 Wnt Signaling Pathway
"Wnt Signaling Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, which when mutated results in the wingless phenotype, and the vertebrate INT gene, which is located near integration sites of MOUSE MAMMARY TUMOR VIRUS. The signaling pathway is initiated by the binding of WNT PROTEINS to cells surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.
| Descriptor ID |
D060449
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| MeSH Number(s) |
G02.149.115.800.925
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| Concept/Terms |
Wnt Signaling Pathway- Wnt Signaling Pathway
- Pathway, Wnt Signaling
- Pathways, Wnt Signaling
- Signaling Pathway, Wnt
- Signaling Pathways, Wnt
- Wnt Signaling Pathways
- Wnt Pathway
- Pathway, Wnt
- Pathways, Wnt
- Wnt Pathways
Wnt beta-Catenin Signaling Pathway- Wnt beta-Catenin Signaling Pathway
- Wnt beta Catenin Signaling Pathway
- Wnt Pathway, Canonical
- Canonical Wnt Pathway
- Canonical Wnt Pathways
- Pathway, Canonical Wnt
- Pathways, Canonical Wnt
- Wnt Pathways, Canonical
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Below are MeSH descriptors whose meaning is more general than "Wnt Signaling Pathway".
Below are MeSH descriptors whose meaning is more specific than "Wnt Signaling Pathway".
This graph shows the total number of publications written about "Wnt Signaling Pathway" by people in UAMS Profiles by year, and whether "Wnt Signaling Pathway" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 2 | 3 | | 2023 | 0 | 2 | 2 | | 2022 | 0 | 2 | 2 | | 2021 | 1 | 2 | 3 | | 2020 | 1 | 3 | 4 | | 2019 | 1 | 1 | 2 | | 2018 | 2 | 3 | 5 | | 2017 | 3 | 2 | 5 | | 2016 | 2 | 3 | 5 | | 2015 | 4 | 2 | 6 | | 2014 | 4 | 0 | 4 | | 2013 | 2 | 4 | 6 | | 2012 | 1 | 1 | 2 | | 2011 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Wnt Signaling Pathway" by people in Profiles over the past ten years.
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Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K. The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/?-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-? catenin-p300 Interactions in Hepatocellular Carcinoma. Adv Sci (Weinh). 2024 Aug; 11(29):e2308539.
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Scalise CB, Kincaid K, Thigpen H, Moore J, Dover B, Norian L, Meza-Perez S, Randall T, Birrer M, Odunsi K, Arend RC. A spatial proteomic study of platinum refractory HGSOC implicates dual AKT and WNT activity linked to an immunosuppressive tumor microenvironment. Gynecol Oncol. 2024 06; 185:83-94.
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Feng J, Zhang Q, Pu F, Zhu Z, Lu K, Lu WW, Tong L, Yu H, Chen D. Signalling interaction between ?-catenin and other signalling molecules during osteoarthritis development. Cell Prolif. 2024 Jun; 57(6):e13600.
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Delgado-Calle J, Roodman GD. Doubling Down on Wnt Signaling to Overcome Myeloma Bone Disease. J Bone Miner Res. 2023 06; 38(6):812-813.
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Alam J, Huda MN, Tackett AJ, Miah S. Oncogenic signaling-mediated regulation of chromatin during tumorigenesis. Cancer Metastasis Rev. 2023 06; 42(2):409-425.
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Dufour D, Dumontet T, Sahut-Barnola I, Carusi A, Onzon M, Pussard E, Wilmouth JJ, Olabe J, Lucas C, Levasseur A, Damon-Soubeyrand C, Pointud JC, Roucher-Boulez F, Tauveron I, Bossis G, Yeh ET, Breault DT, Val P, Lefran?ois-Martinez AM, Martinez A. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 12 21; 13(1):7858.
