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Robert Wolfe

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Faculty
Address2135 Institute on Aging
629 Jack Stephens Drive
Mail Slot # 806
Little Rock AR 72205
Phone501-526-5708
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    Collapse Research 
    Collapse research activities and funding
    R44DK135312     (WOLFE, ROBERT R)Sep 20, 2023 - Aug 31, 2025
    NIH
    Amino Acids and Pediatric Hepatic Steatosis
    Role: Principal Investigator
    W81XWH1C0067     (FERRANDO, ARNY)Mar 29, 2021 - Mar 31, 2025
    U.S. Army Research Institute of Environmental Medicine
    Protein Kinetic Response to Calorie Deprivation:
    Role: Principal Investigator
    R44DK125151     (WOLFE, ROBERT R)Jun 1, 2020 - Feb 28, 2024
    NIH
    Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery
    Role: Principal Investigator
    R25DK111362     (WOLFE, ROBERT R)Sep 13, 2018 - Aug 31, 2023
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Vanderbilt University
    Wolfe SubK-Vanderbilt Tracer Course 2018 - Continuation
    Role: Principal Investigator
    043959     (WOLFE, ROBERT R)Jan 1, 2018 - Jun 30, 2019
    MYOS RENS - Pass Through: University of California, Berkeley
    Wolfe-FORTE: Effects of Fortetropin on Skeletal Muscle Protein Fractional Synthetic Rate in Older Men and Women
    Role: Principal Investigator
    3000289848     (WOLFE, ROBERT R)Dec 11, 2017 - Jun 30, 2019
    Zespri Group Limited - Pass Through: Massey University
    Wolfe-KIWI Sub w/Massey: Speeding Up a Slow Protein for Muscle Mass with Hayward Kiwi fruit
    Role: Principal Investigator
    R42AG050375     (AZHAR, GOHAR)Sep 15, 2017 - May 31, 2019
    NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC
    Subcontract w/Essential Blends, LLC: UpBeat Phase 2
    Role: Principal Investigator
    U24DK076169     (WOLFE, ROBERT R)Jul 3, 2017 - Jun 30, 2018
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Vanderbilt University
    Sub w/Vanderbilt: 2017 T-Course Isotope Tracers in Metabolic Research
    Role: Principal Investigator
    R43AG051298     (WOLFE, ROBERT R)Sep 1, 2015 - Feb 28, 2017
    NIH
    Muscle preservation during weight loss in older, overweight individuals
    Role: Principal Investigator
    R41AG050375     (AZHAR, GOHAR)Aug 15, 2015 - Jan 31, 2017
    NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC
    Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission
    Role: Principal Investigator
    AN777     (WOLFE, ROBERT R)Jul 23, 2014 - Jul 22, 2017
    Abbott, Inc.
    No FP attached
    Role: Principal Investigator
    CT     (WOLFE, ROBERT)May 3, 2013
    Baxter Healthcare Corporation
    Protocol No. CT-12-0012 entitled “Determination of the Optimal Infusion Rate of Amino Acids in Seriously Ill Patients
    Role: Principal Investigator
    CT-12-0012     (WOLFE, ROBERT R)May 3, 2013
    Baxter Healthcare Corporation
    Protocol No. CT-12-0012 entitled “Determination of the Optimal Infusion Rate of Amino Acids in Seriously Ill Patients
    Role: Principal Investigator
    AN777-BK33     (WOLFE, ROBERT R)Feb 9, 2012 - Feb 8, 2015
    Abbott, Inc.
    “Evaluation of an Oral Nutritional Supplement Containing AN777 in Older Hospitalized Patients - BK33”
    Role: Principal Investigator
    BK96 AN777     (WOLFE, ROBERT R)Sep 27, 2011 - Sep 26, 2014
    Abbott, Inc.
    Comparison of Medical Nutritional Supplements With or Without AN777 in Elderly Men
    Role: Principal Investigator
    BK96AN777     (WOLFE, ROBERT R)Sep 27, 2011 - Sep 26, 2014
    Abbott, Inc.
    Comparison of Medical Nutritional Supplements With or Without AN777 in Elderly Men
    Role: Principal Investigator
    P30AG028718     (WEI, JEANNE Y)Sep 1, 2011 - Aug 31, 2018
    NIH
    Arkansas Claude Pepper Older Americans Independence Center at UAMS
    Role: Co-Investigator
    1050     (FERRANDO, ARNY)Jun 1, 2011 - Dec 31, 2012
    National Dairy Council
    Ferrando: Effect of Dietary Protein Intake Pattern on Skeletal Muscle in Older Individuals
    Role: Co-Investigator
    RC2GM092277     (WOLFE, ROBERT R)Sep 30, 2009 - Aug 31, 2011
    NIH
    Stable Isotope Analytical Core for Studies in Human Metabolism
    Role: Principal Investigator
    Spectator     (WOLFE, ROBERT R)Mar 4, 2009 - Mar 3, 2011
    Danone Research
    Skeletal Muscle Protein synthesis in healthy elderly after bolus intake of a high whey-protein leucine-rich oral nutritional supplement Spa.1/C/A AKA
    Role: Principal Investigator
    R25DK082376     (WOLFE, ROBERT R)Mar 1, 2009 - Jan 31, 2014
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Case Western Reserve University
    Wolfe - Subcontract w Case Western - Isotope Tracers in Metabolic Research
    Role: Principal Investigator
    R01GM084447     (DEUTZ, NICOLAAS E)Dec 15, 2008 - Nov 30, 2014
    NIH
    Optimal Amino Acid Nutrition in Sepsis
    Role: Co-Principal Investigator
    Pilot Study     (WOLFE, ROBERT R)Jan 28, 2008 - Dec 15, 2008
    Glanbia Nutritionals
    Dose Response to peptide mixture enriched with branched chain amino acids: A Pilot Study
    Role: Principal Investigator
    PilotStudy     (WOLFE, ROBERT R)Jan 28, 2008 - Dec 15, 2008
    Glanbia Nutritionals
    Dose Response to peptide mixture enriched with branched chain amino acids: A Pilot Study
    Role: Principal Investigator
    Protocol #4     (WOLFE, ROBERT R)Aug 1, 2007 - Jul 31, 2008
    NOVARTIS Pharmaceuticals Corporation
    RES-DZ-01-03 Study in Septic-shock ICU Patients in Which Arginine was Infused to Improve Their Condition-Nicolaas Deitz, Co-I
    Role: Principal Investigator
    Protocol#4     (WOLFE, ROBERT R)Aug 1, 2007 - Jul 31, 2008
    NOVARTIS Pharmaceuticals Corporation
    RES-DZ-01-03 Study in Septic-shock ICU Patients in Which Arginine was Infused to Improve Their Condition-Nicolaas Deitz, Co-I
    Role: Principal Investigator
    Protocol 2     (WOLFE, ROBERT R)May 1, 2007 - Apr 30, 2011
    NOVARTIS Pharmaceuticals Corporation
    PROTOCOL #2: The Effect of Frequent EAA Ingestion on Resting Energy Expenditure and 24hr Muscle Protein Synthesis
    Role: Principal Investigator
    Protocol2     (WOLFE, ROBERT R)May 1, 2007 - Apr 30, 2011
    NOVARTIS Pharmaceuticals Corporation
    PROTOCOL #2: The Effect of Frequent EAA Ingestion on Resting Energy Expenditure and 24hr Muscle Protein Synthesis
    Role: Principal Investigator
    Protocol 3     (WOLFE, ROBERT R)Dec 1, 2006 - Dec 31, 2009
    NOVARTIS Pharmaceuticals Corporation
    Protocol 3: Use of Dietery Nucleotides to Stimulate tRNA Synthesis for Enhanced Protein Synthesis in Chronic Wasting of Elderly
    Role: Principal Investigator
    Protocol3     (WOLFE, ROBERT R)Dec 1, 2006 - Dec 31, 2009
    NOVARTIS Pharmaceuticals Corporation
    Protocol 3: Use of Dietery Nucleotides to Stimulate tRNA Synthesis for Enhanced Protein Synthesis in Chronic Wasting of Elderly
    Role: Principal Investigator
    NPFR00403     (WOLFE, ROBERT R)Aug 1, 2006 - Jul 31, 2009
    National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine
    Nutritional Countermeasures to Ameliorate Losses in Muscle Mass and Function
    Role: Principal Investigator
    R01AR049038     (WOLFE, ROBERT R)Jul 1, 2002 - Jun 30, 2008
    NIH
    Amino Acids and Muscle Protein Synthesis
    Role: Principal Investigator
    R01AG015780     (WOLFE, ROBERT R)Sep 1, 1998 - Jul 31, 2004
    NIH
    MUSCLE PROTEIN METABOLISM AND NUTRITION IN THE ELDERLY
    Role: Principal Investigator
    R13DK047827     (WOLFE, ROBERT R)Mar 20, 1994 - Feb 28, 1995
    NIH
    MODELING IN METABOLISM AND NUTRITION
    Role: Principal Investigator
    R01DK046017     (WOLFE, ROBERT R)Sep 1, 1993 - Mar 31, 2004
    NIH
    EXERCISE, LIPOLYSIS AND FAT OXIDATION
    Role: Principal Investigator
    R01DK037484     (WOLFE, ROBERT R)Jun 15, 1989 - Dec 31, 1992
    NIH
    ASSESSMENT OF SUBSTRATE KINETIC ANALYSIS USING TRACERS
    Role: Principal Investigator
    R01GM041089     (WOLFE, ROBERT R)Apr 1, 1989 - Mar 31, 1993
    NIH
    ENERGY EXPENDITURE IN BURNED PATIENTS
    Role: Principal Investigator
    R01DK038010     (WOLFE, ROBERT R)Jan 1, 1987 - Jun 30, 2004
    NIH
    EXERCISE EFFECTS ON PROTEIN METABOLISM
    Role: Principal Investigator
    R01DK034817     (WOLFE, ROBERT R)Dec 1, 1984 - Sep 30, 2014
    NIH
    Substrate Cycling in Energy Metabolism
    Role: Principal Investigator
    R01AM034817     (WOLFE, ROBERT R)Dec 1, 1984 - Nov 30, 1989
    NIH
    THE ROLE OF SUBSTRATE CYCLING IN ENERGY METABOLISM
    Role: Principal Investigator
    R01DK033952     (WOLFE, ROBERT R)Dec 1, 1983 - Jun 30, 2000
    NIH
    GLUCOSE METABOLISM IN SEPTIC PATIENTS
    Role: Principal Investigator
    R01AM033952     (WOLFE, ROBERT R)Dec 1, 1983 - Nov 30, 1986
    NIH
    GLUCOSE METABOLISM IN SEPTIC PATIENTS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Church DD, Hirsch KR, Kviatkovsky SA, Matthews JJ, Ferrando AA, Azhar G, Wolfe RR. The anabolic response to a ground beef patty and soy-based meat alternative: a randomized controlled trial. Am J Clin Nutr. 2024 Aug 31. PMID: 39222687.
