Jesus Delgado-Calle
Title | Associate Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Physiology & Cell Biology, College of Medicine |
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Address | 325 S. Elm St. Mail Slot # 505 Little Rock AR 72205
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ORCID
| 0000-0002-2083-2774 |
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vCard | Download vCard |
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Director, Bone Imaging Core, Center for Musculoskeletal Disease Research |
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Overview Teaching Research P20GM125503 (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028 NIH/Nat. Inst. of General Medical Sciences Center for Musculoskeletal Disease Research (CMDR) Role: Co-Investigator |
| Seeds of Sciences (Jesus Delgado-Calle)Mar 1, 2023 - Feb 29, 2024 UAMS Cancer Institute haracterization of the Senescent Secretome of the Bone Metastatic Tumor Niche Role: Principle Investigator |
| (Jesus Delgado-Calle)Nov 15, 2022 - Nov 14, 2023 UAMS Musculoskeletal Hub) Role of Extrachromosomal DNA in Bone Role: Principle Investigator |
| R01AR080116 (G. David Roodman)Apr 1, 2022 - Mar 31, 2027 NIH/NIAMS Osteoclast-Osteocyte Interaction's in Paget's Disease. Role: Co-Investigator |
| R01 CA241677 (DELGADO-CALLE, JESUS)Mar 1, 2022 - Feb 28, 2028 NIH/National Institutes of Health - Pass Through: Indiana University Osteoclast-Osteocyte Interaction's in Paget's Disease- Sub with Indiana University Role: Principal Investigator |
| R01 CA241677-03 (DELGADO-CALLE, JESUS)Mar 1, 2022 - Feb 28, 2028 NIH/National Institutes of Health - Pass Through: Indiana University Osteoclast-Osteocyte Interaction's in Paget's Disease- Sub with Indiana University Role: Principal Investigator |
| R01AR080116 (DELGADO-CALLE, JESUS)Feb 22, 2022 - Dec 31, 2026 NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases - Pass Through: Indiana University Osteoclast-Osteocyte Interaction's in Paget's Disease- Sub with Indiana University Role: Principal Investigator |
| (Jesus Delgado-Calle)Sep 1, 2021 - Aug 31, 2023 Arkansas Breast Cancer Research Program Pathological Cross-talk Between Senescent Osteocytes and Breast Cancer Cells in Bone Metastasis. Role: Principle Investigator |
| R37CA251763 (DELGADO-CALLE, JESUS)Sep 1, 2020 - May 31, 2025 NIH/Nat. Cancer Institute Bone-Targeted Therapies to Improve Bone Health and Prevent Relapse in Multiple Myeloma Role: Principal Investigator |
| R37CA251763 (DELGADO-CALLE, JESUS)Sep 1, 2020 - May 31, 2025 NIH Bone-Targeted Therapies to Improve Bone Health and Prevent Relapse in Multiple Myeloma Role: Principal Investigator |
| R01CA241677 (DELGADO-CALLE, JESUS)Jul 1, 2020 - Feb 28, 2025 NIH/Nat. Cancer Institute - Pass Through: Indiana University Manipulating the N-end Rule Protein Degradation Pathway to Build Bone and Decrease Tumor Growth in Multiple Myeloma Bone Disease Role: Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Kaur J, Adhikari M, Sabol HM, Anloague A, Khan S, Kurihara N, Diaz-delCastillo M, Andreasen CM, Barnes CL, Stambough JB, Palmieri M, Reyes-Castro O, Zarrer J, Taipaleenm?ki H, Ambrogini E, Almeida M, O'Brien CA, Nookaw I, Delgado-Calle J. Single-Cell Transcriptomic Analysis Identifies Senescent Osteocytes That Trigger Bone Destruction in Breast Cancer Metastasis. Cancer Res. 2024 Dec 02; 84(23):3936-3952. PMID: 39312185.
