 Serotonin
"Serotonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
| Descriptor ID |
D012701
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| MeSH Number(s) |
D02.092.211.215.801.852 D03.438.473.914.814 D23.469.050.650
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| Concept/Terms |
Serotonin- Serotonin
- 5-HT
- Enteramine
- Hippophaine
- 3-(2-Aminoethyl)-1H-indol-5-ol
- 5-Hydroxytryptamine
- 5 Hydroxytryptamine
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Below are MeSH descriptors whose meaning is more general than "Serotonin".
Below are MeSH descriptors whose meaning is more specific than "Serotonin".
This graph shows the total number of publications written about "Serotonin" by people in UAMS Profiles by year, and whether "Serotonin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2020 | 1 | 2 | 3 | | 2018 | 2 | 1 | 3 | | 2017 | 5 | 1 | 6 | | 2016 | 1 | 1 | 2 | | 2015 | 2 | 2 | 4 | | 2014 | 2 | 0 | 2 | | 2013 | 5 | 0 | 5 | | 2012 | 1 | 2 | 3 | | 2011 | 5 | 3 | 8 | | 2010 | 1 | 1 | 2 | | 2009 | 3 | 2 | 5 | | 2008 | 3 | 2 | 5 | | 2007 | 2 | 5 | 7 | | 2006 | 2 | 2 | 4 | | 2005 | 2 | 2 | 4 | | 2004 | 2 | 2 | 4 | | 2003 | 2 | 1 | 3 | | 2002 | 4 | 0 | 4 | | 2000 | 2 | 3 | 5 | | 1999 | 2 | 1 | 3 | | 1998 | 2 | 1 | 3 | | 1997 | 1 | 1 | 2 | | 1996 | 4 | 1 | 5 | | 1995 | 3 | 0 | 3 | | 1994 | 3 | 2 | 5 | | 1993 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1991 | 3 | 1 | 4 | | 1990 | 6 | 2 | 8 | | 1989 | 4 | 2 | 6 |
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Below are the most recent publications written about "Serotonin" by people in Profiles over the past ten years.
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Kelly TJ, Bonniwell EM, Mu L, Liu X, Hu Y, Friedman V, Yu H, Su W, McCorvy JD, Liu QS. Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala. Neuropsychopharmacology. 2024 Apr; 49(5):854-863.
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Hansen AL, Ambroziak G, Thornton D, Mundt JC, Kahn RE, Dahl L, Waage L, Kattenbraker D, Araujo P, Murison R, Rypdal K, Grung B. Vitamin D Supplementation during Winter: Effects on Stress Resilience in a Randomized Control Trial. Nutrients. 2020 Oct 24; 12(11).
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Alam M, Zameer S, Najmi AK, Ahmad FJ, Imam SS, Akhtar M. Thymoquinone Loaded Solid Lipid Nanoparticles Demonstrated Antidepressant-Like Activity in Rats via Indoleamine 2, 3- Dioxygenase Pathway. Drug Res (Stuttg). 2020 May; 70(5):206-213.
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Ikram H, Tasneem S, Perveen S, Haleem DJ. Neurochemical and behavioral effects of midazolam: A dose related study. Pak J Pharm Sci. 2020 Jan; 33(1):85-93.
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Maroteaux L, Kilic F. Frontiers of Serotonin Beyond the Brain. Pharmacol Res. 2019 02; 140:1-6.
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Kim SY, Jones DR, Kang JY, Yun CH, Miller GP. Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin. Xenobiotica. 2019 Apr; 49(4):397-403.
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Fantegrossi WE, Wilson CD, Berquist MD. Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems. Drug Metab Rev. 2018 Feb; 50(1):65-73.
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Hankosky ER, Joolakanti SR, Nickell JR, Janganati V, Dwoskin LP, Crooks PA. Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [3H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett. 2017 12 15; 27(24):5467-5472.
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Saraf MK, Piccolo BD, Bowlin AK, Mercer KE, LeRoith T, Chintapalli SV, Shankar K, Badger TM, Yeruva L. Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon?. Microbiome. 2017 07 14; 5(1):77.
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Lantz SM, Rosas-Hernandez H, Cuevas E, Robinson B, Rice KC, Fantegrossi WE, Imam SZ, Paule MG, Ali SF. Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study. Neurosci Lett. 2017 Aug 10; 655:76-81.
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Lowery CL, Elliott C, Cooper A, Hadden C, Sonon RN, Azadi P, Williams DK, Marsh JD, Woulfe DS, Kilic F. Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets. J Am Heart Assoc. 2017 May 18; 6(5).
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Hadden C, Fahmi T, Cooper A, Savenka AV, Lupashin VV, Roberts DJ, Maroteaux L, Hauguel-de Mouzon S, Kilic F. Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway. J Cell Physiol. 2017 Dec; 232(12):3520-3529.
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Perez J, Diaz N, Tandon I, Plate R, Martindale C, Balachandran K. Elevated Serotonin Interacts with Angiotensin-II to Result in Altered Valve Interstitial Cell Contractility and Remodeling. Cardiovasc Eng Technol. 2018 06; 9(2):168-180.
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Li Y, Hadden C, Cooper A, Ahmed A, Wu H, Lupashin VV, Mayeux PR, Kilic F. Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability. Sci Rep. 2016 Mar 09; 6:22747.
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Li Y, Cooper A, Odibo IN, Ahmed A, Murphy P, Koonce R, Dajani NK, Lowery CL, Roberts DJ, Maroteaux L, Kilic F. Discrepancy in Insulin Regulation between Gestational Diabetes Mellitus (GDM) Platelets and Placenta. J Biol Chem. 2016 Apr 29; 291(18):9657-65.
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Goitia B, Rivero-Echeto MC, Weisstaub NV, Gingrich JA, Garcia-Rill E, Bisagno V, Urbano FJ. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. J Neurochem. 2016 Feb; 136(3):526-35.
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Kutsuno Y, Hirashima R, Sakamoto M, Ushikubo H, Michimae H, Itoh T, Tukey RH, Fujiwara R. Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain. Drug Metab Dispos. 2015 Jul; 43(7):1071-6.
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Fraer M, Kilic F. Serotonin: a different player in hypertension-associated thrombosis. Hypertension. 2015 May; 65(5):942-8.
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Helton SG, Lohoff FW. Serotonin pathway polymorphisms and the treatment of major depressive disorder and anxiety disorders. Pharmacogenomics. 2015; 16(5):541-53.
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Li Y, Hadden C, Singh P, Mercado CP, Murphy P, Dajani NK, Lowery CL, Roberts DJ, Maroteaux L, Kilic F. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):E5697-705.
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Ziu E, Hadden C, Li Y, Lowery CL, Singh P, Ucer SS, Mercado CP, Gu HH, Kilic F. Effect of serotonin on platelet function in cocaine exposed blood. Sci Rep. 2014 Aug 05; 4:5945.
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