 Arginine
"Arginine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential amino acid that is physiologically active in the L-form.
| Descriptor ID |
D001120
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| MeSH Number(s) |
D12.125.068.050 D12.125.095.104 D12.125.142.087
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| Concept/Terms |
Arginine- Arginine
- L-Arginine
- Arginine, L-Isomer
- Arginine, L Isomer
- L-Isomer Arginine
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Below are MeSH descriptors whose meaning is more general than "Arginine".
Below are MeSH descriptors whose meaning is more specific than "Arginine".
This graph shows the total number of publications written about "Arginine" by people in UAMS Profiles by year, and whether "Arginine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 0 | 1 | 1 | | 2022 | 1 | 2 | 3 | | 2020 | 1 | 1 | 2 | | 2019 | 2 | 1 | 3 | | 2017 | 2 | 4 | 6 | | 2016 | 3 | 0 | 3 | | 2015 | 3 | 3 | 6 | | 2013 | 3 | 0 | 3 | | 2012 | 3 | 0 | 3 | | 2011 | 3 | 1 | 4 | | 2010 | 2 | 4 | 6 | | 2009 | 3 | 0 | 3 | | 2008 | 7 | 3 | 10 | | 2007 | 9 | 1 | 10 | | 2006 | 4 | 1 | 5 | | 2005 | 3 | 4 | 7 | | 2004 | 8 | 1 | 9 | | 2003 | 2 | 2 | 4 | | 2002 | 8 | 3 | 11 | | 2001 | 2 | 1 | 3 | | 2000 | 1 | 1 | 2 | | 1999 | 1 | 1 | 2 | | 1998 | 2 | 1 | 3 | | 1996 | 0 | 2 | 2 | | 1995 | 1 | 3 | 4 | | 1994 | 1 | 1 | 2 | | 1992 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Arginine" by people in Profiles over the past ten years.
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Sontam T, Deutz NEP, Cruthirds CL, Mbilinyi R, Ruebush LE, Ten Have GA, Thaden JJ, Engelen MPKJ. Prolonged disturbances in citrulline metabolism following resistance exercise in COPD. Clin Nutr. 2025 Jun; 49:21-32.
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Wierzchowska-McNew RA, Engelen MPKJ, Thaden JJ, Ten Have GAM, Deutz NEP. Obesity- and sex-related metabolism of arginine and nitric oxide in adults. Am J Clin Nutr. 2022 12 19; 116(6):1610-1620.
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Lin CC, Chang TY, Lu YC, Wu YS, Huang W, Lo WC, Liu GF, Hsu WC, Ohashi PS, Mak TW, Fuh JL, Chen HC, Tarng DC, Chen NJ. TREM-2 mediates dendritic cell-induced NO to suppress Th17 activation and ameliorate chronic kidney diseases. J Mol Med (Berl). 2022 06; 100(6):917-931.
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Hawley AL, Liang X, B?rsheim E, Wolfe RR, Salisbury L, Hendy E, Wu H, Walker S, Tacinelli AM, Baum JI. The potential role of beef and nutrients found in beef on outcomes of wellbeing in healthy adults 50?years of age and older: A systematic review of randomized controlled trials. Meat Sci. 2022 Jul; 189:108830.
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Wan Z, Rosenbaum ER, Liu W, Song B, Yue X, Kong Y, Li T, Zhai Y, Ma Z, Cao Z. Benchmark Examination of Blood Amino Acids Patterns in Phenylketonuria Neonates and Young Children on Phenylalanine-Restricted Dietary Treatment. Fetal Pediatr Pathol. 2022 Jun; 41(3):443-450.
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Granados JZ, Ten Have GAM, Letsinger AC, Thaden JJ, Engelen MPKJ, Lightfoot JT, Deutz NEP. Activated whole-body arginine pathway in high-active mice. PLoS One. 2020; 15(6):e0235095.
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Assia Batzir N, Kishor Bhagwat P, Larson A, Coban Akdemir Z, Baglaj M, Bofferding L, Bosanko KB, Bouassida S, Callewaert B, Cannon A, Enchautegui Colon Y, Garnica AD, Harr MH, Heck S, Hurst ACE, Jhangiani SN, Isidor B, Littlejohn RO, Liu P, Magoulas P, Mar Fan H, Marom R, McLean S, Nezarati MM, Nugent KM, Petersen MB, Rocha ML, Roeder E, Smigiel R, Tully I, Weisfeld-Adams J, Wells KO, Posey JE, Lupski JR, Beaudet AL, Wangler MF. Recurrent arginine substitutions in the ACTG2 gene are the primary driver of disease burden and severity in visceral myopathy. Hum Mutat. 2020 03; 41(3):641-654.