      View in: PubMed
    2. Gwin JA, Church DD, Allen JT, Wilson MA, Carrigan CT, Murphy NE, Varanoske AN, Margolis LM, Wolfe RR, Ferrando AA, Pasiakos SM. Consuming Whey Protein with Added Essential Amino Acids, not Carbohydrate, Maintains Post-Exercise Anabolism while Underfed. Med Sci Sports Exerc. 2024 Aug 23. PMID: 39160756.
      View in: PubMed
    3. Park S, Cha HN, Shin MG, Park S, Kim Y, Kim MS, Shin KH, Thoudam T, Lee EJ, Wolfe RR, Dan J, Koh JH, Kim IY, Choi I, Lee IK, Sung HK, Park SY. Inhibitory Regulation of FOXO1 in PPARd Expression Drives Mitochondrial Dysfunction and Insulin Resistance. Diabetes. 2024 Jul 01; 73(7):1084-1098. PMID: 38656552.
      View in: PubMed
    4. Jang J, Kim Y, Song T, Park S, Kim HJ, Koh JH, Cho Y, Park SY, Sadayappan S, Kwak HB, Wolfe RR, Kim IY, Choi CS. Free essential amino acid feeding improves endurance during resistance training via DRP1-dependent mitochondrial remodelling. J Cachexia Sarcopenia Muscle. 2024 Oct; 15(5):1651-1663. PMID: 38881251.
      View in: PubMed
    5. Church DD, Ferrando AA, Wolfe RR. Stimulation of muscle protein synthesis with low-dose amino acid composition in older individuals. Front Nutr. 2024; 11:1360312. PMID: 38524852.
      View in: PubMed
    6. Fordham TM, Morelli NS, Garcia-Reyes Y, Ware MA, Rahat H, Sundararajan D, Fuller KNZ, Severn C, Pyle L, Malloy CR, Jin ES, Parks EJ, Wolfe RR, Cree MG. Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity. Obesity (Silver Spring). 2024 04; 32(4):678-690. PMID: 38439205.
      View in: PubMed
    7. Azhar G, Verma A, Robeson MS, Patyal P, Nookaew I, Sharma S, Pangle A, Che Y, Wolfe RR, Wei JY. Short-Term Ingestion of Essential Amino Acid Based Nutritional Supplements or Whey Protein Improves the Physical Function of Older Adults Independently of Gut Microbiome. Mol Nutr Food Res. 2024 Mar; 68(6):e2300716. PMID: 38426663.
      View in: PubMed
    8. Moughan PJ, Fulgoni VL, Wolfe RR. The Importance of Dietary Protein Quality in Mid- to High-Income Countries. J Nutr. 2024 03; 154(3):804-814. PMID: 38253225.
      View in: PubMed
    9. Ferrando AA, Wolfe RR, Hirsch KR, Church DD, Kviatkovsky SA, Roberts MD, Stout JR, Gonzalez DE, Sowinski RJ, Kreider RB, Kerksick CM, Burd NA, Pasiakos SM, Ormsbee MJ, Arent SM, Arciero PJ, Campbell BI, VanDusseldorp TA, Jager R, Willoughby DS, Kalman DS, Antonio J. International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance. J Int Soc Sports Nutr. 2023 Dec; 20(1):2263409. PMID: 37800468.
      View in: PubMed
    10. Azhar G, Verma A, Zhang X, Pangle A, Patyal P, Zhang W, Che Y, Coker K, Wolfe RR, Wei JY. Correction to: Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement versus whey protein in low physical functioning older adults. Geroscience. 2023 Jun; 45(3):2087. PMID: 36763242.
      View in: PubMed
    11. Azhar G, Verma A, Zhang X, Pangle A, Patyal P, Zhang W, Che Y, Coker K, Wolfe RR, Wei JY. Differential plasma protein expression after ingestion of essential amino acid-based dietary supplement verses whey protein in low physical functioning older adults. Geroscience. 2023 06; 45(3):1729-1743. PMID: 36720768.
      View in: PubMed
    12. Kim IY, Park S, Kim Y, Kim HJ, Wolfe RR. Tracing metabolic flux in vivo: basic model structures of tracer methodology. Exp Mol Med. 2022 09; 54(9):1311-1322. PMID: 36075950.
      View in: PubMed
    13. Kim IY, Wolfe RR. Tracing metabolic flux in vivo: motion pictures differ from snapshots. Exp Mol Med. 2022 09; 54(9):1309-1310. PMID: 36075946.
      View in: PubMed
    14. Wolfe RR, Kim IY, Park S, Ferrando A. Tracing metabolic flux to assess optimal dietary protein and amino acid consumption. Exp Mol Med. 2022 09; 54(9):1323-1331. PMID: 36075948.
      View in: PubMed
    15. Kim IY, Wolfe RR. Author Correction: Tracing metabolic flux in vivo: motion pictures differ from snapshots. Exp Mol Med. 2022 Sep; 54(9):1596. PMID: 36163252.
      View in: PubMed
    16. Jang J, Koh JH, Kim Y, Kim HJ, Park S, Chang Y, Jung J, Wolfe RR, Kim IY. Balanced Free Essential Amino Acids and Resistance Exercise Training Synergistically Improve Dexamethasone-Induced Impairments in Muscle Strength, Endurance, and Insulin Sensitivity in Mice. Int J Mol Sci. 2022 Aug 27; 23(17). PMID: 36077132.
      View in: PubMed
    17. Diaz EC, Williams DK, Cotter M, Sims CR, Wolfe RR, Andres A, B?rsheim E. Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation. Am J Clin Nutr. 2022 08 04; 116(2):404-414. PMID: 35404455.
      View in: PubMed
    18. Coker MS, Barati Z, Murphy CJ, Bateman T, Newcomer BR, Wolfe RR, Coker RH. Essential amino acid enriched meal replacement improves body composition and physical function in obese older adults: A randomized controlled trial. Clin Nutr ESPEN. 2022 10; 51:104-111. PMID: 36184194.
