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Praveen Juvvadi

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCOM | Peds Infectious Diseases
Address4301 W Markham
Little Rock AR 72205
ORCID ORCID Icon0000-0002-5112-7824 Additional info
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    Other Roles
    Associate Professor (Research track) 03/01/2020 – 06/30/2022 Department of Pediatrics, Duke University Medical Center; Assistant Professor (Research track) 10/01/2012 – 02/29/2020 Department of Pediatrics, Duke University Medical Center; Research Scientist 12/1/2010 – 09/30/2012 Department of Pediatrics, Duke University Medical Center

    Collapse Affiliation 
    Collapse collaborator
    Dr. William Steinbach
    Dr. Andrew Morris

    Collapse Biography 
    Collapse education and training
    Osmania University, IndiaPh.D.08/1999Biochemistry
    University of Tokyo, JapanPostdoctoral Fellow10/2001Microbiology
    University of Sevilla, SpainPostdoctoral Fellow10/2002Microbiology
    University of Tokyo, JapanResearch Associate03/2006Microbiology
    University of Tokyo, JapanResearch Scientist05/2007Microbiology
    Duke University, United StatesSenior Research Associate11/2010Microbiology

    Collapse Teaching 

    Collapse Research 
    Collapse research overview
    Invasive fungal infections caused by species of Aspergillus, Candida, and Cryptococcus contribute to significant morbidity and mortality in immunocompromised patients. Our laboratory’s research is focused on the human fungal pathogen, Aspergillus fumigatus, that causes deadly Invasive Aspergillosis (IA) disease in immunocompromised patients. The mortality rate for IA is rising due to emerging resistance to guideline-recommended treatments using the azoles and echinocandins. While the growing immunocompromised patient population has outpaced antifungal development, the increasing incidence of antifungal resistance is further hampering effective treatment. As a result, there is a greater and an urgent need for innovative approaches to exploring broad, new antifungal targets with novel mechanisms of action. To design effective antifungal therapeutics a fundamental understanding of fungal growth and pathogenesis mechanisms is necessary.

    Our laboratory research is primarily directed toward identifying genes that are indispensable for fungal growth, drug response, and virulence by utilizing a variety of molecular strategies including genetic, biochemical, proteomic techniques and animal models of infection. Over the last 15 years our laboratory research has demonstrated the importance of calcineurin (CN) a calmodulin-dependent protein phosphatase for fungal growth and drug resistance. Our broader whole CN proteomic and phosphoproteomic approaches uncovered several cell wall- and cell membrane-related proteins as potential CN effectors. We also defined unique changes in the A. fumigatus CN proteome in direct response to azole and echinocandin antifungals. Our first fungal CN ternary complex crystal structure-guided inhibitor strategies showed that targeting CN was effective in animal models.

    Our overall goal is to elucidate the molecular mechanisms controlling fungal growth, pathogenesis, and drug resistance which will ultimately enable us to identify fungal-specific targets to help design potentially more effective strategies to combat IA.

    Ongoing Research:

    • Calcineurin regulatory network control of Aspergillus fumigatus hyphal growth.
    • Calcineurin role in Aspergillus fumigatus antifungal response and resistance mechanisms.
    • Structural approaches to design novel fungal-specific calcineurin inhibitors.
    • Protein Kinase A control over Aspergillus fumigatus autophagy and pathogenesis mechanisms.

    Impact: Antifungal drug resistance is rapidly emerging and crippling therapeutic options for IA. Novel approaches to deciphering antifungal resistance pathways are urgently needed. Our studies will provide mechanistic understanding of how the CN network drives antifungal response and resistance in A. fumigatus, generating substantial future translational potential for improved strategies to combat invasive fungal disease.

