 Cocaine
"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
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| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.869.388 D04.075.080.875.099.722.388
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in UAMS Profiles by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 0 | 2 | 2 | | 2024 | 3 | 0 | 3 | | 2023 | 1 | 0 | 1 | | 2022 | 2 | 0 | 2 | | 2021 | 2 | 0 | 2 | | 2020 | 2 | 1 | 3 | | 2019 | 2 | 2 | 4 | | 2018 | 1 | 0 | 1 | | 2017 | 1 | 2 | 3 | | 2016 | 0 | 3 | 3 | | 2014 | 3 | 2 | 5 | | 2013 | 3 | 1 | 4 | | 2012 | 2 | 0 | 2 | | 2011 | 2 | 3 | 5 | | 2010 | 0 | 3 | 3 | | 2009 | 4 | 0 | 4 | | 2007 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2005 | 1 | 1 | 2 | | 2004 | 0 | 2 | 2 | | 2003 | 1 | 3 | 4 | | 2002 | 2 | 2 | 4 | | 2000 | 3 | 0 | 3 | | 1999 | 1 | 0 | 1 | | 1998 | 4 | 0 | 4 | | 1997 | 4 | 2 | 6 | | 1996 | 5 | 0 | 5 | | 1995 | 2 | 0 | 2 | | 1994 | 4 | 1 | 5 | | 1993 | 8 | 1 | 9 | | 1992 | 4 | 0 | 4 | | 1991 | 3 | 0 | 3 | | 1990 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cocaine" by people in Profiles over the past ten years.
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Oliveto AH, McGaugh J, Chopra MP, Thostenson J, Mancino MJ. A randomized clinical trial of disulfiram at higher doses for the treatment of cocaine use disorder among methadone-stabilized patients. J Psychiatr Res. 2025 Jun; 186:387-395.
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Hiranita T, Hong WC, Sharma A, Lopez JP, Mesangeau C, Whittaker DA, Alsharif W, Kopajtic TA, Jamalapuram S, Avery BA, Tanda G, McCurdy CR, Katz JL. Preclinical Profile of CM699 as a Medication Candidate for Stimulant Use Disorder. ACS Chem Neurosci. 2025 Apr 16; 16(8):1454-1468.
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Hiranita T, Soto PL, Katz JL. Dopamine D1-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats. J Pharmacol Exp Ther. 2024 Nov 19; 391(3):415-429.
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Hiranita T, Li SM, Katz JL. Effects of Dual Inhibition at Dopamine Transporter and s Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats. J Pharmacol Exp Ther. 2024 Oct 18; 391(2):308-316.
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Hersey M, Mereu M, Jones CS, Bartole MK, Chen AY, Cao J, Hiranita T, Chun LE, Lopez JP, Katz JL, Newman AH, Tanda G. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. Eur J Neurosci. 2024 May; 59(10):2436-2449.
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Ware OD, Sweeney MM, Cunningham C, Umbricht A, Stitzer M, Dunn KE. Bupropion Slow Release vs Placebo With Adaptive Incentives for Cocaine Use Disorder in Persons Receiving Methadone for Opioid Use Disorder: A Randomized Clinical Trial. JAMA Netw Open. 2023 03 01; 6(3):e232278.
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Liu X, Vickstrom CR, Yu H, Liu S, Snarrenberg ST, Friedman V, Mu L, Chen B, Kelly TJ, Baker DA, Liu QS. Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via enhancement of dopamine release. Elife. 2022 08 22; 11.
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Liachenko S, Chelonis J, Paule MG, Li M, Sadovova N, Talpos JC. The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey. Neurotoxicol Teratol. 2022 Sep-Oct; 93:107119.
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Doyle MR, Gannon BM, Mesmin MP, Collins GT. Application of dose-addition analyses to characterize the abuse-related effects of drug mixtures. J Exp Anal Behav. 2022 05; 117(3):442-456.
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Kaddour H, Kopcho S, Lyu Y, Shouman N, Paromov V, Pratap S, Dash C, Kim EY, Martinson J, McKay H, Epeldegui M, Margolick JB, Stapleton JT, Okeoma CM. HIV-infection and cocaine use regulate semen extracellular vesicles proteome and miRNAome in a manner that mediates strategic monocyte haptotaxis governed by miR-128 network. Cell Mol Life Sci. 2021 Dec 22; 79(1):5.