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Chen J, Cuevas PL, Dworan JS, Dawid I, Turkkahraman H, Tran K, Delgado-Calle J, Bellido T, Gorski JP, Liu B, Brunski JB, Helms JA. Wnt/?-catenin Signaling Controls Maxillofacial Hyperostosis. J Dent Res. 2022 07; 101(7):793-801.
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Dole NS, Yoon J, Monteiro DA, Yang J, Mazur CM, Kaya S, Belair CD, Alliston T. Mechanosensitive miR-100 coordinates TGF? and Wnt signaling in osteocytes during fluid shear stress. FASEB J. 2021 10; 35(10):e21883.
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Tsai J, Rostom M, Garza LA. Understanding and Harnessing Epithelial?Mesenchymal Interactions in the Development of Palmoplantar Identity. J Invest Dermatol. 2022 02; 142(2):282-284.
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Chen JR, Zhao H, Wankhade UD, Chintapalli SV, Li C, Gai D, Shankar K, Zhan F, Lazarenko OP. GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice. Commun Biol. 2021 01 08; 4(1):53.
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Kinney BA, Al Anber A, Row RH, Tseng YJ, Weidmann MD, Knaut H, Martin BL. Sox2 and Canonical Wnt Signaling Interact to Activate a Developmental Checkpoint Coordinating Morphogenesis with Mesoderm Fate Acquisition. Cell Rep. 2020 10 27; 33(4):108311.
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Yazici Y, McAlindon TE, Gibofsky A, Lane NE, Clauw D, Jones M, Bergfeld J, Swearingen CJ, DiFrancesco A, Simsek I, Tambiah J, Hochberg MC. Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial. Arthritis Rheumatol. 2020 10; 72(10):1694-1706.
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Manukjan N, Ahmed Z, Fulton D, Blankesteijn WM, Foulquier S. A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions: Potential Relevance to Cerebral Small Vessel Disease. Cells. 2020 06 25; 9(6).
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Behrens A, Jousheghany F, Yao-Borengasser A, Siegel ER, Kieber-Emmons T, Monzavi-Karbassi B. Carbohydrate (Chondroitin 4) Sulfotransferase-11-Mediated Induction of Epithelial-Mesenchymal Transition and Generation of Cancer Stem Cells. Pharmacology. 2020; 105(5-6):246-259.
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Kluz PN, Kolb R, Xie Q, Borcherding N, Liu Q, Luo Y, Kim MC, Wang L, Zhang Y, Li W, Stipp C, Gibson-Corley KN, Zhao C, Qi HH, Bellizzi A, Tao AW, Sugg S, Weigel RJ, Zhou D, Shen X, Zhang W. Cancer cell-intrinsic function of CD177 in attenuating ?-catenin signaling. Oncogene. 2020 04; 39(14):2877-2889.
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Zhao Y, Yuan X, Bellido T, Helms JA. A Correlation between Wnt/Beta-catenin Signaling and the Rate of Dentin Secretion. J Endod. 2019 Nov; 45(11):1357-1364.e1.
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Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, J?hn K, Long CL, Schl?ter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenm?ki H, Hesse E. TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Nat Commun. 2019 03 22; 10(1):1354.
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Wu Y, Yuan X, Perez KC, Hyman S, Wang L, Pellegrini G, Salmon B, Bellido T, Helms JA. Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis. Bone. 2019 05; 122:176-183.
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Cheema AK, Byrum SD, Sharma NK, Altadill T, Kumar VP, Biswas S, Balgley BM, Hauer-Jensen M, Tackett AJ, Ghosh SP. Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol. Radiat Res. 2018 11; 190(5):449-463.
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So J, Khaliq M, Evason K, Ninov N, Martin BL, Stainier DYR, Shin D. Wnt/?-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating notch activity. Hepatology. 2018 06; 67(6):2352-2366.
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Xiong J, Almeida M, O'Brien CA. The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone. 2018 07; 112:1-9.