    Collapse research activities and funding
    1R21AI180334-01A1     (JUVVADI PRAVEEN, WILLIAM STEINBACH (MPI))Jul 5, 2024 - May 31, 2026
    NIH/NIAID
    PKA-Dependent Autophagy Control in Aspergillus fumigatus Pathogenesis
    Role: Principal Investigator
    R01AI179593-01A1     (JUVVADI PRAVEEN, WILLIAM STEINBACH (MPI))Jun 14, 2024 - May 31, 2029
    NIH/NIAID
    Calcineurin Control over Aspergillus fumigatus Antifungal Response Mechanisms
    Role: Principal Investigator
    ACRI-Systems Mass Spectrometry Pilot Award     (JUVVADI PRAVEEN, MORRIS ANDREW)Jul 1, 2023 - Jun 30, 2025
    CTPR-COBRE
    Omics approaches to define antifungal drug response and resistance in Aspergillus fumigatus.
    Role Description: To date very few targets of Calcineurin have been identified in fungi and through this integrated omics approaches we expect to obtain novel insights into Calcineurin effectors that are regulated via phosphorylation-dephosphorylation mechanism and responsible for antifungal response and resistance.
    Role: Principal Investigator
    R21AI163301     (JUVVADI PRAVEEN, WILLIAM STEINBACH (MPI))Jun 1, 2021 - May 30, 2024
    NIH/NIAID
    Calcineurin regulatory network control of Aspergillus fumigatus hyphal septation.
    Role: Principal Investigator
    R01AI135812     (ANDES, DAVID R;BURKE, MARTIN D ;FAN, TIMOTHY M;STEINBACH, WILLIAM J)Jun 8, 2018 - May 31, 2024
    NIH
    Development of non-toxic amphotericin B derivatives targeting invasive fungal infections
    Role: Co-Investigator
    R21AI132911     (JUVVADI PRAVEEN, WILLIAM STEINBACH (MPI))Jan 1, 2018 - Dec 31, 2019
    NIH/NIAID
    Phosphoproteome identification of Aspergillus fumigatus virulence-associated Protein kinase A downstream effectors.
    Role: Principal Investigator
    R21AI127551     (JUVVADI PRAVEEN, WILLIAM STEINBACH (MPI))Dec 15, 2016 - Nov 30, 2018
    NIH/NIAID
    Defining the Aspergillus fumigatus calcineurin-dependent regulatory network through whole phosphoproteome analysis.
    Role: Principal Investigator
    P01AI104533     (PERFECT, JOHN R.)Jun 25, 2015 - May 31, 2021
    NIH
    Transdisciplinary Program to Identify Novel Antifungal Targets and Inhibitors
    Role: Co-Investigator
    R56AI112595     (HEITMAN, JOSEPH)Aug 4, 2014 - Aug 31, 2021
    NIH
    Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
    Role: Co-Investigator
    R01AI112595     (HEITMAN, JOSEPH)Aug 4, 2014 - Jul 31, 2019
    NIH
    Structural Biological Development of Fungal-Specific Calcineurin Inhibitors
    Role: Co-Investigator
    R21AI097541     (STEINBACH, WILLIAM J)Jul 1, 2012 - Jun 30, 2014
    NIH
    Identification of calcineurin-binding proteins in A. fumigatus septum formation
    Role: Co-Investigator
    R56AI077648     (STEINBACH, WILLIAM J)Sep 30, 2010 - Aug 31, 2012
    NIH
    Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence
    Role: Co-Investigator
    R33AI085401     (GUNN, MICHAEL D)Jan 1, 2010 - Feb 28, 2015
    NIH
    Development of anti-Aspergillus single chain Abs as serum and imaging diagnostics
    Role: Co-Investigator

    Collapse Outreach 
    Collapse outreach overview
    SCIENTIFIC PEER/MERIT REVIEW COMMITTEES
    French Private Foundation (FRM) 2015
    German Research Foundation (DFG) 2016
    Pasteur Institute Partnerships and Incentive Research Programs 2015-2024
    CSR (NIH) Immunology and Infectious Diseases A Review Branch (PTHE) 2022
    CSR (NIH) Disease Control and Applied Immunology Review Branch (AIRT) 2023

    EDITORIAL BOARD MEMBER
    International Journal of Biology 2010-2012
    Journal of Mycology 2012-2017
    Frontiers in Microbiology 2014-to date
    Frontiers in Fungal Biology 2020-to date
    Journal of Fungi 2021-to date
    PLoS One 2021-2024