      View in: PubMed
    19. Park S, Chang Y, Wolfe RR, Kim IY. Prevention of Loss of Muscle Mass and Function in Older Adults during COVID-19 Lockdown: Potential Role of Dietary Essential Amino Acids. Int J Environ Res Public Health. 2022 07 01; 19(13). PMID: 35805748.
      View in: PubMed
    20. Song BS, Moon JS, Tian J, Lee HY, Sim BC, Kim SH, Kang SG, Kim JT, Nga HT, Benfeitas R, Kim Y, Park S, Wolfe RR, Eun HS, Shong M, Lee S, Kim IY, Yi HS. Mitoribosomal defects aggravate liver cancer via aberrant glycolytic flux and T cell exhaustion. J Immunother Cancer. 2022 05; 10(5). PMID: 35580931.
      View in: PubMed
    21. Hawley AL, Liang X, B?rsheim E, Wolfe RR, Salisbury L, Hendy E, Wu H, Walker S, Tacinelli AM, Baum JI. The potential role of beef and nutrients found in beef on outcomes of wellbeing in healthy adults 50?years of age and older: A systematic review of randomized controlled trials. Meat Sci. 2022 Jul; 189:108830. PMID: 35483315.
      View in: PubMed
    22. Hirsch KR, Church DD, Wolfe RR, Ferrando AA. Continuous oral stable isotope ingestion to measure whole-body protein turnover. Clin Nutr ESPEN. 2022 06; 49:385-389. PMID: 35623841.
      View in: PubMed
    23. Kim Y, Park S, Lee J, Jang J, Jung J, Koh JH, Choi CS, Wolfe RR, Kim IY. Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice. Metabolites. 2022 Jan 16; 12(1). PMID: 35050206.
      View in: PubMed
    24. Hudson JL, Cotter M, Herndon DN, Wolfe RR, B?rsheim E. Comparison of Arterial-Venous Balance and Tracer Incorporation Methods for Measuring Muscle Fractional Synthesis and Fractional Breakdown Rates. J Burn Care Res. 2022 01 05; 43(1):156-162. PMID: 33908606.
      View in: PubMed
    25. Coker MS, Schutzler SE, Park S, Williams RH, Ferrando AA, Deutz NEP, Wolfe RR, Coker RH. Equivalent servings of free-range reindeer promote greater net protein balance compared to commercial beef. Int J Circumpolar Health. 2021 12; 80(1):1897222. PMID: 33704030.
      View in: PubMed
    26. Church DD, Schutzler SE, Wolfe RR, Ferrando AA. Perioperative amino acid infusion reestablishes muscle net balance during total hip arthroplasty. Physiol Rep. 2021 09; 9(18):e15055. PMID: 34558214.
      View in: PubMed
    27. Azhar G, Wei JY, Schutzler SE, Coker K, Gibson RV, Kirby MF, Ferrando AA, Wolfe RR. Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning. J Gerontol A Biol Sci Med Sci. 2021 06 14; 76(7):1184-1191. PMID: 33475727.
      View in: PubMed
    28. Hirsch KR, Wolfe RR, Ferrando AA. Pre- and Post-Surgical Nutrition for Preservation of Muscle Mass, Strength, and Functionality Following Orthopedic Surgery. Nutrients. 2021 May 15; 13(5). PMID: 34063333.
      View in: PubMed
    29. Park S, Church DD, Schutzler SE, Azhar G, Kim IY, Ferrando AA, Wolfe RR. Metabolic Evaluation of the Dietary Guidelines' Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial. J Nutr. 2021 05 11; 151(5):1190-1196. PMID: 33693735.
      View in: PubMed
    30. Jang J, Park S, Kim Y, Jung J, Lee J, Chang Y, Lee SP, Park BC, Wolfe RR, Choi CS, Kim IY. Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice. Nutrients. 2021 Apr 29; 13(5). PMID: 33947024.
      View in: PubMed
    31. Park S, Church DD, Starck C, Schutzler SE, Azhar G, Kim IY, Ferrando AA, Moughan PJ, Wolfe RR. Correction to: The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism. Eur J Nutr. 2021 Mar; 60(2):1149-1151. PMID: 33306152.
      View in: PubMed
    32. Soeters PB, Shenkin A, Sobotka L, Soeters MR, de Leeuw PW, Wolfe RR. The anabolic role of the Warburg, Cori-cycle and Crabtree effects in health and disease. Clin Nutr. 2021 05; 40(5):2988-2998. PMID: 33674148.
      View in: PubMed
    33. Gwin JA, Church DD, Hatch-McChesney A, Allen JT, Wilson MA, Varanoske AN, Carrigan CT, Murphy NE, Margolis LM, Carbone JW, Wolfe RR, Ferrando AA, Pasiakos SM. Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study. J Int Soc Sports Nutr. 2021 Jan 07; 18(1):4. PMID: 33413462.
      View in: PubMed
    34. Evans W, Shankaran M, Nyangau E, Field T, Mohammed H, Wolfe R, Schutzler S, Hellerstein M. Effects of Fortetropin on the Rate of Muscle Protein Synthesis in Older Men and Women: A Randomized, Double-Blinded, Placebo-Controlled Study. J Gerontol A Biol Sci Med Sci. 2021 01 01; 76(1):108-114. PMID: 32598445.
      View in: PubMed
    35. Kim IY, Park S, Kim Y, Chang Y, Choi CS, Suh SH, Wolfe RR. In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench. Endocrinol Metab (Seoul). 2020 12; 35(4):733-749. PMID: 33397035.
      View in: PubMed
    36. Azhar G, Raza S, Pangle A, Coleman K, Dawson A, Schrader A, Wolfe RR, Wei JY. Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction. Gerontol Geriatr Med. 2020 Jan-Dec; 6:2333721420982808. PMID: 33426179.
      View in: PubMed
    37. Church DD, Hirsch KR, Park S, Kim IY, Gwin JA, Pasiakos SM, Wolfe RR, Ferrando AA. Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding. Nutrients. 2020 Dec 02; 12(12). PMID: 33276485.
      View in: PubMed
    38. Hirsch KR, Church DD, Kim IY, Park S, Wolfe RR, Ferrando AA. Comparison of basal whole-body protein kinetics and muscle protein synthesis between young and older adults. Physiol Rep. 2020 12; 8(23):e14633. PMID: 33278070.
      View in: PubMed
    39. Park S, Jang J, Choi MD, Shin YA, Schutzler S, Azhar G, Ferrando AA, Wolfe RR, Kim IY. The Anabolic Response to Dietary Protein Is Not Limited by the Maximal Stimulation of Protein Synthesis in Healthy Older Adults: A Randomized Crossover Trial. Nutrients. 2020 Oct 26; 12(11). PMID: 33114585.
      View in: PubMed
    40. Wu H, Jang J, Dridi S, Ferrando AA, Wolfe RR, Kim IY, Baum JI. Net protein balance correlates with expression of autophagy, mitochondrial biogenesis, and fat metabolism-related genes in skeletal muscle from older adults. Physiol Rep. 2020 10; 8(19):e14575. PMID: 33063954.
      View in: PubMed
    41. Park S, Church DD, Starck C, Schutzler SE, Azhar G, Kim IY, Ferrando AA, Moughan PJ, Wolfe RR. The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism. Eur J Nutr. 2021 Mar; 60(2):1141-1148. PMID: 32970234.
      View in: PubMed
    42. Gwin JA, Church DD, Wolfe RR, Ferrando AA, Pasiakos SM. Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit. Nutrients. 2020 Aug 15; 12(8). PMID: 32824200.
      View in: PubMed
    43. Kim IY, Park S, Jang J, Wolfe RR. Understanding Muscle Protein Dynamics: Technical Considerations for Advancing Sarcopenia Research. Ann Geriatr Med Res. 2020 Sep; 24(3):157-165. PMID: 32752586.
      View in: PubMed
    44. Gu C, Brereton N, Schweitzer A, Cotter M, Duan D, B?rsheim E, Wolfe RR, Pham LV, Polotsky VY, Jun JC. Metabolic Effects of Late Dinner in Healthy Volunteers-A Randomized Crossover Clinical Trial. J Clin Endocrinol Metab. 2020 08 01; 105(8). PMID: 32525525.
      View in: PubMed
    45. Wardle SL, Macnaughton LS, McGlory C, Witard OC, Dick JR, Whitfield PD, Ferrando AA, Wolfe RR, Kim IY, Hamilton DL, Moran CN, Tipton KD, Galloway SDR. Human skeletal muscle metabolic responses to 6 days of high-fat overfeeding are associated with dietary n-3PUFA content and muscle oxidative capacity. Physiol Rep. 2020 08; 8(16):e14529. PMID: 32845565.
