 Ligands
"Ligands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
| Descriptor ID |
D008024
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| MeSH Number(s) |
D27.720.470.480
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Ligands".
Below are MeSH descriptors whose meaning is more specific than "Ligands".
This graph shows the total number of publications written about "Ligands" by people in UAMS Profiles by year, and whether "Ligands" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2023 | 0 | 2 | 2 | | 2022 | 0 | 6 | 6 | | 2021 | 0 | 1 | 1 | | 2020 | 1 | 3 | 4 | | 2018 | 0 | 4 | 4 | | 2017 | 0 | 2 | 2 | | 2016 | 0 | 3 | 3 | | 2015 | 1 | 2 | 3 | | 2014 | 0 | 6 | 6 | | 2013 | 0 | 3 | 3 | | 2012 | 0 | 3 | 3 | | 2011 | 0 | 9 | 9 | | 2010 | 1 | 5 | 6 | | 2009 | 0 | 7 | 7 | | 2008 | 0 | 6 | 6 | | 2007 | 0 | 4 | 4 | | 2006 | 0 | 9 | 9 | | 2005 | 0 | 15 | 15 | | 2004 | 0 | 10 | 10 | | 2003 | 0 | 8 | 8 | | 2002 | 1 | 8 | 9 | | 2001 | 0 | 4 | 4 | | 2000 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1996 | 0 | 2 | 2 | | 1993 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ligands" by people in Profiles over the past ten years.
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Shahbazi Nia S, Hossain MA, Ji G, Jonnalagadda SK, Obeng S, Rahman MA, Sifat AE, Nozohouri S, Blackwell C, Patel D, Thompson J, Runyon S, Hiranita T, McCurdy CR, McMahon L, Abbruscato TJ, Trippier PC, Neugebauer V, German NA. Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands. Eur J Med Chem. 2023 Jun 05; 254:115309.
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Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, Zhou S, Hua N, Mackintosh SG, Zhang X, Basso KB, Kamat M, Yang Q, Licht JD, Zheng G, Zhou D, Lv D. Piperlongumine conjugates induce targeted protein degradation. Cell Chem Biol. 2023 02 16; 30(2):203-213.e17.
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Piehl N, van Olst L, Ramakrishnan A, Teregulova V, Simonton B, Zhang Z, Tapp E, Channappa D, Oh H, Losada PM, Rutledge J, Trelle AN, Mormino EC, Elahi F, Galasko DR, Henderson VW, Wagner AD, Wyss-Coray T, Gate D. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment. Cell. 2022 12 22; 185(26):5028-5039.e13.
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Li Y, Zhou D, Zheng G, Li X, Wu D, Yuan Y. DyScore: A Boosting Scoring Method with Dynamic Properties for Identifying True Binders and Nonbinders in Structure-Based Drug Discovery. J Chem Inf Model. 2022 11 28; 62(22):5550-5567.
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Fetse J, Zhao Z, Liu H, Mamani UF, Mustafa B, Adhikary P, Ibrahim M, Liu Y, Patel P, Nakhjiri M, Alahmari M, Li G, Cheng K. Discovery of Cyclic Peptide Inhibitors Targeting PD-L1 for Cancer Immunotherapy. J Med Chem. 2022 09 22; 65(18):12002-12013.
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Woolbright BL, Nguyen NT, McGill MR, Sharpe MR, Curry SC, Jaeschke H. Generation of pro-and anti-inflammatory mediators after acetaminophen overdose in surviving and non-surviving patients. Toxicol Lett. 2022 Aug 15; 367:59-66.
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Kore RA, Bagchi AK, Varughese KI, Mehta JL. The structural basis of effective LOX-1 inhibition. Future Med Chem. 2022 05; 14(10):731-743.
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Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T. Structural basis of BAK activation in mitochondrial apoptosis initiation. Nat Commun. 2022 01 11; 13(1):250.
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Shoeib AM, Yarbrough AL, Ford BM, Franks LN, Urbaniak A, Hensley LL, Benson LN, Mu S, Radominska-Pandya A, Prather PL. Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development. Life Sci. 2021 Nov 15; 285:119993.