    Collapse reviewer of

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Dome PA, Jeong P, Nam G, Jang H, Rivera A, Averette AF, Park E, Liao TC, Ciofani M, Wu J, Chi JA, Venters RA, Park HJ, Steinbach WJ, Juvvadi PR, Heitman J, Hong J. Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi. bioRxiv. 2024 Nov 08. PMID: 39386510.
      View in: PubMed
    2. Maji A, Soutar CP, Zhang J, Lewandowska A, Uno BE, Yan S, Shelke Y, Murhade G, Nimerovsky E, Borcik CG, Arango AS, Lange JD, Marin-Toledo JP, Lyu Y, Bailey KL, Roady PJ, Holler JT, Khandelwal A, SantaMaria AM, Sanchez H, Juvvadi PR, Johns G, Hageman MJ, Krise J, Gebremariam T, Youssef EG, Bartizal K, Marr KA, Steinbach WJ, Ibrahim AS, Patterson TF, Wiederhold NP, Andes DR, Pogorelov TV, Schwieters CD, Fan TM, Rienstra CM, Burke MD. Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal. Nature. 2023 Nov; 623(7989):1079-1085. PMID: 37938782.
      View in: PubMed
    3. Rivera A, Young Lim W, Park E, Dome PA, Hoy MJ, Spasojevic I, Sun S, Averette AF, Pina-Oviedo S, Juvvadi PR, Steinbach WJ, Ciofani M, Hong J, Heitman J. Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22-modified FK520 analog against C. neoformans. mBio. 2023 Oct 31; 14(5):e0181023. PMID: 37737622.
      View in: PubMed
    4. Juvvadi PR, Bobay BG, Cole DC, Awwa M, Steinbach WJ. Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus. J Fungi (Basel). 2022 Dec 07; 8(12). PMID: 36547614.
      View in: PubMed
    5. Hoy MJ, Park E, Lee H, Lim WY, Cole DC, DeBouver ND, Bobay BG, Pierce PG, Fox D, Ciofani M, Juvvadi PR, Steinbach W, Hong J, Heitman J. Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. mBio. 2022 06 28; 13(3):e0104922. PMID: 35604094.
      View in: PubMed
    6. Shwab EK, Juvvadi PR, Shaheen SK, Allen J, Waitt G, Soderblom EJ, Asfaw YG, Moseley MA, Steinbach WJ. Protein Kinase A Regulates Autophagy-Associated Proteins Impacting Growth and Virulence of Aspergillus fumigatus. J Fungi (Basel). 2022 Mar 30; 8(4). PMID: 35448585.
      View in: PubMed
    7. Gobeil SM, Bobay BG, Juvvadi PR, Cole DC, Heitman J, Steinbach WJ, Venters RA, Spicer LD. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 12 21; 12(6):e0300021. PMID: 34809463.
      View in: PubMed
    8. Shaheen SK, Juvvadi PR, Allen J, Shwab EK, Cole DC, Asfaw YG, Kapoor M, Shaw KJ, Steinbach WJ. In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0068221. PMID: 34310205.
      View in: PubMed
    9. Shwab EK, Juvvadi PR, Waitt G, Shaheen S, Allen J, Soderblom EJ, Bobay BG, Asfaw YG, Moseley MA, Steinbach WJ. The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets. mBio. 2020 12 15; 11(6). PMID: 33323509.
      View in: PubMed
    10. Roundtree MT, Juvvadi PR, Shwab EK, Cole DC, Steinbach WJ. Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors. Antimicrob Agents Chemother. 2020 09 21; 64(10). PMID: 32660997.
      View in: PubMed
    11. Xu-Vanpala S, Deerhake ME, Wheaton JD, Parker ME, Juvvadi PR, MacIver N, Ciofani M, Shinohara ML. Functional heterogeneity of alveolar macrophage population based on expression of CXCL2. Sci Immunol. 2020 08 07; 5(50). PMID: 32769172.
      View in: PubMed
    12. Renshaw H, Juvvadi PR, Cole DC, Steinbach WJ. The class V myosin interactome of the human pathogen Aspergillus fumigatus reveals novel interactions with COPII vesicle transport proteins. Biochem Biophys Res Commun. 2020 06 18; 527(1):232-237. PMID: 32446373.
      View in: PubMed
    13. Juvvadi PR, Bobay BG, Gobeil SMC, Cole DC, Venters RA, Heitman J, Spicer LD, Steinbach WJ. FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2020 05 21; 526(1):48-54. PMID: 32192767.
      View in: PubMed
    14. Juvvadi PR, Fox D, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun. 2019 09 19; 10(1):4275. PMID: 31537789.
      View in: PubMed
