 Neurodegenerative Diseases
"Neurodegenerative Diseases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Descriptor ID |
D019636
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| MeSH Number(s) |
C10.574
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| Concept/Terms |
Neurodegenerative Diseases- Neurodegenerative Diseases
- Neurodegenerative Disease
- Degenerative Diseases, Neurologic
- Neurologic Degenerative Disease
- Degenerative Neurologic Diseases
- Degenerative Neurologic Disease
- Neurologic Disease, Degenerative
- Neurologic Diseases, Degenerative
- Nervous System Degenerative Diseases
- Neurodegenerative Disorders
- Neurodegenerative Disorder
- Neurologic Degenerative Conditions
- Degenerative Condition, Neurologic
- Degenerative Conditions, Neurologic
- Neurologic Degenerative Condition
- Neurologic Degenerative Diseases
- Degenerative Diseases, Nervous System
- Degenerative Neurologic Disorders
- Degenerative Neurologic Disorder
- Neurologic Disorder, Degenerative
- Neurologic Disorders, Degenerative
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Below are MeSH descriptors whose meaning is more general than "Neurodegenerative Diseases".
Below are MeSH descriptors whose meaning is more specific than "Neurodegenerative Diseases".
This graph shows the total number of publications written about "Neurodegenerative Diseases" by people in UAMS Profiles by year, and whether "Neurodegenerative Diseases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 0 | 1 | | 2024 | 2 | 0 | 2 | | 2023 | 1 | 0 | 1 | | 2022 | 4 | 0 | 4 | | 2021 | 2 | 0 | 2 | | 2020 | 4 | 0 | 4 | | 2019 | 2 | 1 | 3 | | 2018 | 4 | 0 | 4 | | 2017 | 3 | 1 | 4 | | 2016 | 3 | 1 | 4 | | 2015 | 2 | 0 | 2 | | 2014 | 2 | 0 | 2 | | 2012 | 1 | 0 | 1 | | 2011 | 3 | 0 | 3 | | 2010 | 0 | 1 | 1 | | 2009 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2007 | 2 | 0 | 2 | | 2004 | 3 | 1 | 4 | | 2002 | 1 | 0 | 1 | | 2001 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Neurodegenerative Diseases" by people in Profiles over the past ten years.
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Pahal S, Mainali N, Balasubramaniam M, Shmookler Reis RJ, Ayyadevara S. Mitochondria in aging and age-associated diseases. Mitochondrion. 2025 May; 82:102022.
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Albert-Gasco H, Smith HL, Alvarez-Castelao B, Swinden D, Halliday M, Janaki-Raman S, Butcher AJ, Mallucci GR. Trazodone rescues dysregulated synaptic and mitochondrial nascent proteomes in prion neurodegeneration. Brain. 2024 02 01; 147(2):649-664.
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Isik AT, Kaya D, Gokden M. Brain Banking in Dementia Studies. Methods Mol Biol. 2024; 2785:287-295.
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Espahbodi S, Hogervorst E, Macnab TP, Thanoon A, Fernandes GS, Millar B, Duncan A, Goodwin M, Batt M, Fuller CW, Fuller G, Ferguson E, Bast T, Doherty M, Zhang W. Heading Frequency and Risk of Cognitive Impairment in Retired Male Professional Soccer Players. JAMA Netw Open. 2023 07 03; 6(7):e2323822.
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Reddy PH, Kshirsagar S, Bose C, Pradeepkiran JA, Hindle A, Singh SP, Reddy AP. Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights. Biochim Biophys Acta Mol Basis Dis. 2023 10; 1869(7):166759.
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Piehl N, van Olst L, Ramakrishnan A, Teregulova V, Simonton B, Zhang Z, Tapp E, Channappa D, Oh H, Losada PM, Rutledge J, Trelle AN, Mormino EC, Elahi F, Galasko DR, Henderson VW, Wagner AD, Wyss-Coray T, Gate D. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment. Cell. 2022 12 22; 185(26):5028-5039.e13.
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Ganne A, Balasubramaniam M, Mainali N, Atluri P, Shmookler Reis RJ, Ayyadevara S. Physiological Consequences of Targeting 14-3-3 and Its Interacting Partners in Neurodegenerative Diseases. Int J Mol Sci. 2022 Dec 07; 23(24).
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Gomez-Arboledas A, Carvalho K, Balderrama-Gutierrez G, Chu SH, Liang HY, Schartz ND, Selvan P, Petrisko TJ, Pan MA, Mortazavi A, Tenner AJ. C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2022 08 17; 10(1):116.
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Kumari S, Maddeboina K, Bachu RD, Boddu SHS, Trippier PC, Tiwari AK. Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery. Drug Discov Today. 2022 10; 27(10):103322.
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Simanaviciute U, Brown RE, Wong A, Fertan E, Grant RA. Abnormal whisker movements in the 3xTg-AD mouse model of Alzheimer's disease. Genes Brain Behav. 2022 11; 21(8):e12813.