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Anloague A, Sabol HM, Kaur J, Khan S, Ashby C, Schinke C, Barnes CL, Alturkmani F, Ambrogini E, Gundesen MT, Lund T, Amstrup AK, Andersen TL, Diaz-delCastillo M, Roodman GD, Bellido T, Delgado-Calle J. Novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma. Haematologica. 2024 Nov 28. PMID: 39605211.
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Sabol HM, Ashby C, Adhikari M, Anloague A, Kaur J, Khan S, Choudhury SR, Schinke C, Palmieri M, Barnes CL, Ambrogini E, Nookaew I, Delgado-Calle J. A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma. Haematologica. 2024 08 01; 109(8):2606-2618. PMID: 38385272.
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Marino S, Petrusca DN, Bishop RT, Anderson JL, Sabol HM, Ashby C, Layer JH, Cesarano A, Dav? UP, Perna F, Delgado-Calle J, Chirgwin JM, Roodman GD. Pharmacologic targeting of the p62 ZZ domain enhances both anti-tumor and bone-anabolic effects of bortezomib in multiple myeloma. Haematologica. 2024 05 01; 109(5):1501-1513. PMID: 37981834.
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Adhikari M, Kaur J, Sabol HM, Anloague A, Khan S, Kurihara N, Diaz-delCastillo M, Andreasen CM, Barnes CL, Stambough JB, Palmieri M, Reyes-Castro O, Ambrogini E, Almeida M, O'Brien CA, Nookaw I, Delgado-Calle J. Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis. Res Sq. 2024 Mar 14. PMID: 38558984.
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Tenshin H, Delgado-Calle J, Windle JJ, Roodman GD, Chirgwin JM, Kurihara N. Osteocytes and Paget's Disease of Bone. Curr Osteoporos Rep. 2024 04; 22(2):266-272. PMID: 38457001.
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Garc?a-S?nchez D, Gonz?lez-Gonz?lez A, ?lvarez-Iglesias I, Dujo-Guti?rrez MD, Bolado-Carrancio A, Certo M, P?rez-N??ez MI, Riancho JA, Rodr?guez-Rey JC, Delgado-Calle J, P?rez-Campo FM. Engineering a Pro-Osteogenic Secretome through the Transient Silencing of the Gene Encoding Secreted Frizzled Related Protein 1. Int J Mol Sci. 2023 Aug 03; 24(15). PMID: 37569774.
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Miyagawa K, Tenshin H, Mulcrone PL, Delgado-Calle J, Subler MA, Windle JJ, Chirgwin JM, Roodman GD, Kurihara N. Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation. JCI Insight. 2023 07 24; 8(14). PMID: 37338990.
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Delgado-Calle J, Roodman GD. Doubling Down on Wnt Signaling to Overcome Myeloma Bone Disease. J Bone Miner Res. 2023 06; 38(6):812-813. PMID: 37277117.
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Anloague A, Delgado-Calle J. Osteocytes: New Kids on the Block for Cancer in Bone Therapy. Cancers (Basel). 2023 May 07; 15(9). PMID: 37174109.
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Schinke C, Weinhold N, Delgado-Calle J. Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy. Front Oncol. 2023; 13:1157555. PMID: 36895479.
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Wanchai V, Jenjaroenpun P, Leangapichart T, Arrey G, Burnham CM, T?mmler MC, Delgado-Calle J, Regenberg B, Nookaew I. CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences. Brief Bioinform. 2022 11 19; 23(6). PMID: 36198068.
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Sabol HM, Amorim T, Ashby C, Halladay D, Anderson J, Cregor M, Sweet M, Nookaew I, Kurihara N, Roodman GD, Bellido T, Delgado-Calle J. Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction. Neoplasia. 2022 06; 28:100785. PMID: 35390742.
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Delgado-Calle J, McAndrews K, Wu G, Orr AL, Ferrari A, Tu X, Srinivasan V, Roodman GD, Ebetino FH, Boeckman RK, Bellido T. The Notch pathway regulates the bone gain induced by PTH anabolic signaling. FASEB J. 2022 03; 36(3):e22196. PMID: 35137455.