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Mu L, Liu X, Yu H, Hu M, Friedman V, Kelly TJ, Zhao L, Liu QS. Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. Neuropharmacology. 2021 12 15; 201:108830.
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McClenahan SJ, Gunnell MG, Owens SM, Fantegrossi WE. Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine. Psychopharmacology (Berl). 2020 Sep; 237(9):2613-2620.
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Hyatt WS, Hirsh CE, Russell LN, Chitre NM, Murnane KS, Rice KC, Fantegrossi WE. The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats. Behav Pharmacol. 2020 06; 31(4):309-321.
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Mereu M, Hiranita T, Jordan CJ, Chun LE, Lopez JP, Coggiano MA, Quarterman JC, Bi GH, Keighron JD, Xi ZX, Newman AH, Katz JL, Tanda G. Modafinil potentiates cocaine self-administration by a dopamine-independent mechanism: possible involvement of gap junctions. Neuropsychopharmacology. 2020 08; 45(9):1518-1526.
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Hall FS, Raman D, Tiwari AK. CCR5 and responses to cocaine: Addiction is not just about the brain. Brain Behav Immun. 2020 02; 84:8-9.
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Alzghoul BN, Abualsuod A, Alqam B, Innabi A, Palagiri DR, Gheith Z, Amer FN, Meena NK, Kenchaiah S. Cocaine Use and Pulmonary Hypertension. Am J Cardiol. 2020 01 15; 125(2):282-288.
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Hyatt WS, Berquist MD, Chitre NM, Russell LN, Rice KC, Murnane KS, Fantegrossi WE. Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats. Behav Pharmacol. 2019 10; 30(7):555-565.
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Kroska EB, Meller EW, Doyle R, Coker JL, Knight BT, Ray-Griffith SL, Nembhard WN, Stowe ZN. Drug screening during pregnancy: Urine dip cups measure up. Drug Alcohol Depend. 2019 11 01; 204:107461.
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Gannon BM, Baumann MH, Walther D, Jimenez-Morigosa C, Sulima A, Rice KC, Collins GT. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Neuropsychopharmacology. 2018 11; 43(12):2399-2407.
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Hammad AM, Alasmari F, Sari Y, Scott Hall F, Tiwari AK. Alcohol and Cocaine Exposure Modulates ABCB1 and ABCG2 Transporters in Male Alcohol-Preferring Rats. Mol Neurobiol. 2019 Mar; 56(3):1921-1932.
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Bashiri M, Mancino MJ, Stanick VA, Thostenson J, Kosten TR, Oliveto AH. Moderators of response to sertraline versus placebo among recently abstinent, cocaine dependent patients: A retrospective analysis of two clinical trials. Am J Addict. 2017 Dec; 26(8):807-814.
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Hanlon CA, Dowdle LT, Correia B, Mithoefer O, Kearney-Ramos T, Lench D, Griffin M, Anton RF, George MS. Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users. Drug Alcohol Depend. 2017 09 01; 178:310-317.
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Hiranita T, Hong WC, Kopajtic T, Katz JL. s Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration. J Pharmacol Exp Ther. 2017 07; 362(1):2-13.
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Tanda G, Mereu M, Hiranita T, Quarterman JC, Coggiano M, Katz JL. Lack of Specific Involvement of (+)-Naloxone and (+)-Naltrexone on the Reinforcing and Neurochemical Effects of Cocaine and Opioids. Neuropsychopharmacology. 2016 10; 41(11):2772-81.
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Berquist MD, Traxler HK, Mahler AM, Baker LE. Sensitization to the locomotor stimulant effects of "bath salt" constituents, 4-methylmethcathinone (4-MMC) and 3,4-methylenedioxypyrovalerone (MDPV), in male Sprague-Dawley rats. Drug Alcohol Depend. 2016 Jul 01; 164:128-134.
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Cheney AM, Booth BM, Borders TF, Curran GM. The Role of Social Capital in African Americans' Attempts to Reduce and Quit Cocaine Use. Subst Use Misuse. 2016 05 11; 51(6):777-87.
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Gonz?lez CR, Gonz?lez B, Matzkin ME, Mu?iz JA, Cadet JL, Garcia-Rill E, Urbano FJ, Vitullo AD, Bisagno V. Psychostimulant-Induced Testicular Toxicity in Mice: Evidence of Cocaine and Caffeine Effects on the Local Dopaminergic System. PLoS One. 2015; 10(11):e0142713.
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