 Protein Kinase C
"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725
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| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in UAMS Profiles by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 | | 2010 | 2 | 1 | 3 | | 2008 | 2 | 2 | 4 | | 2007 | 2 | 1 | 3 | | 2006 | 0 | 2 | 2 | | 2005 | 0 | 3 | 3 | | 2004 | 3 | 1 | 4 | | 2003 | 1 | 5 | 6 | | 2002 | 4 | 2 | 6 | | 2001 | 0 | 4 | 4 | | 2000 | 1 | 1 | 2 | | 1998 | 0 | 2 | 2 | | 1997 | 1 | 0 | 1 | | 1996 | 3 | 2 | 5 | | 1995 | 0 | 3 | 3 | | 1994 | 1 | 3 | 4 | | 1993 | 2 | 0 | 2 | | 1992 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles over the past ten years.
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Wang W, Duclot F, Groveman BR, Carrier N, Qiao H, Fang XQ, Wang H, Xin W, Jiang XH, Salter MW, Ding XS, Kabbaj M, Yu XM. Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats. PLoS One. 2018; 13(4):e0195095.
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Rahal OM, Wolfe AR, Mandal PK, Larson R, Tin S, Jimenez C, Zhang D, Horton J, Reuben JM, McMurray JS, Woodward WA. Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. Int J Radiat Oncol Biol Phys. 2018 03 15; 100(4):1034-1043.
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Zhao EY, Efendizade A, Cai L, Ding Y. The role of Akt (protein kinase B) and protein kinase C in ischemia-reperfusion injury. Neurol Res. 2016 Apr; 38(4):301-8.
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Fang XQ, Qiao H, Groveman BR, Feng S, Pflueger M, Xin WK, Ali MK, Lin SX, Xu J, Duclot F, Kabbaj M, Wang W, Ding XS, Santiago-Sim T, Jiang XH, Salter MW, Yu XM. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. Mol Brain. 2015 Nov 19; 8(1):75.
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