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Chen J, Cuevas PL, Dworan JS, Dawid I, Turkkahraman H, Tran K, Delgado-Calle J, Bellido T, Gorski JP, Liu B, Brunski JB, Helms JA. Wnt/?-catenin Signaling Controls Maxillofacial Hyperostosis. J Dent Res. 2022 07; 101(7):793-801. PMID: 35114849.
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Sabol HM, Ferrari AJ, Adhikari M, Amorim T, McAndrews K, Anderson J, Vigolo M, Lehal R, Cregor M, Khan S, Cuevas PL, Helms JA, Kurihara N, Srinivasan V, Ebetino FH, Boeckman RK, Roodman GD, Bellido T, Delgado-Calle J. Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity. Cancer Res. 2021 10 01; 81(19):5102-5114. PMID: 34348968.
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Delgado-Calle J, Bellido T. The osteocyte as a signaling cell. Physiol Rev. 2022 01 01; 102(1):379-410. PMID: 34337974.
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Sabol HM, Delgado-Calle J. The multifunctional role of Notch signaling in multiple myeloma. J Cancer Metastasis Treat. 2021; 7. PMID: 34778567.
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Adhikari M, Delgado-Calle J. Role of Osteocytes in Cancer Progression in the Bone and the Associated Skeletal Disease. Curr Osteoporos Rep. 2021 06; 19(3):247-255. PMID: 33818732.
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Chen J, Yuan X, Pilawski I, Liu X, Delgado-Calle J, Bellido T, Turkkahraman H, Helms JA. Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion. J Dent Res. 2021 03; 100(3):310-317. PMID: 33078679.
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Mulcrone PL, Edwards SKE, Petrusca DN, Haneline LS, Delgado-Calle J, Roodman GD. Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23. Sci Rep. 2020 10 14; 10(1):17319. PMID: 33057033.
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Miyagawa K, Ohata Y, Delgado-Calle J, Teramachi J, Zhou H, Dempster DD, Subler MA, Windle JJ, Chirgwin JM, Roodman GD, Kurihara N. Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo. JCI Insight. 2020 03 26; 5(6). PMID: 32078587.
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Bellido T, Delgado-Calle J. Ex Vivo Organ Cultures as Models to Study Bone Biology. JBMR Plus. 2020 Mar; 4(3). PMID: 32161838.
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Delgado-Calle J, Kurihara N, Atkinson EG, Nelson J, Miyagawa K, Galmarini CM, Roodman GD, Bellido T. Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts. Oncotarget. 2019 Apr 12; 10(28):2709-2721. PMID: 31105871.
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Fern?ndez AF, Bay?n GF, Urdinguio RG, Tora?o EG, Garc?a MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, Garc?a-Castro J, Delgado-Calle J, P?rez-Campo FM, Riancho JA, Bueno C, Men?ndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nistic? L, Stazi MA, Fraga MF. Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Res. 2019 04; 29(4):710.2. PMID: 30936177.
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Atkinson EG, Delgado-Calle J. The Emerging Role of Osteocytes in Cancer in Bone. JBMR Plus. 2019 Mar; 3(3):e10186. PMID: 30918922.
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Marino S, Bishop RT, de Ridder D, Delgado-Calle J, Reagan MR. 2D and 3D In Vitro Co-Culture for Cancer and Bone Cell Interaction Studies. Methods Mol Biol. 2019; 1914:71-98. PMID: 30729461.
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Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB J. 2018 05; 32(5):2878-2890. PMID: 29401593.
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McDonald MM, Delgado-Calle J. Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease. Curr Osteoporos Rep. 2017 12; 15(6):532-541. PMID: 28956252.
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Delgado-Calle J, Anderson J, Cregor MD, Condon KW, Kuhstoss SA, Plotkin LI, Bellido T, Roodman GD. Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth. Leukemia. 2017 12; 31(12):2686-2694. PMID: 28529307.
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Delgado-Calle J, Bellido T. New Insights Into the Local and Systemic Functions of Sclerostin: Regulation of Quiescent Bone Lining Cells and Beige Adipogenesis in Peripheral Fat Depots. J Bone Miner Res. 2017 05; 32(5):889-891. PMID: 28370281.
