 Phenylalanine
"Phenylalanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
| Descriptor ID |
D010649
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| MeSH Number(s) |
D12.125.072.050.685 D12.125.142.666
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| Concept/Terms |
Phenylalanine- Phenylalanine
- Phenylalanine, L-Isomer
- L-Isomer Phenylalanine
- Phenylalanine, L Isomer
- L-Phenylalanine
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Below are MeSH descriptors whose meaning is more general than "Phenylalanine".
Below are MeSH descriptors whose meaning is more specific than "Phenylalanine".
This graph shows the total number of publications written about "Phenylalanine" by people in UAMS Profiles by year, and whether "Phenylalanine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2022 | 2 | 1 | 3 | | 2021 | 0 | 2 | 2 | | 2020 | 2 | 2 | 4 | | 2019 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2017 | 2 | 1 | 3 | | 2016 | 0 | 2 | 2 | | 2015 | 0 | 3 | 3 | | 2014 | 1 | 1 | 2 | | 2013 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2010 | 0 | 2 | 2 | | 2009 | 0 | 3 | 3 | | 2008 | 2 | 2 | 4 | | 2007 | 1 | 2 | 3 | | 2006 | 2 | 5 | 7 | | 2005 | 0 | 4 | 4 | | 2004 | 2 | 9 | 11 | | 2003 | 0 | 10 | 10 | | 2002 | 1 | 7 | 8 | | 2000 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 1998 | 0 | 3 | 3 | | 1996 | 1 | 1 | 2 | | 1995 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phenylalanine" by people in Profiles over the past ten years.
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Trefz F, Frauendienst-Egger G, Dienel G, Cannet C, Schmidt-Mader B, Haas D, Blau N, Himmelreich N, Spraul M, Freisinger P, Dobrowolski S, Berg D, Pilotto A. Does hyperphenylalaninemia induce brain glucose hypometabolism? Cerebral spinal fluid findings in treated adult phenylketonuric patients. Mol Genet Metab. 2024 May; 142(1):108464.
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Hadidi SA. Melflufen in multiple myeloma: the conclusion matters. Lancet Haematol. 2022 04; 9(4):e244.
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Hirsch KR, Church DD, Wolfe RR, Ferrando AA. Continuous oral stable isotope ingestion to measure whole-body protein turnover. Clin Nutr ESPEN. 2022 06; 49:385-389.
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Hudson JL, Cotter M, Herndon DN, Wolfe RR, B?rsheim E. Comparison of Arterial-Venous Balance and Tracer Incorporation Methods for Measuring Muscle Fractional Synthesis and Fractional Breakdown Rates. J Burn Care Res. 2022 01 05; 43(1):156-162.
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Bilder DA, Arnold GL, Dimmock D, Grant ML, Janzen D, Longo N, Nguyen-Driver M, Jurecki E, Merilainen M, Amato G, Waisbren S. Improved attention linked to sustained phenylalanine reduction in adults with early-treated phenylketonuria. Am J Med Genet A. 2022 03; 188(3):768-778.
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Gwin JA, Church DD, Hatch-McChesney A, Allen JT, Wilson MA, Varanoske AN, Carrigan CT, Murphy NE, Margolis LM, Carbone JW, Wolfe RR, Ferrando AA, Pasiakos SM. Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study. J Int Soc Sports Nutr. 2021 Jan 07; 18(1):4.
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Church DD, Hirsch KR, Park S, Kim IY, Gwin JA, Pasiakos SM, Wolfe RR, Ferrando AA. Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding. Nutrients. 2020 Dec 02; 12(12).
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Monteyne AJ, Coelho MOC, Porter C, Abdelrahman DR, Jameson TSO, Finnigan TJA, Stephens FB, Dirks ML, Wall BT. Branched-Chain Amino Acid Fortification Does Not Restore Muscle Protein Synthesis Rates following Ingestion of Lower- Compared with Higher-Dose Mycoprotein. J Nutr. 2020 11 19; 150(11):2931-2941.