    15. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Barrington BC, Asfaw YG, Moseley MA, Steinbach WJ. Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. Mol Microbiol. 2019 07; 112(1):62-80. PMID: 30927289.
      View in: PubMed
    16. Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2018 11 02; 505(3):740-746. PMID: 30292408.
      View in: PubMed
    17. Renshaw H, Vargas-Mu?iz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. J Cell Sci. 2018 02 07; 131(3). PMID: 29222113.
      View in: PubMed
    18. Moseley MA, Hughes CJ, Juvvadi PR, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Steinbach WJ, Geromanos SJ, Wildgoose J, Langridge JI, Richardson K, Vissers JPC. Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization. J Proteome Res. 2018 02 02; 17(2):770-779. PMID: 28901143.
      View in: PubMed
    19. Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ. Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. J Proteome Res. 2018 02 02; 17(2):780-793. PMID: 29251506.
      View in: PubMed
    20. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ. Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. FEBS Lett. 2017 11; 591(22):3730-3744. PMID: 29067690.
      View in: PubMed
    21. Moreno-Vel?squez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND. Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in ?-1,3-Glucan Synthase Localization. Antimicrob Agents Chemother. 2017 10; 61(10). PMID: 28760907.
      View in: PubMed
    22. Vargas-Mu?iz JM, Renshaw H, Waitt G, Soderblom EJ, Moseley MA, Palmer JM, Juvvadi PR, Keller NP, Steinbach WJ. Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. Biochem Biophys Res Commun. 2017 04 01; 485(2):221-226. PMID: 28238781.
      View in: PubMed
    23. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ. A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. mBio. 2017 02 07; 8(1). PMID: 28174315.
      View in: PubMed
    24. Juvvadi PR. Balancing iron and calcium: Flavin carrier family proteins in Aspergillus fumigatus virulence. Virulence. 2017 08 18; 8(6):621-624. PMID: 27820672.
      View in: PubMed
    25. Vargas-Mu?iz JM, Juvvadi PR, Steinbach WJ. Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures. Microbiology (Reading). 2016 09; 162(9):1527-1534. PMID: 27559018.
      View in: PubMed
    26. Vargas-Mu?iz JM, Renshaw H, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Asfaw Y, Juvvadi PR, Steinbach WJ. Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus. Front Microbiol. 2016; 7:997. PMID: 27446037.
      View in: PubMed
    27. Juvvadi PR, Lee SC, Heitman J, Steinbach WJ. Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach. Virulence. 2017 02 17; 8(2):186-197. PMID: 27325145.
      View in: PubMed
    28. Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA. Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. mBio. 2016 Apr 26; 7(2):e00492-16. PMID: 27118592.
      View in: PubMed
    29. Renshaw H, Vargas-Mu?iz JM, Richards AD, Asfaw YG, Juvvadi PR, Steinbach WJ. Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis. Infect Immun. 2016 05; 84(5):1556-64. PMID: 26953327.
      View in: PubMed
    30. Juvvadi PR, Pemble CW, Ma Y, Steinbach WJ. Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. FEBS Lett. 2016 Feb; 590(4):501-8. PMID: 26864964.
      View in: PubMed
    31. Lamoth F, Juvvadi PR, Steinbach WJ. Editorial: Advances in Aspergillus fumigatus Pathobiology. Front Microbiol. 2016; 7:43. PMID: 26870009.
      View in: PubMed
    32. Juvvadi PR, Steinbach WJ. Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here? Pathogens. 2015 Dec 16; 4(4):883-93. PMID: 26694470.
      View in: PubMed
    33. Steinbach WJ, Lamoth F, Juvvadi PR. Potential Microbiological Effects of Higher Dosing of Echinocandins. Clin Infect Dis. 2015 Dec 01; 61 Suppl 6:S669-77. PMID: 26567286.
      View in: PubMed
