 Pancreatic Elastase
"Pancreatic Elastase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.
| Descriptor ID |
D010196
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| MeSH Number(s) |
D08.811.277.656.300.760.560 D08.811.277.656.959.350.560
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| Concept/Terms |
Pancreatic Elastase- Pancreatic Elastase
- Elastase, Pancreatic
- Pancreatic Elastase I
- Elastase I, Pancreatic
- Elastase
- Pancreatopeptidase
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Below are MeSH descriptors whose meaning is more general than "Pancreatic Elastase".
Below are MeSH descriptors whose meaning is more specific than "Pancreatic Elastase".
This graph shows the total number of publications written about "Pancreatic Elastase" by people in UAMS Profiles by year, and whether "Pancreatic Elastase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 | | 2015 | 2 | 0 | 2 | | 2014 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pancreatic Elastase" by people in Profiles over the past ten years.
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Ojha M, Smith NJ, Devine AJ, Joshi R, Goodman EM, Fan Q, Schuman R, Porollo A, Wells JM, Tiwary E, Batie MR, Gray J, Deshmukh H, Borchers MT, Ammerman SA, Varisco BM. Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling. JCI Insight. 2024 Jan 09; 9(1).
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Joshi I, Devine AJ, Joshi R, Smith NJ, Varisco BM. A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase. Sci Rep. 2023 09 14; 13(1):15259.
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Ho JP, Galex IA, Sadeghi NB, Weledji N, Cabello Bermudez SI, Mitchell BA, Bush DM, Yap E, Davis NC, Catalino MP, Godfrey V, Nielsen JN, Lee YZ, Sasaki-Adams DM. Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing. World Neurosurg. 2021 04; 148:e242-e251.
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Abo-Aly M, George B, Shokri E, Chelvarajan L, El-Helw M, Smyth SS, Abdel-Latif A, Ziada K. Cangrelor in addition to standard therapy reduces cardiac damage and inflammatory markers in patients with ST-segment elevation myocardial infarction. J Thromb Thrombolysis. 2021 Oct; 52(3):934-940.
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Joshi R, Heinz A, Fan Q, Guo S, Monia B, Schmelzer CEH, Weiss AS, Batie M, Parameshwaran H, Varisco BM. Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema. Am J Respir Cell Mol Biol. 2018 08; 59(2):167-178.
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Claushuis TAM, de Stoppelaar SF, de Vos AF, Grootemaat AE, van der Wel NN, Roelofs JJTH, Ware J, Van't Veer C, van der Poll T. Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1772-1784.
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Joshi R, Liu S, Brown MD, Young SM, Batie M, Kofron JM, Xu Y, Weaver TE, Apsley K, Varisco BM. Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung. FASEB J. 2016 Feb; 30(2):590-600.
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Young SM, Liu S, Joshi R, Batie MR, Kofron M, Guo J, Woods JC, Varisco BM. Localization and stretch-dependence of lung elastase activity in development and compensatory growth. J Appl Physiol (1985). 2015 Apr 01; 118(7):921-31.
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Oliphant SS, Nygaard IE, Zong W, Canavan TP, Moalli PA. Maternal adaptations in preparation for parturition predict uncomplicated spontaneous delivery outcome. Am J Obstet Gynecol. 2014 Dec; 211(6):630.e1-7.
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Liu S, Young SM, Varisco BM. Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15; 306(12):L1104-16.
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