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Yin GN, Jin HR, Choi MJ, Limanjaya A, Ghatak K, Minh NN, Ock J, Kwon MH, Song KM, Park HJ, Kim HM, Kwon YG, Ryu JK, Suh JK. Pericyte-Derived Dickkopf2 Regenerates Damaged Penile Neurovasculature Through an Angiopoietin-1-Tie2 Pathway. Diabetes. 2018 06; 67(6):1149-1161.
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Kim D, Garza LA. The Negative Regulator CXXC5: Making WNT Look a Little Less?Dishevelled. J Invest Dermatol. 2017 11; 137(11):2248-2250.
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Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study. Osteoarthritis Cartilage. 2017 10; 25(10):1598-1606.
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Zhu AS, Li A, Ratliff TS, Melsom M, Garza LA. After Skin Wounding, Noncoding dsRNA Coordinates Prostaglandins and Wnts to Promote Regeneration. J Invest Dermatol. 2017 07; 137(7):1562-1568.
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Goto H, Kimmey SC, Row RH, Matus DQ, Martin BL. FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from tailbud neuromesodermal progenitors through regulation of a two-step epithelial to mesenchymal transition. Development. 2017 04 15; 144(8):1412-1424.
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Xavier S, Sahu RK, Landes SG, Yu J, Taylor RP, Ayyadevara S, Megyesi J, Stallcup WB, Duffield JS, Reis ES, Lambris JD, Portilla D. Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis. Am J Physiol Renal Physiol. 2017 03 01; 312(3):F516-F532.
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Mahapatra S, Gallaher B, Smith SC, Graham JG, Voth DE, Shaw EI. Coxiella burnetii Employs the Dot/Icm Type IV Secretion System to Modulate Host NF-?B/RelA Activation. Front Cell Infect Microbiol. 2016; 6:188.
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Delgado-Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone. 2017 03; 96:29-37.
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Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. J Bone Miner Res. 2016 10; 31(10):1791-1802.
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Kim D, Hossain MZ, Nieves A, Gu L, Ratliff TS, Mi Oh S, Park A, Han S, Yang NB, Qi J, Taube JM, Kang S, Garza LA. To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease. Am J Pathol. 2016 05; 186(5):1140-50.
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Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73.
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Shukla S, Sinha S, Khan S, Kumar S, Singh K, Mitra K, Maurya R, Meeran SM. Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/?-catenin signaling axis. Sci Rep. 2016 Feb 24; 6:21860.
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Ulrich F, Carretero-Ortega J, Men?ndez J, Narvaez C, Sun B, Lancaster E, Pershad V, Trzaska S, V?liz E, Kamei M, Prendergast A, Kidd KR, Shaw KM, Castranova DA, Pham VN, Lo BD, Martin BL, Raible DW, Weinstein BM, Torres-V?zquez J. Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development. 2016 Jan 01; 143(1):147-59.
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Martin BL. Factors that coordinate mesoderm specification from neuromesodermal progenitors with segmentation during vertebrate axial extension. Semin Cell Dev Biol. 2016 Jan; 49:59-67.
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Nelson AM, Garza LA. Bad Hair Day: Testosterone and Wnts. J Invest Dermatol. 2015 Nov; 135(11):2567-2569.
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Yan S, Tsurumi A, Que YA, Ryan CM, Bandyopadhaya A, Morgan AA, Flaherty PJ, Tompkins RG, Rahme LG. Prediction of multiple infections after severe burn trauma: a prospective cohort study. Ann Surg. 2015 Apr; 261(4):781-92.
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Tu X, Delgado-Calle J, Condon KW, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr DB, Plotkin LI, Bellido T. Osteocytes mediate the anabolic actions of canonical Wnt/?-catenin signaling in bone. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E478-86.
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Mercer KE, Hennings L, Ronis MJ. Alcohol consumption, Wnt/?-catenin signaling, and hepatocarcinogenesis. Adv Exp Med Biol. 2015; 815:185-95.
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Schickling BM, England SK, Aykin-Burns N, Norian LA, Leslie KK, Frieden-Korovkina VP. BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway. Oncol Rep. 2015 Feb; 33(2):533-8.
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