    34. Falloon K, Juvvadi PR, Richards AD, Vargas-Mu?iz JM, Renshaw H, Steinbach WJ. Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. PLoS One. 2015; 10(9):e0137869. PMID: 26366742.
      View in: PubMed
    35. Juvvadi PR, Mu?oz A, Lamoth F, Soderblom EJ, Moseley MA, Read ND, Steinbach WJ. Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus. Antimicrob Agents Chemother. 2015 Aug; 59(8):4946-55. PMID: 26055379.
      View in: PubMed
    36. Vargas-Mu?iz JM, Renshaw H, Richards AD, Lamoth F, Soderblom EJ, Moseley MA, Juvvadi PR, Steinbach WJ. The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. Fungal Genet Biol. 2015 Aug; 81:41-51. PMID: 26051489.
      View in: PubMed
    37. Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Steinbach WJ. Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2015 Aug; 59(8):4727-33. PMID: 26014950.
      View in: PubMed
    38. Juvvadi PR, Ma Y, Richards AD, Soderblom EJ, Moseley MA, Lamoth F, Steinbach WJ. Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus. Front Microbiol. 2015; 6:175. PMID: 25821446.
      View in: PubMed
    39. Lamoth F, Juvvadi PR, Steinbach WJ. Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. Front Microbiol. 2015; 6:96. PMID: 25762988.
      View in: PubMed
    40. Lamoth F, Alexander BD, Juvvadi PR, Steinbach WJ. Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species. J Antimicrob Chemother. 2015 May; 70(5):1408-11. PMID: 25558076.
      View in: PubMed
    41. Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latge JP, Steinbach WJ. . Human Fungal Pathogens (Casadevall A, Mitchell AP, Berman J, Kwon-Chung KJ, Perfect JR, and Heitman J, eds), Cold Spring Harbor Laboratory Press. Aspergillus fumigatus and related Species. 2015; 431-447.
    42. Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latg? JP, Steinbach WJ. Aspergillus fumigatus and related species. Cold Spring Harb Perspect Med. 2014 Nov 06; 5(2):a019786. PMID: 25377144.
      View in: PubMed
    43. Juvvadi PR, Lamoth F, Steinbach WJ. Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis. Fungal Biol Rev. 2014 Oct; 28(2-3):56-69. PMID: 25383089.
      View in: PubMed
    44. Lamoth F, Juvvadi PR, Steinbach WJ. Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus. Crit Rev Microbiol. 2016; 42(2):310-21. PMID: 25243616.
      View in: PubMed
    45. Juvvadi PR, Lamoth F, Steinbach WJ. Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus. Mycopathologia. 2014 Dec; 178(5-6):341-8. PMID: 25118871.
      View in: PubMed
    46. Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Asfaw YG, Steinbach WJ. Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2014; 58(4):1889-96. PMID: 24395240.
      View in: PubMed
    47. Lamoth F, Juvvadi PR, Gehrke C, Asfaw YG, Steinbach WJ. Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus. J Infect Dis. 2014 Feb 01; 209(3):473-81. PMID: 24096332.
      View in: PubMed
    48. Juvvadi PR, Gehrke C, Fortwendel JR, Lamoth F, Soderblom EJ, Cook EC, Hast MA, Asfaw YG, Moseley MA, Creamer TP, Steinbach WJ. Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus. PLoS Pathog. 2013; 9(8):e1003564. PMID: 23990785.
      View in: PubMed
    49. Juvvadi PR, Belina D, Soderblom EJ, Moseley MA, Steinbach WJ. Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2013 Feb 15; 431(3):547-53. PMID: 23321313.
      View in: PubMed
    50. Lamoth F, Juvvadi PR, Gehrke C, Steinbach WJ. In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. Antimicrob Agents Chemother. 2013 Feb; 57(2):1035-9. PMID: 23165466.
      View in: PubMed
    51. Lamoth F, Juvvadi PR, Fortwendel JR, Steinbach WJ. Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. Eukaryot Cell. 2012 Nov; 11(11):1324-32. PMID: 22822234.
      View in: PubMed
    52. Fortwendel JR, Juvvadi PR, Rogg LE, Asfaw YG, Burns KA, Randell SH, Steinbach WJ. Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus. Eukaryot Cell. 2012 Aug; 11(8):966-77. PMID: 22562470.