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Delgado-Calle J. Osteoclasts Control Lipid Secretion to Regulate Breast Cancer Bone Metastasis. Endocrinology. 2017 03 01; 158(3):458-460. PMID: 28430916.
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Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini GG, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T. Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor. J Bone Miner Res. 2017 Mar; 32(3):522-535. PMID: 27704638.
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Delgado-Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone. 2017 03; 96:29-37. PMID: 27742498.
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Tora?o EG, Bay?n GF, Del Real ?, Sierra MI, Garc?a MG, Carella A, Belmonte T, Urdinguio RG, Cubillo I, Garc?a-Castro J, Delgado-Calle J, P?rez-Campo FM, Riancho JA, Fraga MF, Fern?ndez AF. Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells. J Transl Med. 2016 07 08; 14(1):207. PMID: 27393146.
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Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. J Bone Miner Res. 2016 10; 31(10):1791-1802. PMID: 27163932.
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P?rez-Campo FM, May T, Zauers J, Sa?udo C, Delgado-Calle J, Arozamena J, Berciano MT, Lafarga M, Riancho JA. Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies. J Bone Miner Metab. 2017 Mar; 35(2):150-160. PMID: 27038990.
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Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. Cancer Res. 2016 Mar 01; 76(5):1089-100. PMID: 26833121.
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Delgado-Calle J, Bellido T. Osteocytes and Skeletal Pathophysiology. Curr Mol Biol Rep. 2015 Dec; 1(4):157-167. PMID: 26693137.
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Tu X, Delgado-Calle J, Condon KW, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr DB, Plotkin LI, Bellido T. Osteocytes mediate the anabolic actions of canonical Wnt/?-catenin signaling in bone. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E478-86. PMID: 25605937.
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Delgado-Calle J, Bellido T, Roodman GD. Role of osteocytes in multiple myeloma bone disease. Curr Opin Support Palliat Care. 2014 Dec; 8(4):407-13. PMID: 25289928.
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Garmilla-Ezquerra P, Sa?udo C, Delgado-Calle J, P?rez-Nu?ez MI, Sumillera M, Riancho JA. Analysis of the bone microRNome in osteoporotic fractures. Calcif Tissue Int. 2015 Jan; 96(1):30-7. PMID: 25432767.
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Fern?ndez AF, Bay?n GF, Urdinguio RG, Tora?o EG, Garc?a MG, Carella A, Petrus-Reurer S, Ferrero C, Martinez-Camblor P, Cubillo I, Garc?a-Castro J, Delgado-Calle J, P?rez-Campo FM, Riancho JA, Bueno C, Men?ndez P, Mentink A, Mareschi K, Claire F, Fagnani C, Medda E, Toccaceli V, Brescianini S, Moran S, Esteller M, Stolzing A, de Boer J, Nistic? L, Stazi MA, Fraga MF. H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. Genome Res. 2015 Jan; 25(1):27-40. PMID: 25271306.
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P?rez-Campo FM, Sa?udo C, Delgado-Calle J, Arozamena J, Zarrabeitia MT, Riancho JA. A Sclerostin super-producer cell line derived from the human cell line SaOS-2: a new tool for the study of the molecular mechanisms driving Sclerostin expression. Calcif Tissue Int. 2014 Aug; 95(2):194-9. PMID: 24913258.
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Ben-awadh AN, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T. Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology. 2014 Aug; 155(8):2797-809. PMID: 24877630.
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Delgado-Calle J, Riancho JA, Klein-Nulend J. Nitric oxide is involved in the down-regulation of SOST expression induced by mechanical loading. Calcif Tissue Int. 2014 Apr; 94(4):414-22. PMID: 24322886.
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Garc?a-Ibarbia C, Delgado-Calle J, Casafont I, Velasco J, Arozamena J, P?rez-N??ez MI, Alonso MA, Berciano MT, Ortiz F, P?rez-Castrill?n JL, Fern?ndez AF, Fraga MF, Zarrabeitia MT, Riancho JA. Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders. Gene. 2013 Dec 15; 532(2):165-72. PMID: 24096177.
