 Carcinogens
"Carcinogens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
| Descriptor ID |
D002273
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| MeSH Number(s) |
D27.888.569.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Carcinogens".
Below are MeSH descriptors whose meaning is more specific than "Carcinogens".
This graph shows the total number of publications written about "Carcinogens" by people in UAMS Profiles by year, and whether "Carcinogens" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 1 | 2 | 3 | | 2021 | 1 | 3 | 4 | | 2020 | 0 | 2 | 2 | | 2019 | 3 | 2 | 5 | | 2018 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2016 | 3 | 1 | 4 | | 2015 | 2 | 2 | 4 | | 2014 | 2 | 2 | 4 | | 2013 | 1 | 0 | 1 | | 2012 | 2 | 1 | 3 | | 2011 | 2 | 3 | 5 | | 2010 | 1 | 1 | 2 | | 2009 | 2 | 2 | 4 | | 2008 | 5 | 4 | 9 | | 2007 | 2 | 5 | 7 | | 2006 | 6 | 1 | 7 | | 2005 | 4 | 4 | 8 | | 2004 | 4 | 2 | 6 | | 2003 | 5 | 5 | 10 | | 2002 | 4 | 1 | 5 | | 2001 | 7 | 3 | 10 | | 2000 | 3 | 1 | 4 | | 1999 | 4 | 0 | 4 | | 1998 | 2 | 0 | 2 | | 1997 | 3 | 1 | 4 | | 1996 | 3 | 1 | 4 | | 1995 | 7 | 0 | 7 | | 1994 | 2 | 0 | 2 | | 1993 | 2 | 1 | 3 | | 1992 | 2 | 2 | 4 | | 1991 | 2 | 1 | 3 | | 1989 | 4 | 0 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Carcinogens" by people in Profiles over the past ten years.
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Caipa Garcia AL, Kucab JE, Al-Serori H, Beck RSS, Bellamri M, Turesky RJ, Groopman JD, Francies HE, Garnett MJ, Huch M, Drost J, Zilbauer M, Arlt VM, Phillips DH. Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation. Chem Res Toxicol. 2024 02 19; 37(2):234-247.
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Corton JC, Mitchell CA, Auerbach S, Bushel P, Ellinger-Ziegelbauer H, Escobar PA, Froetschl R, Harrill AH, Johnson K, Klaunig JE, Pandiri AR, Podtelezhnikov AA, Rager JE, Tanis KQ, van der Laan JW, Vespa A, Yauk CL, Pettit SD, Sistare FD. A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies. Toxicol Sci. 2022 06 28; 188(1):4-16.
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Boysen G, Rusyn I, Chiu WA, Wright FA. Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice. Regul Toxicol Pharmacol. 2022 Jul; 132:105171.
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Brauer PR, Bryson PC, Wu SS, Gau VL, Lamarre ED, Kominsky AH. Cancer Risk Associated with Continuous Positive Airway Pressure: A National Study. Laryngoscope. 2022 11; 132(11):2270-2274.
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Goodman S, Chappell G, Guyton KZ, Pogribny IP, Rusyn I. Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review. Mutat Res Rev Mutat Res. 2022 Jan-Jun; 789:108408.
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Nellis M, Caperton CO, Liu K, Tran V, Go YM, Hallberg LM, Ameredes BT, Jones DP, Boysen G. Lung metabolome of 1,3-butadiene exposed Collaborative Cross mice reflects metabolic phenotype of human lung cancer. Toxicology. 2021 11; 463:152987.
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Hu SC, Min S, Kang HK, Yang DJ, Lewis SM, Davis KJ, Patton RE, Bryant MS, Sepehr E, Trbojevich R, Pearce MG, Bishop ME, Heflich RH, Maisha MP, Felton R, Chemerynski S, Yee SB, Coraggio M, Rosenfeldt H, Yeager RP, Howard PC, Tang Y. 14-Day Nose-Only Inhalation Toxicity and Haber's Rule Study of NNK in Sprague-Dawley Rats. Toxicol Sci. 2021 09 28; 183(2):319-337.
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Gokulan K, Kumar A, Lahiani MH, Sutherland VL, Cerniglia CE, Khare S. Differential Toxicological Outcome of Corn Oil Exposure in Rats and Mice as Assessed by Microbial Composition, Epithelial Permeability, and Ileal Mucosa-Associated Immune Status. Toxicol Sci. 2021 02 26; 180(1):89-102.
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Wen Y, Vechetti IJ, Alimov AP, Hoffman JF, Vergara VB, Kalinich JF, McCarthy JJ, Peterson CA. Time-course analysis of the effect of embedded metal on skeletal muscle gene expression. Physiol Genomics. 2020 12 01; 52(12):575-587.
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Hayes M, Ferruzzi MG. Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives. Nutr Res. 2020 09; 81:19-37.
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Reed L, Jarvis IWH, Phillips DH, Arlt VM. Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase. Mutat Res Genet Toxicol Environ Mutagen. 2020 Apr; 852:503162.
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Phillips DH, Arlt VM. 32P-Postlabeling Analysis of DNA Adducts. Methods Mol Biol. 2020; 2102:291-302.
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Yauk CL, Harrill AH, Ellinger-Ziegelbauer H, van der Laan JW, Moggs J, Froetschl R, Sistare F, Pettit S. A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies. Regul Toxicol Pharmacol. 2020 Feb; 110:104526.
