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Gunnar Boysen

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentEnvironmental Health Sciences, College of Public Health
DivisionEnvironmental Health Sciences
Address1/1220 ED III College of Public Health
220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
Phone501-526-4956
ORCID ORCID Icon0000-0001-8364-9881 Additional info
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    Collapse Affiliation 
    Collapse member of
    American Chemistry Society
    American Association for Research on Cancer (AACR)
    American Society for Mass Spectrometry
    Society of Toxicology (SOT)
    Collapse collaborator
    University of Texas Medical Branch (UTMB)

    Collapse Research 
    Collapse research overview
    Our research focus on the interplay between chemical exposure and nutritional or lifestyle habits, such as diet selection and physical activity. To achieve this we utilize DNA and protein adducts to study carcinogen metabolism, how it is modified by nutritional components and the underlying mechanisms regulating corresponding enzyme activities. In addition, studies investigate exposures related changes in common metabolic pathways, using targeted and un-targeted mass spectrometry based metabolomic approaches.

    A second line of research applies systems biology approaches such as metabolomics to improve diagnosis of lung cancer patients and to elucidate mechanism that can be targeted with common or novel drugs.

    Collapse research activities and funding
    G21AP10581     (BOYSEN, GUNNAR)Sep 1, 2023 - Aug 31, 2024
    US Department of Interior - Pass Through: University of Arkansas at Fayetteville
    Monitoring Perfluoroalkyl and Polyfluoroalkyl Substances in Central Arkansas water systems
    Role: Principal Investigator
    G21AP10581-02     (BOYSEN, GUNNAR)Sep 1, 2023 - Aug 31, 2024
    US Department of Interior - Pass Through: University of Arkansas at Fayetteville
    Monitoring Perfluoroalkyl and Polyfluoroalkyl Substances in Central Arkansas water systems
    Role: Principal Investigator
    P01CA138338     (BOYSEN, GUNNAR)Sep 16, 2022 - Aug 31, 2024
    NIH/Nat. Cancer Institute - Pass Through: University of Minnesota
    Mechanisms of Ethnic/Racial Differences in Lung Cancer Due to Cigarette Smoking
    Role: Principal Investigator
    CPPS Pilot Award 2017     (QUICK, CHARLES M)Jul 1, 2017 - Dec 31, 2018
    UAMS College of Medicine
    Cancer Prevention and Population Sciences Program
    Role: Principal Investigator
    R01 DK102206-01A1     Sep 1, 2014 - Aug 31, 2019
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
    Lipid Stress and MC4R
    Role: Co-Investigator
    R21ES023046     (BOYSEN, GUNNAR)May 7, 2014 - Apr 30, 2017
    NIH
    Effects of Genetic Diversity on Carcinogen Metabolism
    Role: Principal Investigator
    n/a     (BOYSEN, GUNNAR)Apr 1, 2013 - Mar 31, 2014
    UAMS, Translational Research Institute (TRI)
    Systems Biology Based Diagnosis of Lung Cancer
    Role: Principal Investigator
    CR     (BOYSEN, GUNNAR)Apr 1, 2012 - Apr 30, 2013
    Environmental Protection Agency - Pass Through: The Health Effects Institute
    ProfilingDoses of Reactive Compounds Derived from various Air Pollutant Exposures
    Role: Principal Investigator
    CR-83234701     (BOYSEN, GUNNAR)Apr 1, 2012 - Apr 30, 2013
    Environmental Protection Agency - Pass Through: The Health Effects Institute
    ProfilingDoses of Reactive Compounds Derived from various Air Pollutant Exposures
    Role: Principal Investigator
    R21ES019684     (BOYSEN, GUNNAR)Aug 19, 2011 - Jul 31, 2014
    NIH
    A novel approach for quantitation of N-terminal valine adducts
    Role: Principal Investigator
    UL1TR000039     (JAMES, LAURA P)Jul 14, 2009 - Mar 31, 2016
    NIH
    Arkansas Center for Clinical and Translational Research
    Role: Co-Investigator
    1F32ES013107     (BOYSEN, GUNNAR)Nov 16, 2003 - Nov 15, 2005
    National Institute for Environmental Health Sciences (NIEHS)
    The Role of N1-Inosine Adducts in Butadiene Mutagenesis
    Role: Principal Investigator
    F32ES013107     (BOYSEN, GUNNAR)Nov 16, 2003 - Nov 15, 2005
    NIH
    The Role of N1-Inosine Adducts in Butadiene Mutagenesis
    Role: Principal Investigator

    Collapse Outreach 

    Collapse Bibliographic 
    Collapse additional bibliographic sources
    The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Jamshidi-Parsian A, Jenkins SV, Tran A, Bragg A, Davis R, Griffin C, Siegel E, Dings RPM, Griffin RJ, Boysen G. CB-839 induces reversible dormancy in lung tumor-cells. Eur J Pharmacol. 2024 Nov 05; 982:176912. PMID: 39159716.
