 Nucleic Acid Denaturation
"Nucleic Acid Denaturation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
| Descriptor ID |
D009691
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| MeSH Number(s) |
E05.393.640 G02.111.087.615 G02.149.115.615 G05.355.720
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| Concept/Terms |
Nucleic Acid Denaturation- Nucleic Acid Denaturation
- Acid Denaturation, Nucleic
- Denaturation, Nucleic Acid
- Nucleic Acid Denaturations
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Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Denaturation".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Denaturation".
This graph shows the total number of publications written about "Nucleic Acid Denaturation" by people in UAMS Profiles by year, and whether "Nucleic Acid Denaturation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 |
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Below are the most recent publications written about "Nucleic Acid Denaturation" by people in Profiles over the past ten years.
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Reynolds KA, Cameron CE, Raney KD. Melting of Duplex DNA in the Absence of ATP by the NS3 Helicase Domain through Specific Interaction with a Single-Strand/Double-Strand Junction. Biochemistry. 2015 Jul 14; 54(27):4248-58.
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Roy S, Sadhukhan R, Ghosh U, Das TK. Interaction studies between biosynthesized silver nanoparticle with calf thymus DNA and cytotoxicity of silver nanoparticles. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 15; 141:176-84.
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