 Cytochrome P-450 CYP1A2
"Cytochrome P-450 CYP1A2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
| Descriptor ID |
D019388
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| MeSH Number(s) |
D08.244.453.040.777 D08.811.682.690.708.170.040.443 D12.776.422.220.453.040.555
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| Concept/Terms |
Cytochrome P-450 CYP1A2- Cytochrome P-450 CYP1A2
- CYP1A2, Cytochrome P-450
- Cytochrome P 450 CYP1A2
- Cytochrome P-450d
- Cytochrome P 450d
- Phenacetin O-Dealkylase
- O-Dealkylase, Phenacetin
- Phenacetin O Dealkylase
- Caffeine Demethylase
- Demethylase, Caffeine
- Cytochrome P-450 LM4
- Cytochrome P450 1A2
- CYP1A2
- CYP 1A2
- Cytochrome P-450 LM(4)
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP1A2".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP1A2".
This graph shows the total number of publications written about "Cytochrome P-450 CYP1A2" by people in UAMS Profiles by year, and whether "Cytochrome P-450 CYP1A2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2008 | 2 | 2 | 4 | | 2007 | 1 | 0 | 1 | | 2006 | 1 | 2 | 3 | | 2004 | 1 | 0 | 1 | | 2003 | 0 | 2 | 2 | | 2002 | 1 | 0 | 1 | | 2001 | 1 | 1 | 2 | | 1997 | 1 | 0 | 1 | | 1994 | 0 | 2 | 2 |
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Below are the most recent publications written about "Cytochrome P-450 CYP1A2" by people in Profiles over the past ten years.
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H?lzl-Armstrong L, N?visdal A, Cox JA, Long AS, Chepelev NL, Phillips DH, White PA, Arlt VM. In vitro mutagenicity of selected environmental carcinogens and their metabolites in MutaMouse FE1 lung epithelial cells. Mutagenesis. 2020 12 31; 35(6):453-463.
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Barnette DA, Schleiff MA, Datta A, Flynn N, Swamidass SJ, Miller GP. Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam. Toxicol Lett. 2021 Mar 01; 338:10-20.
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McCullough S, Dweep H, McGill MR, Bhattacharyya S, James L, Frankowski S, Woodall A, Kearns G, Gill P. Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. Microrna. 2020; 9(2):121-132.
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Gill P, Bhattacharyya S, McCullough S, Letzig L, Mishra PJ, Luo C, Dweep H, James L. MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. Sci Rep. 2017 09 26; 7(1):12331.
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