 Complement Factor I
"Complement Factor I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.
| Descriptor ID |
D017244
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| MeSH Number(s) |
D08.811.277.656.300.760.210 D08.811.277.656.959.350.210 D12.776.124.486.274.920.325.210
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| Concept/Terms |
Complement Factor I- Complement Factor I
- C4b-C3b-INA
- C4b C3b INA
- C3b Inactivator
- Inactivator, C3b
- C4bC3bINA
- Complement C4b-C3b Inactivator
- C4b-C3b Inactivator, Complement
- Complement C4b C3b Inactivator
- Inactivator, Complement C4b-C3b
- C3b-C4b Inactivator
- C3b C4b Inactivator
- Inactivator, C3b-C4b
- Complement 3b-Complement 4b Inactivator
- Complement 3b Complement 4b Inactivator
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Below are MeSH descriptors whose meaning is more general than "Complement Factor I".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor I".
This graph shows the total number of publications written about "Complement Factor I" by people in UAMS Profiles by year, and whether "Complement Factor I" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement Factor I" by people in Profiles over the past ten years.
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Ipe TS, Lim J, Reyes MA, Ero M, Leveque C, Lewis B, Kain J. An extremely rare splice site mutation in the gene encoding complement factor I in a patient with atypical hemolytic uremic syndrome. J Clin Apher. 2017 Dec; 32(6):584-588.
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Larsen CP, Durfee T, Wilson JD, Beggs ML. A Custom Targeted Next-Generation Sequencing Gene Panel for the Diagnosis of Genetic Nephropathies. Am J Kidney Dis. 2016 06; 67(6):992-3.
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