 Cyclin-Dependent Kinases
"Cyclin-Dependent Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
| Descriptor ID |
D018844
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| MeSH Number(s) |
D08.811.913.696.620.682.700.200 D08.811.913.696.620.682.700.646.500 D12.644.360.250 D12.776.167.200 D12.776.476.250
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| Concept/Terms |
Cyclin-Dependent Kinases- Cyclin-Dependent Kinases
- Cyclin Dependent Kinases
- Cyclin-Dependent Protein Kinases
- Cyclin Dependent Protein Kinases
- cdk Proteins
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinases".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinases".
This graph shows the total number of publications written about "Cyclin-Dependent Kinases" by people in UAMS Profiles by year, and whether "Cyclin-Dependent Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 1 | 0 | 1 | | 2021 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2004 | 3 | 1 | 4 | | 2003 | 0 | 2 | 2 | | 2002 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinases" by people in Profiles over the past ten years.
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Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB. CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Nucleic Acids Res. 2023 08 11; 51(14):7288-7313.
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Morabito RD, Adikes RC, Matus DQ, Martin BL. Cyclin-Dependent Kinase Sensor Transgenic Zebrafish Lines for Improved Cell Cycle State Visualization in Live Animals. Zebrafish. 2021 12; 18(6):374-375.
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Zarate YA, Uehara T, Abe K, Oginuma M, Harako S, Ishitani S, Lehesjoki AE, Bierhals T, Kloth K, Ehmke N, Horn D, Holtgrewe M, Anderson K, Viskochil D, Edgar-Zarate CL, Sacoto MJG, Schnur RE, Morrow MM, Sanchez-Valle A, Pappas J, Rabin R, Muona M, Anttonen AK, Platzer K, Luppe J, Gburek-Augustat J, Kaname T, Okamoto N, Mizuno S, Kaido Y, Ohkuma Y, Hirose Y, Ishitani T, Kosaki K. CDK19-related disorder results from both loss-of-function and gain-of-function de novo missense variants. Genet Med. 2021 06; 23(6):1050-1057.
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Adikes RC, Kohrman AQ, Martinez MAQ, Palmisano NJ, Smith JJ, Medwig-Kinney TN, Min M, Sallee MD, Ahmed OB, Kim N, Liu S, Morabito RD, Weeks N, Zhao Q, Zhang W, Feldman JL, Barkoulas M, Pani AM, Spencer SL, Martin BL, Matus DQ. Visualizing the metazoan proliferation-quiescence decision in vivo. Elife. 2020 12 22; 9.
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Gao L, Li B, Yang G, Liu P, Lan X, Chang S, Tao Y, Xu Z, Xie B, Sun X, Wang Y, Hu L, Yu D, Xie Y, Bu W, Wu X, Zhu W, Shi J. Dual inhibition of mTORC1/2 by DCZ0358 induces cytotoxicity in multiple myeloma and overcomes the protective effect of the bone marrow microenvironment. Cancer Lett. 2018 05 01; 421:135-144.
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Naumov A, Kratzer S, Ting LM, Kim K, Suvorova ES, White MW. The Toxoplasma Centrocone Houses Cell Cycle Regulatory Factors. mBio. 2017 08 22; 8(4).
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Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition. Mol Cancer Ther. 2016 Feb; 15(2):241-50.
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Eichhorn JM, Kothari A, Chambers TC. Cyclin B1 overexpression induces cell death independent of mitotic arrest. PLoS One. 2014; 9(11):e113283.
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