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Tryndyak V, Borowa-Mazgaj B, Beland FA, Pogribny IP. Gene expression and cytosine DNA methylation alterations in induced pluripotent stem-cell-derived human hepatocytes treated with low doses of chemical carcinogens. Arch Toxicol. 2019 11; 93(11):3335-3344.
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Faramawi MF, Johnson ES. A Case-Cohort Study to Investigate the Excess of Liver Cancer Observed in Workers in Poultry Slaughtering & Processing Plants. Nutr Cancer. 2019; 71(7):1118-1131.
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de Conti A, Tryndyak V, VonTungeln LS, Churchwell MI, Beland FA, Antunes AMM, Pogribny IP. Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study. Chem Res Toxicol. 2019 05 20; 32(5):869-877.
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Seo JE, Tryndyak V, Wu Q, Dreval K, Pogribny I, Bryant M, Zhou T, Robison TW, Mei N, Guo X. Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay. Arch Toxicol. 2019 05; 93(5):1433-1448.
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Reed L, Arlt VM, Phillips DH. The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox. Carcinogenesis. 2018 07 03; 39(7):851-859.
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Kromhout H, Friesen M, Marques MM, Sergi CM, Abdallah M, Benke G, Cesta M, Germolec D, Houck K, Ichihara G, Jameson CW, Kanno J, Pogribny I, Svendsen C, Benbrahim-Tallaa L, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Hall A, Jaillet C, Mattock H, Straif K. Carcinogenicity of isobutyl nitrite, ?-picoline, and some acrylates. Lancet Oncol. 2018 08; 19(8):1020-1022.
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Willis AJ, Indra R, Wohak LE, Sozeri O, Feser K, Mrizova I, Phillips DH, Stiborova M, Arlt VM. The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells. Toxicology. 2018 04 01; 398-399:1-12.
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Shpyleva S, Dreval K, de Conti A, Kindrat I, Melnyk S, Yan J, Chen T, Beland FA, Pogribny IP. Editor's Highlight: Organ-Specific Epigenetic Changes Induced by the Nongenotoxic Liver Carcinogen Methapyrilene in Fischer 344 Rats. Toxicol Sci. 2017 03 01; 156(1):190-198.
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Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 03 01; 378:114-124.
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Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA. Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study. Food Chem Toxicol. 2017 Jan; 99:170-181.
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Nunes J, Martins IL, Charneira C, Pogribny IP, de Conti A, Beland FA, Marques MM, Jacob CC, Antunes AMM. New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan. Toxicol Lett. 2016 Dec 15; 264:106-113.
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Arlt VM, Meinl W, Florian S, Nagy E, Barta F, Thomann M, Mrizova I, Krais AM, Liu M, Richards M, Mirza A, Kopka K, Phillips DH, Glatt H, Stiborova M, Schmeiser HH. Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone. Arch Toxicol. 2017 Apr; 91(4):1957-1975.
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Chappell G, Pogribny IP, Guyton KZ, Rusyn I. Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review. Mutat Res Rev Mutat Res. 2016 Apr-Jun; 768:27-45.
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Kindrat I, Tryndyak V, de Conti A, Shpyleva S, Mudalige TK, Kobets T, Erstenyuk AM, Beland FA, Pogribny IP. MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis. Oncotarget. 2016 Jan 12; 7(2):1276-87.
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Govindarajah V, Leung YK, Ying J, Gear R, Bornschein RL, Medvedovic M, Ho SM. In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands. J Nutr Biochem. 2016 Mar; 29:73-82.
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Marrone AK, Tryndyak V, Beland FA, Pogribny IP. MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells. Toxicol Sci. 2016 Feb; 149(2):496-502.
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Pogribny IP, Beland FA, Rusyn I. The role of microRNAs in the development and progression of chemical-associated cancers. Toxicol Appl Pharmacol. 2016 Dec 01; 312:3-10.
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Chepelev NL, Long AS, Williams A, Kuo B, Gagn? R, Kennedy DA, Phillips DH, Arlt VM, White PA, Yauk CL. Transcriptional Profiling of Dibenzo[def,p]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse. Toxicol Sci. 2016 Jan; 149(1):251-68.
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Krais AM, Speksnijder EN, Melis JP, Singh R, Caldwell A, Gamboa da Costa G, Luijten M, Phillips DH, Arlt VM. Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice. Int J Cancer. 2016 Feb 15; 138(4):976-82.
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Ronis MJ, Hakkak R, Korourian S, Badger TM. Whey Protein Hydrolysate but not Whole Whey Protein Protects Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats. Nutr Cancer. 2015; 67(6):949-53.
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Arlt VM, Krais AM, Godschalk RW, Riffo-Vasquez Y, Mrizova I, Roufosse CA, Corbin C, Shi Q, Frei E, Stiborova M, van Schooten FJ, Phillips DH, Spina D. Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene. Toxicol Sci. 2015 Aug; 146(2):213-25.
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Shukla S, Khan S, Kumar S, Sinha S, Farhan M, Bora HK, Maurya R, Meeran SM. Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis. Cancer Prev Res (Phila). 2015 Jun; 8(6):552-62.
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Zhou H, Chen JX, Yang CS, Yang MQ, Deng Y, Wang H. Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer. BMC Genomics. 2014; 15 Suppl 11:S3.
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