      View in: PubMed
    46. Gwin JA, Church DD, Hatch-McChesney A, Howard EE, Carrigan CT, Murphy NE, Wilson MA, Margolis LM, Carbone JW, Wolfe RR, Ferrando AA, Pasiakos SM. Effects of high versus standard essential amino acid intakes on whole-body protein turnover and mixed muscle protein synthesis during energy deficit: A randomized, crossover study. Clin Nutr. 2021 03; 40(3):767-777. PMID: 32768315.
      View in: PubMed
    47. Gawel SH, Davis GJ, Luo M, Deutz NEP, Wolfe RR, Pereira SL. Serum biomarkers that predict lean mass loss over bed rest in older adults: An exploratory study. Clin Chim Acta. 2020 Oct; 509:72-78. PMID: 32505773.
      View in: PubMed
    48. Park S, Church DD, Azhar G, Schutzler SE, Ferrando AA, Wolfe RR. Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults. J Int Soc Sports Nutr. 2020 Feb 10; 17(1):9. PMID: 32041644.
      View in: PubMed
    49. Coker MS, Ladd KR, Kim J, Murphy CJ, DeCort R, Newcomer BR, Wolfe RR, Coker RH. Essential Amino Acid Supplement Lowers Intrahepatic Lipid despite Excess Alcohol Consumption. Nutrients. 2020 Jan 19; 12(1). PMID: 31963802.
      View in: PubMed
    50. Kim IY, Park S, Jang J, Wolfe RR. Quantifications of Lipid Kinetics In Vivo Using Stable Isotope Tracer Methodology. J Lipid Atheroscler. 2020 Jan; 9(1):110-123. PMID: 32821725.
      View in: PubMed
    51. Moughan PJ, Wolfe RR. Determination of Dietary Amino Acid Digestibility in Humans. J Nutr. 2019 12 01; 149(12):2101-2109. PMID: 31529051.
      View in: PubMed
    52. Margolis LM, Wilson MA, Whitney CC, Carrigan CT, Murphy NE, Radcliffe PN, Gwin JA, Church DD, Wolfe RR, Ferrando AA, Young AJ, Pasiakos SM. Acute hypoxia reduces exogenous glucose oxidation, glucose turnover, and metabolic clearance rate during steady-state aerobic exercise. Metabolism. 2020 02; 103:154030. PMID: 31778707.
      View in: PubMed
    53. Ludwig DS, Ebbeling CB, Wong JMW, Wolfe RR, Wong WW. Methodological error in measurement of energy expenditure by the doubly labeled water method: much ado about nothing? Am J Clin Nutr. 2019 11 01; 110(5):1253-1254. PMID: 31667511.
      View in: PubMed
    54. Wolfe RR, Park S, Kim IY, Moughan PJ, Ferrando AA. Advances in stable isotope tracer methodology part 2: new thoughts about an "old" method-measurement of whole body protein synthesis and breakdown in the fed state. J Investig Med. 2020 01; 68(1):11-15. PMID: 31554677.
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    399. Goran MI, Beer WH, Wolfe RR, Poehlman ET, Young VR. Variation in total energy expenditure in young healthy free-living men. Metabolism. 1993; 42(4):487 - 496.
    400. Wolfe RR. Metabolic response to burn injury: nutritional implications. Keio J Med. 1993; 42(1):1 - 8.
    401. Chinkes DL, Rosenblatt J, Wolfe RR. Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique. Clin Sci (Lond). 1993; 84(2):177 - 183.
    402. Townsend RR, DiPette DJ, Lieux TR, Wolfe RR. The role of the renin-angiotensin system in insulin sensitivity in normotensive subjects. Am J Med Sci. 1993; 305(2):67 - 71.
    403. Wolfe RR. Incidence of acute rheumatic fever. J Pediatr. 1993; 122(2):327 - 328.
    404. Wolfe RR, Driscoll DJ, Gersony WM, Hayes CJ, Keane JF, Kidd L, O'Fallon WM, Pieroni DR, Weidman WH. Arrhythmias in patients with valvar aortic stenosis, valvar pulmonary stenosis, and ventricular septal defect. Results of 24-hour ECG monitoring. Circulation. 1993; 87(2 Suppl):I89 - 101.
    405. Wolfe RR, George S. Stable isotopic tracers as metabolic probes in exercise. Exerc Sport Sci Rev. 1993; 21:1 - 31.
    406. Catalano PM, Tyzbir ED, Wolfe RR, Calles J, Roman NM, Amini SB, Sims EA. Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes. Am J Physiol. 1993; 264(1 Pt 1):E60 - E67.
    407. Klein S, Jahoor F, Baba H, Townsend CM, Shepherd M, Wolfe RR. In vivo assessment of the metabolic alterations in glucagonoma syndrome. Metabolism. 1992; 41(11):1171 - 1175.
    408. Catalano PM, Tyzbir ED, Wolfe RR, Roman NM, Amini SB, Sims EA. Longitudinal changes in basal hepatic glucose production and suppression during insulin infusion in normal pregnant women. Am J Obstet Gynecol. 1992; 167(4 Pt 1):913 - 919.
    409. Rosenblatt J, Chinkes D, Wolfe M, Wolfe RR. Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects. Am J Physiol. 1992; 263(3 Pt 1):E584 - E596.
    410. Klein S, Jahoor F, Wolfe RR, Stuart CA. Generalized lipodystrophy: in vivo evidence for hypermetabolism and insulin-resistant lipid, glucose, and amino acid kinetics. Metabolism. 1992; 41(8):893 - 896.
    411. Biolo G, Chinkes D, Zhang XJ, Wolfe RR. Harry M. Vars Research Award. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle. JPEN J Parenter Enteral Nutr. 1992; 16(4):305 - 315.
    412. Romijn JA, Coyle EF, Hibbert J, Wolfe RR. Comparison of indirect calorimetry and a new breath 13C/12C ratio method during strenuous exercise. Am J Physiol. 1992; 263(1 Pt 1):E64 - E71.
    413. Brooks GA, Wolfel EE, Groves BM, Bender PR, Butterfield GE, Cymerman A, Mazzeo RS, Sutton JR, Wolfe RR, Reeves JT. Muscle accounts for glucose disposal but not blood lactate appearance during exercise after acclimatization to 4,300 m. J Appl Physiol (1985 ). 1992; 72(6):2435 - 2445.
    414. Fleming RY, Rutan RL, Jahoor F, Barrow RE, Wolfe RR, Herndon DN. Effect of recombinant human growth hormone on catabolic hormones and free fatty acids following thermal injury. J Trauma. 1992; 32(6):698 - 702.
    415. Carraro F, Wolfe RR. High-protein intake alters the response of fasting in normal human subjects. Am J Clin Nutr. 1992; 55(5):959 - 962.
    416. Klein S, Wolfe RR. Carbohydrate restriction regulates the adaptive response to fasting. Am J Physiol. 1992; 262(5 Pt 1):E631 - E636.
    417. Jahoor F, Zhang XJ, Baba H, Sakurai Y, Wolfe RR. Comparison of constant infusion and flooding dose techniques to measure muscle protein synthesis rate in dogs. J Nutr. 1992; 122(4):878 - 887.
    418. Cowett RM, Wolfe RR. Glucose and lactate kinetics in the neonate. J Dev Physiol. 1991; 16(6):341 - 347.
    419. Gore DC, Honeycutt D, Jahoor F, Rutan T, Wolfe RR, Herndon DN. Effect of exogenous growth hormone on glucose utilization in burn patients. J Surg Res. 1991; 51(6):518 - 523.
    420. Peters EJ, Klein S, Wolfe RR. Effect of short-term fasting on the lipolytic response to theophylline. Am J Physiol. 1991; 261(4 Pt 1):E500 - E504.
    421. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT. Decreased reliance on lactate during exercise after acclimatization to 4,300 m. J Appl Physiol (1985 ). 1991; 71(1):333 - 341.
    422. Zhang XJ, Kunkel KR, Jahoor F, Wolfe RR. Role of basal insulin in the regulation of protein kinetics and energy metabolism in septic patients. JPEN J Parenter Enteral Nutr. 1991; 15(4):394 - 399.
    423. Goran MI, Broemeling L, Herndon DN, Peters EJ, Wolfe RR. Estimating energy requirements in burned children: a new approach derived from measurements of resting energy expenditure. Am J Clin Nutr. 1991; 54(1):35 - 40.
    424. Wolfe RR, Jahoor F, Herndon DN, Miyoshi H. Isotopic evaluation of the metabolism of pyruvate and related substrates in normal adult volunteers and severely burned children: effect of dichloroacetate and glucose infusion. Surgery. 1991; 110(1):54 - 67.
