 Cytochrome P-450 CYP2E1
"Cytochrome P-450 CYP2E1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include alcohol; NITROSAMINES; BENZENE; URETHANE; and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
| Descriptor ID |
D019392
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| MeSH Number(s) |
D08.244.453.040.972 D08.811.682.662.582.338 D08.811.682.690.708.170.040.777 D12.776.422.220.453.040.944
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| Concept/Terms |
Cytochrome P-450 CYP2E1- Cytochrome P-450 CYP2E1
- Cytochrome P 450 CYP2E1
- CYP 2E1
- Cytochrome P-450 IIE1
- Cytochrome P 450 IIE1
- CYP IIE1
- Cytochrome P450 2E1
- N-Nitrosodimethylamine Demethylase
- N Nitrosodimethylamine Demethylase
- Cytochrome P-450 (ALC)
- Cytochrome P-450-J
- Cytochrome P 450 J
- 4-Nitrophenol-2-Hydroxylase
- 4 Nitrophenol 2 Hydroxylase
- Dimethylnitrosamine N-Demethylase
- Dimethylnitrosamine N Demethylase
- CYP2E1
- CYPIIE1
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Below are MeSH descriptors whose meaning is more general than "Cytochrome P-450 CYP2E1".
Below are MeSH descriptors whose meaning is more specific than "Cytochrome P-450 CYP2E1".
This graph shows the total number of publications written about "Cytochrome P-450 CYP2E1" by people in UAMS Profiles by year, and whether "Cytochrome P-450 CYP2E1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 2 | 2 | | 2017 | 2 | 0 | 2 | | 2015 | 2 | 0 | 2 | | 2014 | 3 | 2 | 5 | | 2013 | 4 | 1 | 5 | | 2012 | 1 | 1 | 2 | | 2010 | 0 | 2 | 2 | | 2008 | 2 | 1 | 3 | | 2007 | 3 | 3 | 6 | | 2006 | 2 | 1 | 3 | | 2005 | 0 | 3 | 3 | | 2004 | 0 | 2 | 2 | | 2003 | 2 | 2 | 4 | | 2002 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1993 | 0 | 5 | 5 | | 1992 | 0 | 2 | 2 |
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Below are the most recent publications written about "Cytochrome P-450 CYP2E1" by people in Profiles over the past ten years.
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H?lzl-Armstrong L, N?visdal A, Cox JA, Long AS, Chepelev NL, Phillips DH, White PA, Arlt VM. In vitro mutagenicity of selected environmental carcinogens and their metabolites in MutaMouse FE1 lung epithelial cells. Mutagenesis. 2020 12 31; 35(6):453-463.
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McCullough S, Dweep H, McGill MR, Bhattacharyya S, James L, Frankowski S, Woodall A, Kearns G, Gill P. Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. Microrna. 2020; 9(2):121-132.
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Gill P, Bhattacharyya S, McCullough S, Letzig L, Mishra PJ, Luo C, Dweep H, James L. MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. Sci Rep. 2017 09 26; 7(1):12331.
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Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 03 01; 378:114-124.
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Hartman JH, Martin HC, Caro AA, Pearce AR, Miller GP. Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates. Toxicology. 2015 Dec 02; 338:47-58.
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Hartman JH, Letzig LG, Roberts DW, James LP, Fifer EK, Miller GP. Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures. Biochem Pharmacol. 2015 Oct 01; 97(3):341-9.
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Levy JW, Hartman JH, Perry MD, Miller GP. Structural basis for cooperative binding of azoles to CYP2E1 as interpreted through guided molecular dynamics simulations. J Mol Graph Model. 2015 Mar; 56:43-52.
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Wang Z, Shah SV, Liu H, Baliga R. Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury. Kidney Int. 2014 Aug; 86(2):338-49.
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Hartman JH, Miller GP, Boysen G. Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity. Toxicology. 2014 Apr 06; 318:51-8.
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Ronis MJ, Mercer K, Suva LJ, Vantrease J, Ferguson M, Hogue WR, Sharma N, Cleves MA, Blackburn ML, Badger TM. Influence of fat/carbohydrate ratio on progression of fatty liver disease and on development of osteopenia in male rats fed alcohol via total enteral nutrition (TEN). Alcohol. 2014 Mar; 48(2):133-44.
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James L, Roberts D. Isoniazid hepatotoxicity: progress in understanding the immunologic component. Hepatology. 2014 Mar; 59(3):746-8.
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Hartman JH, Knott K, Miller GP. CYP2E1 hydroxylation of aniline involves negative cooperativity. Biochem Pharmacol. 2014 Feb 01; 87(3):523-33.
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