      View in: PubMed
    53. Juvvadi PR, Fortwendel JR, Rogg LE, Burns KA, Randell SH, Steinbach WJ. Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. Mol Microbiol. 2011 Dec; 82(5):1235-59. PMID: 22066998.
      View in: PubMed
    54. Rogg LE, Fortwendel JR, Juvvadi PR, Lilley A, Steinbach WJ. The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2011 Aug 05; 411(3):549-54. PMID: 21763289.
      View in: PubMed
    55. Rogg LE, Fortwendel JR, Juvvadi PR, Steinbach WJ. Regulation of expression, activity and localization of fungal chitin synthases. Med Mycol. 2012 Jan; 50(1):2-17. PMID: 21526913.
      View in: PubMed
    56. Fortwendel JR, Juvvadi PR, Rogg LE, Steinbach WJ. Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus. Eukaryot Cell. 2011 Apr; 10(4):611-5. PMID: 21278230.
      View in: PubMed
    57. Juvvadi PR, Fortwendel JR, Rogg LE, Steinbach WJ. Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):238-43. PMID: 21219860.
      View in: PubMed
    58. Steinbach WJ, Juvvadi PR, Fortwendel JR, Rogg LE. Newer combination antifungal therapies for invasive aspergillosis. Med Mycol. 2011 Apr; 49 Suppl 1:S77-81. PMID: 20608784.
      View in: PubMed
    59. Seshime Y, Juvvadi PR, Kitamoto K, Ebizuka Y, Nonaka T, Fujii I. Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid. Bioorg Med Chem Lett. 2010 Aug 15; 20(16):4785-8. PMID: 20630753.
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    60. Seshime Y, Juvvadi PR, Kitamoto K, Ebizuka Y, Fujii I. Identification of csypyrone B1 as the novel product of Aspergillus oryzae type III polyketide synthase CsyB. Bioorg Med Chem. 2010 Jun 15; 18(12):4542-6. PMID: 20471846.
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    61. Fortwendel JR, Juvvadi PR, Perfect BZ, Rogg LE, Perfect JR, Steinbach WJ. Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. Antimicrob Agents Chemother. 2010 Apr; 54(4):1555-63. PMID: 20124000.
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    62. Pinchai N, Juvvadi PR, Fortwendel JR, Perfect BZ, Rogg LE, Asfaw YG, Steinbach WJ. The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. Eukaryot Cell. 2010 Mar; 9(3):472-6. PMID: 20097742.
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    63. Seshime Y, Juvvadi PR, Tokuoka M, Koyama Y, Kitamoto K, Ebizuka Y, Fujii I. Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid. Bioorg Med Chem Lett. 2009 Jun 15; 19(12):3288-92. PMID: 19410456.
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    64. Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryot Cell. 2009 Apr; 8(4):511-9. PMID: 19252123.
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    65. Esca?o CS, Juvvadi PR, Jin FJ, Takahashi T, Koyama Y, Yamashita S, Maruyama J, Kitamoto K. Disruption of the Aopex11-1 gene involved in peroxisome proliferation leads to impaired Woronin body formation in Aspergillus oryzae. Eukaryot Cell. 2009 Mar; 8(3):296-305. PMID: 19136573.
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    66. Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ. Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus. Antimicrob Agents Chemother. 2009 Feb; 53(2):476-82. PMID: 19015336.
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    67. Juvvadi PR, Fortwendel JR, Pinchai N, Perfect BZ, Heitman J, Steinbach WJ. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. Eukaryot Cell. 2008 Sep; 7(9):1606-10. PMID: 18606829.
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    68. Juvvadi PR, Maruyama J, Kitamoto K. Phosphorylation of the Aspergillus oryzae Woronin body protein, AoHex1, by protein kinase C: evidence for its role in the multimerization and proper localization of the Woronin body protein. Biochem J. 2007 Aug 01; 405(3):533-40. PMID: 17441786.