    425. Gore DC, Honeycutt D, Jahoor F, Barrow RE, Wolfe RR, Herndon DN. Propranolol diminishes extremity blood flow in burned patients. Ann Surg. 1991; 213(6):568 - 573.
    426. Klein S, Peters EJ, Shangraw RE, Wolfe RR. Lipolytic response to metabolic stress in critically ill patients. Crit Care Med. 1991; 19(6):776 - 779.
    427. Carraro F, Rosenblatt J, Wolfe RR. Isotopic determination of fibronectin synthesis in humans. Metabolism. 1991; 40(6):553 - 561.
    428. Wolfe RR. Current thoughts on the assessment of protein metabolism in humans. J Burn Care Rehabil. 1991; 12(3):211 - 213.
    429. Wolfe RR. Empirical assessment of model validity. JPEN J Parenter Enteral Nutr. 1991; 15(3):50S - 54S.
    430. Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT. Increased dependence on blood glucose after acclimatization to 4,300 m. J Appl Physiol (1985 ). 1991; 70(2):919 - 927.
    431. Wolfe RR, Loehr JP, Schaffer MS, Wiggins JW. Hemodynamic effects of ketamine, hypoxia and hyperoxia in children with surgically treated congenital heart disease residing greater than or equal to 1,200 meters above sea level. Am J Cardiol. 1991; 67(1):84 - 87.
    432. Gore DC, Honeycutt D, Jahoor F, Wolfe RR, Herndon DN. Effect of exogenous growth hormone on whole-body and isolated-limb protein kinetics in burned patients. Arch Surg. 1991; 126(1):38 - 43.
    433. Wolfe RR, Klein S, Herndon DN, Jahoor F. Substrate cycling in thermogenesis and amplification of net substrate flux in human volunteers and burned patients. J Trauma. 1990; 30(12 Suppl):S6 - S9.
    434. Klein S, Wolfe RR. Whole-body lipolysis and triglyceride-fatty acid cycling in cachectic patients with esophageal cancer. J Clin Invest. 1990; 86(5):1403 - 1408.
    435. Carraro F, Stuart CA, Hartl WH, Rosenblatt J, Wolfe RR. Effect of exercise and recovery on muscle protein synthesis in human subjects. Am J Physiol. 1990; 259(4 Pt 1):E470 - E476.
    436. Hartl WH, Herndon DN, Wolfe RR. Kinin/prostaglandin system: its therapeutic value in surgical stress. Crit Care Med. 1990; 18(10):1167 - 1174.
    437. Goran MI, Peters EJ, Herndon DN, Wolfe RR. Total energy expenditure in burned children using the doubly labeled water technique. Am J Physiol. 1990; 259(4 Pt 1):E576 - E585.
    438. Stuart CA, Shangraw RE, Peters EJ, Wolfe RR. Effect of dietary protein on bed-rest-related changes in whole-body-protein synthesis. Am J Clin Nutr. 1990; 52(3):509 - 514.
    439. Hartl WH, Miyoshi H, Jahoor F, Klein S, Elahi D, Wolfe RR. Bradykinin attenuates glucagon-induced leucine oxidation in humans. Am J Physiol. 1990; 259(2 Pt 1):E239 - E245.
    440. Hartl WH, Wolfe RR. The phospholipid/arachidonic acid second messenger system: its possible role in physiology and pathophysiology of metabolism. JPEN J Parenter Enteral Nutr. 1990; 14(4):416 - 427.
    441. Wolfe RR. Isotopic measurement of glucose and lactate kinetics. Ann Med. 1990; 22(3):163 - 170.
    442. Carraro F, Hartl WH, Stuart CA, Layman DK, Jahoor F, Wolfe RR. Whole body and plasma protein synthesis in exercise and recovery in human subjects. Am J Physiol. 1990; 258(5 Pt 1):E821 - E831.
    443. Weber JM, Klein S, Wolfe RR. Role of the glucose cycle in control of net glucose flux in exercising humans. J Appl Physiol (1985 ). 1990; 68(5):1815 - 1819.
    444. Jahoor F, Peters EJ, Wolfe RR. The relationship between gluconeogenic substrate supply and glucose production in humans. Am J Physiol. 1990; 258(2 Pt 1):E288 - E296.
    445. Wolfe RR, Jahoor F. Recovery of labeled CO2 during the infusion of C-1- vs C-2-labeled acetate: implications for tracer studies of substrate oxidation. Am J Clin Nutr. 1990; 51(2):248 - 252.
    446. Wolfe RR, Klein S, Carraro F, Weber JM. Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am J Physiol. 1990; 258(2 Pt 1):E382 - E389.
    447. Klein S, Holland OB, Wolfe RR. Importance of blood glucose concentration in regulating lipolysis during fasting in humans. Am J Physiol. 1990; 258(1 Pt 1):E32 - E39.
    448. Hartl W, Jauch KW, Herndon DN, Cohnert TU, Wolfe RR, Schildberg FW. Effect of low-dose bradykinin on glucose metabolism and nitrogen balance in surgical patients. Lancet. 1990; 335(8681):69 - 71.
    449. Hartl WH, Jauch KW, Cohnert TU, Wolfe RR, Schildberg FW. [Pyruvate metabolism using stable isotopes]. Beitr Infusionsther. 1990; 25:389 - 398.
    450. Hartl WH, Jauch KW, Wolfe RR, Schildberg FW. Effects of kinins on glucose metabolism in vivo. Horm Metab Res Suppl. 1990; 22:79 - 84.
    451. Beer WH, Murray E, Oh SH, Pedersen HE, Wolfe RR, Young VR. A long-term metabolic study to assess the nutritional value of and immunological tolerance to two soy-protein concentrates in adult humans. Am J Clin Nutr. 1989; 50(5):997 - 1007.
    452. Oldham KT, Guice KS, Stetson PS, Wolfe RR. Bacteremia-induced suppression of alveolar surfactant production. J Surg Res. 1989; 47(5):397 - 402.
    453. Shangraw RE, Jahoor F, Miyoshi H, Neff WA, Stuart CA, Herndon DN, Wolfe RR. Differentiation between septic and postburn insulin resistance. Metabolism. 1989; 38(10):983 - 989.
    454. Stein TP, Hoyt RW, Toole MO, Leskiw MJ, Schluter MD, Wolfe RR, Hiller WD. Protein and energy metabolism during prolonged exercise in trained athletes. Int J Sports Med. 1989; 10(5):311 - 316.
    455. Jahoor F, Shangraw RE, Miyoshi H, Wallfish H, Herndon DN, Wolfe RR. Role of insulin and glucose oxidation in mediating the protein catabolism of burns and sepsis. Am J Physiol. 1989; 257(3 Pt 1):E323 - E331.
    456. Hartl WH, Miyoshi H, Elahi D, Wolfe RR. Glucagon and hepatic glucose production: modulation by low-dose bradykinin infusion. Metabolism. 1989; 38(9):878 - 882.
    457. Klein S, Peters EJ, Holland OB, Wolfe RR. Effect of short- and long-term beta-adrenergic blockade on lipolysis during fasting in humans. Am J Physiol. 1989; 257(1 Pt 1):E65 - E73.
    458. Wolfe RR, Jahoor F, Hartl WH. Protein and amino acid metabolism after injury. Diabetes Metab Rev. 1989; 5(2):149 - 164.
    459. Carraro F, Klein S, Rosenblatt JI, Wolfe RR. Effect of dichloroacetate on lactate concentration in exercising humans. J Appl Physiol (1985 ). 1989; 66(2):591 - 597.
    460. Durkot MJ, Wolfe RR. Hyper and hypodynamic models of sepsis in guinea pigs. J Surg Res. 1989; 46(2):118 - 122.
    461. Shaw JH, Wolfe RR. An integrated analysis of glucose, fat, and protein metabolism in severely traumatized patients. Studies in the basal state and the response to total parenteral nutrition. Ann Surg. 1989; 209(1):63 - 72.
    462. Jahoor F, Klein S, Miyoshi H, Wolfe RR. Effect of isotope infusion and sampling sites on glucose kinetics during a euglycemic clamp. Am J Physiol. 1988; 255(6 Pt 1):E871 - E874.
    463. Katz J, Wolfe RR. On the measurement of lactate turnover in humans. Metabolism. 1988; 37(11):1078 - 1080.
    464. Shangraw RE, Stuart CA, Prince MJ, Peters EJ, Wolfe RR. Insulin responsiveness of protein metabolism in vivo following bedrest in humans. Am J Physiol. 1988; 255(4 Pt 1):E548 - E558.