      View in: PubMed
    2. Jenkins SV, Shah S, Jamshidi-Parsian A, Mortazavi A, Kristian H, Boysen G, Vang KB, Griffin RJ, Rajaram N, Dings RPM. Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance. Radiat Res. 2024 02 01; 201(2):174-187. PMID: 38329819.
      View in: PubMed
    3. Miousse IR, Hale RB, Alsbrook S, Boysen G, Broadnax T, Murry C, Williams C, Park CH, Richards R, Reedy J, Chalbot MC, Kavouras IG, Koturbash I. Climate Change and New Challenges for Rural Communities: Particulate Matter Matters. Sustainability. 2023 Dec 01; 15(23). PMID: 39119507.
      View in: PubMed
    4. Wongsurawat T, Jenjaroenpun P, Anekwiang P, Arigul T, Thongrattana W, Jamshidi-Parsian A, Boysen G, Suriyaphol P, Suktitipat B, Srirabheebhat P, Cheunsuchon P, Tanboon J, Nookaew I, Sathornsumetee S. Exploiting nanopore sequencing for characterization and grading of IDH-mutant gliomas. Brain Pathol. 2024 01; 34(1):e13203. PMID: 37574201.
      View in: PubMed
    5. Crosby SV, Ahmed IY, Osborn LR, Wang Z, Schleiff MA, Fantegrossi WE, Nagar S, Prather PL, Boysen G, Miller GP. Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes. Metabolites. 2022 Aug 22; 12(8). PMID: 36005645.
      View in: PubMed
    6. Boysen G, Rusyn I, Chiu WA, Wright FA. Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice. Regul Toxicol Pharmacol. 2022 Jul; 132:105171. PMID: 35469930.
      View in: PubMed
    7. Wadley T, Moon SH, DeMott MS, Wanchai V, Huang E, Dedon PC, Boysen G, Nookaew I. Nanopore Sequencing for Detection and Characterization of Phosphorothioate Modifications in Native DNA Sequences. Front Microbiol. 2022; 13:871937. PMID: 35531280.
      View in: PubMed
    8. Boysen G, Nookaew I. Current and Future Methodology for Quantitation and Site-Specific Mapping the Location of DNA Adducts. Toxics. 2022 Jan 19; 10(2). PMID: 35202232.
      View in: PubMed
    9. Pujari SS, Jokipii Krueger CC, Chao C, Hutchins S, Hurben AK, Boysen G, Tretyakova N. DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA. Chemistry. 2022 Jan 13; 28(3):e202103245. PMID: 34767297.
      View in: PubMed
    10. Schleiff MA, Crosby S, Blue M, Schleiff BM, Boysen G, Miller GP. CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs. Biochem Pharmacol. 2021 12; 194:114824. PMID: 34748821.
      View in: PubMed
    11. Nellis M, Caperton CO, Liu K, Tran V, Go YM, Hallberg LM, Ameredes BT, Jones DP, Boysen G. Lung metabolome of 1,3-butadiene exposed Collaborative Cross mice reflects metabolic phenotype of human lung cancer. Toxicology. 2021 11; 463:152987. PMID: 34648870.
      View in: PubMed
    12. Flynn NR, Ward MD, Schleiff MA, Laurin CMC, Farmer R, Conway SJ, Boysen G, Swamidass SJ, Miller GP. Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors. Metabolites. 2021 Jun 15; 11(6). PMID: 34203690.
      View in: PubMed
    13. Schleiff MA, Payakachat S, Schleiff BM, Swamidass SJ, Boysen G, Miller GP. Impacts of diphenylamine NSAID halogenation on bioactivation risks. Toxicology. 2021 06 30; 458:152832. PMID: 34107285.