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Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG. Neurons undergo pathogenic metabolic reprogramming in models of familial ALS. Mol Metab. 2022 06; 60:101468.
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Kiaei L, Kiaei M. RNA as a source of biomarkers for amyotrophic lateral sclerosis. Metab Brain Dis. 2022 08; 37(6):1697-1702.
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Ryu WI, Bormann MK, Shen M, Kim D, Forester B, Park Y, So J, Seo H, Sonntag KC, Cohen BM. Brain cells derived from Alzheimer's disease patients have multiple specific innate abnormalities in energy metabolism. Mol Psychiatry. 2021 10; 26(10):5702-5714.
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Oh H, Leventhal O, Channappa D, Henderson VW, Wyss-Coray T, Lehallier B, Gate D. Methods to investigate intrathecal adaptive immunity in neurodegeneration. Mol Neurodegener. 2021 01 22; 16(1):3.
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Bryant L, Li D, Cox SG, Marchione D, Joiner EF, Wilson K, Janssen K, Lee P, March ME, Nair D, Sherr E, Fregeau B, Wierenga KJ, Wadley A, Mancini GMS, Powell-Hamilton N, van de Kamp J, Grebe T, Dean J, Ross A, Crawford HP, Powis Z, Cho MT, Willing MC, Manwaring L, Schot R, Nava C, Afenjar A, Lessel D, Wagner M, Klopstock T, Winkelmann J, Catarino CB, Retterer K, Schuette JL, Innis JW, Pizzino A, L?ttgen S, Denecke J, Strom TM, Monaghan KG, Yuan ZF, Dubbs H, Bend R, Lee JA, Lyons MJ, Hoefele J, G?nthner R, Reutter H, Keren B, Radtke K, Sherbini O, Mrokse C, Helbig KL, Odent S, Cogne B, Mercier S, Bezieau S, Besnard T, Kury S, Redon R, Reinson K, Wojcik MH, ?unap K, Ilves P, Innes AM, Kernohan KD, Costain G, Meyn MS, Chitayat D, Zackai E, Lehman A, Kitson H, Martin MG, Martinez-Agosto JA, Nelson SF, Palmer CGS, Papp JC, Parker NH, Sinsheimer JS, Vilain E, Wan J, Yoon AJ, Zheng A, Brimble E, Ferrero GB, Radio FC, Carli D, Barresi S, Brusco A, Tartaglia M, Thomas JM, Umana L, Weiss MM, Gotway G, Stuurman KE, Thompson ML, McWalter K, Stumpel CTRM, Stevens SJC, Stegmann APA, Tveten K, V?llo A, Prescott T, Fagerberg C, Laulund LW, Larsen MJ, Byler M, Lebel RR, Hurst AC, Dean J, Schrier Vergano SA, Norman J, Mercimek-Andrews S, Neira J, Van Allen MI, Longo N, Sellars E, Louie RJ, Cathey SS, Brokamp E, Heron D, Snyder M, Vanderver A, Simon C, de la Cruz X, Padilla N, Crump JG, Chung W, Garcia B, Hakonarson HH, Bhoj EJ. Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients. Sci Adv. 2020 12; 6(49).
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Schartz ND, Tenner AJ. The good, the bad, and the opportunities of the complement system in neurodegenerative disease. J Neuroinflammation. 2020 Nov 25; 17(1):354.
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McCormick JJ, Dokladny K, Moseley PL, Kenny GP. Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease. J Appl Physiol (1985). 2021 01 01; 130(1):1-9.
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Abdelaal AY, Mousa MH, Gamal M, Khalil MI, Elbasiouny SM, Eldawlatly S. A Classification Approach to Recognize the Firing of Spinal Motoneurons in Amyotrophic Lateral Sclerosis. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:3680-3683.
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Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Sch?tzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR. Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration. Neuron. 2020 03 04; 105(5):855-866.e5.
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Simanaviciute U, Ahmed J, Brown RE, Connor-Robson N, Farr TD, Fertan E, Gambles N, Garland H, Morton AJ, Staiger JF, Skillings EA, Trueman RC, Wade-Martins R, Wood NI, Wong AA, Grant RA. Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits. J Neurosci Methods. 2020 02 01; 331:108532.
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Pandanaboina SC, Alghazali KM, Nima ZA, Alawajji RA, Sharma KD, Watanabe F, Saini V, Biris AS, Srivatsan M. Plasmonic nano surface for neuronal differentiation and manipulation. Nanomedicine. 2019 10; 21:102048.
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Gregory A, Lotia M, Jeong SY, Fox R, Zhen D, Sanford L, Hamada J, Jahic A, Beetz C, Freed A, Kurian MA, Cullup T, van der Weijden MCM, Nguyen V, Setthavongsack N, Garcia D, Krajbich V, Pham T, Woltjer R, George BP, Minks KQ, Paciorkowski AR, Hogarth P, Jankovic J, Hayflick SJ. Autosomal dominant mitochondrial membrane protein-associated neurodegeneration (MPAN). Mol Genet Genomic Med. 2019 07; 7(7):e00736.
