 Inflammasomes
"Inflammasomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multiprotein complexes that mediate the activation of CASPASE-1. Dysregulation of inflammasomes has also been linked to a number of autoinflammatory and autoimmune disorders.
| Descriptor ID |
D058847
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| MeSH Number(s) |
D05.500.224
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Inflammasomes".
Below are MeSH descriptors whose meaning is more specific than "Inflammasomes".
This graph shows the total number of publications written about "Inflammasomes" by people in UAMS Profiles by year, and whether "Inflammasomes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 2 | 3 | | 2022 | 1 | 2 | 3 | | 2021 | 0 | 1 | 1 | | 2020 | 3 | 2 | 5 | | 2019 | 0 | 2 | 2 | | 2018 | 1 | 0 | 1 | | 2017 | 3 | 1 | 4 | | 2016 | 1 | 1 | 2 | | 2015 | 5 | 0 | 5 | | 2014 | 4 | 0 | 4 | | 2013 | 2 | 1 | 3 | | 2012 | 0 | 3 | 3 | | 2011 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Inflammasomes" by people in Profiles over the past ten years.
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Li C, Wang X, Tian M, Zhang M, Zhang X, Fu Q, Liu L, Zhang L, Wang H. The JNK-associated leucine zipper protein exerts a protective effect on renal parenchymal injury by limiting the inflammatory secretome in tubular cells. Cell Signal. 2024 Dec; 124:111428.
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Ghimire L, Paudel S, Le J, Jin L, Cai S, Bhattarai D, Jeyaseelan S. NLRP6 negatively regulates host defense against polymicrobial sepsis. Front Immunol. 2024; 15:1248907.
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Drew PD. Targeting the Nlrp3 inflammasome as potential treatment for ethanol-induced non-communicable diseases. Am J Drug Alcohol Abuse. 2024 Mar 03; 50(2):125-127.
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Oh C, Li L, Verma A, Reuven AD, Miao EA, Bliska JB, Aachoui Y. Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins. Cell Rep. 2022 11 22; 41(8):111688.
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Lin J, Huang D, Xu H, Zhan F, Tan X. Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases. Front Immunol. 2022; 13:952040.
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Zhang Y, Wu C, Li L, Pandeya A, Zhang G, Cui J, Kirchhofer D, Wood JP, Smyth SS, Wei Y, Li Z. Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death. Int J Mol Sci. 2022 Jun 18; 23(12).
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Yang F, Bettadapura SN, Smeltzer MS, Zhu H, Wang S. Pyroptosis and pyroptosis-inducing cancer drugs. Acta Pharmacol Sin. 2022 Oct; 43(10):2462-2473.
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Zhang Y, Cui J, Zhang G, Wu C, Abdel-Latif A, Smyth SS, Shiroishi T, Mackman N, Wei Y, Tao M, Li Z. Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Adv. 2021 06 22; 5(12):2619-2623.
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Kane CJM, Douglas JC, Rafferty T, Johnson JW, Niedzwiedz-Massey VM, Phelan KD, Majewska AK, Drew PD. Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders. J Neurosci Res. 2021 08; 99(8):1986-2007.
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Wang X, Li X, Liu S, Brickell AN, Zhang J, Wu Z, Zhou S, Ding Z. PCSK9 regulates pyroptosis via mtDNA damage in chronic myocardial ischemia. Basic Res Cardiol. 2020 11 12; 115(6):66.
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Oh C, Verma A, Aachoui Y. Caspase-11 Non-canonical Inflammasomes in the Lung. Front Immunol. 2020; 11:1895.
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Kovacs SB, Oh C, Maltez VI, McGlaughon BD, Verma A, Miao EA, Aachoui Y. Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. Cell Rep. 2020 07 28; 32(4):107967.
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Ding Z, Wang X, Liu S, Zhou S, Kore RA, Mu S, Deng X, Fan Y, Mehta JL. NLRP3 inflammasome via IL-1? regulates PCSK9 secretion. Theranostics. 2020; 10(16):7100-7110.
