 Actins
"Actins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
| Descriptor ID |
D000199
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| MeSH Number(s) |
D05.750.078.730.250 D12.776.210.500.100 D12.776.220.525.255
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Actins".
Below are MeSH descriptors whose meaning is more specific than "Actins".
This graph shows the total number of publications written about "Actins" by people in UAMS Profiles by year, and whether "Actins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2022 | 2 | 0 | 2 | | 2021 | 0 | 2 | 2 | | 2020 | 1 | 1 | 2 | | 2019 | 2 | 1 | 3 | | 2018 | 0 | 2 | 2 | | 2017 | 1 | 0 | 1 | | 2016 | 1 | 4 | 5 | | 2015 | 1 | 0 | 1 | | 2014 | 0 | 3 | 3 | | 2013 | 2 | 5 | 7 | | 2012 | 3 | 1 | 4 | | 2011 | 1 | 5 | 6 | | 2010 | 1 | 4 | 5 | | 2008 | 0 | 3 | 3 | | 2007 | 0 | 6 | 6 | | 2006 | 0 | 3 | 3 | | 2005 | 1 | 2 | 3 | | 2004 | 0 | 2 | 2 | | 2003 | 1 | 6 | 7 | | 2002 | 0 | 1 | 1 | | 2001 | 1 | 1 | 2 | | 2000 | 1 | 1 | 2 | | 1999 | 1 | 1 | 2 | | 1998 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1993 | 0 | 2 | 2 | | 1991 | 1 | 1 | 2 | | 1990 | 0 | 1 | 1 |
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Below are the most recent publications written about "Actins" by people in Profiles over the past ten years.
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Liu J, Lu F, Ithychanda SS, Apostol M, Das M, Deshpande G, Plow EF, Qin J. A mechanism of platelet integrin aIIb?3 outside-in signaling through a novel integrin aIIb subunit-filamin-actin linkage. Blood. 2023 05 25; 141(21):2629-2641.
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Patyal P, Nguyen B, Zhang X, Azhar G, Ameer FS, Verma A, Crane J, Kc G, Che Y, Wei JY. Rho/SRF Inhibitor Modulates Mitochondrial Functions. Int J Mol Sci. 2022 Sep 29; 23(19).
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Mondal C, Gacha-Garay MJ, Larkin KA, Adikes RC, Di Martino JS, Chien CC, Fraser M, Eni-Aganga I, Agullo-Pascual E, Cialowicz K, Ozbek U, Naba A, Gaitas A, Fu TM, Upadhyayula S, Betzig E, Matus DQ, Martin BL, Bravo-Cordero JJ. A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-?2 signaling. Cell Rep. 2022 09 20; 40(12):111358.
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Rollins BT, Cassarino DS, Lindberg M. Primary cutaneous epithelioid mesenchymal neoplasm with ACTB-GLI1 fusion: a case report. J Cutan Pathol. 2022 Mar; 49(3):284-287.
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Mehdi SJ, Moerman-Herzog A, Wong HK. Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma. BMC Cancer. 2021 May 03; 21(1):492.
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Limzerwala JF, Jeganathan KB, Kloeber JA, Davies BA, Zhang C, Sturmlechner I, Zhong J, Fierro Velasco R, Fields AP, Yuan Y, Baker DJ, Zhou D, Li H, Katzmann DJ, van Deursen JM. FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer. Nat Cancer. 2020 10; 1(10):1010-1024.
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Zhang H, Ramsey A, Xiao Y, Karki U, Xie JY, Xu J, Kelly T, Ono S, Zhou GL. Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion. Mol Cell Biol. 2020 01 30; 40(4).
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Assia Batzir N, Kishor Bhagwat P, Larson A, Coban Akdemir Z, Baglaj M, Bofferding L, Bosanko KB, Bouassida S, Callewaert B, Cannon A, Enchautegui Colon Y, Garnica AD, Harr MH, Heck S, Hurst ACE, Jhangiani SN, Isidor B, Littlejohn RO, Liu P, Magoulas P, Mar Fan H, Marom R, McLean S, Nezarati MM, Nugent KM, Petersen MB, Rocha ML, Roeder E, Smigiel R, Tully I, Weisfeld-Adams J, Wells KO, Posey JE, Lupski JR, Beaudet AL, Wangler MF. Recurrent arginine substitutions in the ACTG2 gene are the primary driver of disease burden and severity in visceral myopathy. Hum Mutat. 2020 03; 41(3):641-654.
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Eubanks HB, Lavoie EG, Goree J, Kamykowski JA, Gokden N, Fausther M, Dranoff JA. Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells. Gene Expr. 2020 06 12; 20(1):25-37.
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Urbano FJ, Bisagno V, Garcia-Rill E. Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications. Am J Physiol Cell Physiol. 2020 02 01; 318(2):C282-C288.
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Kiaei M, Balasubramaniam M, Govind Kumar V, Shmookler Reis RJ, Moradi M, Varughese KI. ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation. Sci Rep. 2018 08 30; 8(1):13102.
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Renshaw H, Vargas-Mu?iz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. J Cell Sci. 2018 02 07; 131(3).
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Williams ED, Rogers SC, Zhang X, Azhar G, Wei JY. p49/STRAP, a Serum Response Factor Binding Protein (SRFBP1), Is Involved in the Redistribution of Cytoskeletal F-Actin Proteins during Glucose Deprivation. J Nutr Health Aging. 2017; 21(10):1142-1150.
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Alkam D, Feldman EZ, Singh A, Kiaei M. Profilin1 biology and its mutation, actin(g) in disease. Cell Mol Life Sci. 2017 03; 74(6):967-981.
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Wang XW, Zhang FX, Yang F, Ding ZF, Agarwal N, Guo ZK, Mehta JL. Effects of linagliptin and liraglutide on glucose- and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro. Acta Pharmacol Sin. 2016 Sep; 37(10):1349-1358.
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Roche PL, Nagalingam RS, Bagchi RA, Aroutiounova N, Belisle BM, Wigle JT, Czubryt MP. Role of scleraxis in mechanical stretch-mediated regulation of cardiac myofibroblast phenotype. Am J Physiol Cell Physiol. 2016 08 01; 311(2):C297-307.
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Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD. Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. Int J Mol Sci. 2016 May 18; 17(5).
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Bagchi RA, Roche P, Aroutiounova N, Espira L, Abrenica B, Schweitzer R, Czubryt MP. The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype. BMC Biol. 2016 Mar 17; 14:21.
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Manzano M, Forte E, Raja AN, Schipma MJ, Gottwein E. Divergent target recognition by coexpressed 5'-isomiRs of miR-142-3p and selective viral mimicry. RNA. 2015 Sep; 21(9):1606-20.
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Ronis MJ, Mercer KE, Gannon B, Engi B, Zimniak P, Shearn CT, Orlicky DJ, Albano E, Badger TM, Petersen DR. Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-a double knockout mice enhance injury during early stages of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 01; 308(5):G403-15.
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Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nat Commun. 2014 Oct 03; 5:5092.
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Zhang H, Okamoto M, Panzhinskiy E, Zawada WM, Das M. PKCd/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells. Am J Physiol Cell Physiol. 2014 Apr 01; 306(7):C648-58.
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