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Search Results to Michael Birrer

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One or more keywords matched the following items that are connected to Birrer, Michael

Item TypeName
Academic Article Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer.
Academic Article Regulation of tumor angiogenesis by EZH2.
Academic Article The c-Jun NH(2)-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine.
Concept Protein Kinase C
Concept Protein Kinases
Concept Protein-Tyrosine Kinases
Concept HMGA1a Protein
Concept Protein Processing, Post-Translational
Concept BRCA1 Protein
Concept cdc42 GTP-Binding Protein
Concept Mitogen-Activated Protein Kinase 9
Concept Cyclic AMP Response Element-Binding Protein
Concept Early Growth Response Protein 1
Concept Protein Binding
Concept Receptor Protein-Tyrosine Kinases
Concept Protein Transport
Concept Mitogen-Activated Protein Kinase 3
Concept Tumor Suppressor Protein p53
Concept bcl-X Protein
Concept Protein Phosphatase 1
Concept Oncogene Protein p21(ras)
Concept Amyloid Precursor Protein Secretases
Concept JNK Mitogen-Activated Protein Kinases
Concept BRCA2 Protein
Concept Protein Biosynthesis
Concept Protein Tyrosine Phosphatases
Concept Mitogen-Activated Protein Kinase Kinases
Concept Protein Kinase Inhibitors
Concept Retinoblastoma Protein
Concept Mitogen-Activated Protein Kinase 1
Concept Protein Structure, Tertiary
Concept Protein Prenylation
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Mitogen-Activated Protein Kinases
Concept Insulin-Like Growth Factor Binding Protein 3
Concept Focal Adhesion Protein-Tyrosine Kinases
Concept Protein Isoforms
Concept p38 Mitogen-Activated Protein Kinases
Academic Article Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Academic Article Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.
Academic Article p75-Ras-GRF1 is a c-Jun/AP-1 target protein: its up regulation results in increased Ras activity and is necessary for c-Jun-induced nonadherent growth of Rat1a cells.
Academic Article Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence.
Academic Article Targeting the Nuclear Import Receptor Kpnß1 as an Anticancer Therapeutic.
Academic Article Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma.
Academic Article Tumor mutational analysis of GOG248, a phase II study of temsirolimus or temsirolimus and alternating megestrol acetate and tamoxifen for advanced endometrial cancer (EC): An NRG Oncology/Gynecologic Oncology Group study.
Academic Article Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.
Academic Article ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.
Academic Article Overexpression of enhance of Zeste homolog 2 (EZH2) in endometrial carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.
Academic Article Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip.
Academic Article Better therapeutic trials in ovarian cancer.
Academic Article Calcineurin activates cytoglobin transcription in hypoxic myocytes.
Academic Article Complete Remission Following Pembrolizumab in a Woman with Mismatch Repair-Deficient Endometrial Cancer and a Germline BRCA1 Mutation.
Academic Article A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer.
Academic Article NORE1A tumor suppressor candidate modulates p21CIP1 via p53.
Academic Article Novel therapeutic targets.
Academic Article Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth.
Academic Article Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.
Academic Article EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.
Academic Article Prognostically relevant gene signatures of high-grade serous ovarian carcinoma.
Academic Article Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-arm, phase 2 study.
Academic Article Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinoma.
Academic Article Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors.
Academic Article A link between histone deacetylase inhibitors and NF- kappaB signaling.
Academic Article TGF-ß modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment.
Academic Article Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.
Academic Article Spleen Tyrosine Kinase Confers Paclitaxel Resistance in Ovarian Cancer.
Academic Article Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-Jun.
Academic Article Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer.
Academic Article Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis.
Academic Article Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.
Academic Article Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.
Academic Article Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.
Academic Article Cyclin E amplification and overexpression in clear cell adenocarcinoma of the ovary.
Academic Article RRP22 is a farnesylated, nucleolar, Ras-related protein with tumor suppressor potential.
Academic Article Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study.
Academic Article A randomized phase II non-comparative study of PF-04691502 and gedatolisib (PF-05212384) in patients with recurrent endometrial cancer.
Academic Article CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.
Academic Article EMR 20006-012: A phase II randomized double-blind placebo controlled trial comparing the combination of pimasertib (MEK inhibitor) with SAR245409 (PI3K inhibitor) to pimasertib alone in patients with previously treated unresectable borderline or low grade ovarian cancer.
Academic Article Common variation in Nemo-like kinase is associated with risk of ovarian cancer.
Academic Article Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancer.
Academic Article Retinoblastoma protein-mediated apoptosis after gamma-irradiation.
Academic Article CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.
