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Melda Onal

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Cell Biology, College of Medicine
DivisionPhysiology & Cell Biology Faculty
Address200 South Cedar
Mail Slot # 505
Little Rock AR 72202
Phone501-320-7682
ORCID ORCID Icon0000-0002-5804-495X Additional info
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    Collapse Research 
    Collapse research activities and funding
    2P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jun 30, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Principal Investigator
    P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Principal Investigator
    R21AR076575     (ONAL, MELDA)Jan 1, 2020 - Dec 31, 2021
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    CRISPR inhibition as an alternate for Cre-loxP
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Resende-Coelho A, Ali MM, James A, Warren A, Gatrell L, Kadhim I, Fu Q, Xiong J, Onal M, Almeida M. Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness. Aging (Albany NY). 2025 Mar 18; 17(3):610-629. PMID: 40105873.
      View in: PubMed
    2. Dimori M, Toulany M, Sultana LS, Onal M, Thostenson JD, Carroll JL, O'Brien CA, Morello R. A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta. J Bone Miner Res. 2024 Dec 31; 40(1):114-124. PMID: 39566076.
      View in: PubMed
    3. James A, Hendrixson J, Kadhim I, Marques-Carvalho A, Laster J, Crawford J, Thostenson J, Sato A, Almeida M, Onal M. CRISPR activation of Tfeb , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength. bioRxiv. 2024 Sep 26. PMID: 39386619.
      View in: PubMed
    4. Nookaew I, Xiong J, Onal M, Bustamante-Gomez C, Wanchai V, Fu Q, Kim HN, Almeida M, O'Brien CA. Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone. J Biol Chem. 2024 04; 300(4):107158. PMID: 38479598.
      View in: PubMed
    5. Hendrixson JA, James A, Akel NS, Laster DJ, Crawford JA, Berryhill SB, Onal M. Loss of chaperone-mediated autophagy does not alter age-related bone loss in male mice. FASEB Bioadv. 2024 Mar; 6(3):73-84. PMID: 38463697.
      View in: PubMed
    6. Nookaew I, Xiong J, Onal M, Bustamante-Gomez C, Wanchai V, Fu Q, Kim HN, Almeida M, O'Brien CA. A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone. bioRxiv. 2023 Nov 17. PMID: 38014179.
      View in: PubMed
    7. Laster DJ, Akel NS, Hendrixson JA, James A, Crawford JA, Fu Q, Berryhill SB, Thostenson JD, Nookaew I, O'Brien CA, Onal M. CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system. iScience. 2023 Aug 18; 26(8):107428. PMID: 37575184.
      View in: PubMed
    8. Cassidy A, Onal M, Pelletier S. Novel methods for the generation of genetically engineered animal models. Bone. 2023 02; 167:116612. PMID: 36379415.
      View in: PubMed
    9. Akel N, MacLeod RS, Berryhill SB, Laster DJ, Dimori M, Crawford JA, Fu Q, Onal M. Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass. Sci Rep. 2022 02 24; 12(1):3134. PMID: 35210514.
      View in: PubMed
    10. MacLeod RS, Meyer MB, Xiong J, Cawley KM, Liu Y, Onal M, Benkusky NA, Thostenson JD, Pike JW, O'Brien CA. Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLoS One. 2021; 16(5):e0250974. PMID: 33970941.
      View in: PubMed
    11. Lee SM, Carlson AH, Onal M, Benkusky NA, Meyer MB, Pike JW. A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In Vivo. Endocrinology. 2019 12 01; 160(12):2877-2891. PMID: 31599948.
      View in: PubMed
    12. MacLeod RS, Cawley KM, Gubrij I, Nookaew I, Onal M, O'Brien CA. Effective CRISPR interference of an endogenous gene via a single transgene in mice. Sci Rep. 2019 Nov 21; 9(1):17312. PMID: 31754144.
      View in: PubMed
    13. Onal M, Carlson AH, Thostenson JD, Benkusky NA, Meyer MB, Lee SM, Pike JW. A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene. JBMR Plus. 2018 Jan; 2(1):32-47. PMID: 29527594.
      View in: PubMed
    14. Meyer MB, Benkusky NA, Kaufmann M, Lee SM, Onal M, Jones G, Pike JW. A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation. J Biol Chem. 2017 10 20; 292(42):17541-17558. PMID: 28808057.
      View in: PubMed
    15. Shamsuzzaman S, Onal M, St John HC, Pike JW. Deletion of a Distal RANKL Gene Enhancer Delays Progression of Atherosclerotic Plaque Calcification in Hypercholesterolemic Mice. J Cell Biochem. 2017 12; 118(12):4240-4253. PMID: 28419519.
      View in: PubMed
    16. Pike JW, Meyer MB, Lee SM, Onal M, Benkusky NA. The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest. 2017 Apr 03; 127(4):1146-1154. PMID: 28240603.
      View in: PubMed
    17. Shamsuzzaman S, Onal M, St John HC, Jeffery JJ, Pike JW. Absence of the Vitamin D Receptor Inhibits Atherosclerotic Plaque Calcification in Female Hypercholesterolemic Mice. J Cell Biochem. 2017 05; 118(5):1050-1064. PMID: 27567005.
      View in: PubMed
    18. Piemontese M, Onal M, Xiong J, Han L, Thostenson JD, Almeida M, O'Brien CA. Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage. Sci Rep. 2016 Apr 11; 6:24262. PMID: 27064143.
      View in: PubMed
    19. Onal M, St John HC, Danielson AL, Pike JW. Deletion of the Distal Tnfsf11 RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice. J Bone Miner Res. 2016 Feb; 31(2):416-29. PMID: 26332516.
      View in: PubMed
    20. Pike JW, Meyer MB, Benkusky NA, Lee SM, St John H, Carlson A, Onal M, Shamsuzzaman S. Genomic Determinants of Vitamin D-Regulated Gene Expression. Vitam Horm. 2016; 100:21-44. PMID: 26827947.
      View in: PubMed
    21. Xiong J, Piemontese M, Onal M, Campbell J, Goellner JJ, Dusevich V, Bonewald L, Manolagas SC, O'Brien CA. Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone. PLoS One. 2015; 10(9):e0138189. PMID: 26393791.
      View in: PubMed
    22. Meyer MB, Benkusky NA, Onal M, Pike JW. Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers. J Steroid Biochem Mol Biol. 2016 11; 164:258-264. PMID: 26348136.
      View in: PubMed
    23. Onal M, Bishop KA, St John HC, Danielson AL, Riley EM, Piemontese M, Xiong J, Goellner JJ, O'Brien CA, Pike JW. A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse. J Bone Miner Res. 2015 May; 30(5):855-68. PMID: 25431114.
      View in: PubMed
    24. Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone. Bone. 2015 Jun; 75:18-26. PMID: 25700544.
      View in: PubMed
    25. Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013 Jun 14; 288(24):17432-40. PMID: 23645674.
      View in: PubMed
    26. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013 Jan; 123(1):394-404. PMID: 23221342.
      View in: PubMed
    27. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012 Aug 24; 287(35):29851-60. PMID: 22782898.
      View in: PubMed
    28. Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, O'Brien CA. The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol Endocrinol. 2012 Feb; 26(2):341-8. PMID: 22207718.
      View in: PubMed
    29. Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA. Matrix-embedded cells control osteoclast formation. Nat Med. 2011 Sep 11; 17(10):1235-41. PMID: 21909103.
      View in: PubMed
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