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    69. Jin FJ, Watanabe T, Juvvadi PR, Maruyama J, Arioka M, Kitamoto K. Double disruption of the proteinase genes, tppA and pepE, increases the production level of human lysozyme by Aspergillus oryzae. Appl Microbiol Biotechnol. 2007 Oct; 76(5):1059-68. PMID: 17622525.
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    70. Akao T, Sano M, Yamada O, Akeno T, Fujii K, Goto K, Ohashi-Kunihiro S, Takase K, Yasukawa-Watanabe M, Yamaguchi K, Kurihara Y, Maruyama J, Juvvadi PR, Tanaka A, Hata Y, Koyama Y, Yamaguchi S, Kitamoto N, Gomi K, Abe K, Takeuchi M, Kobayashi T, Horiuchi H, Kitamoto K, Kashiwagi Y, Machida M, Akita O. Analysis of expressed sequence tags from the fungus Aspergillus oryzae cultured under different conditions. DNA Res. 2007 Apr; 14(2):47-57. PMID: 17540709.
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    71. Kobayashi T, Abe K, Asai K, Gomi K, Juvvadi PR, Kato M, Kitamoto K, Takeuchi M, Machida M. Genomics of Aspergillus oryzae. Biosci Biotechnol Biochem. 2007 Mar; 71(3):646-70. PMID: 17341818.
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    72. Juvvadi PR, Chivukula S. Putative calmodulin-binding domains in aflatoxin biosynthesis-regulatory proteins. Curr Microbiol. 2006 Jun; 52(6):493-6. PMID: 16732462.
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    73. Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, Kusumoto K, Arima T, Akita O, Kashiwagi Y, Abe K, Gomi K, Horiuchi H, Kitamoto K, Kobayashi T, Takeuchi M, Denning DW, Galagan JE, Nierman WC, Yu J, Archer DB, Bennett JW, Bhatnagar D, Cleveland TE, Fedorova ND, Gotoh O, Horikawa H, Hosoyama A, Ichinomiya M, Igarashi R, Iwashita K, Juvvadi PR, Kato M, Kato Y, Kin T, Kokubun A, Maeda H, Maeyama N, Maruyama J, Nagasaki H, Nakajima T, Oda K, Okada K, Paulsen I, Sakamoto K, Sawano T, Takahashi M, Takase K, Terabayashi Y, Wortman JR, Yamada O, Yamagata Y, Anazawa H, Hata Y, Koide Y, Komori T, Koyama Y, Minetoki T, Suharnan S, Tanaka A, Isono K, Kuhara S, Ogasawara N, Kikuchi H. Genome sequencing and analysis of Aspergillus oryzae. Nature. 2005 Dec 22; 438(7071):1157-61. PMID: 16372010.
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    74. Juvvadi PR, Seshime Y, Kitamoto K. Genomics reveals traces of fungal phenylpropanoid-flavonoid metabolic pathway in the f ilamentous fungus Aspergillus oryzae. J Microbiol. 2005 Dec; 43(6):475-86. PMID: 16410762.
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    75. Ishi K, Watanabe T, Juvvadi PR, Maruyama J, Kitamoto K. Development of a modified positive selection medium that allows to isolate Aspergillus oryzae strains cured of the integrated niaD-based plasmid. Biosci Biotechnol Biochem. 2005 Dec; 69(12):2463-5. PMID: 16377911.
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    76. Seshime Y, Juvvadi PR, Fujii I, Kitamoto K. Genomic evidences for the existence of a phenylpropanoid metabolic pathway in Aspergillus oryzae. Biochem Biophys Res Commun. 2005 Nov 25; 337(3):747-51. PMID: 16182237.
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    77. Maruyama J, Juvvadi PR, Ishi K, Kitamoto K. Three-dimensional image analysis of plugging at the septal pore by Woronin body during hypotonic shock inducing hyphal tip bursting in the filamentous fungus Aspergillus oryzae. Biochem Biophys Res Commun. 2005 Jun 17; 331(4):1081-8. PMID: 15882988.
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    78. Unno K, Juvvadi PR, Nakajima H, Shirahige K, Kitamoto K. Identification and characterization of rns4/vps32 mutation in the RNase T1 expression-sensitive strain of Saccharomyces cerevisiae: Evidence for altered ambient response resulting in transportation of the secretory protein to vacuoles. FEMS Yeast Res. 2005 Jun; 5(9):801-12. PMID: 15925308.
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    79. Seshime Y, Juvvadi PR, Fujii I, Kitamoto K. Discovery of a novel superfamily of type III polyketide synthases in Aspergillus oryzae. Biochem Biophys Res Commun. 2005 May 27; 331(1):253-60. PMID: 15845386.
