 Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
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| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
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| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Activase- Activase
- Hoffmann-La Roche Brand of Alteplase
- Hoffmann La Roche Brand of Alteplase
- Genentech Brand of Alteplase
- Alteplase Genentech Brand
Actilyse- Actilyse
- Boehringer Ingelheim Brand of Alteplase
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
- Promeco Brand of Alteplase
- Alteplase Promeco Brand
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Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in UAMS Profiles by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2023 | 1 | 2 | 3 | | 2022 | 1 | 3 | 4 | | 2021 | 1 | 2 | 3 | | 2020 | 2 | 3 | 5 | | 2019 | 3 | 1 | 4 | | 2018 | 3 | 1 | 4 | | 2017 | 1 | 0 | 1 | | 2016 | 1 | 1 | 2 | | 2015 | 4 | 3 | 7 | | 2013 | 2 | 0 | 2 | | 2012 | 2 | 0 | 2 | | 2011 | 4 | 2 | 6 | | 2010 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2008 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 1992 | 1 | 0 | 1 | | 1991 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles over the past ten years.
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Eastin C. In minor, nondisabling, acute ischemic stroke, DAPT was noninferior to IV alteplase for excellent functional outcome at 90 d. Ann Intern Med. 2023 10; 176(10):JC110.
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Desai R, Mondal A, Prasad A, Vyas A, Jain A, Rupareliya C, Shah M, Paul T, Kumar G, Sachdeva R. Concurrent Cardio-Cerebral Infarctions in COVID-19: A Systematic Review of Published Case Reports/Series. Curr Probl Cardiol. 2023 Oct; 48(10):101814.
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Dockery PW, Clegg AM, Sallam AB. Complete Fibrin Degradation 1 Day after Intracameral Alteplase. Ophthalmol Retina. 2023 Jul; 7(7):611.
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Warach SJ, Dula AN, Milling TJ, Miller S, Allen L, Zuck ND, Miller C, Jesser CA, Misra LR, Miley JT, Mawla M, Ding MC, Bertelson JA, Tsui AY, Jefferson JR, Davison HM, Shah DN, Ellington KT, Padrick MM, Nova AS, Krishna VR, Davis LA, Paydarfar D. Prospective Observational Cohort Study of Tenecteplase Versus Alteplase in Routine Clinical Practice. Stroke. 2022 12; 53(12):3583-3593.
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Shah VA, Thompson RE, Yenokyan G, Acosta JN, Avadhani R, Dlugash R, McBee N, Li Y, Hansen BM, Ullman N, Falcone G, Awad IA, Hanley DF, Ziai WC. One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability. JAMA Neurol. 2022 09 01; 79(9):856-868.
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Doiron T, Ramseyer A, Phelps EN, Williams AJ, Teal LN, Hollenbach LL, Magann EF. Pregnancy-Related Stroke: A Review. Obstet Gynecol Surv. 2022 Jun; 77(6):367-378.
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James CA, Lewis PS, Moore MB, Wong K, Rader EK, Roberson PK, Ghaleb NA, Jensen HK, Pezeshkmehr AH, Stroud MH, Ashton DJ. Efficacy of standardizing fibrinolytic therapy for parapneumonic effusion. Pediatr Radiol. 2022 11; 52(12):2413-2420.
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Yaghi S, Mistry E, de Havenon A, Leon Guerrero CR, Nouh A, Liberman AL, Giles J, Liu A, Nagy M, Kaushal A, Azher I, Mac Grory B, Fakhri H, Brown Espaillat K, Asad SD, Pasupuleti H, Martin H, Tan J, Veerasamy M, Esenwa C, Cheng N, Moncrieffe K, Moeini-Naghani I, Siddu M, Scher E, Trivedi T, Wu T, Khan M, Keyrouz S, Furie K, Henninger N. Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study. J Am Heart Assoc. 2021 08 03; 10(15):e020945.
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Sidorov E, Iser C, Kapoor N, Ray B, Chainakul J, Xu C, Alexandrov AV, Gordon DL. Criteria for Emergency Brain MRI During Stroke-Alert. J Stroke Cerebrovasc Dis. 2021 Aug; 30(8):105890.
