 G-Quadruplexes
"G-Quadruplexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
| Descriptor ID |
D054856
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| MeSH Number(s) |
G02.111.570.790.486.550 G05.360.580.550
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| Concept/Terms |
G-Quadruplexes- G-Quadruplexes
- G Quadruplexes
- Guanine-Quadruplexes
- Guanine Quadruplexes
Guanine-Tetrads- Guanine-Tetrads
- Guanine Tetrads
- Guanine-Tetrad
- Guanine-Quartets
- Guanine Quartets
- Guanine-Quartet
G-Quadruplexes, DNA- G-Quadruplexes, DNA
- G Quadruplexes, DNA
- Tetraplex DNA
- DNA, Tetraplex
- DNA G-Quadruplexes
- DNA G Quadruplexes
- DNA, Quadruplex
- Quadruplex DNA
G-Quadruplexes, RNA- G-Quadruplexes, RNA
- G Quadruplexes, RNA
- RNA G-Quadruplexes
- RNA, G-Quadruplexes
- G-Quadruplexes RNA
- G-Quadruplexes RNAs
- RNA, G Quadruplexes
- RNAs, G-Quadruplexes
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Below are MeSH descriptors whose meaning is more general than "G-Quadruplexes".
Below are MeSH descriptors whose meaning is more specific than "G-Quadruplexes".
This graph shows the total number of publications written about "G-Quadruplexes" by people in UAMS Profiles by year, and whether "G-Quadruplexes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2026 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2021 | 3 | 0 | 3 | | 2020 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2017 | 3 | 3 | 6 | | 2016 | 3 | 0 | 3 | | 2015 | 2 | 1 | 3 | | 2013 | 2 | 0 | 2 | | 2010 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "G-Quadruplexes" by people in Profiles over the past ten years.
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McCrury M, Sanchez A, Mangold R, Spears TJ, Doshier C, Buisson R, Miah M, Akdeniz D, Kendrick S. DNA secondary structures in BCL2 and MYC elicit activation-induced cytidine deaminase binding and activity. Nucleic Acids Res. 2026 Feb 24; 54(5).
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Thompson MD, Byrd AK. Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments. Nucleic Acids Res. 2025 Jul 19; 53(14).
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Hong Z, Byrd AK, Gao J, Das P, Tan VQ, Malone EG, Osei B, Marecki JC, Protacio RU, Wahls WP, Raney KD, Song H. Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge. Nat Commun. 2024 Jul 19; 15(1):6104.
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Chib S, Griffin WC, Gao J, Proffitt DR, Byrd AK, Raney KD. Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA. Biochemistry. 2023 12 05; 62(23):3360-3372.
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Papp C, Mukundan VT, Jenjaroenpun P, Winnerdy FR, Ow GS, Phan AT, Kuznetsov VA. Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization. Nucleic Acids Res. 2023 05 22; 51(9):4148-4177.
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Malone EG, Thompson MD, Byrd AK. Role and Regulation of Pif1 Family Helicases at the Replication Fork. Int J Mol Sci. 2022 Mar 29; 23(7).
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Gao J, Gao Z, Putnam AA, Byrd AK, Venus SL, Marecki JC, Edwards AD, Lowe HM, Jankowsky E, Raney KD. G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p. Chem Commun (Camb). 2021 Jul 27; 57(60):7445-7448.
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Ketkar A, Smith L, Johnson C, Richey A, Berry M, Hartman JH, Maddukuri L, Reed MR, Gunderson JEC, Leung JWC, Eoff RL. Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs. Nucleic Acids Res. 2021 02 26; 49(4):2065-2084.
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Edwards AD, Marecki JC, Byrd AK, Gao J, Raney KD. G-Quadruplex loops regulate PARP-1 enzymatic activation. Nucleic Acids Res. 2021 01 11; 49(1):416-431.
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Zafar MK, Hazeslip L, Chauhan MZ, Byrd AK. The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter. Biochemistry. 2020 07 07; 59(26):2401-2409.
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Butler TJ, Estep KN, Sommers JA, Maul RW, Moore AZ, Bandinelli S, Cucca F, Tuke MA, Wood AR, Bharti SK, Bogenhagen DF, Yakubovskaya E, Garcia-Diaz M, Guilliam TA, Byrd AK, Raney KD, Doherty AJ, Ferrucci L, Schlessinger D, Ding J, Brosh RM. Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro. Hum Mol Genet. 2020 05 28; 29(8):1292-1309.
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Gao J, Byrd AK, Zybailov BL, Marecki JC, Guderyon MJ, Edwards AD, Chib S, West KL, Waldrip ZJ, Mackintosh SG, Gao Z, Putnam AA, Jankowsky E, Raney KD. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Chem Commun (Camb). 2019 Apr 11; 55(31):4467-4470.
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Byrd AK, Bell MR, Raney KD. Pif1 helicase unfolding of G-quadruplex DNA is highly dependent on sequence and reaction conditions. J Biol Chem. 2018 11 16; 293(46):17792-17802.
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Kuznetsov VA, Bondarenko V, Wongsurawat T, Yenamandra SP, Jenjaroenpun P. Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers. Nucleic Acids Res. 2018 09 06; 46(15):7566-7585.
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Sadhukhan R, Chowdhury P, Ghosh S, Ghosh U. Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation. Cell Biochem Biophys. 2018 Jun; 76(1-2):311-319.
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Byrd AK, Raney KD. Structure and function of Pif1 helicase. Biochem Soc Trans. 2017 Oct 15; 45(5):1159-1171.
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Kendrick S, Muranyi A, Gokhale V, Hurley LH, Rimsza LM. Simultaneous Drug Targeting of the Promoter MYC G-Quadruplex and BCL2 i-Motif in Diffuse Large B-Cell Lymphoma Delays Tumor Growth. J Med Chem. 2017 08 10; 60(15):6587-6597.
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Lopez CR, Singh S, Hambarde S, Griffin WC, Gao J, Chib S, Yu Y, Ira G, Raney KD, Kim N. Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. Nucleic Acids Res. 2017 Jun 02; 45(10):5850-5862.
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Griffin WC, Gao J, Byrd AK, Chib S, Raney KD. A biochemical and biophysical model of G-quadruplex DNA recognition by positive coactivator of transcription 4. J Biol Chem. 2017 06 09; 292(23):9567-9582.
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Ketkar A, Voehler M, Mukiza T, Eoff RL. Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA. J Biol Chem. 2017 02 24; 292(8):3154-3163.
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Eddy S, Tillman M, Maddukuri L, Ketkar A, Zafar MK, Eoff RL. Human Translesion Polymerase ? Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA. Biochemistry. 2016 09 20; 55(37):5218-29.
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