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Wan Z, Rosenbaum ER, Liu W, Song B, Yue X, Kong Y, Li T, Zhai Y, Ma Z, Cao Z. Benchmark Examination of Blood Amino Acids Patterns in Phenylketonuria Neonates and Young Children on Phenylalanine-Restricted Dietary Treatment. Fetal Pediatr Pathol. 2022 Jun; 41(3):443-450.
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Khedr M, Cooper MS, Hughes AT, Milan AM, Davison AS, Norman BP, Sutherland H, Jarvis JC, Fitzgerald R, Markinson L, Psarelli EE, Ghane P, Deutz NEP, Gallagher JA, Ranganath LR. Nitisinone causes acquired tyrosinosis in alkaptonuria. J Inherit Metab Dis. 2020 09; 43(5):1014-1023.
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Ten Have GAM, Engelen MPKJ, Wolfe RR, Deutz NEP. Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa-induced sepsis pig model. Am J Physiol Gastrointest Liver Physiol. 2019 06 01; 316(6):G755-G762.
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Baladi MG, Forster MJ, Gatch MB, Mailman RB, Hyman DL, Carter LP, Janowsky A. Characterization of the Neurochemical and Behavioral Effects of Solriamfetol (JZP-110), a Selective Dopamine and Norepinephrine Reuptake Inhibitor. J Pharmacol Exp Ther. 2018 08; 366(2):367-376.
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Jonker R, Deutz NEP, Harrykissoon R, Zachria AJ, Veley EA, Engelen MPKJ. A critical evaluation of the anabolic response after bolus or continuous feeding in COPD and healthy older adults. Clin Sci (Lond). 2018 01 16; 132(1):17-31.
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Ten Have GAM, Engelen MPKJ, Wolfe RR, Deutz NEP. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. Am J Physiol Endocrinol Metab. 2017 06 01; 312(6):E519-E529.
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Mason A, Engelen MPKJ, Ivanov I, Toffolo GM, Deutz NEP. A four-compartment compartmental model to assess net whole body protein breakdown using a pulse of phenylalanine and tyrosine stable isotopes in humans. Am J Physiol Endocrinol Metab. 2017 07 01; 313(1):E63-E74.
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de Betue CTI, Garcia Casal XC, van Waardenburg DA, Schexnayder SM, Joosten KFM, Deutz NEP, Engelen MPKJ. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study. Clin Nutr. 2017 06; 36(3):876-887.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism. 2017 Apr; 69:120-129.
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Kramer IF, Verdijk LB, Hamer HM, Verlaan S, Luiking YC, Kouw IWK, Senden JM, van Kranenburg J, Gijsen AP, Bierau J, Poeze M, van Loon LJC. Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males. Clin Nutr. 2017 10; 36(5):1440-1449.
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Molina-Santiago C, Cordero BF, Daddaoua A, Udaondo Z, Manzano J, Valdivia M, Segura A, Ramos JL, Duque E. Pseudomonas putida as a platform for the synthesis of aromatic compounds. Microbiology (Reading). 2016 09; 162(9):1535-1543.
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Dienel GA, Cruz NF. Biochemical, Metabolic, and Behavioral Characteristics of Immature Chronic Hyperphenylalanemic Rats. Neurochem Res. 2016 Feb; 41(1-2):16-32.
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Franco FM, Jones DE, Harris PK, Han Z, Wildman SA, Jarvis CM, Janetka JW. Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets. Bioorg Med Chem. 2015 May 15; 23(10):2328-43.
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Tsien C, Davuluri G, Singh D, Allawy A, Ten Have GA, Thapaliya S, Schulze JM, Barnes D, McCullough AJ, Engelen MP, Deutz NE, Dasarathy S. Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology. 2015 Jun; 61(6):2018-29.
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