 Secologanin Tryptamine Alkaloids
"Secologanin Tryptamine Alkaloids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds formed by condensation of secologanin with tryptamine resulting in a tetrahydro-beta-carboline which is processed further to a number of bioactive compounds. These are especially found in plants of the APOCYNACEAE; LOGANIACEAE; and RUBIACEAE families.
| Descriptor ID |
D046948
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| MeSH Number(s) |
D03.132.436.681 D03.438.473.402.681
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| Concept/Terms |
Secologanin Tryptamine Alkaloids- Secologanin Tryptamine Alkaloids
- Alkaloids, Secologanin Tryptamine
- Tryptamine Alkaloids, Secologanin
- Secologanin Indole Alkaloids
- Alkaloids, Secologanin Indole
- Indole Alkaloids, Secologanin
- Terpenoid Indole Alkaloids
- Alkaloids, Terpenoid Indole
- Indole Alkaloids, Terpenoid
- Monoterpenoid Indole Alkaloids
- Alkaloids, Monoterpenoid Indole
- Indole Alkaloids, Monoterpenoid
Rauwolfia Alkaloids- Rauwolfia Alkaloids
- Alkaloids, Rauwolfia
- Rauvolfia Alkaloids
- Alkaloids, Rauvolfia
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Below are MeSH descriptors whose meaning is more general than "Secologanin Tryptamine Alkaloids".
Below are MeSH descriptors whose meaning is more specific than "Secologanin Tryptamine Alkaloids".
This graph shows the total number of publications written about "Secologanin Tryptamine Alkaloids" by people in UAMS Profiles by year, and whether "Secologanin Tryptamine Alkaloids" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 | | 2021 | 2 | 1 | 3 | | 2020 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 |
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Below are the most recent publications written about "Secologanin Tryptamine Alkaloids" by people in Profiles over the past ten years.
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Obeng S, Crowley ML, Mottinelli M, Le?n F, Zuarth Gonzalez JD, Chen Y, Gamez-Jimenez LR, Restrepo LF, Ho NP, Patel A, Martins Rocha J, Alvarez MA, Thadisetti AM, Park CR, Pallares VLC, Milner MJ, Canal CE, Hampson AJ, McCurdy CR, McMahon LR, Wilkerson JL, Hiranita T. The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic a2 receptor activity in vitro and in vivo. Eur J Pharmacol. 2024 Oct 05; 980:176863.
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Kamble SH, Obeng S, Le?n F, Restrepo LF, King TI, Berthold EC, Kanumuri SRR, Gamez-Jimenez LR, Pallares VLC, Patel A, Ho NP, Hampson A, McCurdy CR, McMahon LR, Wilkerson JL, Sharma A, Hiranita T. Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats. J Pharmacol Exp Ther. 2023 06; 385(3):180-192.
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Obeng S, Leon F, Patel A, Zuarth Gonzalez JD, Chaves Da Silva L, Restrepo LF, Gamez-Jimenez LR, Ho NP, Guerrero Calvache MP, Pallares VLC, Helmes JA, Shiomitsu SK, Soto PL, McCurdy CR, McMahon LR, Wilkerson JL, Hiranita T. Interactive Effects of ?-Opioid and Adrenergic-a2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine. J Pharmacol Exp Ther. 2022 12; 383(3):182-198.
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Berthold EC, Kamble SH, Raju KS, Kuntz MA, Senetra AS, Mottinelli M, Le?n F, Restrepo LF, Patel A, Ho NP, Hiranita T, Sharma A, McMahon LR, McCurdy CR. The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study. Drug Metab Dispos. 2022 02; 50(2):158-167.
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Le?n F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londo?o C, Hiranita T, Sharma A, Hampson AJ, Canal CE, McMahon LR, McCurdy CR. Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors. J Med Chem. 2021 09 23; 64(18):13510-13523.
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Chear NJ, Le?n F, Sharma A, Kanumuri SRR, Zwolinski G, Abboud KA, Singh D, Restrepo LF, Patel A, Hiranita T, Ramanathan S, Hampson AJ, McMahon LR, McCurdy CR. Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors. J Nat Prod. 2021 04 23; 84(4):1034-1043.
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Obeng S, Wilkerson JL, Le?n F, Reeves ME, Restrepo LF, Gamez-Jimenez LR, Patel A, Pennington AE, Taylor VA, Ho NP, Braun T, Fortner JD, Crowley ML, Williamson MR, Pallares VLC, Mottinelli M, Lopera-Londo?o C, McCurdy CR, McMahon LR, Hiranita T. Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for ?-Opioid Receptor and Opioid-Like Behavioral Effects in Rats. J Pharmacol Exp Ther. 2021 03; 376(3):410-427.
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Behnood-Rod A, Chellian R, Wilson R, Hiranita T, Sharma A, Leon F, McCurdy CR, McMahon LR, Bruijnzeel AW. Evaluation of the rewarding effects of mitragynine and 7-hydroxymitragynine in an intracranial self-stimulation procedure in male and female rats. Drug Alcohol Depend. 2020 10 01; 215:108235.
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Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear NJ, Ramanathan S, Sharma A, Le?n F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids. J Med Chem. 2020 01 09; 63(1):433-439.
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Hiranita T, Leon F, Felix JS, Restrepo LF, Reeves ME, Pennington AE, Obeng S, Avery BA, McCurdy CR, McMahon LR, Wilkerson JL. The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats. Psychopharmacology (Berl). 2019 Sep; 236(9):2725-2734.
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