7):589-94.
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Williams ED, Rogers SC, Zhang X, Azhar G, Wei JY. Elevated oxygen consumption rate in response to acute low-glucose stress: Metformin restores rate to normal level. Exp Gerontol. 2015 Oct; 70:157-62.
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