    465. Herndon DN, Barrow RE, Rutan TC, Minifee P, Jahoor F, Wolfe RR. Effect of propranolol administration on hemodynamic and metabolic responses of burned pediatric patients. Ann Surg. 1988; 208(4):484 - 492.
    466. Stuart CA, Shangraw RE, Prince MJ, Peters EJ, Wolfe RR. Bed-rest-induced insulin resistance occurs primarily in muscle. Metabolism. 1988; 37(8):802 - 806.
    467. Miyoshi H, Shulman GI, Peters EJ, Wolfe MH, Elahi D, Wolfe RR. Hormonal control of substrate cycling in humans. J Clin Invest. 1988; 81(5):1545 - 1555.
    468. Shaw JH, Croxon M, Holdaway I, Collins JP, Wolfe RR. Glucose, fat, and protein kinetics in patients with primary and secondary hyperparathyroidism. Surgery. 1988; 103(5):526 - 532.
    469. Jahoor F, Desai M, Herndon DN, Wolfe RR. Dynamics of the protein metabolic response to burn injury. Metabolism. 1988; 37(4):330 - 337.
    470. Wolfe BM, Klein S, Peters EJ, Schmidt BF, Wolfe RR. Effect of elevated free fatty acids on glucose oxidation in normal humans. Metabolism. 1988; 37(4):323 - 329.
    471. Rosenblatt J, Wolfe RR. Calculation of substrate flux using stable isotopes. Am J Physiol. 1988; 254(4 Pt 1):E526 - E531.
    472. Wolfe RR, Jahoor F, Miyoshi H. Evaluation of the isotopic equilibration between lactate and pyruvate. Am J Physiol. 1988; 254(4 Pt 1):E532 - E535.
    473. Shaw JH, Humberstone DM, Wolfe RR. Energy and protein metabolism in sarcoma patients. Ann Surg. 1988; 207(3):283 - 289.
    474. Shaw JH, Wolfe RR. Metabolic intervention in surgical patients. An assessment of the effect of somatostatin, ranitidine, naloxone, diclophenac, dipyridamole, or salbutamol infusion on energy and protein kinetics in surgical patients using stable and radioisotopes. Ann Surg. 1988; 207(3):274 - 282.
    475. Jauch KW, Hartl WH, Georgieff M, Wolfe RR, Dietze GJ, Gunther B. Low-dose bradykinin infusion reduces endogenous glucose production in surgical patients. Metabolism. 1988; 37(2):185 - 190.
    476. Zawadzki JK, Wolfe RR, Mott DM, Lillioja S, Howard BV, Bogardus C. Increased rate of Cori cycle in obese subjects with NIDDM and effect of weight reduction. Diabetes. 1988; 37(2):154 - 159.
    477. Shaw JH, Wolfe RR. Whole-body protein kinetics in patients with early and advanced gastrointestinal cancer: the response to glucose infusion and total parenteral nutrition. Surgery. 1988; 103(2):148 - 155.
    478. Klein S, Young VR, Blackburn GL, Bistrian BR, Wolfe RR. The impact of body composition on the regulation of lipolysis during short-term fasting. J Am Coll Nutr. 1988; 7(1):77 - 84.
    479. Wolfe RR, Cuminale JA, Carr RF. The role of the forensic dentist. LDA J. 1988; 46(4):8 - 10.
    480. Jahoor F, Wolfe RR. Regulation of urea production by glucose infusion in vivo. Am J Physiol. 1987; 253(5 Pt 1):E543 - E550.
    481. Klein S, Wolfe RR. The use of isotopic tracers in studying lipid metabolism in human subjects. Baillieres Clin Endocrinol Metab. 1987; 1(4):797 - 816.
    482. Wolfe RR. Does exercise stimulate protein breakdown in humans? Isotopic approaches to the problem. Med Sci Sports Exerc. 1987; 19(5 Suppl):S172 - S178.
    483. Jahoor F, Wolfe RR. Regulation of protein catabolism. Kidney Int Suppl. 1987; 22:S81 - S93.
    484. Layman DK, Wolfe RR. Sample site selection for tracer studies applying a unidirectional circulatory approach. Am J Physiol. 1987; 253(2 Pt 1):E173 - E178.
    485. Wolfe RR, Herndon DN, Jahoor F, Miyoshi H, Wolfe M. Effect of severe burn injury on substrate cycling by glucose and fatty acids. N Engl J Med. 1987; 317(7):403 - 408.
    486. Wolfe RR, Herndon DN, Peters EJ, Jahoor F, Desai MH, Holland OB. Regulation of lipolysis in severely burned children. Ann Surg. 1987; 206(2):214 - 221.
    487. Shaw JH, Wolfe RR. Fatty acid and glycerol kinetics in septic patients and in patients with gastrointestinal cancer. The response to glucose infusion and parenteral feeding. Ann Surg. 1987; 205(4):368 - 376.
    488. Jahoor F, Wolfe RR. Reassessment of primed constant-infusion tracer method to measure urea kinetics. Am J Physiol. 1987; 252(4 Pt 1):E557 - E564.
    489. Wolfe RR, Jahoor F, Shaw JH. Effect of alanine infusion on glucose and urea production in man. JPEN J Parenter Enteral Nutr. 1987; 11(2):109 - 111.
    490. Shaw JH, Wildbore M, Wolfe RR. Whole body protein kinetics in severely septic patients. The response to glucose infusion and total parenteral nutrition. Ann Surg. 1987; 205(3):288 - 294.
    491. Shaw JH, Wolfe RR. The integrated effect of adrenergic blockade on glucose, fatty acid, and glycerol kinetics: responses in the basal state and during hormonal control with somatostatin-hormonal infusion. J Surg Res. 1987; 42(3):257 - 272.
    492. Wolfe RR, Peters EJ. Lipolytic response to glucose infusion in human subjects. Am J Physiol. 1987; 252(2 Pt 1):E218 - E223.
    493. Wolfe RR, Peters EJ, Klein S, Holland OB, Rosenblatt J, Gary H. Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects. Am J Physiol. 1987; 252(2 Pt 1):E189 - E196.
    494. Shaw JH, Wolfe RR. Glucose and urea kinetics in patients with early and advanced gastrointestinal cancer: the response to glucose infusion, parenteral feeding, and surgical resection. Surgery. 1987; 101(2):181 - 191.
    495. Wolfe RR. Carbohydrate metabolism in the critically ill patient. Implications for nutritional support. Crit Care Clin. 1987; 3(1):11 - 24.
    496. Shaw JH, Wolfe RR. Energy and protein metabolism in sepsis and trauma. Aust N Z J Surg. 1987; 57(1):41 - 47.
    497. Guice KS, Oldham KT, Wolfe RR, Simon RH. Lung injury in acute pancreatitis: primary inhibition of pulmonary phospholipid synthesis. Am J Surg. 1987; 153(1):54 - 61.
    498. Catalano PM, Bernstein IM, Wolfe RR, Srikanta S, Tyzbir E, Sims EA. Subclinical abnormalities of glucose metabolism in subjects with previous gestational diabetes. Am J Obstet Gynecol. 1986; 155(6):1255 - 1262.
    499. Shaw JH, Wolfe RR. Glucose, fatty acid, and urea kinetics in patients with severe pancreatitis. The response to substrate infusion and total parenteral nutrition. Ann Surg. 1986; 204(6):665 - 672.
    500. Klein S, Young VR, Blackburn GL, Bistrian BR, Wolfe RR. Palmitate and glycerol kinetics during brief starvation in normal weight young adult and elderly subjects. J Clin Invest. 1986; 78(4):928 - 933.
    501. Shaw JH, Wolfe RR. Determinations of glucose turnover and oxidation in normal volunteers and septic patients using stable and radio-isotopes: the response to glucose infusion and total parenteral feeding. Aust N Z J Surg. 1986; 56(10):785 - 791.
    502. Wolfe RR, Washington R, Daberkow E, Murphy JR, Brammel HL. Anaerobic threshold as a predictor of athletic performance in prepubertal female runners. Am J Dis Child. 1986; 140(9):922 - 924.
    503. Jahoor F, Herndon DN, Wolfe RR. Role of insulin and glucagon in the response of glucose and alanine kinetics in burn-injured patients. J Clin Invest. 1986; 78(3):807 - 814.
    504. Schaffer MS, Campbell DN, Clarke DR, Wiggins JW, Wolfe RR. Aortoventriculoplasty in children. J Thorac Cardiovasc Surg. 1986; 92(3 Pt 1):391 - 395.
