 Amyloid beta-Protein Precursor
"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
| Descriptor ID |
D016564
|
| MeSH Number(s) |
D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
|
| Concept/Terms |
Amyloid beta-Protein Precursor- Amyloid beta-Protein Precursor
- Amyloid beta Protein Precursor
- beta-Protein Precursor, Amyloid
- Amyloid beta Precursor Protein
- Protease Nexin II
- Nexin II, Protease
- beta-Amyloid Protein Precursor
- beta Amyloid Protein Precursor
- Protease Nexin 2
- Nexin 2, Protease
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
|
Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".
Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".
This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in UAMS Profiles by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 | | 2010 | 2 | 0 | 2 | | 2009 | 1 | 0 | 1 | | 2008 | 2 | 0 | 2 | | 2007 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2001 | 1 | 1 | 2 | | 1996 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles over the past ten years.
-
Cohen BM, Sonntag KC. Identifying the earliest-occurring clinically targetable precursors of late-onset Alzheimer's disease. EBioMedicine. 2024 Aug; 106:105238.
-
Gendron WH, Fertan E, Roddick KM, Wong AA, Maliougina M, Hiani YE, Anini Y, Brown RE. Intranasal insulin treatment ameliorates spatial memory, muscular strength, and frailty deficits in 5xFAD mice. Physiol Behav. 2024 Jul 01; 281:114583.
-
Reddy PH, Kshirsagar S, Bose C, Pradeepkiran JA, Hindle A, Singh SP, Reddy AP. Rlip overexpression reduces oxidative stress and mitochondrial dysfunction in Alzheimer's disease: Mechanistic insights. Biochim Biophys Acta Mol Basis Dis. 2023 10; 1869(7):166759.
-
O'Leary TP, Brown RE. Visuo-spatial learning and memory impairments in the 5xFAD mouse model of Alzheimer's disease: Effects of age, sex, albinism, and motor impairments. Genes Brain Behav. 2022 04; 21(4):e12794.
-
Vijayan M, Bose C, Reddy PH. Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer's disease. Mitochondrion. 2021 07; 59:17-29.
-
Fertan E, Wong AA, Vienneau NA, Brown RE. Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb-Williams maze. Behav Brain Res. 2019 09 16; 370:111937.
-
G?r E, Fertan E, Kosel F, Wong AA, Balci F, Brown RE. Sex differences in the timing behavior performance of 3xTg-AD and wild-type mice in the peak interval procedure. Behav Brain Res. 2019 03 15; 360:235-243.
-
Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab. 2019 01 01; 316(1):E106-E120.
-
Wang W, Bodles-Brakhop AM, Barger SW. A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid ? -Peptide from the Brain. Curr Alzheimer Res. 2016; 13(6):615-20.
-
Deng J, Habib A, Obregon DF, Barger SW, Giunta B, Wang YJ, Hou H, Sawmiller D, Tan J. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3? signaling pathway. J Neurochem. 2015 Nov; 135(3):630-7.
-
Howell MD, Bailey LA, Cozart MA, Gannon BM, Gottschall PE. Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice. Acta Neuropathol Commun. 2015 Sep 04; 3:54.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|