      View in: PubMed
    14. Jenjaroenpun P, Wongsurawat T, Wadley TD, Wassenaar TM, Liu J, Dai Q, Wanchai V, Akel NS, Jamshidi-Parsian A, Franco AT, Boysen G, Jennings ML, Ussery DW, He C, Nookaew I. Decoding the epitranscriptional landscape from native RNA sequences. Nucleic Acids Res. 2021 01 25; 49(2):e7. PMID: 32710622.
      View in: PubMed
    15. Boysen G, Arora R, Degner A, Vevang KR, Chao C, Rodriguez F, Walmsley SJ, Erber L, Tretyakova NY, Peterson LA. Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines. Chem Res Toxicol. 2021 01 18; 34(1):119-131. PMID: 33381973.
      View in: PubMed
    16. Schleiff MA, Flynn NR, Payakachat S, Schleiff BM, Pinson AO, Province DW, Swamidass SJ, Boysen G, Miller GP. Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics. Drug Metab Dispos. 2021 02; 49(2):133-141. PMID: 33239334.
      View in: PubMed
    17. Pinson AO, Pouncey DL, Schleiff MA, Fantegrossi WE, Prather PL, Radominska-Pandya A, Boysen G, Miller GP. Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics. Molecules. 2020 Oct 20; 25(20). PMID: 33092129.
      View in: PubMed
    18. Nookaew I, Jenjaroenpun P, Du H, Wang P, Wu J, Wongsurawat T, Moon SH, Huang E, Wang Y, Boysen G. Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing. Chem Res Toxicol. 2020 12 21; 33(12):2944-2952. PMID: 32799528.
      View in: PubMed
    19. Trentzsch M, Nyamugenda E, Miles TK, Griffin H, Russell S, Koss B, Cooney KA, Phelan KD, Tackett AJ, Iyer S, Boysen G, Baldini G. Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum. Cell Death Discov. 2020; 6:8. PMID: 32123584.
      View in: PubMed
    20. Boysen G, Shimoni A, Danylesko I, Varda-Bloom N, Nagler A. A simplified method for detection of N-terminal valine adducts in patients receiving treosulfan. Rapid Commun Mass Spectrom. 2019 Nov 15; 33(21):1635-1642. PMID: 31240802.
      View in: PubMed
    21. Clemens MM, Cardenas VM, Fischbach LA, Cen R, Siegel ER, Eswaran H, Ekanem US, Policherla A, Moody HL, Magann EF, Boysen G. Use of electronic nicotine delivery systems by pregnant women II: Hair biomarkers for exposures to nicotine and tobacco-specific nitrosamines. Tob Induc Dis. 2019; 17:50. PMID: 31516493.
      View in: PubMed
    22. Cardenas VM, Cen R, Clemens MM, Moody HL, Ekanem US, Policherla A, Fischbach LA, Eswaran H, Magann EF, Delongchamp RR, Boysen G. Use of Electronic Nicotine Delivery Systems (ENDS) by pregnant women I: Risk of small-for-gestational-age birth. Tob Induc Dis. 2019; 17:44. PMID: 31516487.
      View in: PubMed
    23. Davis MA, Barnette DA, Flynn NR, Pidugu AS, Swamidass SJ, Boysen G, Miller GP. CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches. Chem Res Toxicol. 2019 06 17; 32(6):1151-1164. PMID: 30925039.
      View in: PubMed
    24. Nyamugenda E, Trentzsch M, Russell S, Miles T, Boysen G, Phelan KD, Baldini G. Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high-fat diet in male and female mice. J Neurochem. 2019 04; 149(1):73-97. PMID: 30615192.
      View in: PubMed
    25. Boysen G, Jamshidi-Parsian A, Davis MA, Siegel ER, Simecka CM, Kore RA, Dings RPM, Griffin RJ. Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice. Int J Radiat Biol. 2019 04; 95(4):436-442. PMID: 30557074.
      View in: PubMed
    26. Pouncey DL, Hartman JH, Moore PC, Dillinger DJ, Dickerson KW, Sappington DR, Smith ES, Boysen G, Miller GP. Novel isomeric metabolite profiles correlate with warfarin metabolism phenotype during maintenance dosing in a pilot study of 29 patients. Blood Coagul Fibrinolysis. 2018 Nov; 29(7):602-612. PMID: 30334816.