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Carneiro T, Dashkoff J, Leung L, Nobleza COS, Marulanda-Londono E, Hathidara M, Koch S, Sur N, Boske A, Voetsch B, Daneshmand A, Shulman J, Curiale G, Greer DM, Romero JR, Anand P, Cervantes-Arslanian AM. Response to the Letter to the Editor: Consideration Needed for Early Anticoagulation Following Intravenous tPA in Patients with COVID-19. J Stroke Cerebrovasc Dis. 2021 07; 30(7):105789.
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Ortega-Gutierrez S, Farooqui M, Zha A, Czap A, Sebaugh J, Desai S, Jadhav A, Vora N, Rai V, Jovin TG, Thon JM, Heslin M, Thau L, Zevallos C, Quispe-Orozco D, Jillella DV, Nahab F, Mohammaden MH, Nogueira RG, Haussen DC, Nguyen TN, Romero JR, Aparicio HJ, Osman M, Haq IU, Liebeskind D, Hassan AE, Zaidat O, Siegler JE. Decline in mild stroke presentations and intravenous thrombolysis during the COVID-19 pandemic: The Society of Vascular and Interventional Neurology Multicenter Collaboration. Clin Neurol Neurosurg. 2021 02; 201:106436.
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Kheir F, Thakore S, Mehta H, Jantz M, Parikh M, Chee A, Kaphle U, Sisnega C, Fernandez-Bussy S, Majid A. Intrapleural Fibrinolytic Therapy versus Early Medical Thoracoscopy for Treatment of Pleural Infection. Randomized Controlled Clinical Trial. Ann Am Thorac Soc. 2020 08; 17(8):958-964.
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Carneiro T, Dashkoff J, Leung LY, Nobleza COS, Marulanda-Londono E, Hathidara M, Koch S, Sur N, Boske A, Voetsch B, Aboul Nour H, Miller DJ, Daneshmand A, Shulman J, Curiale G, Greer DM, Romero JR, Anand P, Cervantes-Arslanian AM. Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19. J Stroke Cerebrovasc Dis. 2020 Nov; 29(11):105201.
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Onteddu SR, Nalleballe K, Sharma R, Brown AT. Underutilization of health care for strokes during the COVID-19 outbreak. Int J Stroke. 2020 07; 15(5):NP9-NP10.
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Rajah G, Saber H, Lieber B, Kappel A, Smitt M, Chamiraju P, Narayanan S, Luqman A. A Moving Target? The Fate of Large Vessel Occlusion Strokes Pretreated with Intravenous Tissue Plasminogen Activator in the Era of Mechanical Thrombectomy. World Neurosurg. 2020 09; 141:e447-e452.
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Wayne NB, Davis GA, Macaulay TE, Beavers CJ, Messerli AW, Dugan A, Smyth SS. Reduced dose thrombolysis with ultrasound-facilitated catheter-directed administration for acute pulmonary embolism reduces length of stay. J Thromb Thrombolysis. 2020 May; 49(4):540-544.
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Akhtar N, Kamran S, Elkhider H, Al-Makki S, Mhjob N, ElShiekh L, AlHussain H, Ali M, Khodair R, Wadiwala F, Salam A, Deleu D, Francis R, Shuaib A. Progression of stroke deficits in patients presenting with mild symptoms: The underlying etiology determines outcome. PLoS One. 2020; 15(4):e0231448.
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Fatima N, Razzaq S, El Beltagi A, Shuaib A, Saqqur M. Decompressive Craniectomy: A Preliminary Study of Comparative Radiographic Characteristics Predicting Outcome in Malignant Ischemic Stroke. World Neurosurg. 2020 Jan; 133:e267-e274.
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Nalleballe K, Sharma R, Kovvuru S, Brown A, Sheng S, Gundapaneni S, Ranabothu S, Veerapaneni P, Joiner R, Kapoor N, Culp W, Onteddu S. Why are acute ischemic stroke patients not receiving thrombolysis in a telestroke network? J Telemed Telecare. 2020 Jul; 26(6):317-321.
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Knadler JJ, Zobeck M, Masand P, Sartain S, Kyle WB. In Utero Aortic Arch Thrombosis Masquerading as Interrupted Aortic Arch: A Case Report and Review of the Literature. Pediatr Cardiol. 2019 Mar; 40(3):658-663.