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Liu D, Zeng X, Li X, Cui C, Hou R, Guo Z, Mehta JL, Wang X. Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators. Biochem Pharmacol. 2020 05; 175:113863.
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Greene E, Flees J, Dhamad A, Alrubaye A, Hennigan S, Pleimann J, Smeltzer M, Murray S, Kugel J, Goodrich J, Robertson A, Wideman R, Rhoads D, Dridi S. Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. Am J Pathol. 2019 10; 189(10):2077-2089.
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Arnold MG, Gokulan K, Doerge DR, Vanlandingham M, Cerniglia CE, Khare S. A single or short time repeated arsenic oral exposure in mice impacts mRNA expression for signaling and immunity related genes in the gut. Food Chem Toxicol. 2019 Oct; 132:110597.
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Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover SP, Zhang X, Li L, Xiang B, Shi J, Li XA, Daugherty A, Smyth SS, Kirchhofer D, Shiroishi T, Shao F, Mackman N, Wei Y, Li Z. Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity. 2019 06 18; 50(6):1401-1411.e4.
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Lyu JJ, Mehta JL, Li Y, Ye L, Sun SN, Sun HS, Li JC, Zhang DM, Wei J. Mitochondrial Autophagy and NLRP3 Inflammasome in Pulmonary Tissues from Severe Combined Immunodeficient Mice after Cardiac Arrest and Cardiopulmonary Resuscitation. Chin Med J (Engl). 2018 May 20; 131(10):1174-1184.
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Liu D, Zeng X, Li X, Mehta JL, Wang X. Role of NLRP3 inflammasome in the pathogenesis of cardiovascular diseases. Basic Res Cardiol. 2018 01 08; 113(1):5.
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Pothineni NVK, Subramany S, Kuriakose K, Shirazi LF, Romeo F, Shah PK, Mehta JL. Infections, atherosclerosis, and coronary heart disease. Eur Heart J. 2017 Nov 14; 38(43):3195-3201.
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Dai Y, Cao Y, Zhang Z, Vallurupalli S, Mehta JL. Xanthine Oxidase Induces Foam Cell Formation through LOX-1 and NLRP3 Activation. Cardiovasc Drugs Ther. 2017 Feb; 31(1):19-27.
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Wright F, Hammer M, Paul SM, Aouizerat BE, Kober KM, Conley YP, Cooper BA, Dunn LB, Levine JD, DEramo Melkus G, Miaskowski C. Inflammatory pathway genes associated with inter-individual variability in the trajectories of morning and evening fatigue in patients receiving chemotherapy. Cytokine. 2017 03; 91:187-210.
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Kane CJ, Drew PD. Inflammatory responses to alcohol in the CNS: nuclear receptors as potential therapeutics for alcohol-induced neuropathologies. J Leukoc Biol. 2016 11; 100(5):951-959.
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Simmen RC, Kelley AS. Reversal of fortune: estrogen receptor-? in endometriosis. J Mol Endocrinol. 2016 08; 57(2):F23-7.
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Aachoui Y, Miao EA. Down with doublespeak: NAIP/NLRC4 inflammasomes get specific. J Exp Med. 2016 05 02; 213(5):646.
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Maltez VI, Tubbs AL, Cook KD, Aachoui Y, Falcone EL, Holland SM, Whitmire JK, Miao EA. Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. Immunity. 2015 Nov 17; 43(5):987-97.
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Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J. Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. Infect Immun. 2015 Dec; 83(12):4740-9.
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Aachoui Y, Kajiwara Y, Leaf IA, Mao D, Ting JP, Coers J, Aderem A, Buxbaum JD, Miao EA. Canonical Inflammasomes Drive IFN-? to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015 Sep 09; 18(3):320-32.
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Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol Cell Endocrinol. 2015 Nov 05; 415:45-55.
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Cieniewicz B, Dong Q, Li G, Forrest JC, Mounce BC, Tarakanova VL, van der Velden A, Krug LT. Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1? Production upon Extrinsic Stimulation in Culture. J Virol. 2015 Jul; 89(13):6562-74.
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