      View in: PubMed
    27. Boysen G. Response to Interpretation of Mass Spectral Data for the Cisplatin 1,2 Intrastrand Guanine-Guanine Adduct. Chem Res Toxicol. 2018 11 19; 31(11):1108. PMID: 30215251.
      View in: PubMed
    28. Apopa PL, Alley L, Penney RB, Arnaoutakis K, Steliga MA, Jeffus S, Bircan E, Gopalan B, Jin J, Patumcharoenpol P, Jenjaroenpun P, Wongsurawat T, Shah N, Boysen G, Ussery D, Nookaew I, Fagan P, Bebek G, Orloff MS. PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin. Front Microbiol. 2018; 9:1757. PMID: 30127774.
      View in: PubMed
    29. Barnette DA, Davis MA, Dang NL, Pidugu AS, Hughes T, Swamidass SJ, Boysen G, Miller GP. Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches. Biochem Pharmacol. 2018 10; 156:10-21. PMID: 30076845.
      View in: PubMed
    30. Sappington D, Helms S, Siegel E, Penney RB, Jeffus S, Bartter T, Bartter T, Boysen G. Diagnosis of lung tumor types based on metabolomic profiles in lymph node aspirates. Cancer Treat Res Commun. 2018; 14:1-6. PMID: 30104001.
      View in: PubMed
    31. Boysen G. The Glutathione Conundrum: Stoichiometric Disconnect between Its Formation and Oxidative Stress. Chem Res Toxicol. 2017 05 15; 30(5):1113-1116. PMID: 28426193.
      View in: PubMed
    32. Hartman JH, Miller GP, Caro AA, Byrum SD, Orr LM, Mackintosh SG, Tackett AJ, MacMillan-Crow LA, Hallberg LM, Ameredes BT, Boysen G. 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice. Toxicology. 2017 03 01; 378:114-124. PMID: 28082109.
      View in: PubMed
    33. Sappington DR, Siegel ER, Hiatt G, Desai A, Penney RB, Jamshidi-Parsian A, Griffin RJ, Boysen G. Glutamine drives glutathione synthesis and contributes to radiation sensitivity of A549 and H460 lung cancer cell lines. Biochim Biophys Acta. 2016 Apr; 1860(4):836-43. PMID: 26825773.
      View in: PubMed
    34. Bogusiewicz A, Boysen G, Mock DM. In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency. J Nutr. 2015 Jan; 145(1):32-40. PMID: 25527659.
      View in: PubMed
    35. Pugh CP, Pouncey DL, Hartman JH, Nshimiyimana R, Desrochers LP, Goodwin TE, Boysen G, Miller GP. Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites. Arch Biochem Biophys. 2014 Dec 15; 564:244-53. PMID: 25447818.
      View in: PubMed
    36. Hartman JH, Miller GP, Boysen G. Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity. Toxicology. 2014 Apr 06; 318:51-8. PMID: 24561005.
      View in: PubMed
    37. Pianalto KM, Hartman JH, Boysen G, Miller GP. Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites. Toxicol Lett. 2013 Nov 25; 223(2):221-7. PMID: 24021170.
      View in: PubMed
    38. Edavana VK, Dhakal IB, Williams S, Penney R, Boysen G, Yao-Borengasser A, Kadlubar S. Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics. Drug Metab Dispos. 2013 Apr; 41(4):870-7. PMID: 23371966.
      View in: PubMed
    39. Hartman JH, Boysen G, Miller GP. Cooperative effects for CYP2E1 differ between styrene and its metabolites. Xenobiotica. 2013 Sep; 43(9):755-64. PMID: 23327532.
      View in: PubMed
    40. Goel S, Evans-Johnson JA, Georgieva NI, Boysen G. Exposure profiling of reactive compounds in complex mixtures. Toxicology. 2013 Nov 16; 313(2-3):145-150. PMID: 23219592.
      View in: PubMed
    41. Kim SY, Kang JY, Hartman JH, Park SH, Jones DR, Yun CH, Boysen G, Miller GP. Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins. Drug Metab Lett. 2012 Sep 01; 6(3):157-64. PMID: 23331088.
      View in: PubMed
    42. Bogusiewicz A, Horvath TD, Stratton SL, Mock DM, Boysen G. Measurement of acylcarnitine substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans. J Nutr. 2012 Sep; 142(9):1621-5. PMID: 22833654.