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Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV. Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Ann Neurol. 2019 01; 85(1):125-136.
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McTaggart RA, Moldovan K, Oliver LA, Dibiasio EL, Baird GL, Hemendinger ML, Haas RA, Goyal M, Wang TY, Jayaraman MV. Door-in-Door-Out Time at Primary Stroke Centers May Predict Outcome for Emergent Large Vessel Occlusion Patients. Stroke. 2018 12; 49(12):2969-2974.
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Onyeama SN, Hanson SJ, Dasgupta M, Baker K, Simpson PM, Punzalan RC. Central Venous Catheter-associated Venous Thromboembolism in Children With Hematologic Malignancy. J Pediatr Hematol Oncol. 2018 11; 40(8):e519-e524.
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Nalleballe K, Sharma R, Brown A, Joiner R, Kapoor N, Morgan T, Benton T, Williamson C, Culp W, Lowery C, Onteddu S. Ideal telestroke time targets: Telestroke-based treatment times in the United States stroke belt. J Telemed Telecare. 2020 04; 26(3):174-179.
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Ishrat T, Fouda AY, Pillai B, Eldahshan W, Ahmed H, Waller JL, Ergul A, Fagan SC. Dose-response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab. 2019 08; 39(8):1635-1647.
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Al-Hashimi MR, Hardin J, Sallam AB. Treatment of Postvitrectomy Fibrin Using Intravitreal Tissue Plasminogen Activator. Retina. 2017 09; 37(9):e97-e98.
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Ali SF, Siddiqui K, Ay H, Silverman S, Singhal A, Viswanathan A, Rost N, Lev M, Schwamm LH. Baseline Predictors of Poor Outcome in Patients Too Good to Treat With Intravenous Thrombolysis. Stroke. 2016 12; 47(12):2986-2992.
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James CA, Braswell LE, Pezeshkmehr AH, Roberson PK, Parks JA, Moore MB. Stratifying fibrinolytic dosing in pediatric parapneumonic effusion based on ultrasound grade correlation. Pediatr Radiol. 2017 Jan; 47(1):89-95.
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Ruebel M, Shankar K, Gaddy D, Lindsey F, Badger T, Andres A. Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1. Am J Physiol Endocrinol Metab. 2016 07 01; 311(1):E269-77.
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Bashiri M, Greenfield LJ, Oliveto A. Telemedicine Interest for Routine Follow-Up Care Among Neurology Patients in Arkansas. Telemed J E Health. 2016 06; 22(6):514-8.
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Chandra D, Pothineni NV, Meena N. "The Scalpel or the Needle for Superior Vena Cava syndrome"? J Ark Med Soc. 2015 Aug; 112(3):34-5.
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Sardar P, Chatterjee S, Giri J, Kundu A, Tandar A, Sen P, Nairooz R, Huston J, Ryan JJ, Bashir R, Parikh SA, White CJ, Meyers PM, Mukherjee D, Majersik JJ, Gray WA. Endovascular therapy for acute ischaemic stroke: a systematic review and meta-analysis of randomized trials. Eur Heart J. 2015 Sep 14; 36(35):2373-80.
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Culp WC, Brown AT, Lowery JD, Arthur MC, Roberson PK, Skinner RD. Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model. Mol Neurobiol. 2015 Oct; 52(2):979-84.
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Yaghi S, Harik SI, Hinduja A, Bianchi N, Johnson DM, Keyrouz SG. Post t-PA transfer to hub improves outcome of moderate to severe ischemic stroke patients. J Telemed Telecare. 2015 Oct; 21(7):396-9.
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Yaghi S, Hinduja A, Bianchi N. Predictors of major improvement after intravenous thrombolysis in acute ischemic stroke. Int J Neurosci. 2016; 126(1):67-9.
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Hanson SJ, Havens PL, Simpson PM, Nugent ML, Wells RG. Intrapleural alteplase decreases parapneumonic effusion volume in children more than saline irrigation. Pediatr Pulmonol. 2015 Dec; 50(12):1328-35.
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Kensinger CD, Sexton KW, Baron CM, Lipnik AJ, Meranze SG, Gorden DL. Management of portal vein thrombosis after liver transplantation with a combined open and endovascular approach. Liver Transpl. 2015 Jan; 21(1):132-4.
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