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Delgado-Calle J, Arozamena J, P?rez-L?pez J, Bolado-Carrancio A, Sa?udo C, Agudo G, de la Vega R, Alonso MA, Rodr?guez-Rey JC, Riancho JA. Role of BMPs in the regulation of sclerostin as revealed by an epigenetic modifier of human bone cells. Mol Cell Endocrinol. 2013 Apr 30; 369(1-2):27-34. PMID: 23415712.
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Delgado-Calle J, Fern?ndez AF, Sainz J, Zarrabeitia MT, Sa?udo C, Garc?a-Renedo R, P?rez-N??ez MI, Garc?a-Ibarbia C, Fraga MF, Riancho JA. Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheum. 2013 Jan; 65(1):197-205. PMID: 23124911.
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Delgado-Calle J, Riancho JA. The role of DNA methylation in common skeletal disorders. Biology (Basel). 2012 Nov 22; 1(3):698-713. PMID: 24832515.
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Garc?a-Renedo RJ, Carranza-Bencano A, Delgado-Calle J, N??ez-Samper M, Llanos-Alc?zar LF. [Disruption of anterointernal weight bearing: sequelae of surgical treatment of hallux valgus]. Acta Ortop Mex. 2012 Nov-Dec; 26(6):393-7. PMID: 24712209.
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Delgado-Calle J, Garmilla P, Riancho JA. Do epigenetic marks govern bone mass and homeostasis? Curr Genomics. 2012 May; 13(3):252-63. PMID: 23115526.
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Delgado-Calle J, Sa?udo C, Bolado A, Fern?ndez AF, Arozamena J, Pascual-Carra MA, Rodriguez-Rey JC, Fraga MF, Bonewald L, Riancho JA. DNA methylation contributes to the regulation of sclerostin expression in human osteocytes. J Bone Miner Res. 2012 Apr; 27(4):926-37. PMID: 22162201.
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Delgado-Calle J, Sa?udo C, Fern?ndez AF, Garc?a-Renedo R, Fraga MF, Riancho JA. Role of DNA methylation in the regulation of the RANKL-OPG system in human bone. Epigenetics. 2012 Jan 01; 7(1):83-91. PMID: 22207352.
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Delgado-Calle J, Arozamena J, Garc?a-Renedo R, Garc?a-Ibarbia C, Pascual-Carra MA, Gonz?lez-Mac?as J, Riancho JA. Osteocyte deficiency in hip fractures. Calcif Tissue Int. 2011 Oct; 89(4):327-34. PMID: 21874545.
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Riancho JA, Delgado-Calle J. [Osteoblast-osteoclast interaction mechanisms]. Reumatol Clin. 2011 Sep; 7 Suppl 2:S1-4. PMID: 21924211.
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Delgado-Calle J, Sa?udo C, S?nchez-Verde L, Garc?a-Renedo RJ, Arozamena J, Riancho JA. Epigenetic regulation of alkaline phosphatase in human cells of the osteoblastic lineage. Bone. 2011 Oct; 49(4):830-8. PMID: 21700004.
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C?rcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fern?ndez-Rueda J, Pennington DJ, Trigueros C. Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk. J Bone Miner Res. 2010 Oct; 25(10):2115-25. PMID: 20499359.
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C?rcamo-Orive I, Tejados N, Delgado J, Gaztelumendi A, Otaegui D, Lang V, Trigueros C. ERK2 protein regulates the proliferation of human mesenchymal stem cells without affecting their mobilization and differentiation potential. Exp Cell Res. 2008 May 01; 314(8):1777-88. PMID: 18378228.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2008 | 1 | 2010 | 1 | 2011 | 3 | 2012 | 5 | 2013 | 4 | 2014 | 5 | 2015 | 2 | 2016 | 6 | 2017 | 4 | 2018 | 1 | 2019 | 4 | 2020 | 4 | 2021 | 4 | 2022 | 4 | 2023 | 5 | 2024 | 6 |
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