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Luiking YC, Poeze M, Deutz NE. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clin Nutr. 2020 06; 39(6):1764-1773.
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Sun J, Beger RD, Sloper DT, Nakamura N. Metabolomics-based pathway changes in testis fragments treated with ethinylestradiol in vitro. Birth Defects Res. 2019 12 01; 111(20):1643-1654.
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Bhatta A, Yao L, Xu Z, Toque HA, Chen J, Atawia RT, Fouda AY, Bagi Z, Lucas R, Caldwell RB, Caldwell RW. Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. Cardiovasc Res. 2017 Nov 01; 113(13):1664-1676.
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van Zwol A, Oosterloo NBC, de Betue CT, Bogers A, de Liefde II, Deutz NEP, Joosten KFM. Effects of glucocorticoids on serum amino acid levels during cardiac surgery in children. Clin Nutr ESPEN. 2018 02; 23:212-216.
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Engelen MPKJ, Klimberg VS, Allasia A, Deutz NEP. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Clin Nutr. 2018 10; 37(5):1645-1653.
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Smeets ETHC, Schutzler SE, Wei JY, Azhar G, Wolfe RR. Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure? Physiol Rep. 2017 Aug; 5(15).
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Liu Z, Nemec-Bakk A, Khaper N, Chen A. Sensitive Electrochemical Detection of Nitric Oxide Release from Cardiac and Cancer Cells via a Hierarchical Nanoporous Gold Microelectrode. Anal Chem. 2017 08 01; 89(15):8036-8043.
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Mulkey SB, Ben-Zeev B, Nicolai J, Carroll JL, Gr?nborg S, Jiang YH, Joshi N, Kelly M, Koolen DA, Mikati MA, Park K, Pearl PL, Scheffer IE, Spillmann RC, Taglialatela M, Vieker S, Weckhuysen S, Cooper EC, Cilio MR. Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H. Epilepsia. 2017 03; 58(3):436-445.
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de Betue CTI, Garcia Casal XC, van Waardenburg DA, Schexnayder SM, Joosten KFM, Deutz NEP, Engelen MPKJ. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study. Clin Nutr. 2017 06; 36(3):876-887.
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Millichap JJ, Miceli F, De Maria M, Keator C, Joshi N, Tran B, Soldovieri MV, Ambrosino P, Shashi V, Mikati MA, Cooper EC, Taglialatela M. Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. Epilepsia. 2017 01; 58(1):e10-e15.
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Brooks JR, Oketch-Rabah H, Low Dog T, Gorecki DK, Barrett ML, Cantilena L, Chung M, Costello RB, Dwyer J, Hardy ML, Jordan SA, Maughan RJ, Marles RJ, Osterberg RE, Rodda BE, Wolfe RR, Zuniga JM, Valerio LG, Jones D, Deuster P, Giancaspro GI, Sarma ND. Safety and performance benefits of arginine supplements for military personnel: a systematic review. Nutr Rev. 2016 11; 74(11):708-721.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016 06; 103(6):1458-64.
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Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. Reduced arginine availability and nitric oxide synthesis?in cancer?is related to impaired endogenous arginine synthesis. Clin Sci (Lond). 2016 07 01; 130(14):1185-95.
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Exley SE, Paslay LC, Sahukhal GS, Abel BA, Brown TD, McCormick CL, Heinhorst S, Koul V, Choudhary V, Elasri MO, Morgan SE. Antimicrobial Peptide Mimicking Primary Amine and Guanidine Containing Methacrylamide Copolymers Prepared by Raft Polymerization. Biomacromolecules. 2015 Dec 14; 16(12):3845-52.
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Kim IY, Schutzler SE, Schrader A, Spencer HJ, Azhar G, Deutz NE, Wolfe RR. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. Am J Physiol Endocrinol Metab. 2015 Dec 01; 309(11):E915-24.
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Hakkak R, Zeng H, Dhakal IB, Korourian S. Short- and Long-Term Soy Diet Versus Casein Protects Liver Steatosis Independent of the Arginine Content. J Med Food. 2015 Nov; 18(11):1274-80.
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