 Microglia
"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
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| MeSH Number(s) |
A08.637.400 A11.650.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in UAMS Profiles by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 0 | 1 | 1 | | 2023 | 2 | 0 | 2 | | 2022 | 3 | 2 | 5 | | 2021 | 2 | 3 | 5 | | 2020 | 4 | 2 | 6 | | 2019 | 1 | 1 | 2 | | 2018 | 2 | 1 | 3 | | 2017 | 1 | 2 | 3 | | 2016 | 3 | 2 | 5 | | 2015 | 3 | 1 | 4 | | 2014 | 1 | 4 | 5 | | 2013 | 4 | 1 | 5 | | 2012 | 4 | 5 | 9 | | 2011 | 3 | 0 | 3 | | 2010 | 2 | 0 | 2 | | 2009 | 1 | 1 | 2 | | 2008 | 0 | 2 | 2 | | 2007 | 5 | 0 | 5 | | 2006 | 6 | 0 | 6 | | 2005 | 12 | 1 | 13 | | 2004 | 2 | 5 | 7 | | 2003 | 4 | 2 | 6 | | 2002 | 1 | 2 | 3 | | 2001 | 2 | 0 | 2 | | 2000 | 3 | 0 | 3 | | 1998 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1995 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Microglia" by people in Profiles over the past ten years.
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Cealie MY, Douglas JC, Swan HK, Vonkaenel ED, McCall MN, Drew PD, Majewska AK. Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum. Cells. 2024 Feb 23; 13(5).
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Gajewski MP, Barger SW. Design, synthesis, and characterization of novel system xC- transport inhibitors: inhibition of microglial glutamate release and neurotoxicity. J Neuroinflammation. 2023 Dec 06; 20(1):292.
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Tsujikawa S, DeMeulenaere KE, Centeno MV, Ghazisaeidi S, Martin ME, Tapies MR, Maneshi MM, Yamashita M, Stauderman KA, Apkarian AV, Salter MW, Prakriya M. Regulation of neuropathic pain by microglial Orai1 channels. Sci Adv. 2023 01 27; 9(4):eade7002.
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Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Br?ne B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, Gonz?lez B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 11 02; 110(21):3458-3483.
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Gomez-Arboledas A, Carvalho K, Balderrama-Gutierrez G, Chu SH, Liang HY, Schartz ND, Selvan P, Petrisko TJ, Pan MA, Mortazavi A, Tenner AJ. C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2022 Aug 17; 10(1):116.
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Carvalho K, Schartz ND, Balderrama-Gutierrez G, Liang HY, Chu SH, Selvan P, Gomez-Arboledas A, Petrisko TJ, Fonseca MI, Mortazavi A, Tenner AJ. Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression. J Neuroinflammation. 2022 Jul 11; 19(1):178.
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Tu Y, Muley MM, Beggs S, Salter MW. Microglia-independent peripheral neuropathic pain in male and female mice. Pain. 2022 11 01; 163(11):e1129-e1144.
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Tansley S, Uttam S, Ure?a Guzm?n A, Yaqubi M, Pacis A, Parisien M, Deamond H, Wong C, Rabau O, Brown N, Haglund L, Ouellet J, Santaguida C, Ribeiro-da-Silva A, Tahmasebi S, Prager-Khoutorsky M, Ragoussis J, Zhang J, Salter MW, Diatchenko L, Healy LM, Mogil JS, Khoutorsky A. Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nat Commun. 2022 02 11; 13(1):843.
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Niedzwiedz-Massey VM, Douglas JC, Rafferty T, Wight PA, Kane CJM, Drew PD. Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders. Neurotoxicol Teratol. 2021 Sep-Oct; 87:107015.
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Zhang Y, Yan Y, Meng J, Girotra M, Ramakrishnan S, Roy S. Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids. Mucosal Immunol. 2021 07; 14(4):887-898.
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Candadai AA, Liu F, Fouda AY, Alfarhan M, Palani CD, Xu Z, Caldwell RB, Narayanan SP. Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis. PLoS One. 2021; 16(3):e0247901.
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Lowery RL, Cealie MY, Lamantia CE, Mendes MS, Drew PD, Majewska AK. Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure. J Neurosci Res. 2021 08; 99(8):2008-2025.
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Kane CJM, Douglas JC, Rafferty T, Johnson JW, Niedzwiedz-Massey VM, Phelan KD, Majewska AK, Drew PD. Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders. J Neurosci Res. 2021 08; 99(8):1986-2007.
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Tam TH, Salter MW. Purinergic signalling in spinal pain processing. Purinergic Signal. 2021 03; 17(1):49-54.
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Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, Gonzalez SZ, Guan Y, Cohen BM, McPhie DL, Coyle JT, Lanz TA, Xi HS, Yin C, Huang W, Kim HY, Chung S. Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nat Neurosci. 2020 11; 23(11):1352-1364.
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Kane CJM, Drew PD. Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders. J Neurosci Res. 2021 08; 99(8):1973-1985.