    505. Wolfe RR, Shaw JH. Effect of epinephrine infusion and adrenergic blockade on glucose oxidation in conscious dogs. Metabolism. 1986; 35(7):673 - 678.
    506. Wolfe RR, Shaw JH, Jahoor F, Herndon DN, Wolfe MH. Response to glucose infusion in humans: role of changes in insulin concentration. Am J Physiol. 1986; 250(3 Pt 1):E306 - E311.
    507. Wolfe RR, Nadel ER, Shaw JH, Stephenson LA, Wolfe MH. Role of changes in insulin and glucagon in glucose homeostasis in exercise. J Clin Invest. 1986; 77(3):900 - 907.
    508. Wolfe RR. Glucose metabolism in burn injury: a review. J Burn Care Rehabil. 1985; 6(5):408 - 418.
    509. Dietz WH, Wolfe RR. Interrelationships of glucose and protein metabolism in obese adolescents during short-term hypocaloric dietary therapy. Am J Clin Nutr. 1985; 42(3):380 - 390.
    510. Shulman GI, Ladenson PW, Wolfe MH, Ridgway EC, Wolfe RR. Substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man. J Clin Invest. 1985; 76(2):757 - 764.
    511. Wolfe RR, Shaw JH, Durkot MJ. Effect of sepsis on VLDL kinetics: responses in basal state and during glucose infusion. Am J Physiol. 1985; 248(6 Pt 1):E732 - E740.
    512. Shaw JH, Wolfe RR. Response to glucose and lipid infusions in sepsis: a kinetic analysis. Metabolism. 1985; 34(5):442 - 449.
    513. Shaw JH, Klein S, Wolfe RR. Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis with stable isotopic tracers. Surgery. 1985; 97(5):557 - 568.
    514. Wolfe RR, Shaw JH. Glucose and FFA kinetics in sepsis: role of glucagon and sympathetic nervous system activity. Am J Physiol. 1985; 248(2 Pt 1):E236 - E243.
    515. Wolfe RR, Durkot MJ. Role of very low density lipoproteins in the energy metabolism of the rat. J Lipid Res. 1985; 26(2):210 - 217.
    516. Ravussin E, Bogardus C, Schwartz RS, Robbins DC, Wolfe RR, Horton ES, Danforth E Jr, Sims EA. Glucose-induced thermogenesis and insulin resistance in man. Int J Obes. 1985; 9 Suppl 2:103 - 109.
    517. Shaw JH, Wolfe RR. Glucose production in the perfused dog liver: effect of free fatty acids and ketones. J Surg Res. 1984; 37(6):437 - 442.
    518. Shaw JH, Wolfe RR. Influence of beta-hydroxybutyrate infusion on glucose and free fatty acid metabolism in dogs. Am J Physiol. 1984; 247(6 Pt 1):E756 - E764.
    519. Goodenough RD, Wolfe RR. Effect of total parenteral nutrition on free fatty acid metabolism in burned patients. JPEN J Parenter Enteral Nutr. 1984; 8(4):357 - 360.
    520. Wolfe RR. Calculation of substrate turnover rate in stable isotope tracer studies. Am J Physiol. 1984; 246(5 Pt 1):E463 - .
    521. Shaw JH, Wolfe RR. A conscious septic dog model with hemodynamic and metabolic responses similar to responses of humans. Surgery. 1984; 95(5):553 - 561.
    522. Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, Sims EA. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes. 1984; 33(4):311 - 318.
    523. Wolfe RR, Shaw JH. Inhibitory effect of plasma free fatty acids on glucose production in the conscious dog. Am J Physiol. 1984; 246(2 Pt 1):E181 - E186.
    524. Wolfe RR, Wolfe MH, Nadel ER, Shaw JH. Isotopic determination of amino acid-urea interactions in exercise in humans. J Appl Physiol Respir Environ Exerc Physiol. 1984; 56(1):221 - 229.
    525. Wolfe RR, Shaw JH, Nadel ER, Wolfe MH. Effect of substrate intake and physiological state on background 13CO2 enrichment. J Appl Physiol Respir Environ Exerc Physiol. 1984; 56(1):230 - 234.
    526. Shaw JH, Wolfe RR. Energy and substrate kinetics and oxidation during ketone infusion in septic dogs: role of changes in insulin and glucagon. Circ Shock. 1984; 14(1):63 - 79.
    527. Wolfe RR. Tracers in metabolic research: radioisotope and stable isotope/mass spectrometry methods. Lab Res Methods Biol Med. 1984; 9:1 - 287.
    528. Ravussin E, Bogardus C, Schwartz RS, Robbins DC, Wolfe RR, Horton ES, Danforth E Jr, Sims EA. Thermic effect of infused glucose and insulin in man. Decreased response with increased insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Invest. 1983; 72(3):893 - 902.
    529. Phinney SD, Bistrian BR, Wolfe RR, Blackburn GL. The human metabolic response to chronic ketosis without caloric restriction: physical and biochemical adaptation. Metabolism. 1983; 32(8):757 - 768.
    530. Goodenough RD, Wolfe RR. A model for isotopic sampling and administration in constant infusion experiments: a test with 13C-palmitate. Am J Clin Nutr. 1983; 37(6):1004 - 1009.
    531. Radcliffe AG, Wolfe RR, Colpoys MF, Muhlbacher F, Wilmore DW. Ketone-glucose interaction in fed, fasted, and fasted-infected sheep. Am J Physiol. 1983; 244(5):R667 - R675.
    532. Royle GT, Wolfe RR, Burke JF. The measurement of glucose turnover and oxidation using radioactive and stable isotopes. J Surg Res. 1983; 34(2):187 - 193.
    533. Wolfe RR, Goodenough RD, Burke JF, Wolfe MH. Response of protein and urea kinetics in burn patients to different levels of protein intake. Ann Surg. 1983; 197(2):163 - 171.
    534. Wolfe RR, Shaw JH, Durkot MJ. Energy metabolism in trauma and sepsis: the role of fat. Prog Clin Biol Res. 1983; 111:89 - 109.
    535. Wolfe RR, Goodenough RD, Wolfe MH. Isotopic approaches to the estimation of protein requirements in burn patients. Adv Shock Res. 1983; 9:81 - 98.
    536. Black PR, Brooks DC, Bessey PQ, Wolfe RR, Wilmore DW. Mechanisms of insulin resistance following injury. Ann Surg. 1982; 196(4):420 - 435.
    537. Dietz WH, Wolfe MH, Wolfe RR. A method for the rapid determination of protein turnover. Metabolism. 1982; 31(8):749 - 754.
    538. Wolfe RR. Stable isotope approaches for study of energy substrate metabolism. Fed Proc. 1982; 41(10):2692 - 2697.
    539. Goodenough RD, Royle GT, Nadel ER, Wolfe MH, Wolfe RR. Leucine and urea metabolism in acute human cold exposure. J Appl Physiol Respir Environ Exerc Physiol. 1982; 53(2):367 - 372.
    540. Royle GT, Molnar JA, Wolfe MH, Wolfe RR, Burke JF. Urea, glucose and alanine kinetics in man: effects of glucose infusion. Clin Sci (Lond). 1982; 62(5):553 - 556.
    541. Robert JJ, Cummins JC, Wolfe RR, Durkot M, Matthews DE, Zhao XH, Bier DM, Young VR. Quantitative aspects of glucose production and metabolism in healthy elderly subjects. Diabetes. 1982; 31(3):203 - 211.
    542. Royle GT, Wolfe RR, Burke JF. Glucose and fatty acid kinetics in fasted rats: effects of previous protein intake. Metabolism. 1982; 31(3):279 - 283.
    543. Wolfe RR, Goodenough RD, Wolfe MH, Royle GT, Nadel ER. Isotopic analysis of leucine and urea metabolism in exercising humans. J Appl Physiol Respir Environ Exerc Physiol. 1982; 52(2):458 - 466.
    544. Wolfe RR, Durkot MJ, Wolfe MH. Effect of thermal injury on energy metabolism, substrate kinetics, and hormonal concentrations. Circ Shock. 1982; 9(4):383 - 394.
    545. Wolfe RR, Burke JF. Somatostatin infusion inhibits glucose production in burn patients. Circ Shock. 1982; 9(5):521 - 527.
    546. Wolfe RR, Durkot MJ. Evaluation of the role of the sympathetic nervous system in the response of substrate kinetics and oxidation to burn injury. Circ Shock. 1982; 9(4):395 - 406.
