 Amyloid
"Amyloid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
| Descriptor ID |
D000682
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| MeSH Number(s) |
D05.500.049 D12.776.049
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| Concept/Terms |
Amyloid- Amyloid
- Amyloid Substance
- Substance, Amyloid
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Below are MeSH descriptors whose meaning is more general than "Amyloid".
Below are MeSH descriptors whose meaning is more specific than "Amyloid".
This graph shows the total number of publications written about "Amyloid" by people in UAMS Profiles by year, and whether "Amyloid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 5 | 0 | 5 | | 2024 | 2 | 0 | 2 | | 2023 | 0 | 1 | 1 | | 2021 | 2 | 1 | 3 | | 2020 | 1 | 2 | 3 | | 2019 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2017 | 2 | 2 | 4 | | 2016 | 2 | 2 | 4 | | 2015 | 2 | 0 | 2 | | 2014 | 2 | 1 | 3 | | 2013 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amyloid" by people in Profiles over the past ten years.
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Mahmoud M, Ozdag Y, Carry BJ, Gardner JM, Dwyer CL, Klena JC, Grandizio LC. Amyloid Biopsy During Endoscopic Carpal Tunnel Release: A Comparison of Tenosynovial and Antebrachial Fascia Specimens. J Hand Surg Am. 2025 Oct; 50(10):1174-1181.
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Morgan GJ, Prokaeva T. Clone-specific residue changes at multiple positions are associated with amyloid formation by antibody light chains. Front Immunol. 2025; 16:1622207.
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Ozdag Y, Mahmoud M, Carry BJ, Gardner JM, Dwyer CL, Klena JC, Grandizio LC. Differences in the Incidence of Amyloid Deposition in Biopsies Performed During Bilateral Carpal Tunnel Release. J Hand Surg Am. 2025 Jun; 50(6):697-702.
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Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Singh Bawa P, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. Amyloid. 2025 Jun; 32(2):179-192.
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Younes K, Johns E, Young CB, Kennedy G, Mukherjee S, Vossler HA, Winer J, Cody K, Henderson VW, Poston KL, Betthauser TJ, Bevis B, Brooks WM, Burns JM, Coombes SA, DeCarli C, DiFilippo FP, Duara R, Fan AP, Gibbons LE, Golde T, Johnson SC, Lepping RJ, Leverenz J, McDougall S, Rogalski E, Sanders E, Pasaye J, Sridhar J, Saykin AJ, Sridharan A, Swerdlow R, Trittschuh EH, Vaillancourt D, Vidoni E, Wang WE, Mez J, Hohman TJ, Tosun D, Biber S, Kukull WA, Crane PK, Mormino EC. Amyloid PET predicts longitudinal functional and cognitive trajectories in a heterogeneous cohort. Alzheimers Dement. 2025 Mar; 21(3):e70075.
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Ozdag Y, Koshinski JL, Carry BJ, Gardner JM, Garcia VC, Dwyer CL, Klena JC, Grandizio LC. A Comparison of Tenosynovial and Transverse Carpal Ligament Biopsy for Amyloid Detection in Open Carpal Tunnel Release. J Hand Surg Am. 2024 Oct; 49(10):979-985.
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Leach BI, Ferguson JA, Morgan G, Sun X, Kroon G, Oyen D, Dyson HJ, Wright PE. Conformational Dynamics of an Amyloidogenic Intermediate of Transthyretin: Implications for Structural Remodeling and Amyloid Formation. J Mol Biol. 2024 Aug 15; 436(16):168673.
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Edwards L, Thomas KR, Weigand AJ, Edmonds EC, Clark AL, Walker KS, Brenner EK, Nation DA, Maillard P, Bondi MW, Bangen KJ. White Matter Hyperintensity Volume and Amyloid-PET Synergistically Impact Memory Independent of Tau-PET in Older Adults Without Dementia. J Alzheimers Dis. 2023; 94(2):695-707.