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Fouda AY, Xu Z, Narayanan SP, Caldwell RW, Caldwell RB. Utility of LysM-cre and Cdh5-cre Driver Mice in Retinal and Brain Research: An Imaging Study Using tdTomato Reporter Mouse. Invest Ophthalmol Vis Sci. 2020 03 09; 61(3):51.
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Halievski K, Ghazisaeidi S, Salter MW. Sex-Dependent Mechanisms of Chronic Pain: A Focus on Microglia and P2X4R. J Pharmacol Exp Ther. 2020 10; 375(1):202-209.
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Aghaie CI, Hausknecht KA, Wang R, Dezfuli PH, Haj-Dahmane S, Kane CJM, Sigurdson WJ, Shen RY. Prenatal Ethanol Exposure and Postnatal Environmental Intervention Alter Dopaminergic Neuron and Microglia Morphology in the Ventral Tegmental Area During Adulthood. Alcohol Clin Exp Res. 2020 02; 44(2):435-444.
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Palani CD, Fouda AY, Liu F, Xu Z, Mohamed E, Giri S, Smith SB, Caldwell RB, Narayanan SP. Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2019 Dec; 56(12):8589-8602.
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Moriarty O, Tu Y, Sengar AS, Salter MW, Beggs S, Walker SM. Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats. J Neurosci. 2019 04 17; 39(16):3081-3093.
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Walters JL, Zhang X, Talpos JC, Fogle CM, Li M, Chelonis JJ, Paule MG. Sevoflurane exposure has minimal effect on cognitive function and does not alter microglial activation in adult monkeys. Neurotoxicology. 2019 03; 71:159-167.
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Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab. 2019 01 01; 316(1):E106-E120.
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Mapplebeck JCS, Dalgarno R, Tu Y, Moriarty O, Beggs S, Kwok CHT, Halievski K, Assi S, Mogil JS, Trang T, Salter MW. Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats. Pain. 2018 Sep; 159(9):1752-1763.
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Jevtic S, Sengar AS, Salter MW, McLaurin J. The role of the immune system in Alzheimer disease: Etiology and treatment. Ageing Res Rev. 2017 Nov; 40:84-94.
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Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med. 2017 Sep 08; 23(9):1018-1027.
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Mapplebeck JC, Beggs S, Salter MW. Molecules in pain and sex: a developing story. Mol Brain. 2017 03 07; 10(1):9.
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Masuda T, Ozono Y, Mikuriya S, Kohro Y, Tozaki-Saitoh H, Iwatsuki K, Uneyama H, Ichikawa R, Salter MW, Tsuda M, Inoue K. Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain. Nat Commun. 2016 08 12; 7:12529.
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Kane CJ, Drew PD. Inflammatory responses to alcohol in the CNS: nuclear receptors as potential therapeutics for alcohol-induced neuropathologies. J Leukoc Biol. 2016 11; 100(5):951-959.
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Beggs S, Salter MW. SnapShot: Microglia in Disease. Cell. 2016 May 19; 165(5):1294-1294.e1.
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Schartz ND, Herr SA, Madsen L, Butts SJ, Torres C, Mendez LB, Brewster AL. Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus. Sci Rep. 2016 05 04; 6:24988.
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Mapplebeck JCS, Beggs S, Salter MW. Sex differences in pain: a tale of two immune cells. Pain. 2016 Feb; 157 Suppl 1:S2-S6.
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Jalin AM, Rajasekaran M, Prather PL, Kwon JS, Gajulapati V, Choi Y, Kim C, Pahk K, Ju C, Kim WK. Non-Selective Cannabinoid Receptor Antagonists, Hinokiresinols Reduce Infiltration of Microglia/Macrophages into Ischemic Brain Lesions in Rat via Modulating 2-Arachidonolyglycerol-Induced Migration and Mitochondrial Activity. PLoS One. 2015; 10(10):e0141600.
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Gu YH, Kanazawa M, Hung SY, Wang X, Fukuda S, Koziol JA, Del Zoppo GJ. Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia. J Cereb Blood Flow Metab. 2015 Nov; 35(11):1888-900.
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Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci. 2015 Aug; 18(8):1081-3.
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Drew PD, Johnson JW, Douglas JC, Phelan KD, Kane CJ. Pioglitazone blocks ethanol induction of microglial activation and immune responses in the hippocampus, cerebellum, and cerebral cortex in a mouse model of fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2015 Mar; 39(3):445-54.
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Kemp SWP, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH. Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury. Neuroscience. 2015 Jan 22; 284:202-216.
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Sarkar S, Chigurupati S, Raymick J, Mann D, Bowyer JF, Schmitt T, Beger RD, Hanig JP, Schmued LC, Paule MG. Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model. Neurotoxicology. 2014 Sep; 44:250-62.
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Salter MW, Beggs S. Sublime microglia: expanding roles for the guardians of the CNS. Cell. 2014 Jul 03; 158(1):15-24.
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