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    80. Ishi K, Maruyama J, Juvvadi PR, Nakajima H, Kitamoto K. Visualizing nuclear migration during conidiophore development in Aspergillus nidulans and Aspergillus oryzae: multinucleation of conidia occurs through direct migration of plural nuclei from phialides and confers greater viability and early germination in Aspergillus oryzae. Biosci Biotechnol Biochem. 2005 Apr; 69(4):747-54. PMID: 15849413.
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    81. Kitamoto K, Maruyama J, Juvvadi PR. . Seibutsukogaku-kaishi. Development of a novel quadruple auxotrophic host-vector system in Aspergillus oryzae. 2005; 83:277-279.
    82. Jin FJ, Maruyama J, Juvvadi PR, Arioka M, Kitamoto K. Development of a novel quadruple auxotrophic host transformation system by argB gene disruption using adeA gene and exploiting adenine auxotrophy in Aspergillus oryzae. FEMS Microbiol Lett. 2004 Oct 01; 239(1):79-85. PMID: 15451104.
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    83. Jin FJ, Maruyama J, Juvvadi PR, Arioka M, Kitamoto K. Adenine auxotrophic mutants of Aspergillus oryzae: development of a novel transformation system with triple auxotrophic hosts. Biosci Biotechnol Biochem. 2004 Mar; 68(3):656-62. PMID: 15056900.
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    84. Juvvadi PR, Chivukula S. Recent Research Developments in Microbiology, Research Signpost publishers, Editor-Pandalai SG.,ISBN-81-7736-211-9,. The emerging role of calcium and calmodulin in fungal growth, development and metabolism. 2004; 8:161-199.
    85. Juvvadi PR, Kuroki Y, Arioka M, Nakajima H, Kitamoto K. Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation. Arch Microbiol. 2003 Jun; 179(6):416-22. PMID: 12709783.
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    86. Kuroki Y, Juvvadi PR, Arioka M, Nakajima H, Kitamoto K. Cloning and characterization of vmaA, the gene encoding a 69-kDa catalytic subunit of the vacuolar H+-ATPase during alkaline pH mediated growth of Aspergillus oryzae. FEMS Microbiol Lett. 2002 Apr 09; 209(2):277-82. PMID: 12007818.
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    87. Juvvadi PR, Arioka M, Nakajima H, Kitamoto K. Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae. FEMS Microbiol Lett. 2001 Oct 16; 204(1):169-74. PMID: 11682197.
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    88. Rao JP, Subramanyam C. Calmodulin mediated activation of acetyl-CoA carboxylase during aflatoxin production by Aspergillus parasiticus. Lett Appl Microbiol. 2000 Apr; 30(4):277-81. PMID: 10792646.
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    89. Jayashree T, Praveen Rao J, Subramanyam C. Regulation of aflatoxin production by Ca(2+)/calmodulin-dependent protein phosphorylation and dephosphorylation. FEMS Microbiol Lett. 2000 Feb 15; 183(2):215-9. PMID: 10675586.
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    90. Praveen Rao J, Subramanyam C. Requirement of Ca2+ for aflatoxin production: inhibitory effect of Ca2+ channel blockers on aflatoxin production by Aspergillus parasiticus NRRL 2999. Lett Appl Microbiol. 1999 Jan; 28(1):85-8. PMID: 10200037.
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    91. Rao JP, Sashidhar R, Subramanyam C. Inhibition of aflatoxin production by trifluoperazine in Aspergillus parasiticus NRRL 2999. World Journal of Microbiology and Biotechnology. 1998; (14):71-75.
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    92. Rao JP, Reena G, Subramanyam C. Calmodulin-dependent protein phosphorylation during conidial germination and growth of Neurospora crassa. Mycological Research. 1997; 101:1484-1488.
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