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Yang JF, Williams AH, Penthala NR, Prather PL, Crooks PA, Zhan CG. Binding Modes and Selectivity of Cannabinoid 1 (CB1) and Cannabinoid 2 (CB2) Receptor Ligands. ACS Chem Neurosci. 2020 10 21; 11(20):3455-3463.
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Penthala NR, Shoeib A, Dachavaram SS, Cabanlong CV, Yang J, Zhan CG, Prather PL, Crooks PA. 7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands. Bioorg Med Chem Lett. 2020 11 15; 30(22):127501.
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Zhang H, Wei T, Johnson A, Sun R, Richter G, Strub GM. NOTCH pathway activation in infantile hemangiomas. J Vasc Surg Venous Lymphat Disord. 2021 03; 9(2):489-496.
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He Y, Khan S, Huo Z, Lv D, Zhang X, Liu X, Yuan Y, Hromas R, Xu M, Zheng G, Zhou D. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. J Hematol Oncol. 2020 07 27; 13(1):103.
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Lee NR, Gujarathi S, Bommagani S, Siripurapu K, Zheng G, Dwoskin LP. Muscarinic agonist, (?)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M1 - M5 muscarinic acetylcholine receptors. Bioorg Med Chem Lett. 2019 02 01; 29(3):471-476.
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Chintapalli SV, Anishkin A, Adams SH. Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin. Arch Biochem Biophys. 2018 10 01; 655:56-66.
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Zheng JH, Grace CR, Guibao CD, McNamara DE, Llambi F, Wang YM, Chen T, Moldoveanu T. Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis. Cell Rep. 2018 05 15; 23(7):2083-2094.e6.
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Prather PL. Preface to DMR special edition 'Cannabinoid receptors and ligands: therapeutic drug development and abuse potential'. Drug Metab Rev. 2018 02; 50(1):1-2.
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Kikuchi A, Pradhan-Sundd T, Singh S, Nagarajan S, Loizos N, Monga SP. Platelet-Derived Growth Factor Receptor a Contributes to Human Hepatic Stellate Cell Proliferation and Migration. Am J Pathol. 2017 Oct; 187(10):2273-2287.
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PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. J Immunol. 2017 05 15; 198(10):3775-3789.
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Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh SG, Shmookler Reis RJ. PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans. Oncotarget. 2016 Aug 02; 7(31):48870-48886.
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Qin B, Wei T, Wang L, Ma N, Tang Q, Liang Y, Yang Z, Zhou L, Zhong R. Decreased expression of TIPE2 contributes to the hyperreactivity of monocyte to Toll-like receptor ligands in primary biliary cirrhosis. J Gastroenterol Hepatol. 2016 Jun; 31(6):1177-83.
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Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR. Blockade of Cocaine or s Receptor Agonist Self Administration by Subtype-Selective s Receptor Antagonists. J Pharmacol Exp Ther. 2016 07; 358(1):109-24.
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Thakkar S, Wang X, Khaidakov M, Dai Y, Gokulan K, Mehta JL, Varughese KI. Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein. Sci Rep. 2015 Nov 18; 5:16740.
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Stehouwer JS, Bourke CH, Owens MJ, Voll RJ, Kilts CD, Goodman MM. Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5111-4.
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Yang G, Gao M, Zhang Y, Kong Y, Gao L, Tao Y, Han Y, Wu H, Meng X, Xu H, Zhan F, Wu X, Shi J. Carfilzomib enhances natural killer cell-mediated lysis of myeloma linked with decreasing expression of HLA class I. Oncotarget. 2015 Sep 29; 6(29):26982-94.
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Stehouwer JS, Birnbaum MS, Voll RJ, Owens MJ, Plott SJ, Bourke CH, Wassef MA, Kilts CD, Goodman MM. Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor. Bioorg Med Chem. 2015 Aug 01; 23(15):4286-4302.
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Frett B, McConnell N, Smith CC, Wang Y, Shah NP, Li HY. Computer aided drug discovery of highly ligand efficient, low molecular weight imidazopyridine analogs as FLT3 inhibitors. Eur J Med Chem. 2015 Apr 13; 94:123-31.
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Levy JW, Hartman JH, Perry MD, Miller GP. Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations. J Mol Graph Model. 2015 Mar; 56:43-52.
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