Academic Article The regulation of tumor suppressor genes by oncogenes.
Academic Article SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK.
Academic Article MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells.
Academic Article Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.
Academic Article Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial.
Academic Article ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.
Academic Article HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells.
Academic Article Comparison of expression profiles in ovarian epithelium in vivo and ovarian cancer identifies novel candidate genes involved in disease pathogenesis.
Academic Article Reactive oxygen species mediated apoptosis of esophageal cancer cells induced by marine triprenyl toluquinones and toluhydroquinones.
Academic Article Activator protein-1 contributes to high NaCl-induced increase in tonicity-responsive enhancer/osmotic response element-binding protein transactivating activity.
Academic Article Cell cycle and related protein.
Academic Article p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts.
Grant Proteomic, Genomic, and Longitudinal Pathways to Ovarian Cancer Biomarker Discovery
Grant The Use of Transcriptional Factors as Targets and Agents in Carcinogenesis
Grant Proteogenomic studies aimed at understanding ovarian tumor responses to agents targeting the DNA damage response and translating this knowledge into clinical benefit
Academic Article Regions within the c-Myc protein that are necessary for transformation are also required for inhibition of differentiation of murine erythroleukemia cells.
Academic Article A complex pattern of translational initiation and phosphorylation in L-myc proteins.
Academic Article Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73.
Academic Article Transcription factors and recessive oncogenes in the pathogenesis of human lung cancer.
Academic Article p53: a frequent target for genetic abnormalities in lung cancer.
Academic Article The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs.
Academic Article Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant.
Academic Article Initiators and promoters of lung cancer.
Academic Article Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.
Academic Article Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67).
Academic Article Molecular characterization of adenocarcinoma of the cervix.
Academic Article Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
Academic Article AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells.
Academic Article Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells.
Academic Article RRR-alpha-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA-MB-435 breast cancer cells.
Academic Article JunB forms the majority of the AP-1 complex and is a target for redox regulation by receptor tyrosine kinase and G protein-coupled receptor agonists in smooth muscle cells.
Academic Article Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
Academic Article Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun.
Academic Article Mechanism of action of a dominant-negative mutant of c-Jun.
Academic Article Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation.
Academic Article Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene.
Academic Article Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.
Academic Article The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.
Academic Article The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin.
Academic Article Breast cancer cells have lower activating protein 1 transcription factor activity than normal mammary epithelial cells.
Academic Article Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells.
Academic Article The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Academic Article Tumor necrosis factor alpha gene regulation: enhancement of C/EBPbeta-induced activation by c-Jun.
Academic Article The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity.
Academic Article Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues.
Academic Article Expression of human papilloma virus E7 protein causes apoptosis and inhibits DNA synthesis in primary hepatocytes via increased expression of p21(Cip-1/WAF1/MDA6).
Academic Article Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway.
Academic Article Activator protein-1 mediates induced but not basal epidermal growth factor receptor gene expression.
Academic Article p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
Academic Article Endocervical cancer is associated with an increase in the ligands and receptors for transforming growth factor-beta and a contrasting decrease in p27(Kip1).
Academic Article Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint.
Academic Article TNF-alpha gene expression in macrophages: regulation by NF-kappa B is independent of c-Jun or C/EBP beta.
Academic Article Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis.
Academic Article c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase.
Academic Article Abnormal fragile histidine triad (FHIT) expression in advanced cervical carcinoma: a poor prognostic factor.
Academic Article In situ detection of unexpected patterns of mutant p53 gene expression in non-small cell lung cancers.
Academic Article Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.
Academic Article BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study.
Academic Article FOXO3a loss is a frequent early event in high-grade pelvic serous carcinogenesis.
Academic Article Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer.
Academic Article Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancer.

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  • Protein C