 Microsomes, Liver
"Microsomes, Liver" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
| Descriptor ID |
D008862
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| MeSH Number(s) |
A11.284.835.540.541
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microsomes, Liver".
Below are MeSH descriptors whose meaning is more specific than "Microsomes, Liver".
This graph shows the total number of publications written about "Microsomes, Liver" by people in UAMS Profiles by year, and whether "Microsomes, Liver" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 1 | 0 | 1 | | 2021 | 1 | 1 | 2 | | 2020 | 1 | 2 | 3 | | 2019 | 2 | 1 | 3 | | 2018 | 2 | 2 | 4 | | 2016 | 0 | 2 | 2 | | 2015 | 1 | 0 | 1 | | 2014 | 0 | 2 | 2 | | 2013 | 1 | 5 | 6 | | 2012 | 1 | 2 | 3 | | 2011 | 1 | 3 | 4 | | 2010 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2008 | 0 | 4 | 4 | | 2007 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2005 | 0 | 3 | 3 | | 2004 | 1 | 2 | 3 | | 2003 | 0 | 4 | 4 | | 2002 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2000 | 0 | 2 | 2 | | 1999 | 3 | 1 | 4 | | 1998 | 1 | 0 | 1 | | 1996 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1993 | 0 | 1 | 1 | | 1992 | 2 | 3 | 5 | | 1991 | 1 | 1 | 2 |
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Below are the most recent publications written about "Microsomes, Liver" by people in Profiles over the past ten years.
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Jackson KD, Argikar UA, Cho S, Crouch RD, Driscoll JP, Heck CJS, King L, Maw HH, Miller GP, Seneviratne HK, Wang S, Wei C, Zhang D, Khojasteh SC. Bioactivation and reactivity research advances - 2021 year in review. Drug Metab Rev. 2022 08; 54(3):246-281.
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Schleiff MA, Crosby S, Blue M, Schleiff BM, Boysen G, Miller GP. CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs. Biochem Pharmacol. 2021 12; 194:114824.
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Schleiff MA, Payakachat S, Schleiff BM, Swamidass SJ, Boysen G, Miller GP. Impacts of diphenylamine NSAID halogenation on bioactivation risks. Toxicology. 2021 06 30; 458:152832.
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Schleiff MA, Flynn NR, Payakachat S, Schleiff BM, Pinson AO, Province DW, Swamidass SJ, Boysen G, Miller GP. Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics. Drug Metab Dispos. 2021 02; 49(2):133-141.
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Barnette DA, Schleiff MA, Osborn LR, Flynn N, Matlock M, Swamidass SJ, Miller GP. Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam. Toxicology. 2020 07; 440:152478.
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Liu X, Poddar S, Song L, Hendrickson H, Zhang X, Yuan Y, Zhou D, Zheng G. Synthesis and Liver Microsomal Metabolic Stability Studies of a Fluorine-Substituted d-Tocotrienol Derivative. ChemMedChem. 2020 03 18; 15(6):506-516.
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Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear NJ, Ramanathan S, Sharma A, Le?n F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. J Med Chem. 2020 01 09; 63(1):433-439.
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Reed L, Jarvis IWH, Phillips DH, Arlt VM. Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells. Mutagenesis. 2019 12 19; 34(5-6):413-420.
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Barnette DA, Davis MA, Flynn N, Pidugu AS, Swamidass SJ, Miller GP. Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation. Biochem Pharmacol. 2019 12; 170:113661.
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Jones S, Yarbrough AL, Shoeib A, Bush JM, Fantegrossi WE, Prather PL, Radominska-Pandya A, Fujiwara R. Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22). Xenobiotica. 2019 Dec; 49(12):1388-1395.
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Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM. Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine. Toxicol Appl Pharmacol. 2019 03 01; 366:64-74.
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Wilson CD, Tai S, Ewing L, Crane J, Lockhart T, Fujiwara R, Radominska-Pandya A, Fantegrossi WE. Convulsant Effects of Abused Synthetic Cannabinoids JWH-018 and 5F-AB-PINACA Are Mediated by Agonist Actions at CB1 Receptors in Mice. J Pharmacol Exp Ther. 2019 02; 368(2):146-156.
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Kim SY, Jones DR, Kang JY, Yun CH, Miller GP. Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin. Xenobiotica. 2019 Apr; 49(4):397-403.
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Dang NL, Hughes TB, Miller GP, Swamidass SJ. Computationally Assessing the Bioactivation of Drugs by N-Dealkylation. Chem Res Toxicol. 2018 02 19; 31(2):68-80.
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Williams DK, Markwalder JA, Balog AJ, Chen B, Chen L, Donnell J, Haque L, Hart AC, Mandal SK, Nation A, Shan W, Vite GD, Covello K, Hunt JT, Jure-Kunkel MN, Seitz SP. Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg Med Chem Lett. 2018 02 15; 28(4):732-736.
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Koyama M, Shirahata T, Hirashima R, Kobayashi Y, Itoh T, Fujiwara R. Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids. Drug Metab Pharmacokinet. 2017 Aug; 32(4):218-223.
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Haarhoff ZE, Kramer MA, Zvyaga TA, Zhang J, Bhutani P, Subramanian M, Rodrigues AD. Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human. Xenobiotica. 2017 Jun; 47(6):470-478.
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Hines RN, Simpson PM, McCarver DG. Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. Drug Metab Dispos. 2016 07; 44(7):959-66.
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