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Morgan GJ. Transient disorder along pathways to amyloid. Biophys Chem. 2022 02; 281:106711.
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Yan NL, Santos-Martins D, Nair R, Chu A, Wilson IA, Johnson KA, Forli S, Morgan GJ, Petrassi HM, Kelly JW. Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J Med Chem. 2021 05 13; 64(9):6273-6299.
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Gupta HV, Beach TG, Mehta SH, Shill HA, Driver-Dunckley E, Sabbagh MN, Belden CM, Liebsack C, Dugger BN, Serrano GE, Sue LI, Siderowf A, Pontecorvo MJ, Mintun MA, Joshi AD, Adler CH. Clinicopathological Correlation: Dopamine and Amyloid PET Imaging with Neuropathology in Three Subjects Clinically Diagnosed with Alzheimer's Disease or Dementia with Lewy Bodies. J Alzheimers Dis. 2021; 80(4):1603-1612.
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Gokden M. Amyloid Deposition in the Brain. Arch Pathol Lab Med. 2020 10 01; 144(10):1162-1163.
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Morgan GJ, Wall JS. The Process of Amyloid Formation due to Monoclonal Immunoglobulins. Hematol Oncol Clin North Am. 2020 12; 34(6):1041-1054.
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Arya S, Ganguly P, Arsiccio A, Claud SL, Trapp B, Schonfeld GE, Liu X, Lazar Cantrell K, Shea JE, Bowers MT. Terminal Capping of an Amyloidogenic Tau Fragment Modulates Its Fibrillation Propensity. J Phys Chem B. 2020 10 08; 124(40):8772-8783.
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Karamanos TK, Jackson MP, Calabrese AN, Goodchild SC, Cawood EE, Thompson GS, Kalverda AP, Hewitt EW, Radford SE. Structural mapping of oligomeric intermediates in an amyloid assembly pathway. Elife. 2019 09 25; 8.
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Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, Kelly JW. Stabilization of amyloidogenic immunoglobulin light chains by small molecules. Proc Natl Acad Sci U S A. 2019 04 23; 116(17):8360-8369.
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Iadanza MG, Jackson MP, Hewitt EW, Ranson NA, Radford SE. A new era for understanding amyloid structures and disease. Nat Rev Mol Cell Biol. 2018 12; 19(12):755-773.
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Morgan GJ, Usher GA, Kelly JW. Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients? Biochemistry. 2017 Dec 19; 56(50):6597-6614.
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Palmer BW, Harmell AL, Dunn LB, Kim SY, Pinto LL, Golshan S, Jeste DV. Multimedia Aided Consent for Alzheimer's Disease Research. Clin Gerontol. 2018 Jan-Feb; 41(1):20-32.
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Jackson MP, Hewitt EW. Why are Functional Amyloids Non-Toxic in Humans? Biomolecules. 2017 09 22; 7(4).
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Giffin JC, Richards RC, Craft C, Jahan N, Leggiadro C, Chopin T, Szemerda M, MacKinnon SL, Ewart KV. An extract of the marine alga Alaria esculenta modulates a-synuclein folding and amyloid formation. Neurosci Lett. 2017 03 22; 644:87-93.
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Jackson MP, Hewitt EW. Cellular proteostasis: degradation of misfolded proteins by lysosomes. Essays Biochem. 2016 10 15; 60(2):173-180.
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Morgan GJ, Kelly JW. The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains. J Mol Biol. 2016 10 23; 428(21):4280-4297.
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Larsen CP, Beggs ML, Wilson JD, Lathrop SL. Prevalence and organ distribution of leukocyte chemotactic factor 2 amyloidosis (ALECT2) among decedents in New Mexico. Amyloid. 2016 Jun; 23(2):119-23.
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Iadanza MG, Jackson MP, Radford SE, Ranson NA. MpUL-multi: Software for Calculation of Amyloid Fibril Mass per Unit Length from TB-TEM Images. Sci Rep. 2016 Feb 12; 6:21078.
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