    547. Royle GT, Wolfe RR, Burke JF. Techniques for investigating substrate metabolism in patients. Ann R Coll Surg Engl. 1981; 63(6):415 - 419.
    548. Wolfe RR, Durkot MJ, Wolfe MH. Investigation of kinetics of integrated metabolic response to adrenergic blockade in conscious dogs. Am J Physiol. 1981; 241(5):E385 - E395.
    549. Durkot MJ, Wolfe RR. Effects of adrenergic blockade on glucose kinetics in septic and burned guinea pigs. Am J Physiol. 1981; 241(3):R222 - R227.
    550. Wolfe RR. Measurement of urea kinetics in vivo by means of a constant tracer infusion of di-15N-urea. Am J Physiol. 1981; 240(4):E428 - E434.
    551. Wolfe RR. Review: acute versus chronic response to burn injury. Circ Shock. 1981; 8(1):105 - 115.
    552. Wolfe RR, O'Donnell TF, Stone MD, Richmand DA, Burke JF. Investigation of factors determining the optimal glucose infusion rate in total parenteral nutrition. Metabolism. 1980; 29(9):892 - 900.
    553. Mullany CJ, Wolfe RR, Burke JF. The fate of a glucose infusion in fasting and fed guinea pigs: glucose oxidation rates and the distribution of glucose in liver, muscle, and adipose tissue. J Surg Res. 1980; 29(2):116 - 125.
    554. Wolfe RR, Durkot MJ, Clarke CC, Bode HH, Burke JF. Effect of food intake on hypermetabolic response to burn injury in guinea pigs. J Nutr. 1980; 110(7):1310 - 1312.
    555. Wolfe RR, Evans JE, Mullany CJ, Burke JF. Measurement of plasma free fatty acid turnover and oxidation using [1-13C]palmitic acid. Biomed Mass Spectrom. 1980; 7(4):168 - 171.
    556. Wolfe RR, Burke JF. Insulin and glucose kinetics following surgery. Ann Surg. 1980; 191(3):385 - 386.
    557. Allsop JR, Wolfe RR, DiStephano JJ, Burke JF. The reliability of rates of glucose appearance in vivo calculated from single tracer injections. Can J Physiol Pharmacol. 1979; 57(11):1267 - 1274.
    558. Wolfe RR. Burn injury and increased glucose production. J Trauma. 1979; 19(11 Suppl):898 - 899.
    559. Wolfe RR, Durkot MJ, Allsop JR, Burke JF. Glucose metabolism in severely burned patients. Metabolism. 1979; 28(10):1031 - 1039.
    560. Way GL, Pierce JR, Wolfe RR, McGrath R, Wiggins J, Merenstein GB. ST depression suggesting subendocardial ischemia in neonates with respiratory distress syndrome and patent ductus arteriosus. J Pediatr. 1979; 95(4):609 - 611.
    561. Wolfe RR, Snowden JM, Burke JF. Influence of insulin and palmitic acid concentration on pulmonary surfactant synthesis. J Surg Res. 1979; 27(4):262 - 267.
    562. Burke JF, Wolfe RR, Mullany CJ, Mathews DE, Bier DM. Glucose requirements following burn injury. Parameters of optimal glucose infusion and possible hepatic and respiratory abnormalities following excessive glucose intake. Ann Surg. 1979; 190(3):274 - 285.
    563. Wolfe RR, Allsop JR, Burke JF. Glucose metabolism in man: responses to intravenous glucose infusion. Metabolism. 1979; 28(3):210 - 220.
    564. Wolfe RR, Hochachka PW, Trelstad RL, Burke JF. Lactate oxidation in perfused rat lung. Am J Physiol. 1979; 236(3):E276 - E282.
    565. Mullany CJ, Wolfe RR, Burke JF. Interrelationships between glucose and free fatty acid (FFA) metabolism during infusion of glucose and Intralipid. Surg Forum. 1979; 30:70 - 71.
    566. Wolfe RR, Burke JF. Effect of glucose infusion on glucose and lactate metabolism in normal and burned guinea pigs. J Trauma. 1978; 18(12):800 - 805.
    567. Wolfe RR, Burke JF. Glucose and lactate metabolism in experimental septic shock. Am J Physiol. 1978; 235(5):R219 - R227.
    568. Allsop JR, Wolfe RR, Burke JF. Glucose kinetics and responsiveness to insulin in the rat injured by burn. Surg Gynecol Obstet. 1978; 147(4):565 - 573.
    569. Kitajima M, Wolfe RR, Trelstad RL, Allsop JR, Burke JF. Gastric mucosal lesions after burn injury: relationship to H+ back-diffusion and the microcirculation. J Trauma. 1978; 18(9):644 - 650.
    570. Allsop JR, Wolfe RR, Burke JF. Tracer priming the bicarbonate pool. J Appl Physiol Respir Environ Exerc Physiol. 1978; 45(1):137 - 139.
    571. Kien CL, Wolfe RR, Young VR, Burke JF. Nitrogen sparing effect of a branched-chain amino acid infusion during an acute fast in guinea pigs. Life Sci. 1978; 23(2):133 - 136.
    572. Allsop JR, Wolfe RR, Burke JF. The realiability of rates of glucose appearance in vivo calculated from constant tracer infusions. Biochem J. 1978; 172(3):407 - 416.
    573. Wolfe RR, Allsop JR, Burke JF. Increased glucose production following neurotensin administration. Life Sci. 1978; 22(12):1043 - 1048.
    574. Wolfe RR, Allsop JR, Burke JF. Fallibility of the intravenous glucose tolerance test as a measure of endogenous glucose turnover. Metabolism. 1978; 27(2):217 - 226.
    575. Miller HI, Wolfe RR, Ferguson JL, Moss SW. Metabolic and hemodynamic aspects of the hypothermia of early burn shock. Experientia Suppl. 1978; 32:327 - 331.
    576. Wolfe RR, Elahi D, Spitzer JJ. Glucose kinetics in dogs following a lethal dose of endotoxin. Metabolism. 1977; 26(8):847 - 850.
    577. Wolfe RR, Smothermon MM, Miles VN, Wesenberg R, Nora JJ. Atypical radiographic findings in neonates with absent pulmonary valve and tetralogy of Fallot. Chest. 1977; 72(2):245 - 247.
    578. Wolfe RR, Burke JF. Effect of burn trauma on glucose turnover, oxidation, and recycling in guinea pigs. Am J Physiol. 1977; 233(2):E80 - E85.
    579. Wolfe RR, Way GL. Cardiomyopathies in infants of diabetic mothers. Johns Hopkins Med J. 1977; 140(4):177 - 180.
    580. Wolfe RR, Miller HI, Spitzer JJ. Glucose and lactate kinetics in burn shock. Am J Physiol. 1977; 232(4):E415 - E418.
    581. Wolfe RR, Miller HI, Elahi D, Spitzer JJ. Effect of burn injury on glucose turnover in guinea pigs. Surg Gynecol Obstet. 1977; 144(3):359 - 364.
    582. Wolfe RR, Elahi D, Spitzer JJ. Glucose and lactate kinetics after endotoxin administration in dogs. Am J Physiol. 1977; 232(2):E180 - E185.
    583. Wolfe RR, Allsop JR, Burke JF. Experimental sepsis and glucose metabolism: time course of response. Surg Forum. 1977; 28:42 - 43.
    584. Wolfe RR, Miller HI. Burn shock in untreated and saline-resuscitated guinea pigs. Development of a model. J Surg Res. 1976; 21(4):269 - 276.
    585. Wolfe RR, Miller HI. Cardiovascular and metabolic responses during burn shock in the guinea pig. Am J Physiol. 1976; 231(3):892 - 897.
    586. Wolfe RR, Spitzer JJ, Miller RI, Elahi D. Effects of insulin infusion on glucose kinetics in normal and burned guinea pigs. Life Sci. 1976; 19(2):147 - 155.
    587. Wolfe RR, Horvath SM. Hemodynamic responses to acute hematocrit and blood volume alterations in rats. Eur J Appl Physiol Occup Physiol. 1976; 35(2):159 - 166.
    588. Wolfe RR, Miller HI. Ineffectiveness of heparin treatment in burn shock in the guinea pig. Aviat Space Environ Med. 1976; 47(6):652 - 656.
    589. Wolfe RR. Editorial: Kartagner's syndrome: a pediatric responsibility. Chest. 1976; 69(5):573 - 574.
    590. Wolfe RR, Horvath SM. Blood volume responses of rats adppted to different barometric pressures (38482). Proc Soc Exp Biol Med. 1975; 148(1):89 - 93.
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