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Garcia-Rill E. Neuroepigenetics of arousal: Gamma oscillations in the pedunculopontine nucleus. J Neurosci Res. 2019 12; 97(12):1515-1520.
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Sharkia R, Wierenga KJ, Kessel A, Azem A, Bertini E, Carrozzo R, Torraco A, Goffrini P, Ceccatelli Berti C, McCormick ME, Plecko B, Klein A, Abela L, Hengel H, Sch?ls L, Shalev S, Khayat M, Mahajnah M, Spiegel R. Clinical, radiological, and genetic characteristics of 16 patients with ACO2 gene defects: Delineation of an emerging neurometabolic syndrome. J Inherit Metab Dis. 2019 03; 42(2):264-275.
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Corey S, Kvederis L, Kingsbury C, Bonsack B, Sanberg PR, Castelli V, Lee JY, Borlongan CV. Gut Microbiome: Lactation, Childbirth, Lung Dysbiosis, Animal Modeling, Stem Cell Treatment, and CNS Disorders. CNS Neurol Disord Drug Targets. 2019; 18(9):687-694.
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Metz KA, Teng X, Coppens I, Lamb HM, Wagner BE, Rosenfeld JA, Chen X, Zhang Y, Kim HJ, Meadow ME, Wang TS, Haberlandt ED, Anderson GW, Leshinsky-Silver E, Bi W, Markello TC, Pratt M, Makhseed N, Garnica A, Danylchuk NR, Burrow TA, Jayakar P, McKnight D, Agadi S, Gbedawo H, Stanley C, Alber M, Prehl I, Peariso K, Ong MT, Mordekar SR, Parker MJ, Crooks D, Agrawal PB, Berry GT, Loddenkemper T, Yang Y, Maegawa GHB, Aouacheria A, Markle JG, Wohlschlegel JA, Hartman AL, Hardwick JM. KCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect. Ann Neurol. 2018 11; 84(5):766-780.
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Samanta D, Gokden M. PEHO syndrome: KIF1A mutation and decreased activity of mitochondrial respiratory chain complex. J Clin Neurosci. 2019 Mar; 61:298-301.
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Slone J, Peng Y, Chamberlin A, Harris B, Kaylor J, McDonald MT, Lemmon M, El-Dairi MA, Tchapyjnikov D, Gonzalez-Krellwitz LA, Sellars EA, McConkie-Rosell A, Reinholdt LG, Huang T. Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. J Hum Genet. 2018 Dec; 63(12):1211-1222.
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Barham C, Fil D, Byrum SD, Rahmatallah Y, Glazko G, Kiaei M. RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease. Sci Rep. 2018 09 13; 8(1):13737.
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Pogribny IP. MicroRNAs as biomarkers for clinical studies. Exp Biol Med (Maywood). 2018 02; 243(3):283-290.
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Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med. 2017 Sep 08; 23(9):1018-1027.
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Luo X, Rosenfeld JA, Yamamoto S, Harel T, Zuo Z, Hall M, Wierenga KJ, Pastore MT, Bartholomew D, Delgado MR, Rotenberg J, Lewis RA, Emrick L, Bacino CA, Eldomery MK, Coban Akdemir Z, Xia F, Yang Y, Lalani SR, Lotze T, Lupski JR, Lee B, Bellen HJ, Wangler MF. Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genet. 2017 Jul; 13(7):e1006905.
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Ayyadevara S, Balasubramaniam M, Kakraba S, Alla R, Mehta JL, Shmookler Reis RJ. Aspirin-Mediated Acetylation Protects Against Multiple Neurodegenerative Pathologies by Impeding Protein Aggregation. Antioxid Redox Signal. 2017 Dec 10; 27(17):1383-1396.
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Innabi A, Limaye K, Cobb S, Samant R, Virmani T. Caution! Self-supplementation may be injurious to your health. Acta Neurol Belg. 2017 09; 117(3):781-782.
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Smith HL, Mallucci GR. The unfolded protein response: mechanisms and therapy of neurodegeneration. Brain. 2016 08; 139(Pt 8):2113-21.
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Mathevosian S, Singh SR, Pu CY. Multiple System Atrophy Mistaken for Autoimmune Cerebellar Degeneration. Am J Med. 2016 Sep; 129(9):e183-4.
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Ayyadevara S, Mercanti F, Wang X, Mackintosh SG, Tackett AJ, Prayaga SV, Romeo F, Shmookler Reis RJ, Mehta JL. Age- and Hypertension-Associated Protein Aggregates in Mouse Heart Have Similar Proteomic Profiles. Hypertension. 2016 May; 67(5):1006-13.
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Neely BA, Soper JL, Gulland FM, Bell PD, Kindy M, Arthur JM, Janech MG. Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration. Proteomics. 2015 Dec; 15(23-24):4051-63.
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