      View in: PubMed
    43. Hartman JH, Boysen G, Miller GP. CYP2E1 metabolism of styrene involves allostery. Drug Metab Dispos. 2012 Oct; 40(10):1976-83. PMID: 22807108.
      View in: PubMed
    44. Stratton SL, Henrich CL, Matthews NI, Bogusiewicz A, Dawson AM, Horvath TD, Owen SN, Boysen G, Moran JH, Mock DM. Marginal biotin deficiency can be induced experimentally in humans using a cost-effective outpatient design. J Nutr. 2012 Jan; 142(1):22-6. PMID: 22157538.
      View in: PubMed
    45. Boysen G, Georgieva NI, Bordeerat NK, Sram RJ, Vacek P, Albertini RJ, Swenberg JA. Formation of 1,2:3,4-diepoxybutane-specific hemoglobin adducts in 1,3-butadiene exposed workers. Toxicol Sci. 2012 Jan; 125(1):30-40. PMID: 22003190.
      View in: PubMed
    46. Mock DM, Stratton SL, Horvath TD, Bogusiewicz A, Matthews NI, Henrich CL, Dawson AM, Spencer HJ, Owen SN, Boysen G, Moran JH. Urinary excretion of 3-hydroxyisovaleric acid and 3-hydroxyisovaleryl carnitine increases in response to a leucine challenge in marginally biotin-deficient humans. J Nutr. 2011 Nov; 141(11):1925-30. PMID: 21918059.
      View in: PubMed
    47. Horvath TD, Matthews NI, Stratton SL, Mock DM, Boysen G. Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS. Anal Bioanal Chem. 2011 Nov; 401(9):2805-10. PMID: 21892638.
      View in: PubMed
    48. Bhattacharyya D, Ramachandran S, Sharma S, Pathmasiri W, King CL, Baskerville-Abraham I, Boysen G, Swenberg JA, Campbell SL, Dokholyan NV, Chaney SG. Flanking bases influence the nature of DNA distortion by platinum 1,2-intrastrand (GG) cross-links. PLoS One. 2011; 6(8):e23582. PMID: 21853154.
      View in: PubMed
    49. Begemann P, Boysen G, Georgieva NI, Sangaiah R, Koshlap KM, Koc H, Zhang D, Golding BT, Gold A, Swenberg JA. Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro. Chem Res Toxicol. 2011 Jul 18; 24(7):1048-61. PMID: 21548641.
      View in: PubMed
    50. Jones DR, Boysen G, Miller GP. Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 May 01; 879(15-16):1056-62. PMID: 21470921.
      View in: PubMed
    51. Jones DR, Kim SY, Boysen G, Yun CH, Miller GP. Contribution of three CYP3A isoforms to metabolism of R- and S-warfarin. Drug Metab Lett. 2010 Dec; 4(4):213-9. PMID: 20615193.
      View in: PubMed
    52. Swenberg JA, Bordeerat NK, Boysen G, Carro S, Georgieva NI, Nakamura J, Troutman JM, Upton PB, Albertini RJ, Vacek PM, Walker VE, Sram RJ, Goggin M, Tretyakova N. 1,3-Butadiene: Biomarkers and application to risk assessment. Chem Biol Interact. 2011 Jun 30; 192(1-2):150-4. PMID: 20974116.
      View in: PubMed
    53. Georgieva NI, Boysen G, Bordeerat N, Walker VE, Swenberg JA. Exposure-response of 1,2:3,4-diepoxybutane-specific N-terminal valine adducts in mice and rats after inhalation exposure to 1,3-butadiene. Toxicol Sci. 2010 Jun; 115(2):322-9. PMID: 20176624.
      View in: PubMed
    54. Boysen G, Collins LB, Liao S, Luke AM, Pachkowski BF, Watters JL, Swenberg JA. Analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine by ultra high pressure liquid chromatography-heat assisted electrospray ionization-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 01; 878(3-4):375-80. PMID: 20022307.
      View in: PubMed
    55. Watters JL, Satia JA, da Costa KA, Boysen G, Collins LB, Morrow JD, Milne GL, Swenberg JA. Comparison of three oxidative stress biomarkers in a sample of healthy adults. Biomarkers. 2009 Dec; 14(8):587-95. PMID: 20001708.
