 Wnt Signaling Pathway
"Wnt Signaling Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, which when mutated results in the wingless phenotype, and the vertebrate INT gene, which is located near integration sites of MOUSE MAMMARY TUMOR VIRUS. The signaling pathway is initiated by the binding of WNT PROTEINS to cells surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.
| Descriptor ID |
D060449
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| MeSH Number(s) |
G02.149.115.800.925
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| Concept/Terms |
Wnt Signaling Pathway- Wnt Signaling Pathway
- Pathway, Wnt Signaling
- Pathways, Wnt Signaling
- Signaling Pathway, Wnt
- Signaling Pathways, Wnt
- Wnt Signaling Pathways
- Wnt Pathway
- Pathway, Wnt
- Pathways, Wnt
- Wnt Pathways
Wnt beta-Catenin Signaling Pathway- Wnt beta-Catenin Signaling Pathway
- Wnt beta Catenin Signaling Pathway
- Wnt Pathway, Canonical
- Canonical Wnt Pathway
- Canonical Wnt Pathways
- Pathway, Canonical Wnt
- Pathways, Canonical Wnt
- Wnt Pathways, Canonical
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Below are MeSH descriptors whose meaning is more general than "Wnt Signaling Pathway".
Below are MeSH descriptors whose meaning is more specific than "Wnt Signaling Pathway".
This graph shows the total number of publications written about "Wnt Signaling Pathway" by people in UAMS Profiles by year, and whether "Wnt Signaling Pathway" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2020 | 1 | 1 | 2 | | 2019 | 1 | 1 | 2 | | 2018 | 2 | 2 | 4 | | 2017 | 2 | 0 | 2 | | 2016 | 1 | 3 | 4 | | 2015 | 2 | 1 | 3 | | 2014 | 2 | 0 | 2 | | 2013 | 1 | 3 | 4 | | 2012 | 1 | 1 | 2 | | 2011 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Wnt Signaling Pathway" by people in Profiles over the past ten years.
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Feng J, Zhang Q, Pu F, Zhu Z, Lu K, Lu WW, Tong L, Yu H, Chen D. Signalling interaction between ?-catenin and other signalling molecules during osteoarthritis development. Cell Prolif. 2024 Jun; 57(6):e13600.
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Alam J, Huda MN, Tackett AJ, Miah S. Oncogenic signaling-mediated regulation of chromatin during tumorigenesis. Cancer Metastasis Rev. 2023 06; 42(2):409-425.
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Dufour D, Dumontet T, Sahut-Barnola I, Carusi A, Onzon M, Pussard E, Wilmouth JJ, Olabe J, Lucas C, Levasseur A, Damon-Soubeyrand C, Pointud JC, Roucher-Boulez F, Tauveron I, Bossis G, Yeh ET, Breault DT, Val P, Lefran?ois-Martinez AM, Martinez A. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 12 21; 13(1):7858.
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Dole NS, Yoon J, Monteiro DA, Yang J, Mazur CM, Kaya S, Belair CD, Alliston T. Mechanosensitive miR-100 coordinates TGF? and Wnt signaling in osteocytes during fluid shear stress. FASEB J. 2021 10; 35(10):e21883.
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Kinney BA, Al Anber A, Row RH, Tseng YJ, Weidmann MD, Knaut H, Martin BL. Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition. Cell Rep. 2020 10 27; 33(4):108311.
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Manukjan N, Ahmed Z, Fulton D, Blankesteijn WM, Foulquier S. A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions: Potential Relevance to Cerebral Small Vessel Disease. Cells. 2020 06 25; 9(6).
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Kluz PN, Kolb R, Xie Q, Borcherding N, Liu Q, Luo Y, Kim MC, Wang L, Zhang Y, Li W, Stipp C, Gibson-Corley KN, Zhao C, Qi HH, Bellizzi A, Tao AW, Sugg S, Weigel RJ, Zhou D, Shen X, Zhang W. Cancer cell-intrinsic function of CD177 in attenuating ?-catenin signaling. Oncogene. 2020 04; 39(14):2877-2889.
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Zhao Y, Yuan X, Bellido T, Helms JA. A Correlation between Wnt/Beta-catenin Signaling and the Rate of Dentin Secretion. J Endod. 2019 Nov; 45(11):1357-1364.e1.
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Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, J?hn K, Long CL, Schl?ter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenm?ki H, Hesse E. TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Nat Commun. 2019 03 22; 10(1):1354.
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Wu Y, Yuan X, Perez KC, Hyman S, Wang L, Pellegrini G, Salmon B, Bellido T, Helms JA. Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis. Bone. 2019 05; 122:176-183.
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So J, Khaliq M, Evason K, Ninov N, Martin BL, Stainier DYR, Shin D. Wnt/?-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating notch activity. Hepatology. 2018 06; 67(6):2352-2366.
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Xiong J, Almeida M, O'Brien CA. The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone. 2018 07; 112:1-9.
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Yin GN, Jin HR, Choi MJ, Limanjaya A, Ghatak K, Minh NN, Ock J, Kwon MH, Song KM, Park HJ, Kim HM, Kwon YG, Ryu JK, Suh JK. Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway. Diabetes. 2018 06; 67(6):1149-1161.
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Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study. Osteoarthritis Cartilage. 2017 10; 25(10):1598-1606.
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Goto H, Kimmey SC, Row RH, Matus DQ, Martin BL. FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition. Development. 2017 04 15; 144(8):1412-1424.
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Mahapatra S, Gallaher B, Smith SC, Graham JG, Voth DE, Shaw EI. Coxiella burnetii Employs the Dot/Icm Type IV Secretion System to Modulate Host NF-?B/RelA Activation. Front Cell Infect Microbiol. 2016; 6:188.
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Delgado-Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone. 2017 03; 96:29-37.
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Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. J Bone Miner Res. 2016 10; 31(10):1791-1802.
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Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73.
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Ulrich F, Carretero-Ortega J, Men?ndez J, Narvaez C, Sun B, Lancaster E, Pershad V, Trzaska S, V?liz E, Kamei M, Prendergast A, Kidd KR, Shaw KM, Castranova DA, Pham VN, Lo BD, Martin BL, Raible DW, Weinstein BM, Torres-V?zquez J. Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development. 2016 Jan 01; 143(1):147-59.
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Martin BL. Factors that coordinate mesoderm specification from neuromesodermal progenitors with segmentation during vertebrate axial extension. Semin Cell Dev Biol. 2016 Jan; 49:59-67.
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