 Choline
"Choline" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
| Descriptor ID |
D002794
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| MeSH Number(s) |
D02.033.100.291.211 D02.092.063.291.211 D02.092.877.883.333 D02.675.276.232
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| Concept/Terms |
Choline- Choline
- 2-Hydroxy-N,N,N-trimethylethanaminium
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Below are MeSH descriptors whose meaning is more general than "Choline".
Below are MeSH descriptors whose meaning is more specific than "Choline".
This graph shows the total number of publications written about "Choline" by people in UAMS Profiles by year, and whether "Choline" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 | | 2020 | 1 | 1 | 2 | | 2019 | 3 | 0 | 3 | | 2017 | 0 | 2 | 2 | | 2016 | 2 | 1 | 3 | | 2014 | 0 | 1 | 1 | | 2013 | 2 | 1 | 3 | | 2012 | 2 | 0 | 2 | | 2010 | 2 | 0 | 2 | | 2008 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2004 | 2 | 3 | 5 | | 2003 | 2 | 3 | 5 | | 2002 | 1 | 0 | 1 | | 2000 | 1 | 1 | 2 | | 1998 | 0 | 2 | 2 | | 1997 | 1 | 0 | 1 | | 1996 | 2 | 1 | 3 | | 1995 | 2 | 2 | 4 | | 1992 | 1 | 0 | 1 | | 1991 | 2 | 1 | 3 |
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Below are the most recent publications written about "Choline" by people in Profiles over the past ten years.
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Satheesh Babu AK, Petersen C, Iglesias-Carres L, Paz HA, Wankhade UD, Neilson AP, Anandh Babu PV. Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N-oxide by modulating gut microbes. Biofactors. 2024 Mar-Apr; 50(2):392-404.
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Nagumalli SK, Willett RA, de Conti A, Tryndyak VP, Avigan MI, da Costa GG, Beland FA, Rusyn I, Pogribny IP. Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice. J Nutr Biochem. 2022 11; 109:109108.
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Boycott C, Beetch M, Yang T, Lubecka K, Ma Y, Zhang J, Kurzava Kendall L, Ullmer M, Ramsey BS, Torregrosa-Allen S, Elzey BD, Cox A, Lanman NA, Hui A, Villanueva N, de Conti A, Huan T, Pogribny I, Stefanska B. Epigenetic aberrations of gene expression in a rat model of hepatocellular carcinoma. Epigenetics. 2022 11; 17(11):1513-1534.
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Huang JY, Luu HN, Butler LM, Midttun ?, Ulvik A, Wang R, Jin A, Gao YT, Tan Y, Ueland PM, Koh WP, Yuan JM. A prospective evaluation of serum methionine-related metabolites in relation to pancreatic cancer risk in two prospective cohort studies. Int J Cancer. 2020 10 01; 147(7):1917-1927.
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Hernandez GV, Smith VA, Melnyk M, Burd MA, Sprayberry KA, Edwards MS, Peterson DG, Bennet DC, Fanter RK, Columbus DA, Steibel JP, Glanz H, Immoos C, Rice MS, Santiago-Rodriguez TM, Blank J, VanderKelen JJ, Kitts CL, Piccolo BD, La Frano MR, Burrin DG, Maj M, Manjarin R. Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G582-G609.
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Davenport MS, Montgomery JS, Kunju LP, Siddiqui J, Shankar PR, Rajendiran T, Shao X, Lee E, Denton B, Barnett C, Piert M. 18F-Choline PET/mpMRI for Detection of Clinically Significant Prostate Cancer: Part 1. Improved Risk Stratification for MRI-Guided Transrectal Prostate Biopsies. J Nucl Med. 2020 03; 61(3):337-343.
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Lapa C, Kircher M, Da Via M, Schreder M, Rasche L, Kort?m KM, Einsele H, Buck AK, H?nscheid H, Samnick S. Comparison of 11C-Choline and 11C-Methionine PET/CT in Multiple Myeloma. Clin Nucl Med. 2019 Aug; 44(8):620-624.
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Barnett CL, Davenport MS, Montgomery JS, Kunju LP, Denton BT, Piert M. 18F-Choline PET/mpMRI for Detection of Clinically Significant Prostate Cancer: Part 2. Cost-Effectiveness Analysis. J Nucl Med. 2019 12; 60(12):1705-1712.
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Stingone JA, Luben TJ, Carmichael SL, Aylsworth AS, Botto LD, Correa A, Gilboa SM, Langlois PH, Nembhard WN, Richmond-Bryant J, Shaw GM, Olshan AF. Maternal Exposure to Nitrogen Dioxide, Intake of Methyl Nutrients, and Congenital Heart Defects in Offspring. Am J Epidemiol. 2017 Sep 15; 186(6):719-729.
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Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Thakali KM, Shankar K. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS One. 2017; 12(4):e0175675.
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Tryndyak VP, Han T, Fuscoe JC, Ross SA, Beland FA, Pogribny IP. Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice. BMC Genomics. 2016 Apr 22; 17:298.
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Petriello MC, Hoffman JB, Sunkara M, Wahlang B, Perkins JT, Morris AJ, Hennig B. Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors. J Nutr Biochem. 2016 07; 33:145-53.
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Piert M, Montgomery J, Kunju LP, Siddiqui J, Rogers V, Rajendiran T, Johnson TD, Shao X, Davenport MS. 18F-Choline PET/MRI: The Additional Value of PET for MRI-Guided Transrectal Prostate Biopsies. J Nucl Med. 2016 Jul; 57(7):1065-70.
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