 Receptors, sigma
"Receptors, sigma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
| Descriptor ID |
D017480
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| MeSH Number(s) |
D12.776.543.750.100.620.775 D12.776.543.750.720.600.610.775 D12.776.543.750.750.555.610.775
|
| Concept/Terms |
Receptors, sigma- Receptors, sigma
- sigma Receptors
- Receptors, sigma Opioid
- Opioid Receptors, sigma
- sigma Opioid Receptors
- Receptors, Opioid, sigma
- sigma Receptor
- Receptor, sigma
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Below are MeSH descriptors whose meaning is more general than "Receptors, sigma".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Opioid [D12.776.543.750.100.620]
- Receptors, sigma [D12.776.543.750.100.620.775]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Opioid [D12.776.543.750.720.600.610]
- Receptors, sigma [D12.776.543.750.720.600.610.775]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Opioid [D12.776.543.750.750.555.610]
- Receptors, sigma [D12.776.543.750.750.555.610.775]
Below are MeSH descriptors whose meaning is more specific than "Receptors, sigma".
This graph shows the total number of publications written about "Receptors, sigma" by people in UAMS Profiles by year, and whether "Receptors, sigma" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 2 | 0 | 2 | | 2017 | 3 | 0 | 3 | | 2016 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2011 | 3 | 0 | 3 | | 2010 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1991 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptors, sigma" by people in Profiles over the past ten years.
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Hiranita T, Li SM, Katz JL. Effects of Dual Inhibition at Dopamine Transporter and s Receptors in the Discriminative-Stimulus Effects of Cocaine in Male Rats. J Pharmacol Exp Ther. 2024 Oct 18; 391(2):308-316.
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Hersey M, Mereu M, Jones CS, Bartole MK, Chen AY, Cao J, Hiranita T, Chun LE, Lopez JP, Katz JL, Newman AH, Tanda G. Dual DAT and sigma receptor inhibitors attenuate cocaine effects on nucleus accumbens dopamine dynamics in rats. Eur J Neurosci. 2024 May; 59(10):2436-2449.
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Hong WC, Yano H, Hiranita T, Chin FT, McCurdy CR, Su TP, Amara SG, Katz JL. The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. J Biol Chem. 2017 07 07; 292(27):11250-11261.
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Hiranita T, Hong WC, Kopajtic T, Katz JL. s Receptor Effects of N-Substituted Benztropine Analogs: Implications for Antagonism of Cocaine Self-Administration. J Pharmacol Exp Ther. 2017 07; 362(1):2-13.
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Katz JL, Hiranita T, Hong WC, Job MO, McCurdy CR. A Role for Sigma Receptors in Stimulant Self-Administration and Addiction. Handb Exp Pharmacol. 2017; 244:177-218.
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Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR. Blockade of Cocaine or s Receptor Agonist Self Administration by Subtype-Selective s Receptor Antagonists. J Pharmacol Exp Ther. 2016 07; 358(1):109-24.
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Katz JL, Hong WC, Hiranita T, Su TP. A role for sigma receptors in stimulant self-administration and addiction. Behav Pharmacol. 2016 Apr; 27(2-3 Spec Issue):100-15.
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