      View in: PubMed
    56. Bordeerat NK, Georgieva NI, Klapper DG, Collins LB, Cross TJ, Borchers CH, Swenberg JA, Boysen G. Accurate quantitation of standard peptides used for quantitative proteomics. Proteomics. 2009 Aug; 9(15):3939-44. PMID: 19637239.
      View in: PubMed
    57. Kim S, Collins LB, Boysen G, Swenberg JA, Gold A, Ball LM, Bradford BU, Rusyn I. Liquid chromatography electrospray ionization tandem mass spectrometry analysis method for simultaneous detection of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology. 2009 Aug 21; 262(3):230-8. PMID: 19549554.
      View in: PubMed
    58. Boysen G, Pachkowski BF, Nakamura J, Swenberg JA. The formation and biological significance of N7-guanine adducts. Mutat Res. 2009 Aug; 678(2):76-94. PMID: 19465146.
      View in: PubMed
    59. Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Williams J, Tomer KB, Mocanu V, Dicheva N, Parker CE, Schaaper RM, Ball LM. Iminohydantoin lesion induced in DNA by peracids and other epoxidizing oxidants. J Am Chem Soc. 2009 May 06; 131(17):6114-23. PMID: 19354244.
      View in: PubMed
    60. Baskerville-Abraham IM, Boysen G, Troutman JM, Mutlu E, Collins L, Dekrafft KE, Lin W, King C, Chaney SG, Swenberg JA. Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts. Chem Res Toxicol. 2009 May; 22(5):905-12. PMID: 19323581.
      View in: PubMed
    61. Esther CR, Boysen G, Olsen BM, Collins LB, Ghio AJ, Swenberg JW, Boucher RC. Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L987-93. PMID: 19304910.
      View in: PubMed
    62. Lu K, Boysen G, Gao L, Collins LB, Swenberg JA. Formaldehyde-induced histone modifications in vitro. Chem Res Toxicol. 2008 Aug; 21(8):1586-93. PMID: 18656964.
      View in: PubMed
    63. Alderman JM, Flurkey K, Brooks NL, Naik SB, Gutierrez JM, Srinivas U, Ziara KB, Jing L, Boysen G, Bronson R, Klebanov S, Chen X, Swenberg JA, Stridsberg M, Parker CE, Harrison DE, Combs TP. Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice. Exp Gerontol. 2009 Jan-Feb; 44(1-2):26-33. PMID: 18582556.
      View in: PubMed
    64. Esther CR, Jasin HM, Collins LB, Swenberg JA, Boysen G. A mass spectrometric method to simultaneously measure a biomarker and dilution marker in exhaled breath condensate. Rapid Commun Mass Spectrom. 2008; 22(5):701-5. PMID: 18257110.
      View in: PubMed
    65. Swenberg JA, Fryar-Tita E, Jeong YC, Boysen G, Starr T, Walker VE, Albertini RJ. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol. 2008 Jan; 21(1):253-65. PMID: 18161944.
      View in: PubMed
    66. Jiang J, Parker CE, Hoadley KA, Perou CM, Boysen G, Borchers CH. Development of an immuno tandem mass spectrometry (iMALDI) assay for EGFR diagnosis. Proteomics Clin Appl. 2007 Dec; 1(12):1651-9. PMID: 21136662.
      View in: PubMed
    67. Brooks NL, Trent CM, Raetzsch CF, Flurkey K, Boysen G, Perfetti MT, Jeong YC, Klebanov S, Patel KB, Khodush VR, Kupper LL, Carling D, Swenberg JA, Harrison DE, Combs TP. Low utilization of circulating glucose after food withdrawal in Snell dwarf mice. J Biol Chem. 2007 Nov 30; 282(48):35069-77. PMID: 17905742.
      View in: PubMed
    68. Wu Y, Bhattacharyya D, King CL, Baskerville-Abraham I, Huh SH, Boysen G, Swenberg JA, Temple B, Campbell SL, Chaney SG. Solution structures of a DNA dodecamer duplex with and without a cisplatin 1,2-d(GG) intrastrand cross-link: comparison with the same DNA duplex containing an oxaliplatin 1,2-d(GG) intrastrand cross-link. Biochemistry. 2007 Jun 05; 46(22):6477-87. PMID: 17497831.
