Barbiturates
"Barbiturates" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of chemicals derived from barbituric acid or thiobarbituric acid. Many of these are GABA MODULATORS used as HYPNOTICS AND SEDATIVES, as ANESTHETICS, or as ANTICONVULSANTS.
| Descriptor ID |
D001463
|
| MeSH Number(s) |
D03.383.742.698.253
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Barbiturates".
Below are MeSH descriptors whose meaning is more specific than "Barbiturates".
This graph shows the total number of publications written about "Barbiturates" by people in UAMS Profiles by year, and whether "Barbiturates" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 1 | 1 |
| 2015 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Barbiturates" by people in Profiles over the past ten years.
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Traver G, Sekhar KR, Crooks PA, Keeney DS, Freeman ML. Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC. Cancer Lett. 2021 03 01; 500:220-227.
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Penthala NR, Ketkar A, Sekhar KR, Freeman ML, Eoff RL, Balusu R, Crooks PA. 1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1). Bioorg Med Chem. 2015 Nov 15; 23(22):7226-33.
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Penthala NR, Crooks PA, Freeman ML, Sekhar KR. Development and validation of a novel assay to identify radiosensitizers that target nucleophosmin 1. Bioorg Med Chem. 2015 Jul 01; 23(13):3681-6.