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Maroof Zafar

TitleResearch Program Manager
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
DivisionBiochem & Molecular Research
AddressB416 Biomedical Research I
4301 W Markham St.
Mail Slot # 516
Little Rock AR 72205
Phone501-603-1004
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Osei B, May BH, Stiefel CM, West KL, Zafar MK, Thompson MD, Bergstrom E, Leung JW, Enemark EJ, Byrd AK. Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB. bioRxiv. 2024 Mar 02. PMID: 38464108.
      View in: PubMed
    2. Chauhan MZ, Mansour HA, Zafar MK, Uwaydat SH. Anti-Programmed Death Ligand-1 Induced Acute Vision Loss in a Patient With Cancer-Associated Retinopathy. Cureus. 2022 Jan; 14(1):e21709. PMID: 35145825.
      View in: PubMed
    3. Byrd AK, Malone EG, Hazeslip L, Zafar MK, Harrison DK, Thompson MD, Gao J, Perumal SK, Marecki JC, Raney KD. A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA. Protein Sci. 2022 02; 31(2):407-421. PMID: 34761452.
      View in: PubMed
    4. Chappell K, Manna K, Washam CL, Graw S, Alkam D, Thompson MD, Zafar MK, Hazeslip L, Randolph C, Gies A, Bird JT, Byrd AK, Miah S, Byrum SD. Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer. Mol Omics. 2021 10 11; 17(5):677-691. PMID: 34142686.
      View in: PubMed
    5. Reed MR, Maddukuri L, Ketkar A, Byrum SD, Zafar MK, Bostian ACL, Tackett AJ, Eoff RL. Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. NAR Cancer. 2021 Jun; 3(2):zcab014. PMID: 33870196.
      View in: PubMed
    6. Gujarathi S, Zafar MK, Liu X, Eoff RL, Zheng G. A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase ?. Molecules. 2020 Dec 11; 25(24). PMID: 33322249.
      View in: PubMed
    7. Graw S, Tang J, Zafar MK, Byrd AK, Bolden C, Peterson EC, Byrum SD. proteiNorm - A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification. ACS Omega. 2020 Oct 13; 5(40):25625-25633. PMID: 33073088.
      View in: PubMed
    8. Zafar MK, Hazeslip L, Chauhan MZ, Byrd AK. The Expression of Human DNA Helicase B Is Affected by G-Quadruplexes in the Promoter. Biochemistry. 2020 07 07; 59(26):2401-2409. PMID: 32478505.
      View in: PubMed
    9. Hazeslip L, Zafar MK, Chauhan MZ, Byrd AK. Genome Maintenance by DNA Helicase B. Genes (Basel). 2020 05 21; 11(5). PMID: 32455610.
      View in: PubMed
    10. Chauhan MZ, Arcuri J, Park KK, Zafar MK, Fatmi R, Hackam AS, Yin Y, Benowitz L, Goldberg JL, Samarah M, Bhattacharya SK. Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration. iScience. 2020 Feb 21; 23(2):100836. PMID: 32058951.
      View in: PubMed
    11. Ketkar A, Maddukuri L, Penthala NR, Reed MR, Zafar MK, Crooks PA, Eoff RL. Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms. ACS Chem Biol. 2019 06 21; 14(6):1337-1351. PMID: 31082191.
      View in: PubMed
    12. Zafar MK, Maddukuri L, Ketkar A, Penthala NR, Reed MR, Eddy S, Crooks PA, Eoff RL. A Small-Molecule Inhibitor of Human DNA Polymerase ? Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018 02 20; 57(7):1262-1273. PMID: 29345908.
      View in: PubMed
    13. Zafar MK, Eoff RL. Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities. Chem Res Toxicol. 2017 11 20; 30(11):1942-1955. PMID: 28841374.
      View in: PubMed
    14. Eddy S, Tillman M, Maddukuri L, Ketkar A, Zafar MK, Eoff RL. Human Translesion Polymerase ? Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA. Biochemistry. 2016 09 20; 55(37):5218-29. PMID: 27525498.
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    15. Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, Eoff RL. Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA. Biochemistry. 2015 May 26; 54(20):3218-30. PMID: 25903680.
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    16. Zafar MK, Ketkar A, Lodeiro MF, Cameron CE, Eoff RL. Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine. Biochemistry. 2014 Oct 21; 53(41):6584-94. PMID: 25255211.
      View in: PubMed
    17. Maddukuri L, Ketkar A, Eddy S, Zafar MK, Eoff RL. The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa. Nucleic Acids Res. 2014 Oct 29; 42(19):12027-40. PMID: 25294835.
      View in: PubMed
    18. Eddy S, Ketkar A, Zafar MK, Maddukuri L, Choi JY, Eoff RL. Human Rev1 polymerase disrupts G-quadruplex DNA. Nucleic Acids Res. 2014 Mar; 42(5):3272-85. PMID: 24366879.
      View in: PubMed
    19. Ketkar A, Zafar MK, Maddukuri L, Yamanaka K, Banerjee S, Egli M, Choi JY, Lloyd RS, Eoff RL. Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol. 2013 Feb 18; 26(2):221-32. PMID: 23305233.
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    20. Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues. Biochemistry. 2012 Nov 13; 51(45):9234-44. PMID: 23050956.
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    21. Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL. Enhancement of human DNA polymerase ? activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein. J Biol Chem. 2012 Dec 07; 287(50):42312-23. PMID: 23045531.
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    22. Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL. A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota. J Am Chem Soc. 2012 Jun 27; 134(25):10698-705. PMID: 22632140.
      View in: PubMed
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