      View in: PubMed
    69. Swenberg JA, Boysen G, Georgieva N, Bird MG, Lewis RJ. Future directions in butadiene risk assessment and the role of cross-species internal dosimetry. Chem Biol Interact. 2007 Mar 20; 166(1-3):78-83. PMID: 17343837.
      View in: PubMed
    70. Boysen G, Scarlett CO, Temple B, Combs TP, Brooks NL, Borchers CH, Swenberg JA. Identification of covalent modifications in P450 2E1 by 1,2-epoxy-3-butene in vitro. Chem Biol Interact. 2007 Mar 20; 166(1-3):170-5. PMID: 17298833.
      View in: PubMed
    71. Boysen G, Georgieva NI, Upton PB, Walker VE, Swenberg JA. N-terminal globin adducts as biomarkers for formation of butadiene derived epoxides. Chem Biol Interact. 2007 Mar 20; 166(1-3):84-92. PMID: 17084829.
      View in: PubMed
    72. Albertini RJ, Sram RJ, Vacek PM, Lynch J, Rossner P, Nicklas JA, McDonald JD, Boysen G, Georgieva N, Swenberg JA. Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons. Chem Biol Interact. 2007 Mar 20; 166(1-3):63-77. PMID: 16949064.
      View in: PubMed
    73. Meng Q, Walker DM, McDonald JD, Henderson RF, Carter MM, Cook DL, McCash CL, Torres SM, Bauer MJ, Seilkop SK, Upton PB, Georgieva NI, Boysen G, Swenberg JA, Walker VE. Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene. Chem Biol Interact. 2007 Mar 20; 166(1-3):121-31. PMID: 16945358.
      View in: PubMed
    74. Georgieva NI, Boysen G, Upton PB, Jayaraj K, Gold A, Swenberg JA. Quantitative analysis of N-terminal valine peptide adducts specific for 1,2-epoxy-3-butene. Chem Biol Interact. 2007 Mar 20; 166(1-3):219-25. PMID: 16860298.
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    75. Powell CL, Kosyk O, Ross PK, Schoonhoven R, Boysen G, Swenberg JA, Heinloth AN, Boorman GA, Cunningham ML, Paules RS, Rusyn I. Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicol Sci. 2006 Sep; 93(1):213-22. PMID: 16751229.
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    76. Stout MD, Jeong YC, Boysen G, Li Y, Sangaiah R, Ball LM, Gold A, Swenberg JA. LC/MS/MS method for the quantitation of trans-2-hexenal-derived exocyclic 1,N(2)-propanodeoxyguanosine in DNA. Chem Res Toxicol. 2006 Apr; 19(4):563-70. PMID: 16608168.
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    77. Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Williams J, Tomer KB, Ball LM. A 2-iminohydantoin from the oxidation of guanine. Chem Res Toxicol. 2006 Apr; 19(4):506-10. PMID: 16608161.
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    78. Li Y, Warren JT, Boysen G, Gilbert LI, Gold A, Sangaiah R, Ball LM, Swenberg JA. Profiling of ecdysteroids in complex biological samples using liquid chromatography/ion trap mass spectrometry. Rapid Commun Mass Spectrom. 2006; 20(2):185-92. PMID: 16345130.
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    79. Boysen G, Georgieva NI, Upton PB, Jayaraj K, Li Y, Walker VE, Swenberg JA. Analysis of diepoxide-specific cyclic N-terminal globin adducts in mice and rats after inhalation exposure to 1,3-butadiene. Cancer Res. 2004 Dec 01; 64(23):8517-20. PMID: 15574756.
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    80. Wu Y, Pradhan P, Havener J, Boysen G, Swenberg JA, Campbell SL, Chaney SG. NMR solution structure of an oxaliplatin 1,2-d(GG) intrastrand cross-link in a DNA dodecamer duplex. J Mol Biol. 2004 Aug 27; 341(5):1251-69. PMID: 15321720.
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    81. Boysen G, Kenney PM, Upadhyaya P, Wang M, Hecht SS. Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats. Carcinogenesis. 2003 Mar; 24(3):517-25. PMID: 12663513.
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    82. Boysen G, Hecht SS. Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods. Mutat Res. 2003 Jan; 543(1):17-30. PMID: 12510015.
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    83. Sticha KR, Kenney PM, Boysen G, Liang H, Su X, Wang M, Upadhyaya P, Hecht SS. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis. 2002 Sep; 23(9):1433-9. PMID: 12189184.
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