 Ketamine
"Ketamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
| Descriptor ID |
D007649
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| MeSH Number(s) |
D02.455.426.392.368.367.652
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| Concept/Terms |
Ketamine- Ketamine
- 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
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Below are MeSH descriptors whose meaning is more general than "Ketamine".
Below are MeSH descriptors whose meaning is more specific than "Ketamine".
This graph shows the total number of publications written about "Ketamine" by people in UAMS Profiles by year, and whether "Ketamine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2023 | 2 | 0 | 2 | | 2022 | 2 | 1 | 3 | | 2020 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2017 | 4 | 1 | 5 | | 2016 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2010 | 2 | 1 | 3 | | 2009 | 3 | 0 | 3 | | 2008 | 3 | 0 | 3 | | 2007 | 4 | 0 | 4 | | 2006 | 2 | 0 | 2 | | 2003 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 |
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Below are the most recent publications written about "Ketamine" by people in Profiles over the past ten years.
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Shaw HE, Patel DR, Gannon BM, Fitzgerald LR, Carbonaro TM, Johnson CR, Fantegrossi WE. Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents. J Pharmacol Exp Ther. 2024 Jun 21; 390(1):14-28.
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Wang C, Bhutta A, Zhang X, Liu F, Liu S, Latham LE, Talpos JC, Patterson TA, Slikker W. Development of a primate model to evaluate the effects of ketamine and surgical stress on the neonatal brain. Exp Biol Med (Maywood). 2023 04; 248(7):624-632.
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Nigam K, Curseen KA, Beaussant Y. Psychedelics and Related Pharmacotherapies as Integrative Medicine for Older Adults in Palliative Care. Clin Geriatr Med. 2023 08; 39(3):423-436.
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Puzio TJ, Klugh J, Wandling MW, Green C, Balogh J, Prater SJ, Stephens CT, Sergot PB, Wade CE, Kao LS, Harvin JA. Ketamine for acute pain after trauma: the KAPT randomized controlled trial. Trials. 2022 Jul 27; 23(1):599.
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Wilcox MR, Nigam A, Glasgow NG, Narangoda C, Phillips MB, Patel DS, Mesbahi-Vasey S, Turcu AL, V?zquez S, Kurnikova MG, Johnson JW. Inhibition of NMDA receptors through a membrane-to-channel path. Nat Commun. 2022 07 15; 13(1):4114.
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Singh V, Gillespie TW, Lane O, Spektor B, Zarrabi AJ, Egan K, Curseen K, Tsvetkova M, Beumer JH, Sniecinski R, Shteamer JW, Switchenko J, Harvey RD. A dose-escalation clinical trial of intranasal ketamine for uncontrolled cancer-related pain. Pharmacotherapy. 2022 04; 42(4):298-310.
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Choudhary D, Dhillon R, Chadha K, Cross K, Carnevale FP. National Survey to Describe the Current Patterns of Procedural Sedation Practices Among Pediatric Emergency Medicine Practitioners in the United States. Pediatr Emerg Care. 2022 Jan 01; 38(1):e321-e328.
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Conway JA, Kharayat P, Sanders RC, Nett S, Weiss SL, Edwards LR, Breuer R, Kirby A, Krawiec C, Page-Goertz C, Polikoff L, Turner DA, Shults J, Giuliano JS, Orioles A, Balkandier S, Emeriaud G, Rehder KJ, Kian Boon JL, Shenoi A, Vanderford P, Nuthall G, Lee A, Zeqo J, Parsons SJ, Furlong-Dillard J, Meyer K, Harwayne-Gidansky I, Jung P, Adu-Darko M, Bysani GK, McCarthy MA, Shlomovich M, Toedt-Pingel I, Branca A, Esperanza MC, Al-Subu AM, Pinto M, Tallent S, Shetty R, Thyagarajan S, Ikeyama T, Tarquinio KM, Skippen P, Kasagi M, Howell JD, Nadkarni VM, Nishisaki A. Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. Crit Care Med. 2020 06; 48(6):e489-e497.
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Samanta D. Ketamine Infusion for Super Refractory Status Epilepticus in Alternating Hemiplegia of Childhood. Neuropediatrics. 2020 06; 51(3):225-228.
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Samanta D. Ketamine in Refractory Neonatal Seizures. Pediatr Neurol. 2020 05; 106:76.
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Ray-Griffith SL, Eads LA, Han X, Golden K, Stowe ZN. A Randomized Pilot Study Comparing Ketamine and Methohexital Anesthesia for Electroconvulsive Therapy in Patients With Depression. J ECT. 2017 Dec; 33(4):268-271.
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Sin B, Nguyen T, Chew S, Caffarini E, Nawaratne U, Kondamudi N. Intranasal Ketamine in Subdissociative Doses for a 2-Year-Old. Am J Ther. 2017 Jul/Aug; 24(4):e497-e498.
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Lee HG, Grossman SK, Valdes-Rodriguez R, Berenato F, Korbutov J, Chan YH, Lavery MJ, Yosipovitch G. Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability. J Am Acad Dermatol. 2017 04; 76(4):760-761.
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Nazarian DJ, Broder JS, Thiessen MEW, Wilson MP, Zun LS, Brown MD. Clinical Policy: Critical Issues in the Diagnosis and?Management of the Adult Psychiatric Patient in?the Emergency Department. Ann Emerg Med. 2017 Apr; 69(4):480-498.
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Strasburger SE, Bhimani PM, Kaabe JH, Krysiak JT, Nanchanatt DL, Nguyen TN, Pough KA, Prince TA, Ramsey NS, Savsani KH, Scandlen L, Cavaretta MJ, Raffa RB. What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities. J Clin Pharm Ther. 2017 Apr; 42(2):147-154.
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Bujold K, Hauer-Jensen M, Donini O, Rumage A, Hartman D, Hendrickson HP, Stamatopoulos J, Naraghi H, Pouliot M, Ascah A, Sebastian M, Pugsley MK, Wong K, Authier S. Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. Radiat Res. 2016 07; 186(1):71-8.
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Slikker W, Liu F, Rainosek SW, Patterson TA, Sadovova N, Hanig JP, Paule MG, Wang C. Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells. Mol Neurobiol. 2015 Oct; 52(2):959-69.
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Hopper AB, Vilke GM, Castillo EM, Campillo A, Davie T, Wilson MP. Ketamine use for acute agitation in the emergency department. J Emerg Med. 2015 Jun; 48(6):712-9.
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