 Alkylation
"Alkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
| Descriptor ID |
D000478
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| MeSH Number(s) |
G02.111.087.029 G02.149.115.029 G02.149.465.040 G02.607.750.040 G03.495.130
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Alkylation".
Below are MeSH descriptors whose meaning is more specific than "Alkylation".
This graph shows the total number of publications written about "Alkylation" by people in UAMS Profiles by year, and whether "Alkylation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alkylation" by people in Profiles over the past ten years.
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Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019 06 21; 14(6):1337-1351.
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Thevanayagam L, Bell A, Chakraborty I, Sufi B, Gangwar S, Zang A, Rangan V, Rao C, Wang Z, Pan C, Chong C, Cardarelli P, Deshpande S, Srinivasan M. Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications. Bioanalysis. 2013 May; 5(9):1073-81.
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Mudududdla R, Jain SK, Bharate JB, Gupta AP, Singh B, Vishwakarma RA, Bharate SB. ortho-Amidoalkylation of phenols via tandem one-pot approach involving oxazine intermediate. J Org Chem. 2012 Oct 05; 77(19):8821-7.
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Huang JR, Cui HL, Lei J, Sun XH, Chen YC. Organocatalytic chemoselective asymmetric N-allylic alkylation of enamides. Chem Commun (Camb). 2011 Apr 28; 47(16):4784-6.
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