 Prions
"Prions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
| Descriptor ID |
D011328
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| MeSH Number(s) |
D12.776.785
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| Concept/Terms |
Prions- Prions
- PrP Proteins
- Prion Proteins
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Below are MeSH descriptors whose meaning is more general than "Prions".
Below are MeSH descriptors whose meaning is more specific than "Prions".
This graph shows the total number of publications written about "Prions" by people in UAMS Profiles by year, and whether "Prions" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Prions" by people in Profiles over the past ten years.
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Albert-Gasco H, Smith HL, Alvarez-Castelao B, Swinden D, Halliday M, Janaki-Raman S, Butcher AJ, Mallucci GR. Trazodone rescues dysregulated synaptic and mitochondrial nascent proteomes in prion neurodegeneration. Brain. 2024 02 01; 147(2):649-664.
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Peretti D, Smith HL, Verity N, Humoud I, de Weerd L, Swinden DP, Hayes J, Mallucci GR. TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection. Life Sci Alliance. 2021 04; 4(4).
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