 Allosteric Regulation
"Allosteric Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
| Descriptor ID |
D000494
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| MeSH Number(s) |
G02.111.087.040 G02.149.115.040
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| Concept/Terms |
Allosteric Regulation- Allosteric Regulation
- Regulation, Allosteric
- Allosteric Regulations
- Regulations, Allosteric
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Below are MeSH descriptors whose meaning is more general than "Allosteric Regulation".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Regulation".
This graph shows the total number of publications written about "Allosteric Regulation" by people in UAMS Profiles by year, and whether "Allosteric Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2014 | 0 | 2 | 2 | | 2013 | 0 | 2 | 2 | | 2012 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 1989 | 0 | 1 | 1 |
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Below are the most recent publications written about "Allosteric Regulation" by people in Profiles over the past ten years.
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Acker BA, Badescu VO, Berkenpas MB, Groppi VE, Haj?s M, Higdon NR, Hurst RS, Jon Jacobsen E, Margolis BJ, McWhorter WW, Myers JK, Piotrowski DW, Rogers BN, Sarapa D, Vetman TN, Walker DP, Wall TM, Wilhite DM, Wishka DG, Xu W, Yates KM. Positive allosteric modulators of the a7 nicotinic acetylcholine receptor: SAR investigation around PNU-120596. Bioorg Med Chem Lett. 2023 09 01; 93:129433.
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Balasubramaniam M, Lakkaniga NR, Dera AA, Fayi MA, Abohashrh M, Ahmad I, Chandramoorthy HC, Nalini G, Rajagopalan P. FCX-146, a potent allosteric inhibitor of Akt kinase in cancer cells: Lead optimization of the second-generation arylidene indanone scaffold. Biotechnol Appl Biochem. 2021 Feb; 68(1):82-91.
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Stepan AF, Claffey MM, Reese MR, Balan G, Barreiro G, Barricklow J, Bohanon MJ, Boscoe BP, Cappon GD, Chenard LK, Cianfrogna J, Chen L, Coffman KJ, Drozda SE, Dunetz JR, Ghosh S, Hou X, Houle C, Karki K, Lazzaro JT, Mancuso JY, Marcek JM, Miller EL, Moen MA, O'Neil S, Sakurada I, Skaddan M, Parikh V, Smith DL, Trapa P, Tuttle JB, Verhoest PR, Walker DP, Won A, Wright AS, Whritenour J, Zasadny K, Zaleska MM, Zhang L, Shaffer CL. Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. J Med Chem. 2017 09 28; 60(18):7764-7780.
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Bedinger DH, Goldfine ID, Corbin JA, Roell MK, Adams SH. Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody. J Pharmacol Exp Ther. 2015 Apr; 353(1):35-43.
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